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    • 5. 发明申请
    • INJECTABLE VACCINE COMPOSITION
    • 可注射的疫苗组合物
    • US20160287697A1
    • 2016-10-06
    • US14916807
    • 2014-10-02
    • NITTO DENKO CORPORATION
    • Kyohei MATSUSHITAMasahiro FUKASAKAArimichi OKAZAKIEiji KIYOTOHKatsuyuki OKUBODaisuke ASARIMitsuhiko HORI
    • A61K39/39A61K9/00
    • A61K39/39A61K9/0019A61K39/00A61K2039/55572
    • The present invention aims at providing an injectable vaccine composition that is safe, useful as a prophylactic or therapeutic agent for cancers or infectious diseases, and capable of inducing the systemic immune response safely and effectively. The present invention is an injectable vaccine composition to be administered by injection to a human being or an animal, containing: at least one antigen, and as an adjuvant, a lipopolysaccharide derived from at least one gram negative bacterium selected from the group consisting of Serratia, Leclercia, Rahnella, Acidicaldus, Acidiphilium, Acidisphaera, Acidocella, Acidomonas, Asaia, Belnapia, Craurococcus, Gluconacetobacter, Gluconobacter, Kozakia, Leahibacter, Muricoccus, Neoasaia, Oleomonas, Paracraurococcus, Rhodopila, Roseococcus, Rubritepida, Saccharibacter, Stella, Swaminathania, Teichococcus, Zavarzinia, Pseudomonas, Achromobacter, Bacillus, Methanoculleus, Methanosarcina, Clostridium, Micrococcus, Flavobacterium, Pantoea, Acetobacter, Zymomonas, Xanthomonas, and Enterobacter, or a salt thereof.
    • 本发明的目的在于提供一种安全有效的可用作癌症或感染性疾病的预防或治疗剂并且能够安全有效地诱导全身免疫应答的可注射疫苗组合物。 本发明是通过注射给人或动物施用的可注射疫苗组合物,其包含至少一种抗原和佐剂,衍生自至少一种革兰氏阴性细菌的脂多糖,所述至少一种阴性细菌选自沙雷氏菌属 ,Leclercia,Rahnella,Acidicaldus,Acidiphilium,Acidisphaera,Acidocella,Acidomonas,Asaia,Belnapia,Craurococcus,Gluconacetobacter,Gluconobacter,Kozakia,Leahibacter,Muricoccus,Neoasaia,Oleomonas,Paracraurococcus,Rhodopila,Roseococcus,Rubritepida,Saccharibacter,Stella,Swaminathania,Teichococcus ,Zavarzinia,假单胞菌属,无色杆菌属,芽孢杆菌属,甲烷球菌属,甲烷球菌属,梭菌属,微球菌属,黄杆菌属,泛菌属,醋杆菌属,发酵单胞菌属,黄单胞菌属,肠杆菌属或其盐。