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1. 发明授权

US08975227B2 Intraoral dosage forms of glucagon 有权
标题翻译：胰高血糖素的口服剂型
公开(公告)号：US08975227B2
公开(公告)日：2015-03-10
申请号：US11994032
申请日：2006-07-17
申请人： Nai Fang Wang , Puchun Liu , Steven Dinh , Michael M. Goldberg , Ehud Arbit
发明人： Nai Fang Wang , Puchun Liu , Steven Dinh , Michael M. Goldberg , Ehud Arbit
IPC分类号： A61K38/26 , C07K14/605
CPC分类号： A61K38/26 , C07K14/605
摘要： The present invention provides a composition (e.g., a pharmaceutical composition) comprising at least one delivery agent compound and glucagon. Preferably, the composition includes a therapeutically effective amount of glucagon and the delivery agent compound. The composition of the present invention facilitates the delivery of glucagon and increases its bioavailability compared to administration without the delivery agent compound.
摘要翻译：本发明提供包含至少一种递送剂化合物和胰高血糖素的组合物（例如，药物组合物）。优选地，组合物包含治疗有效量的胰高血糖素和递送剂化合物。本发明的组合物有助于胰高血糖素的递送，并且与不含递送剂化合物的给药相比，其生物利用度增加。

2. 发明申请

US20080207514A1 Intraoral Dosage Forms of Glucagon 有权
标题翻译：胰高血糖素的口服剂量形式
公开(公告)号：US20080207514A1
公开(公告)日：2008-08-28
申请号：US11994032
申请日：2006-07-17
申请人： Nai Fang Wang , Puchun Liu , Steven Dinh , Michael M. Goldberg , Ehud Arbit
发明人： Nai Fang Wang , Puchun Liu , Steven Dinh , Michael M. Goldberg , Ehud Arbit
IPC分类号： A61K38/26 , A61P3/10
CPC分类号： A61K38/26 , C07K14/605
摘要： The present invention provides a composition (e.g., a pharmaceutical composition) comprising at least one delivery agent compound and glucagon. Preferably, the composition includes a therapeutically effective amount of glucagon and the delivery agent compound. The composition of the present invention facilitates the delivery of glucagon and increases its bioavailability compared to administration without the delivery agent compound.
摘要翻译：本发明提供包含至少一种递送剂化合物和胰高血糖素的组合物（例如药物组合物）。优选地，组合物包含治疗有效量的胰高血糖素和递送剂化合物。本发明的组合物有助于胰高血糖素的递送，并且与不含递送剂化合物的给药相比，其生物利用度增加。

3. 发明申请

US20100055194A1 PHARMACEUTICAL FORMULATIONS CONTAINING MICROPARTICLES OR NANOPARTICLES OF A DELIVERY AGENT 审中-公开
标题翻译：包含递送剂的微量元素或纳米颗粒的药物制剂
公开(公告)号：US20100055194A1
公开(公告)日：2010-03-04
申请号：US12550281
申请日：2009-08-28
申请人： Shingai Majuru , Puchun Liu , Steven Dinh , Jun Liao , Jongbin Lee , Ehud Arbit , Nikhil Dhoot , Halina Levchik , George Klein , Jamila Harris , Nai Fang Wang
发明人： Shingai Majuru , Puchun Liu , Steven Dinh , Jun Liao , Jongbin Lee , Ehud Arbit , Nikhil Dhoot , Halina Levchik , George Klein , Jamila Harris , Nai Fang Wang
IPC分类号： A61K9/14
CPC分类号： A61K47/12 , A61K9/145 , A61K9/1617 , A61K9/2013 , A61K9/2027 , A61K9/2077 , A61K9/2081 , A61K9/2846 , A61K9/4858 , A61K38/28
摘要： This invention relates to microparticles and/or nanoparticles containing a delivery agent and/or an active agent. This invention also relates to pharmaceutical formulations and solid dosage forms, including controlled release solid dosage forms of active agent and a delivery agent.
摘要翻译：本发明涉及含有递送剂和/或活性剂的微粒和/或纳米颗粒。本发明还涉及药物制剂和固体剂型，包括活性剂的控释固体剂型和递送剂。

4. 发明申请

US20120189666A1 PHARMACEUTICAL FORMULATIONS CONTAINING MICROPARTICLES OR NANOPARTICLES OF A DELIVERY AGENT 审中-公开
标题翻译：包含递送剂的微量元素或纳米颗粒的药物制剂
公开(公告)号：US20120189666A1
公开(公告)日：2012-07-26
申请号：US13303756
申请日：2011-11-23
申请人： Nikhil Dhoot , Halina Levchik , Shingai Majuru , George Klein , Jamila Harris , Puchun Liu , Steven Dinh , Jun Liao , Jongbin Lee , Ehud Arbit , Nai Fang Wang
发明人： Nikhil Dhoot , Halina Levchik , Shingai Majuru , George Klein , Jamila Harris , Puchun Liu , Steven Dinh , Jun Liao , Jongbin Lee , Ehud Arbit , Nai Fang Wang
IPC分类号： A61K9/00 , A61P19/08 , A61K38/23 , A61K47/38 , A61K47/12 , A61K31/727
CPC分类号： A61K47/12 , A61K9/145 , A61K9/1617 , A61K9/2013 , A61K9/2027 , A61K9/2077 , A61K9/2081 , A61K9/2846 , A61K9/4858 , A61K38/28
摘要： This invention relates to microparticles and/or nanoparticles containing a delivery agent and/or an active agent. This invention also relates to pharmaceutical formulations and solid dosage forms, including controlled release solid dosage forms of active agent and a delivery agent.
摘要翻译：本发明涉及含有递送剂和/或活性剂的微粒和/或纳米颗粒。本发明还涉及药物制剂和固体剂型，包括活性剂的控释固体剂型和递送剂。

5. 发明申请

US20090209635A1 TOPICAL CROMOLYN FORMULATIONS 有权
标题翻译：主题CROMOLYN制剂
公开(公告)号：US20090209635A1
公开(公告)日：2009-08-20
申请号：US11569285
申请日：2005-05-19
申请人： Puchun Liu , Steven Dinh , Ehud Arbit , Michael M. Goldberg
发明人： Puchun Liu , Steven Dinh , Ehud Arbit , Michael M. Goldberg
IPC分类号： A61K31/352
CPC分类号： A61K31/609 , A61K9/0014 , A61K9/06 , A61K47/10 , A61K47/183
摘要： The present invention provides a topical composition comprising (a) at least one delivery agent compound and (b) a cromoglycic acid compound. Methods of treatment, and methods of preparing the topical composition are also provided.
摘要翻译：本发明提供一种局部组合物，其包含（a）至少一种递送剂化合物和（b）色甘酸化合物。还提供了治疗方法和制备局部组合物的方法。

6. 发明授权

US09498487B2 Topical cromolyn formulations 有权
标题翻译：局部色甘酸配方
公开(公告)号：US09498487B2
公开(公告)日：2016-11-22
申请号：US11569285
申请日：2005-05-19
申请人： Puchun Liu , Steven Dinh , Ehud Arbit , Michael M. Goldberg
发明人： Puchun Liu , Steven Dinh , Ehud Arbit , Michael M. Goldberg
IPC分类号： A61K31/352 , A61K31/609 , A61K9/00 , A61K9/06 , A61K47/10 , A61K47/18
CPC分类号： A61K31/609 , A61K9/0014 , A61K9/06 , A61K47/10 , A61K47/183
摘要： The present invention provides a topical composition comprising (a) at least one delivery agent compound and (b) a cromoglycic acid compound. Methods of treatment, and methods of preparing the topical composition are also provided.
摘要翻译：本发明提供一种局部组合物，其包含（a）至少一种递送剂化合物和（b）色甘酸化合物。还提供了治疗方法和制备局部组合物的方法。

7. 发明申请

US20060078623A1 Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent 审中-公开
标题翻译：含有递送剂的微粒或纳米颗粒的药物制剂
公开(公告)号：US20060078623A1
公开(公告)日：2006-04-13
申请号：US11204778
申请日：2005-08-15
申请人： Nikhil Dhoot , Halina Levchik , Shingai Majuru , George Klein , Jamila Harris , Puchun Liu , Steven Dinh , Jun Liao , Jongbin Lee , Ehud Arbit , Nai Wang
发明人： Nikhil Dhoot , Halina Levchik , Shingai Majuru , George Klein , Jamila Harris , Puchun Liu , Steven Dinh , Jun Liao , Jongbin Lee , Ehud Arbit , Nai Wang
IPC分类号： A61K9/50 , A61K9/16 , A61K9/14
CPC分类号： A61K47/12 , A61K9/145 , A61K9/1617 , A61K9/2013 , A61K9/2027 , A61K9/2077 , A61K9/2081 , A61K9/2846 , A61K9/4858 , A61K38/28
摘要： This invention relates to microparticles and/or nanoparticles containing a delivery agent and/or an active agent. This invention also relates to pharmaceutical formulations and solid dosage forms, including controlled release solid dosage forms of active agent and a delivery agent.
摘要翻译：本发明涉及含有递送剂和/或活性剂的微粒和/或纳米颗粒。本发明还涉及药物制剂和固体剂型，包括活性剂的控释固体剂型和递送剂。

8. 发明申请

US20060234913A1 Oral insulin therapy 有权
标题翻译：口服胰岛素治疗
公开(公告)号：US20060234913A1
公开(公告)日：2006-10-19
申请号：US10500822
申请日：2003-01-07
申请人： Ehud Arbit , Richat Abbas , Michael Goldberg , T. Woods , Steven Dinh , Vivien Wong
发明人： Ehud Arbit , Richat Abbas , Michael Goldberg , T. Woods , Steven Dinh , Vivien Wong
IPC分类号： A61K38/28 , A61K31/195
CPC分类号： A61K47/18 , A61K9/2013 , A61K9/4858 , A61K38/28 , A61K2300/00
摘要： Pharmaceutical dosage forms for oral administration to a patient for the treatment of diabetes, comprising insulin and a delivery agent that facilitates insulin transport in a therapeutically effective amount to the bloodstream and that result in a lower incidence of vascular diseases associated with the repeated administration of insulin are disclosed. Also disclosed is a method of attenuating the undesirable incidence of diseases associated with chronic dosing of insulin is provided whereby the oral administration to a patient of insulin along with a suitable delivery agent that facilitates the absorption of insulin from the gastrointestinal tract of the patient in a therapeutically effective amount, for treatment of diabetes.
摘要翻译：用于口服给予患者用于治疗糖尿病的药物剂型，其包含胰岛素和促进胰岛素以治疗有效量转运至血液并导致与重复施用胰岛素相关的血管疾病的较低发生率的递送剂被披露。还公开了一种减轻与慢性给药胰岛素相关的疾病的不期望的发病率的方法，其中通过口服给予胰岛素患者以及促进从患者的胃肠道吸收胰岛素的合适的递送剂治疗有效量，用于治疗糖尿病。

9. 发明授权

US07429564B2 Oral insulin therapy 有权
标题翻译：口服胰岛素治疗
公开(公告)号：US07429564B2
公开(公告)日：2008-09-30
申请号：US10500822
申请日：2003-01-07
申请人： Ehud Arbit , Richat Abbas , Michael Goldberg , T. Cooper Woods , Steven Dinh , Vivien Wong
发明人： Ehud Arbit , Richat Abbas , Michael Goldberg , T. Cooper Woods , Steven Dinh , Vivien Wong
IPC分类号： A61K38/28
CPC分类号： A61K47/18 , A61K9/2013 , A61K9/4858 , A61K38/28 , A61K2300/00
摘要： Pharmaceutical dosage forms for oral administration to a patient for the treatment of diabetes, comprising insulin and a delivery agent that facilitates insulin transport in a therapeutically effective amount to the bloodstream and that result in a lower incidence of vascular diseases associated with the repeated administration of insulin are disclosed. Also disclosed is a method of attenuating the undesirable incidence of diseases associated with chronic dosing of insulin is provided whereby the oral administration to a patient of insulin along with a suitable delivery agent that facilitates the absorption of insulin from the gastrointestinal tract of the patient in a therapeutically effective amount, for treatment of diabetes.
摘要翻译：用于口服给予患者用于治疗糖尿病的药物剂型，其包含胰岛素和促进胰岛素以治疗有效量转运至血液并导致与重复施用胰岛素相关的血管疾病的较低发生率的递送剂被披露。还公开了一种减轻与慢性给药胰岛素相关的疾病的不期望的发病率的方法，其中通过口服给予胰岛素患者以及促进从患者的胃肠道吸收胰岛素的合适的递送剂治疗有效量，用于治疗糖尿病。

10. 发明申请

US20100048454A1 Antidiabetic oral insulin-biguanide combination 审中-公开
标题翻译：抗糖尿病口服胰岛素双胍组合
公开(公告)号：US20100048454A1
公开(公告)日：2010-02-25
申请号：US11632808
申请日：2005-08-03
申请人： Ehud Arbit , Steven Dinh , Michael Goldberg
发明人： Ehud Arbit , Steven Dinh , Michael Goldberg
IPC分类号： A61K38/28 , A61P3/10
CPC分类号： A61K38/28 , A61K31/155 , A61K2300/00
摘要： Pharmaceutical dosage forms, comprising insulin, a delivery agent that facilitates insulin transport in a therapeutically effective amount to the bloodstream and a biguanide, such as metformin, are disclosed for oral administration to a patient for the treatment of diabetes. Also disclosed are methods for achieving improved glucose tolerance and glycemic control in a diabetic mammal without any statistically significant increase in weight, risk of hypoglycemia or hyperinsulinemia, and the need for monitoring blood glucose concentrations or HbAlc levels, and methods for reducing the incidence and/or severity of one or more disease states associated with chronic dosing of insulin; for prophylactically sparing (3-cell function or for preventing (3-cell death or dysfunction in a mammal with impaired glucose tolerance or early stage diabetes mellitus; and for long-term protection from developing (or delaying the onset of) overt or insulin dependent diabetes in a mammal with impaired glucose tolerance or early stage diabetes.
摘要翻译：公开了包括胰岛素，促进胰岛素以治疗有效量转运至血液的递送剂和双胍，例如二甲双胍的药物剂型，用于口服给患者治疗糖尿病。还公开了用于在糖尿病哺乳动物中实现改善的葡萄糖耐量和血糖控制的方法，而没有任何统计学显着的重量增加，低血糖或高胰岛素血症的风险，以及监测血糖浓度或HbAlc水平的需要，以及用于降低发生率和/ 或与慢性给药胰岛素相关的一种或多种疾病状态的严重程度; 用于预防性保护（3细胞功能或用于预防（葡萄糖耐量降低或早期糖尿病）的哺乳动物中的3细胞死亡或功能障碍;以及用于长期保护以发展（或延迟发作）明显或胰岛素依赖性具有葡萄糖耐量降低或早期糖尿病的哺乳动物的糖尿病。

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