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1. 发明授权

US08180126B2 Detecting meniscal tears in non-invasive scans 有权
标题翻译：在非侵入性扫描中检测半月板撕裂
公开(公告)号：US08180126B2
公开(公告)日：2012-05-15
申请号：US12190584
申请日：2008-08-12
申请人： Nabile Safdar , Bharath Ramakrishna , Chein-I Chang , Wei-min Liu , Khan Siddiqui , Eliot Siegel
发明人： Nabile Safdar , Bharath Ramakrishna , Chein-I Chang , Wei-min Liu , Khan Siddiqui , Eliot Siegel
IPC分类号： G06K9/00
CPC分类号： A61B5/103 , A61B5/055 , A61B5/4514 , A61B5/4528 , A61B6/03 , G06T7/0012 , G06T7/11 , G06T7/136 , G06T2200/24 , G06T2207/10081 , G06T2207/10088 , G06T2207/20132 , G06T2207/30004
摘要： Techniques for automatically detecting meniscus include receiving pixels from a scanning device directed to a knee of a subject. Also received is a region of interest that includes pixels that correspond to at least a portion of a meniscus of the knee. Without human intervention, a meniscus extraction threshold is determined based on pixel intensities in the region of interest. A meniscus object portion of the scan data is further determined without human intervention based on the meniscus extraction threshold and a geometrical constraint. Other techniques for automatically detecting meniscal tears includes receiving a meniscus object portion of scan data from a scanning device and receiving threshold data that indicates a meniscus extraction threshold. Without human intervention, a propensity for meniscal tears is determined based on the threshold data and the meniscus object portion of the scan data.
摘要翻译：用于自动检测弯液面的技术包括从指向对象的膝盖的扫描装置接收像素。还接收的是包括对应于膝盖的弯液面的至少一部分的像素的感兴趣区域。在没有人为干预的情况下，基于感兴趣区域中的像素强度来确定弯液面提取阈值。基于弯月面提取阈值和几何约束，进一步确定扫描数据的弯液面物体部分，而无需人为干预。用于自动检测半月板眼泪的其它技术包括从扫描装置接收扫描数据的弯月面物体部分，以及接收指示弯月面提取阈值的阈值数据。在没有人为干预的情况下，根据扫描数据的阈值数据和弯月面对象部分来确定半月板撕裂的倾向。

2. 发明申请

US20090046908A1 Detecting Meniscal Tears in Non-Invasive Scans 有权
标题翻译：检测非侵入性扫描中的半月眼泪
公开(公告)号：US20090046908A1
公开(公告)日：2009-02-19
申请号：US12190584
申请日：2008-08-12
申请人： Nabile Safdar , Bharath Ramakrishna , Chein-I Chang , Wei-min Liu , Khan Siddiqui , Eliot Siegel
发明人： Nabile Safdar , Bharath Ramakrishna , Chein-I Chang , Wei-min Liu , Khan Siddiqui , Eliot Siegel
IPC分类号： A61B5/00
CPC分类号： A61B5/103 , A61B5/055 , A61B5/4514 , A61B5/4528 , A61B6/03 , G06T7/0012 , G06T7/11 , G06T7/136 , G06T2200/24 , G06T2207/10081 , G06T2207/10088 , G06T2207/20132 , G06T2207/30004
摘要： Techniques for automatically detecting meniscus include receiving pixels from a scanning device directed to a knee of a subject. Also received is a region of interest that includes pixels that correspond to at least a portion of a meniscus of the knee. Without human intervention, a meniscus extraction threshold is determined based on pixel intensities in the region of interest. A meniscus object portion of the scan data is further determined without human intervention based on the meniscus extraction threshold and a geometrical constraint.Other techniques for automatically detecting meniscal tears includes receiving a meniscus object portion of scan data from a scanning device and receiving threshold data that indicates a meniscus extraction threshold. Without human intervention, a propensity for meniscal tears is determined based on the threshold data and the meniscus object portion of the scan data.
摘要翻译：用于自动检测弯液面的技术包括从指向对象的膝盖的扫描装置接收像素。还接收的是包括对应于膝盖的弯液面的至少一部分的像素的感兴趣区域。在没有人为干预的情况下，基于感兴趣区域中的像素强度来确定弯液面提取阈值。基于弯月面提取阈值和几何约束，进一步确定扫描数据的弯液面物体部分，而无需人为干预。用于自动检测半月板眼泪的其它技术包括从扫描装置接收扫描数据的弯月面物体部分，以及接收指示弯月面提取阈值的阈值数据。在没有人为干预的情况下，根据扫描数据的阈值数据和弯月面对象部分来确定半月板撕裂的倾向。

3. 发明申请

US20130040831A1 Predicting Response to Anti-CD40 Therapy in DLBCL Patients 有权
标题翻译：预测DLBCL患者抗CD40治疗的反应
公开(公告)号：US20130040831A1
公开(公告)日：2013-02-14
申请号：US13205469
申请日：2011-08-08
申请人： Wei-min Liu , Yan Li , Chih-Jian Lih , Yu Chuan Tai
发明人： Wei-min Liu , Yan Li , Chih-Jian Lih , Yu Chuan Tai
IPC分类号： C40B30/04 , C40B40/10 , C40B40/06
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/57407 , G01N2800/52
摘要： This invention provides methods, compositions, and kits relating to biomarkers whose expression levels are correlated with diffuse large B-cell lymphoma (DLCBL) patients' response to treatment with a CD20 antagonist, such as a CD20 antibody, exemplified by rituximab. The methods, compositions, and kits of the invention can be used to identify DLBCL patients who are likely or not likely, to respond to anti-CD20 treatments.
摘要翻译：本发明提供了与生物标志物相关的方法，组合物和试剂盒，其表达水平与弥漫性大B细胞淋巴瘤（DLCBL）患者对用CD20拮抗剂（例如由利妥昔单抗列举的CD20抗体）治疗的反应相关。本发明的方法，组合物和试剂盒可用于鉴定可能或不可能对抗CD20治疗作出反应的DLBCL患者。

4. 发明申请

US20120009177A1 GENE EXPRESSION MARKERS FOR PREDICTING RESPONSE TO INTERLEUKIN-6 RECEPTOR-INHIBITING MONOCLONAL ANTIBODY DRUG TREATMENT 审中-公开
标题翻译：基因表达标记物预测对白细胞介素-6受体抑制性单克隆抗体药物治疗的反应
公开(公告)号：US20120009177A1
公开(公告)日：2012-01-12
申请号：US13154158
申请日：2011-06-06
申请人： Adam Platt , Jianmei Wang , Guiyuan Lei , Laurent Essioux , Wei-min Liu , P. Mickey Williams
发明人： Adam Platt , Jianmei Wang , Guiyuan Lei , Laurent Essioux , Wei-min Liu , P. Mickey Williams
IPC分类号： A61K39/395 , A61P37/02 , C40B40/06 , C12Q1/68 , C40B30/04
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N2800/102 , G01N2800/56
摘要： This invention provides methods, compositions, and kits relating to gene product biomarkers where gene expression levels are correlated with therapeutic response of rheumatoid arthritis patients to treatment with an IL-6 receptor antagonist, such as an IL6-R antibody. The methods, compositions, and kits of the invention can be used to identify rheumatoid arthritis patients who are likely, or not likely, to respond to IL-6 receptor antagonist treatments.
摘要翻译：本发明提供了与基因产物生物标志物相关的方法，组合物和试剂盒，其中基因表达水平与类风湿性关节炎患者对用IL-6受体拮抗剂如IL6-R抗体治疗的治疗反应相关。本发明的方法，组合物和试剂盒可用于鉴定可能或不可能对IL-6受体拮抗剂治疗作出反应的类风湿性关节炎患者。

5. 发明授权

US08592156B2 Predicting response to anti-CD20 therapy in DLBCL patients 有权
标题翻译：预测DLBCL患者抗CD20治疗的反应
公开(公告)号：US08592156B2
公开(公告)日：2013-11-26
申请号：US13205469
申请日：2011-08-08
申请人： Wei-min Liu , Yan Li , Chih-Jian Lih , Yu Chuan Tai
发明人： Wei-min Liu , Yan Li , Chih-Jian Lih , Yu Chuan Tai
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/57407 , G01N2800/52
摘要： This invention provides methods, compositions, and kits relating to biomarkers whose expression levels are correlated with diffuse large B-cell lymphoma (DLCBL) patients' response to treatment with a CD20 antagonist, such as a CD20 antibody, exemplified by rituximab. The methods, compositions, and kits of the invention can be used to identify DLBCL patients who are likely or not likely, to respond to anti-CD20 treatments.
摘要翻译：本发明提供了与生物标志物相关的方法，组合物和试剂盒，其表达水平与弥漫性大B细胞淋巴瘤（DLCBL）患者对用CD20拮抗剂（例如由利妥昔单抗列举的CD20抗体）治疗的反应相关。本发明的方法，组合物和试剂盒可用于鉴定可能或不可能对抗CD20治疗作出反应的DLBCL患者。

6. 发明申请

US20060154273A1 System and Computer Software Products for Comparative Gene Expression Analysis 审中-公开
标题翻译：用于比较基因表达分析的系统和计算机软件产品
公开(公告)号：US20060154273A1
公开(公告)日：2006-07-13
申请号：US11277219
申请日：2006-03-22
申请人： Wei-min Liu , Xiaojun Di
发明人： Wei-min Liu , Xiaojun Di
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G16B25/00
摘要： Methods and computer software products are provided for analyzing gene expression data. In one embodiment, methods, systems and computer software are provided for comparative gene expression analysis using intensity dependent normalization factors.
摘要翻译：提供方法和计算机软件产品，用于分析基因表达数据。在一个实施例中，提供方法，系统和计算机软件用于使用强度依赖的归一化因子的比较基因表达分析。

7. 发明申请

US20050234653A1 Systems and computer software products for gene expression analysis 审中-公开
标题翻译：用于基因表达分析的系统和计算机软件产品
公开(公告)号：US20050234653A1
公开(公告)日：2005-10-20
申请号：US11166497
申请日：2005-06-24
申请人： Wei-min Liu , Rui Mei , Thomas Ryder
发明人： Wei-min Liu , Rui Mei , Thomas Ryder
IPC分类号： C12N15/09 , C12Q1/68 , G01N33/48 , G01N33/50 , G06F17/30 , G06F19/20 , G06F19/24 , G06F19/00
CPC分类号： G16B25/00 , G16B40/00
摘要： Methods and computer software products are provided for analyzing gene expression data. In one embodiment, non-parametric statistics is used to determine whether a transcript is detected in a sample.
摘要翻译：提供方法和计算机软件产品，用于分析基因表达数据。在一个实施例中，使用非参数统计来确定在样本中是否检测到转录物。

8. 发明授权

US08463590B2 Algorithms for classification of disease subtypes and for prognosis with gene expression profiling 有权
标题翻译：疾病亚型分类和基因表达谱分析的预测算法
公开(公告)号：US08463590B2
公开(公告)日：2013-06-11
申请号：US12578417
申请日：2009-10-13
申请人： Wei-min Liu
发明人： Wei-min Liu
IPC分类号： G06F9/455
CPC分类号： G06F19/20 , G06F19/24
摘要： Methods for generating a normalized expression signal for microarray data based on a theoretical distribution at the unit level to produce a normalized expression signal for the single microarray that is independent of other microarrays. The method typically includes receiving microarray data representing a plurality of probe pairs for a single microarray, determining, for each probe pair, differences between intensities of perfect match (PM) probes and intensities of mismatched (MM) probes, determining a difference signal, D, based on the determined differences, and scaling the difference signal, D, to produce an expression signal, DS. The method also typically includes normalizing the expression signal based on a theoretical distribution at the unit level to produce a normalized expression signal for the single microarray that is independent of other microarrays.
摘要翻译：基于单位级别的理论分布产生用于微阵列数据的归一化表达式信号以产生独立于其他微阵列的单个微阵列的归一化表达式信号的方法。该方法通常包括接收表示用于单个微阵列的多个探针对的微阵列数据，为每个探针对确定完美匹配（PM）探针的强度和不匹配（MM）探针的强度之间的差异，确定差异信号D 基于所确定的差异，并且缩放差分信号D以产生表达信号DS。该方法还通常包括基于在单位水平的理论分布来归一化表达信号，以产生独立于其他微阵列的单个微阵列的归一化表达信号。

9. 发明授权

US07197400B2 System and computer software products for comparative gene expression analysis 有权
标题翻译：用于比较基因表达分析的系统和计算机软件产品
公开(公告)号：US07197400B2
公开(公告)日：2007-03-27
申请号：US09735574
申请日：2000-12-12
申请人： Wei-min Liu , Xiaojun Di
发明人： Wei-min Liu , Xiaojun Di
IPC分类号： G01N33/48
CPC分类号： G06F19/20
摘要： Methods and computer software products are provided for analyzing gene expression data. In one embodiment, methods, systems and computer software are provided for comparative gene expression analysis using intensity dependent normalization factors.
摘要翻译：提供方法和计算机软件产品，用于分析基因表达数据。在一个实施例中，提供方法，系统和计算机软件用于使用强度依赖的归一化因子的比较基因表达分析。

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