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    • 4. 发明授权
    • Assay for the measurement of neuronal degradation and uses thereof
    • 测定神经元降解的测定及其用途
    • US6096302A
    • 2000-08-01
    • US725876
    • 1996-10-04
    • Eric R. KandelMary E. BachMin Zhuo
    • Eric R. KandelMary E. BachMin Zhuo
    • G01N33/50G01N33/567C12N5/06
    • G01N33/5091
    • The present invention provides a method to determine the extent of neuronal degradation due to aging, a learning disability, or a neurological disorder, which includes: (a) stimulating a neuronal cell population under suitable conditions so as to induce a late-phase long term potentiation; (b) stimulating a normal neuronal cell population under suitable conditions so as to induce a late-phase long term potentiation; and (c) comparing the duration of the late-phase long term potentiation of the neuronal cell population in step (a) with that of the normal neuronal cell population of step (b) so as to determine the extent of neuronal degradation due to aging, the learning disability or the neurological disorder. The learning disability or neurological disorder may be Alzheimer's Disease, a degenerative disorder associated with learning, memory or cognitive dysfunction, cerebral senility, multi-infarct dementia and senile dementia, electric shock induced amnesia or amnesia.
    • 本发明提供了一种确定由于老化,学习障碍或神经障碍引起的神经元退化程度的方法,其包括:(a)在合适的条件下刺激神经元细胞群,以诱导晚期长期 增强; (b)在合适的条件下刺激正常的神经细胞群,以诱导晚期的长期增强; 和(c)比较步骤(a)中神经元细胞群体的后期长期增强的持续时间与步骤(b)的正常神经元细胞群体的持续时间,以确定由于老化引起的神经元降解程度 ,学习障碍或神经障碍。 学习障碍或神经障碍可能是阿尔茨海默病,与学习,记忆或认知功能障碍,脑衰老,多发性梗死性痴呆和老年痴呆,电击诱发的遗忘症或遗忘症相关的退行性疾病。