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1. 发明申请

US20230044111A1 MARGIN ASSESSMENT METHOD 有权
公开(公告)号：US20230044111A1
公开(公告)日：2023-02-09
申请号：US17505709
申请日：2021-10-20
申请人： NATIONAL TAIWAN UNIVERSITY
发明人： CHI-KUANG SUN , YI-HUA LIAO , CHIA-I CHEN
IPC分类号： G02B21/36 , G06T7/00 , G02B21/00 , G06N3/04
摘要： A margin assessment method is provided. Under cooperation of harmonic generation microscopy (HGM) and a deep learning method, the margin assessment method can instantaneously and digitally determine whether a 3D image group generated by an HGM imaging system is a malignant tumor or the surrounding normal skin, so as to assist in determining margins of a lesion.

2. 发明公开

US20230228666A1 DETECTION DEVICE AND DETECTION METHOD FOR DISTINGUISHING TYPES OF PARTICLES IN AQUEOUS SOLUTION 审中-公开
公开(公告)号：US20230228666A1
公开(公告)日：2023-07-20
申请号：US17830294
申请日：2022-06-01
申请人： NATIONAL TAIWAN UNIVERSITY
发明人： CHI-KUANG SUN , PENG-JUI WANG
IPC分类号： G01N15/10
CPC分类号： G01N15/10
摘要： A detection device and a detection method for distinguishing types of particles in an aqueous solution are provided. The detection device includes a detection chip, a signal source and a processing device. The detection chip includes a substrate, a coplanar waveguide transmission line and a super-hydrophobic film mask. When a to-be-detected aqueous solution that contains to-be-detected particles is provided on the detection chip, the super-hydrophobic film mask of the detection chip can confine the to-be-detected aqueous solution in a detection area. The processing device controls the signal source to provide detection microwave signals with different detection frequencies, simultaneously measures a first output signal and a second output signal at the different detection frequencies to generate a to-be-detected absorption spectrum, and compares the to-be-detected absorption spectrum with historical absorption spectra, so as to determine types of the to-be-detected particles.

3. 发明公开

US20240118453A1 MESOSCALE NONLINEAR OPTICAL GIGASCOPE SYSTEM WITH REAL-TIME GIGAPIXEL MOSAIC-STITCHING AND DIGITAL DISPLAY 审中-公开
公开(公告)号：US20240118453A1
公开(公告)日：2024-04-11
申请号：US17963201
申请日：2022-10-11
申请人： NATIONAL TAIWAN UNIVERSITY
发明人： CHI-KUANG SUN , Bhaskar Jyoti Borah
IPC分类号： G02B1/00
CPC分类号： G02B1/002
摘要： A mesoscale nonlinear optical gigascope (mNLOG) system is provided to assist with rapid gigapixel resonant-raster laser-scanning and post-processing-free digital display of a centimeter-scale biological specimen in real-time. The mNLOG system enables a half-a-micron digital resolution with satisfied Nyquist-Shannon criterion while providing an aliasing-free optically-sectioned cumulative point-scanning area ranging from 1 square millimeter (mm) up-to 400 square mm. The mNLOG system is configured to perform a rapid artifact-compensated two-dimensional large-field mosaic-stitching (rac2D-LMS) process, so as to provide post-processing-free gigapixel mosaic-stitching and real-time digital display with a sustained effective data throughput of at least 500 Megabits per second (Mbps).

4. 发明公开

US20240032999A1 METHOD AND APPARATUS FOR NON-INVASIVE IMAGE-OBSERVING DENSITY OF INTRA-EPIDERMAL NERVE FIBER OF HUMAN SKIN 审中-公开
公开(公告)号：US20240032999A1
公开(公告)日：2024-02-01
申请号：US17815571
申请日：2022-07-28
申请人： NATIONAL TAIWAN UNIVERSITY
发明人： CHI-KUANG SUN , PEI-JHE WU , HSIAO-CHIEH TSENG
IPC分类号： A61B18/20 , A61N5/06
CPC分类号： A61B18/203 , A61N5/0616 , A61B2018/00452
摘要： The present invention relates to a method and apparatus for non-invasive image-observing the density of an intra-epidermal nerve fiber of human skin, in which the method includes: providing a nonlinear optical microscopy device for capturing an intra-epidermal nerve fiber structural image of an acquisition area of a to-be-tested human skin to observe continuous signals of intra-epidermal nerve fiber images, wherein the nonlinear optical microscopy device includes: a laser light source for emitting laser light with a pulsed laser, and an image processing member for processing image signals; focusing the laser light on the intra-epidermal nerve fiber to obtain nerve signals of the intra-epidermal nerve fiber that have a length of at least three points of the intra-epidermal nerve fiber, and constitute a plurality of nerve fibers; and calculating the total number of nerve fiber signals of the to-be-tested human skin, and dividing it by the total area of captured images to obtain the density of the to-be-tested human body; and evaluating and determining whether the human suffers from related neuropathy. such as peripheral neuropathy.

5. 发明申请

US20150157254A1 METHOD FOR DIAGNOSING SKIN DISEASE BASED ON IN VIVO SKIN IMAGING 审中-公开
标题翻译：基于皮肤成像诊断皮肤病的方法
公开(公告)号：US20150157254A1
公开(公告)日：2015-06-11
申请号：US14164144
申请日：2014-01-25
申请人： NATIONAL TAIWAN UNIVERSITY
发明人： CHI-KUANG SUN , YI-HUA LIAO , MING-RUNG TSAI
IPC分类号： A61B5/00
CPC分类号： A61B5/444 , A61B5/0064 , A61B5/7282 , A61B2576/02
摘要： A method for examining skin tissue of a subject based upon in vivo skin imaging includes a harmonic generation microscopy (HGM) device. The HGM device is configured for observing the skin tissue and forming sectioned images of the skin tissue of second harmonic generation (SHG), third harmonic generation (THG), or combination of the SHG and the THG of an excitation light scanning the skin tissue. The method further includes a step to determine whether the morphological feature of the skin tissue is related to a skin disease.
摘要翻译：基于体内皮肤成像检查对象的皮肤组织的方法包括谐波生成显微术（HGM）装置。 HGM装置被配置为观察皮肤组织并形成二次谐波发生（SHG），三次谐波发生（THG）的皮肤组织或扫描皮肤组织的激发光的SHG和THG的组合的分割图像。该方法还包括确定皮肤组织的形态学特征是否与皮肤疾病相关的步骤。

6. 发明公开

US20230153953A1 DATA PROCESSING METHOD FOR RAPIDLY SUPPRESSING HIGH-FREQUENCY BACKGROUND NOISE IN A DIGITIZED IMAGE 审中-公开
公开(公告)号：US20230153953A1
公开(公告)日：2023-05-18
申请号：US17688902
申请日：2022-03-08
申请人： NATIONAL TAIWAN UNIVERSITY
发明人： CHI-KUANG SUN , Bhaskar Jyoti Borah
IPC分类号： G06T5/00 , G06T3/40 , G06T5/20 , G06T5/50
CPC分类号： G06T5/002 , G06T3/4007 , G06T5/20 , G06T5/50 , G06T5/003 , G06T2207/20224
摘要： A data processing method for rapidly suppressing background high frequency noise in a digitized image. The data processing method includes configuring a graphical processing unit to perform a first amplification process, a pixel binning process or a first interpolation process, a first low-pass filtering process, a second interpolation process, a first subtraction process, a second low-pass filtering process, a second amplification process, and a second subtraction process on an input image, so as to subtract a subtraction mask from the input image and generate a noise-suppressed output image.

7. 发明申请

US20230094096A1 PROTECTIVE ASSEMBLY AND IMAGING EQUIPMENT SET 有权
公开(公告)号：US20230094096A1
公开(公告)日：2023-03-30
申请号：US17563313
申请日：2021-12-28
申请人： NATIONAL TAIWAN UNIVERSITY
发明人： CHI-KUANG SUN , PEI-JHE WU , YING-TING HUANG , HSIAO-CHIEH TSENG
IPC分类号： G02B7/02
摘要： A protective assembly and an imaging equipment set are provided. The protective assembly is used to accommodate an imaging lens, and includes a housing, a transparent partition, and an adhesive member. The housing includes a tube body segment and a bottom segment that is connected to the tube body segment. A curved portion is formed on a periphery of the bottom segment, and an accommodating space is defined by the housing. The imaging lens is movably disposed in the accommodating space. An inner side of the curved portion has an inclined surface that is configured to abut against a shell of the imaging lens. The transparent partition is disposed on the bottom segment of the housing. The adhesive member has an outer surface that is sticky and an inner surface that is fixed onto a bottom surface of the housing.

8. 发明申请

US20160228048A1 METHOD OF QUANTIFYING MELANIN MASS DENSITY IN VIVO 审中-公开
标题翻译：在体细胞中量化MELANIN质量密度的方法
公开(公告)号：US20160228048A1
公开(公告)日：2016-08-11
申请号：US14614532
申请日：2015-02-05
申请人： NATIONAL TAIWAN UNIVERSITY
发明人： CHI-KUANG SUN , WEI-MIN LIU
IPC分类号： A61B5/00 , A61B5/1455
CPC分类号： A61B5/443 , A61B5/0077
摘要： A method of quantifying melanin includes receiving at a data processor optical data produced by an optical sensor which receives a light from a tissue; determining a set of intensity values based on the optical data; for each intensity value, converting the intensity value to a quantifying value corresponding to quantity of melanin in the tissue based on a two-dimensional non-linear regression with one variable representing the intensity value and another variable representing the quantity of melanin; collecting at the data processor each quantifying value; generating at the data processor melanin quantity distribution data according to the quantifying values; and outputting the melanin quantity distribution data to be presented on a medium.
摘要翻译：量化黑色素的方法包括在数据处理器处接收由光学传感器产生的光学数据，所述光学传感器接收来自组织的光; 基于所述光学数据确定一组强度值; 对于每个强度值，基于具有代表强度值的一个变量的二维非线性回归和代表黑色素的量的另一变量，将强度值转换为对应于组织中黑色素的量的量化值; 在数据处理器处收集每个量化值; 根据量化值在数据处理器处产生黑色素数量分布数据; 并输出要呈现在介质上的黑色素数量分布数据。

9. 发明申请

US20150268200A1 NONINVASIVE MEASURING METHOD FOR PROBING AN INTERFACE 审中-公开
标题翻译：用于探测接口的非线性测量方法
公开(公告)号：US20150268200A1
公开(公告)日：2015-09-24
申请号：US14729832
申请日：2015-06-03
申请人： NATIONAL TAIWAN UNIVERSITY
发明人： CHI-KUANG SUN , CHIEN-CHENG CHEN , YU-CHIEH WEN
IPC分类号： G01N29/44 , G01N29/30 , G01N29/24
CPC分类号： G01N29/4436 , B82Y15/00 , G01N29/2418 , G01N29/30 , G01N29/348 , G01N29/46 , G01N2291/015 , G01N2291/022 , G01N2291/023 , G01N2291/0237 , G01N2291/02818 , G01N2291/02827 , G01N2291/042
摘要： The present disclosure provides solutions to probing an interface. With a noninvasive measuring device provided in one embodiment of the disclosure, an acoustic wave whose frequency is higher than approximately 300 GHz is generated to propagate in a buffering film. With measuring the reflection from the interface of an object to be measured interfacing with the buffering film, it is possible in one embodiment of the disclosure that at least one physical property of the interface may be analyzed, preferably with approximately 0.3 nm resolution.
摘要翻译：本公开提供了探测接口的解决方案。利用在本公开的一个实施例中提供的非侵入式测量装置，产生频率高于约300GHz的声波，以在缓冲膜中传播。通过测量与缓冲膜接口的待测量物体的界面的反射，在本公开的一个实施方案中，可以分析界面的至少一个物理性质，优选以约0.3nm的分辨率进行分析。

10. 发明申请

US20150268199A1 NONINVASIVE MEASURING METHOD FOR PROBING AN INTERFACE 审中-公开
公开(公告)号：US20150268199A1
公开(公告)日：2015-09-24
申请号：US14729750
申请日：2015-06-03
申请人： NATIONAL TAIWAN UNIVERSITY
发明人： CHI-KUANG SUN , CHIEN-CHENG CHEN , YU-CHIEH WEN
IPC分类号： G01N29/44 , G01N29/30 , G01N29/24
CPC分类号： G01N29/4436 , B82Y15/00 , G01N29/2418 , G01N29/30 , G01N29/348 , G01N29/46 , G01N2291/015 , G01N2291/022 , G01N2291/023 , G01N2291/0237 , G01N2291/02818 , G01N2291/02827 , G01N2291/042
摘要： The present disclosure provides solutions to probing an interface. With a noninvasive measuring device provided in one embodiment of the disclosure, an acoustic wave whose frequency is higher than approximately 300 GHz is generated to propagate in a buffering film. With measuring the reflection from the interface of an object to be measured interfacing with the buffering film, it is possible in one embodiment of the disclosure that at least one physical property of the interface may be analyzed, preferably with approximately 0.3 nm resolution.

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