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1. 发明申请

US20090169485A1 Gene therapy and pharmaceutical composition for prevention and treatment of lung cancer 审中-公开
标题翻译：用于预防和治疗肺癌的基因治疗和药物组合物
公开(公告)号：US20090169485A1
公开(公告)日：2009-07-02
申请号：US12285867
申请日：2008-10-15
申请人： Myung-Haing Cho , Chong-su Cho
发明人： Myung-Haing Cho , Chong-su Cho
IPC分类号： A61K9/12 , A61K31/7088 , A61K38/00 , A61K9/127 , A61P35/04 , A61K9/16 , A61K35/76
CPC分类号： A61K31/7088 , A61K9/0073 , C12N15/1137 , C12N2310/14 , C12N2310/531 , C12N2320/32 , C12Y207/01037
摘要： Disclosed herein is a gene therapeutic agent and pharmaceutical composition for the prevention and treatment of lung cancer. For aerosol delivery, chemically synthesized polyester amine is used as a carrier in the gene therapeutic agent. The polyester amine/Akt1 siRNA complex is found to be effectively delivered to the lungs of K-ras null mice through a nose-only inhalation system and to significantly suppress lung cancer progression as denoted by gene delivery efficiency and inhibition of Akt-related signals and cell cycle. Thus, the aerosol delivery of polyester amine-mediated Akt1 siRNA is provided as an effective model for noninvasive gene therapy.
摘要翻译：本文公开了用于预防和治疗肺癌的基因治疗剂和药物组合物。对于气溶胶输送，化学合成的聚酯胺用作基因治疗剂中的载体。发现聚酯胺/ Akt1 siRNA复合物通过仅鼻吸入系统被有效地递送到K-ras无效小鼠的肺中，并显着抑制肺癌进展，如基因递送效率和Akt相关信号的抑制以及细胞周期。因此，提供聚酯胺介导的Akt1 siRNA的气溶胶递送作为无创基因治疗的有效模型。

2. 发明申请

US20120156686A1 Multifunctional particles providing cellular uptake and magnetic motor effect 审中-公开
标题翻译：多功能颗粒提供细胞摄取和磁力运动效应
公开(公告)号：US20120156686A1
公开(公告)日：2012-06-21
申请号：US12030863
申请日：2008-02-13
申请人： Jin-Kyu Lee , Myung-Haing Cho , Seung-Bum Park , Tae-Jong Yoon
发明人： Jin-Kyu Lee , Myung-Haing Cho , Seung-Bum Park , Tae-Jong Yoon
IPC分类号： C12Q1/00 , G01N33/50
CPC分类号： G01N33/587 , A61K49/0002 , A61K49/0041 , A61K49/0043 , A61K49/0093 , A61K49/183 , A61K49/1848 , A61K49/186 , A61K49/1875 , B82Y5/00
摘要： Preparation of novel multifunctional particles and nanomaterials having a useful combination of magnetic and optical properties and biocompatibility. The internalization efficiencies in various in vitro cell studies have been investigated, and the external magnetic motor effect on the floating cells internalized with magnetic nanoparticles were clearly observed, for the first time. The particle surfaces can be derivatized with, for example, DNA or antibodies. The system is stable, versatile, and well-controlled. Novel gene delivery can be achieved using nanoparticles as a carrier.
摘要翻译：制备具有磁性和光学性质以及生物相容性的有用组合的新型多功能颗粒和纳米材料。已经研究了各种体外细胞研究中的内在化效率，并且首次清楚地观察到磁性纳米颗粒内化的浮动细胞的外部磁电机效应。颗粒表面可以用例如DNA或抗体衍生化。系统稳定，通用性好，控制精良。使用纳米颗粒作为载体可以实现新的基因递送。

3. 发明申请

US20100081130A1 Multifunctional particles providing cellular uptake and magnetic motor effect 审中-公开
标题翻译：多功能颗粒提供细胞摄取和磁力运动效应
公开(公告)号：US20100081130A1
公开(公告)日：2010-04-01
申请号：US12030848
申请日：2008-02-13
申请人： Jin-Kyu Lee , Myung-Haing Cho , Seung-Bum Park , Tae-Jong Yoon
发明人： Jin-Kyu Lee , Myung-Haing Cho , Seung-Bum Park , Tae-Jong Yoon
IPC分类号： C12Q1/68 , C12Q1/02
CPC分类号： G01N33/587 , A61K49/0002 , A61K49/0041 , A61K49/0043 , A61K49/0093 , A61K49/183 , A61K49/1848 , A61K49/186 , A61K49/1875 , B82Y5/00
摘要： Preparation of novel multifunctional particles and nanomaterials having a useful combination of magnetic and optical properties and biocompatibility. The internalization efficiencies in various in vitro cell studies have been investigated, and the external magnetic motor effect on the floating cells internalized with magnetic nanoparticles were clearly observed, for the first time. The particle surfaces can be derivatized with, for example, DNA or antibodies. The system is stable, versatile, and well-controlled. Novel gene delivery can be achieved using nanoparticles as a carrier.
摘要翻译：制备具有磁性和光学性质以及生物相容性的有用组合的新型多功能颗粒和纳米材料。已经研究了各种体外细胞研究中的内在化效率，并且首次清楚地观察到磁性纳米颗粒内化的浮动细胞的外部磁电机效应。颗粒表面可以用例如DNA或抗体衍生化。系统稳定，通用性好，控制精良。使用纳米颗粒作为载体可以实现新的基因递送。

4. 发明授权

US08018582B2 Simultaneous detection apparatus of raman and light scattering 有权
标题翻译：拉曼和光散射的同时检测装置
公开(公告)号：US08018582B2
公开(公告)日：2011-09-13
申请号：US12442109
申请日：2007-08-30
申请人： Dae-Hong Jeong , Yoon-Sik Lee , Myung-Haing Cho , Yong-Kweon Kim
发明人： Dae-Hong Jeong , Yoon-Sik Lee , Myung-Haing Cho , Yong-Kweon Kim
IPC分类号： G01J3/44 , G01N21/47 , G01N21/64 , G01N21/65
CPC分类号： G01J3/02 , G01J3/0227 , G01J3/0291 , G01J3/44 , G01N2015/0038 , G01N2015/0092 , G01N2015/1493
摘要： Provided is a detection apparatus of Raman scattering and light scattering, and more particularly, a simultaneous detection apparatus of Raman scattering and dynamic light scattering and a detection method using the same. The simultaneous detection apparatus of Raman scattering and light scattering includes: a detection unit for applying incident light to a sample, and detecting Raman scattering in 90° or 180° geometry and light scattering in 90° or 180° geometry in order to simultaneously collect Raman scattering and light scattering; and a computer connected to the detection unit to obtain at least one of the size and distribution of particles from the detected light scattering, and to obtain information of the molecular structure from the detected Raman scattering. This apparatus may simultaneously observe the size of nano-sized or larger material and molecular information thereof, and phenomena accompanying changes in molecular environment according to material variation and changes of the material in size and distribution, and thus is very useful for studying nano materials and protein antigens and antibodies.
摘要翻译：提供了拉曼散射和光散射的检测装置，更具体地，涉及拉曼散射和动态光散射的同时检测装置以及使用该检测装置的检测方法。拉曼散射和光散射的同时检测装置包括：用于将入射光施加到样品的检测单元，并且以90°或180°几何形状检测拉曼散射并以90°或180°几何形状的光散射检测拉曼散射，以便同时收集拉曼散射和光散射; 以及连接到检测单元的计算机，以从所检测到的光散射中获得粒子的大小和分布中的至少一个，并且从检测到的拉曼散射获得分子结构的信息。该装置可以根据材料的尺寸和分布的材料变化和材料的变化同时观察纳米尺寸或更大的材料的尺寸及其分子信息，以及伴随分子环境变化的现象，因此对于研究纳米材料和蛋白质抗原和抗体。

5. 发明申请

US20100020312A1 SIMULTANEOUS DETECTION APPARATUS OF RAMAN AND LIGHT SCATTERING 有权
标题翻译：拉曼和光散射同时检测装置
公开(公告)号：US20100020312A1
公开(公告)日：2010-01-28
申请号：US12442109
申请日：2007-08-30
申请人： Dae-Hong Jeong , Yoon-Sik Lee , Myung-Haing Cho , Yong-Kweon Kim
发明人： Dae-Hong Jeong , Yoon-Sik Lee , Myung-Haing Cho , Yong-Kweon Kim
IPC分类号： G01N21/65 , G01N21/47
CPC分类号： G01J3/02 , G01J3/0227 , G01J3/0291 , G01J3/44 , G01N2015/0038 , G01N2015/0092 , G01N2015/1493
摘要： Provided is a detection apparatus of Raman scattering and light scattering, and more particularly, a simultaneous detection apparatus of Raman scattering and dynamic light scattering and a detection method using the same. The simultaneous detection apparatus of Raman scattering and light scattering includes: a detection unit for applying incident light to a sample, and detecting Raman scattering in 90° or 180° geometry and light scattering in 90° or 180° geometry in order to simultaneously collect Raman scattering and light scattering; and a computer connected to the detection unit to obtain at least one of the size and distribution of particles from the detected light scattering, and to obtain information of the molecular structure from the detected Raman scattering. This apparatus may simultaneously observe the size of nano-sized or larger material and molecular information thereof, and phenomena accompanying changes in molecular environment according to material variation and changes of the material in size and distribution, and thus is very useful for studying nano materials and protein antigens and antibodies.
摘要翻译：提供了拉曼散射和光散射的检测装置，更具体地，涉及拉曼散射和动态光散射的同时检测装置以及使用该检测装置的检测方法。拉曼散射和光散射的同时检测装置包括：用于将入射光施加到样品的检测单元，并且以90°或180°几何形状检测拉曼散射并以90°或180°几何形状的光散射检测拉曼散射，以便同时收集拉曼散射和光散射; 以及连接到检测单元的计算机，以从所检测到的光散射中获得粒子的大小和分布中的至少一个，并且从检测到的拉曼散射获得分子结构的信息。该装置可以根据材料的尺寸和分布的材料变化和材料的变化同时观察纳米尺寸或更大的材料的尺寸及其分子信息，以及伴随分子环境变化的现象，因此对于研究纳米材料和蛋白质抗原和抗体。

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