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1. 发明授权

US10662216B2 Nucleoside derivative or salt thereof, polynucleotide synthesis reagent, method for producing polynucleotide, polynucleotide, and method for producing binding nucleic acid molecule 有权
公开(公告)号：US10662216B2
公开(公告)日：2020-05-26
申请号：US16333333
申请日：2017-09-14
申请人： NEC Solution Innovators, Ltd. , NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY
发明人： Hirotaka Minagawa , Katsunori Horii , Jou Akitomi , Naoto Kaneko , Iwao Waga , Masayasu Kuwahara
IPC分类号： C07H19/02 , C07H19/04 , C07H19/14 , C07H19/20 , C07H21/02 , C07H21/04 , C12N15/115 , C07K16/00
摘要： The present invention provides a novel nucleoside derivative or a salt thereof, a polynucleotide synthesis reagent, a method for producing a polynucleotide, a polynucleotide, and a method for producing a binding nucleic acid molecule. The nucleoside derivative or a salt thereof of the present invention is represented by the following chemical formula (1): where in the chemical formula (1), Su is an atomic group having a sugar skeleton at a nucleoside residue or an atomic group having a sugar phosphate skeleton at a nucleotide residue, and may or may not have a protecting group, L1 and L2 are each independently a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms, X1 and X2 are each independently an imino group (—NR1—), an ether group (—O—), or a thioether group (—S—), and the R1 is a hydrogen atom or a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms.

2. 发明授权

US10611791B2 Nucleoside derivative or salt thereof, polynucleotide synthesis reagent, method for producing polynucleotide, polynucleotide, and method for producing binding nucleic acid molecule 有权
公开(公告)号：US10611791B2
公开(公告)日：2020-04-07
申请号：US16333325
申请日：2017-09-14
申请人： NEC Solution Innovators, Ltd. , NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY
发明人： Hirotaka Minagawa , Katsunori Horii , Jou Akitomi , Naoto Kaneko , Iwao Waga , Masayasu Kuwahara
IPC分类号： C07H19/10 , C07H19/067 , C07H19/073 , C07K16/00 , C12N15/115 , C07H21/00
CPC分类号： C07H19/10 , C07H19/073 , C07H21/00 , C07K16/00 , C12N15/115 , Y02P20/55
摘要： The present invention provides a novel nucleoside derivative or a salt thereof, a polynucleotide synthesis reagent, a method for producing a polynucleotide, a polynucleotide, and a method for producing a binding nucleic acid molecule.
The nucleoside derivative or a salt thereof of the present invention is represented by the following chemical formula (1):

where in the chemical formula (1), Su is an atomic group having a sugar skeleton at a nucleoside residue or an atomic group having a sugar phosphate skeleton at a nucleotide residue, and may or may not have a protecting group, L1 and L2 are each independently a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms, X1 and X2 are each independently an imino group (—NR1—), an ether group (—O—), or a thioether group (—S—), and the R1 is a hydrogen atom or a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms.

3. 发明授权

US10760084B2 α-amylase-binding nucleic acid molecule and use thereof 有权
公开(公告)号：US10760084B2
公开(公告)日：2020-09-01
申请号：US15775797
申请日：2016-09-12
申请人： NEC Solution Innovators, Ltd. , Gunma University
发明人： Hirotaka Minagawa , Katsunori Horii , Jou Akitomi , Naoto Kaneko , Ikuo Shiratori , Iwao Waga , Masayasu Kuwahara
IPC分类号： C12N15/11 , C12N15/115 , C12Q1/40 , C12Q1/68 , G01N33/53 , C12N15/10
摘要： The present invention provides a novel nucleic acid molecule that can be used for detection of α-amylase. The α-amylase-binding nucleic acid molecule of the present invention is characterized in that it binds to α-amylase with a dissociation constant of 17 nM or less, and preferably includes a polynucleotide consisting of any of base sequences of SEQ ID NOs: 1 to 22, for example. According to the nucleic acid molecule of the present invention, it is possible to detect α-amylase in saliva.

4. 发明授权

US10781230B2 Nucleoside derivative or salt thereof, polynucleotide synthesis reagent, method for producing polynucleotide, polynucleotide, and method for producing binding nucleic acid molecule 有权
公开(公告)号：US10781230B2
公开(公告)日：2020-09-22
申请号：US16333333
申请日：2017-09-14
申请人： NEC Solution Innovators, Ltd. , NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY
发明人： Hirotaka Minagawa , Katsunori Horii , Jou Akitomi , Naoto Kaneko , Iwao Waga , Masayasu Kuwahara
IPC分类号： C07H19/02 , C07H19/04 , C07H19/14 , C07H19/20 , C07H21/02 , C07H21/04 , C12N15/115 , C07K16/00
摘要： The present invention provides a novel nucleoside derivative or a salt thereof, a polynucleotide synthesis reagent, a method for producing a polynucleotide, a polynucleotide, and a method for producing a binding nucleic acid molecule. The nucleoside derivative or a salt thereof of the present invention is represented by the following chemical formula (1): where in the chemical formula (1), Su is an atomic group having a sugar skeleton at a nucleoside residue or an atomic group having a sugar phosphate skeleton at a nucleotide residue, and may or may not have a protecting group, L1 and L2 are each independently a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms, X1 and X2 are each independently an imino group (—NR1—), an ether group (—O—), or a thioether group (—S—), and the R1 is a hydrogen atom or a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms.

5. 发明授权

US10618928B2 Nucleoside derivative or salt thereof, polynucleotide synthesis reagent, method for producing polynucleotide, polynucleotide, and method for producing binding nucleic acid molecule 有权
公开(公告)号：US10618928B2
公开(公告)日：2020-04-14
申请号：US16333333
申请日：2017-09-14
申请人： NEC Solution Innovators, Ltd. , NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY
发明人： Hirotaka Minagawa , Katsunori Horii , Jou Akitomi , Naoto Kaneko , Iwao Waga , Masayasu Kuwahara
IPC分类号： C07H19/02 , C07H19/04 , C07H19/14 , C07H19/20 , C07H21/02 , C07H21/04 , C12N15/115 , C07K16/00
摘要： The present invention provides a novel nucleoside derivative or a salt thereof, a polynucleotide synthesis reagent, a method for producing a polynucleotide, a polynucleotide, and a method for producing a binding nucleic acid molecule. The nucleoside derivative or a salt thereof of the present invention is represented by the following chemical formula (1): where in the chemical formula (1), Su is an atomic group having a sugar skeleton at a nucleoside residue or an atomic group having a sugar phosphate skeleton at a nucleotide residue, and may or may not have a protecting group, L1 and L2 are each independently a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms, X1 and X2 are each independently an imino group (—NR1—), an ether group (—O—), or a thioether group (—S—), and the R1 is a hydrogen atom or a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms.

6. 发明授权

US11643660B2 Nucleoside derivative or salt thereof, polynucleotide synthesis reagent, method for producing polynucleotide, polynucleotide, and method for producing binding nucleic acid molecule 有权
公开(公告)号：US11643660B2
公开(公告)日：2023-05-09
申请号：US16464057
申请日：2017-10-12
申请人： NEC Solution Innovators, Ltd. , National University Corporation Gunma University
发明人： Hirotaka Minagawa , Katsunori Horii , Jou Akitomi , Naoto Kaneko , Iwao Waga , Masayasu Kuwahara
IPC分类号： C07H19/10 , C07H19/20 , C12N15/115 , C12N15/10 , C07H1/00 , C07H21/00 , C07H21/04 , C07H21/02
CPC分类号： C12N15/115 , C07H1/00 , C07H19/20 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/1048
摘要： The present invention provides a novel nucleoside derivative or a salt thereof, a polynucleotide synthesis reagent, a method for producing a polynucleotide, a polynucleotide, and a method for producing a binding nucleic acid molecule. The nucleoside derivative or a salt thereof of the present invention is represented by the following chemical formula (1).

In the chemical formula (1), Su is an atomic group having a sugar skeleton at a nucleoside residue or an atomic group having a sugar phosphate skeleton at a nucleotide residue, and may or may not have a protecting group, L1 and L2 are each independently a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms, X1 is an imino group (—NR1—), an ether group (—O—), or a thioether group (—S—), and R1 is a hydrogen atom or a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms.

7. 发明授权

US11236342B2 Secretory immunoglobulin a (sIgA)-binding nucleic acid molecule, sIgA analysis sensor, and sIgA analysis method 有权
公开(公告)号：US11236342B2
公开(公告)日：2022-02-01
申请号：US16333293
申请日：2017-04-20
申请人： NEC Solution Innovators, Ltd. , NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY
发明人： Hirotaka Minagawa , Katsunori Horii , Jou Akitomi , Naoto Kaneko , Iwao Waga , Masayasu Kuwahara
IPC分类号： C12N15/115 , C12Q1/68 , G01N33/53 , C12N15/09
摘要： The present invention provides a novel molecule that can be used for detection of sIgA. The sIgA-binding nucleic acid molecule of the present invention is characterized in that it binds to secretory immunoglobulin A (sIgA) with a dissociation constant of 37.7 nM or less, and preferably includes a polynucleotide consisting of any of base sequences of SEQ ID NOs: 1 to 12 or a partial sequence thereof, for example. According to the sIgA-binding nucleic acid molecule of the present invention, it is possible to detect sIgA in saliva.

8. 发明授权

US09797888B2 Nucleic acid element candidate molecule and screening method for screening for nucleic acid element for target analysis using the same 有权
公开(公告)号：US09797888B2
公开(公告)日：2017-10-24
申请号：US14770520
申请日：2014-02-17
申请人： NEC Solution Innovators, Ltd.
发明人： Jou Akitomi , Naoto Kaneko , Katsunori Horii
IPC分类号： G01N33/53 , C12Q1/68
CPC分类号： G01N33/5308 , C12Q1/6816 , C12Q2521/337 , C12Q2521/345
摘要： The present invention provides a novel nucleic acid element candidate molecule for use in screening for a nucleic acid element for target analysis and a novel screening method for screening for a nucleic acid element for target analysis using the same. The candidate molecule according to the present invention is a molecule for screening for a nucleic acid element for target analysis, being the following single-stranded nucleic acid (I): (I) a single-stranded nucleic acid comprising a catalyst sequence (D), a blocking sequence (B), and a binding sequence (A) that binds to a target, linked in this order. The blocking sequence (B) is complementary to a partial region (Dp) in the catalyst sequence (D). A terminal region (Ab) on the blocking sequence (B) side in the binding sequence (A) is complementary to a flanking region (Df) of the partial region (Dp) in the catalyst sequence (D) and is complementary to a terminal region (Af) on the side opposite to the blocking sequence (B) side in the binding sequence (A).

9. 发明申请

US20150167106A1 NUCLEIC ACID MOLECULE THAT BINDS TO INFLUENZA VIRUSES AND USE THEREOF 审中-公开
标题翻译：含有流感病毒的核酸分子及其用途
公开(公告)号：US20150167106A1
公开(公告)日：2015-06-18
申请号：US14405026
申请日：2013-04-25
申请人： NEC Solution Innovators, Ltd.
发明人： Ikuo Shiratori , Jou Akitomi , Katsunori Horii , Makio Furuichi , Iwao Waga
IPC分类号： C12Q1/70
CPC分类号： C12Q1/701 , C12N15/115 , C12N2310/16 , C12Q2600/112
摘要： The present invention provides a nucleic acid molecule applicable to detection of influenza virus. The nucleic acid molecule according to the present invention is a nucleic acid molecule that binds to an influenza virus, including at least one polynucleotide selected from the group consisting of the following polynucleotides (a) to (d): (a) a polynucleotide that has any of base sequences of SEQ ID NOs: 1 to 30; (b) a polynucleotide that has a base sequence obtained by deletion, substitution, insertion, and/or addition of one or more bases in any of the base sequences of the polynucleotide (a) and binds to the influenza virus; (c) a polynucleotide that has a base sequence with an identity of at least 80% to any of the base sequences of the polynucleotide (a) and binds to the influenza virus; and (d) a polynucleotide that has a base sequence complementary to a polynucleotide hybridizing to any of the base sequences of the polynucleotide (a) under stringent conditions and binds to the influenza virus.
摘要翻译：本发明提供了适用于检测流感病毒的核酸分子。根据本发明的核酸分子是结合流感病毒的核酸分子，包括至少一种选自以下多核苷酸的多核苷酸（a）至（d）：（a）具有 SEQ ID NO：1至30的任何碱基序列; （b）具有通过在多核苷酸（a）的任何碱基序列中缺失，取代，插入和/或添加一个或多个碱基并与流感病毒结合而获得的碱基序列的多核苷酸; （c）具有与多核苷酸（a）的任何碱基序列具有至少80％同一性的碱基序列并与流感病毒结合的多核苷酸; 和（d）具有与在严格条件下与多核苷酸（a）的任何碱基序列杂交的多核苷酸互补的碱基序列并与流感病毒结合的多核苷酸。

10. 发明授权

US10900045B2 Protein, novel gene, expression vector, transformant, method for producing transformant, and method for screening for novel fluorescent protein 有权
公开(公告)号：US10900045B2
公开(公告)日：2021-01-26
申请号：US15737517
申请日：2016-06-13
申请人： NEC Solution Innovators, Ltd.
发明人： Ikuo Shiratori , Akihisa Shimizu , Katsunori Horii , Hiroshi Mishima , Iwao Waga
IPC分类号： C12N15/82 , C12N15/09 , C12N5/10 , C07K14/435 , A01H1/04
摘要： The present invention provides a novel fluorescent protein.
A novel protein includes the following protein (F1): (F1) a protein consisting of an amino acid sequence of SEQ ID NO: 1, wherein in the amino acid sequence of SEQ ID NO: 1, a 52nd amino acid Xaa52 is an arbitrary amino acid, a 133rd amino acid Xaa133 is an arbitrary amino acid, and a 154th amino acid Xaa154 is an arbitrary amino acid.

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