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1. 发明申请

US20160235345A1 PROBE, SYSTEM, AND METHOD FOR NON-INVASIVE MEASUREMENT OF BLOOD ANALYTES 审中-公开
标题翻译：探针，系统和方法用于血液分析仪的非入血测量
公开(公告)号：US20160235345A1
公开(公告)日：2016-08-18
申请号：US15026312
申请日：2014-10-01
申请人： NEDERLANDSE ORGANISATIE VOOR TOEGEPAST- NATUURWETENSCHAPPELIJK ONDERZOEK TNO
发明人： Daniel Perez Calero , James Peter Robert Day , Jacobus Thomas Wilhelmus Elisabeth Vogels , Maarten J. Scholtes-Timmerman , Jacobus Johannes Frederik van Veen
IPC分类号： A61B5/1455 , A61B5/145
摘要： The present disclosure concerns a measuring probe (10) for non-invasive in vivo measurement of blood analytes (33) by Raman spectroscopy. The measuring probe (10) comprises a housing (20) having a skin engaging surface (21). The housing (20) comprises a first optical system (1, 3, 4) arranged for providing source light (11) to the skin engaging surface (21) for penetrating a subject's skin (31) by said source light (11) for interacting with the blood analytes (33). The housing (20) further comprises a second optical system (5, 6, 2) arranged for capturing scattered Raman light (12) from the blood analytes (33) for measurement of the blood analytes (33). The first optical system (1, 3, 4) is arranged for providing the source light (11) as a collimated beam (1c) onto the skin (31).
摘要翻译：本公开涉及用于通过拉曼光谱学非血管分析物（33）的非侵入式体内测量的测量探针（10）。测量探针（10）包括具有皮肤接合表面（21）的壳体（20）。壳体（20）包括第一光学系统（1,3,4），其被设置用于向皮肤接合表面（21）提供源光（11），用于通过所述源光（11）穿透受试者的皮肤（31）以进行相互作用与血液分析物（33）。壳体（20）还包括布置成用于从血液分析物（33）捕获散射的拉曼光（12）以测量血液分析物（33）的第二光学系统（5,6）。第一光学系统（1,3,4）布置成将源光（11）作为准直光束（1c）提供到皮肤（31）上。

2. 发明授权

US10478106B2 Probe, system, and method for non-invasive measurement of blood analytes 有权
公开(公告)号：US10478106B2
公开(公告)日：2019-11-19
申请号：US15026312
申请日：2014-10-01
申请人： Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO
发明人： Daniel Perez Calero , James Peter Robert Day , Jacobus Thomas Wilhelmus Elisabeth Vogels , Maarten J. Scholtes-Timmerman , Jacobus Johannes Frederik van Veen
IPC分类号： A61B5/1455 , A61B5/00 , A61B5/145 , G01N21/65 , A61B90/30
摘要： The present disclosure concerns a measuring probe (10) for non-invasive in vivo measurement of blood analytes (33) by Raman spectroscopy. The measuring probe (10) comprises a housing (20) having a skin engaging surface (21). The housing (20) comprises a first optical system (1, 3, 4) arranged for providing source light (11) to the skin engaging surface (21) for penetrating a subject's skin (31) by said source light (11) for interacting with the blood analytes (33). The housing (20) further comprises a second optical system (5, 6, 2) arranged for capturing scattered Raman light (12) from the blood analytes (33) for measurement of the blood analytes (33). The first optical system (1, 3, 4) is arranged for providing the source light (11) as a collimated beam (1c) onto the skin (31).

3. 发明申请

US20150168306A1 FLUID ANALYSIS WITH LIBS 审中-公开
标题翻译：流体分析与LIBS
公开(公告)号：US20150168306A1
公开(公告)日：2015-06-18
申请号：US14412580
申请日：2013-07-04
申请人： Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO
发明人： Jacobus Johannes Frederik van Veen , Jorg Roosma
IPC分类号： G01N21/71
CPC分类号： G01N21/718
摘要： Method for detecting one or more elements of the periodic system of elements, in particular one or more metal ions, in a fluid using LASER induced breakdown spectroscopy (LIBS), the method comprising (a) contacting a sample of the fluid with a surface comprising chelating groups bound to a surface of a solid element-extraction product the chelating group having specific binding affinity for one or more elements to be detected; (b) allowing said one or one or more elements present in the fluid to chelate with the chelating groups; (c) removing the fluid from the solid element-extraction product whilst the one or more elements chelated to the chelating groups remain chelated; thereafter (d) using the solid element-extraction product for a detection specimen, whilst the chelated element or elements remain chelated; (e) and subjecting the detection specimen to LIBS, under conditions that allow detection of the one or more elements chelated to the chelating groups.
摘要翻译：用于使用LASER诱导的击穿光谱法（LIBS）在流体中检测元件的周期性系统的一个或多个元素特别是一种或多种金属离子的方法，所述方法包括（a）使流体的样品与包含螯合基团与固体元素提取产物的表面结合，所述螯合基团对待检测的一种或多种元件具有特异性结合亲合力; （b）允许存在于流体中的所述一种或多种元素与螯合基团螯合; （c）从螯合基团螯合的一个或多个元素保持螯合，从固体元素提取产物中除去流体; 此后（d）使用固体元素提取产物作为检测样本，同时螯合元素保持螯合; （e），并且在允许检测螯合基团的一种或多种元件的条件下，将检测标本经受LIBS。

4. 发明授权

US09664662B2 Means and methods for classifying eggs as organic 有权
公开(公告)号：US09664662B2
公开(公告)日：2017-05-30
申请号：US14154420
申请日：2014-01-14
申请人： Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO
发明人： Jacobus Johannes Frederik van Veen , Ivana Bobeldijk-Pastorova
IPC分类号： C07C35/16 , G01N33/08
CPC分类号： G01N33/08
摘要： Methods are provided for determining whether a chicken egg, or a chicken egg pool, belongs to a class of organic chicken eggs. The yolk scyllo-inositol and myo-inositol concentrations, or concentration-related signals or values, are measured and the ratio between the scyllo-inositol concentration or concentration-related signal or value and the myo-inositol concentration or concentration-related signal or value is determined.

5. 发明申请

US20140199701A1 MEANS AND METHODS FOR CLASSIFYING EGGS 有权
标题翻译：用于分类蛋的手段和方法
公开(公告)号：US20140199701A1
公开(公告)日：2014-07-17
申请号：US14154420
申请日：2014-01-14
申请人： Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO
发明人： Jacobus Johannes Frederik van Veen , Ivana Bobeldijk-Pastorova
IPC分类号： G01N33/08 , C12Q1/68
CPC分类号： G01N33/08
摘要： The invention provides novel markers for classifying the housing systems of eggs. Classification methods as well as kits of parts using these novel markers are also herewith provided.
摘要翻译：本发明提供了用于对鸡蛋的壳体系统进行分类的新型标记。还提供了分类方法以及使用这些新型标记物的试剂盒。

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