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    • 3. 发明授权
    • Rapid non-invasive optical analysis using broad bandpass spectral
processing
    • 使用宽带通光谱处理的快速无创光学分析
    • US6028311A
    • 2000-02-22
    • US137857
    • 1998-08-21
    • Lester SodicksonHoward E. GuthermannMyron J. Block
    • Lester SodicksonHoward E. GuthermannMyron J. Block
    • A61B5/00G01N21/31G01N21/35G01N21/47G01N33/487
    • G01N21/4795A61B5/0059A61B5/14532A61B5/14546A61B5/1455A61B5/6826A61B5/6838G01N21/31G01N21/359G01N2021/3137
    • The present invention provides a generally applicable apparatus and method for achieving measurements of a constituent in a sample. This is achieved by employing a detection means having a plurality of detectors responsive to radiation in a selected region of the spectrum, e.g., the infrared. In most embodiments, at least two of the detectors provide broad wavelength bandpass. If narrow bandpass sources or detectors are used, the information generated is processed in a manner similar to broadband information. The broad bandpass response of the detectors can be contrasted with the approach of classical spectrophotometry, in which the spectral response of the detectors is designed to be as narrow as feasible, and substantially narrower than the spectral features of the constituent or constituents of interest. The data is processed such that the contributions of known background constituents and scattering is eliminated prior to further processing, thereby yielding a better result in high background situations. The use of intensity processing rather than absorbance processing also allows the method and apparatus to be used in a variety of non-ideal situations.
    • 本发明提供了用于实现样品中成分的测量的通用的装置和方法。 这通过采用具有响应于所选频谱范围内的辐射的多个检测器的检测装置来实现,例如红外线。 在大多数实施例中,至少两个检测器提供宽波长带通。 如果使用窄带通源或检测器,则以与宽带信息相似的方式处理所生成的信息。 检测器的宽带通响应可以与经典分光光度法的方法形成对比,其中检测器的光谱响应设计为尽可能窄,并且基本上窄于所关注的成分或成分的光谱特征。 处理数据使得已知背景成分和散射的贡献在进一步处理之前被消除,从而在高背景情况下产生更好的结果。 强度处理而不是吸光度处理的使用也允许该方法和装置在各种非理想情况下使用。
    • 5. 发明授权
    • Non-spectrophotometric measurement of analyte concentrations and optical
properties of objects
    • 非分光光度法测量物体的分析物浓度和光学性质
    • US5434412A
    • 1995-07-18
    • US130257
    • 1993-10-01
    • Lester SodicksonMyron J. Block
    • Lester SodicksonMyron J. Block
    • G01N33/49A61B5/00A61B5/145A61B5/1455G01N21/27G01N21/31G01N21/35G01N21/47G01N21/64G01N33/487
    • A61B5/1455A61B5/14532A61B5/14546A61B5/6826A61B5/6838G01N21/31G01N21/359G01N21/4795G01N2021/3137
    • Improvements in non-invasive detection methods for glucose and other constituents of interest in a sample have been developed. The apparatus and methods of the invention provide an analog of color perception of human vision, preferably in the near infrared region, replacing spectrophotometers and narrow band sources used in other non-invasive near infrared detection methods. A plurality of detector units are used, each covering a broad and overlapping region of the detected spectrum, paralleling color perception and colorimetry. The improvements are primarily concerned with improving the signal-to-background (or noise) ratio such that the data stream is improved. These improvements use congruent sampling, comparison of different data streams from different sample portions or filter sets, using an interrogation system with sufficient speed to allow testing of arterial blood, and using a filter with a spectral structure. In some circumstances, a neural net is used for analysis, allowing the system to learn. A novel method for background discrimination is also described.
    • 已经开发了对样品中葡萄糖和其他感兴趣成分的非侵入性检测方法的改进。 本发明的装置和方法提供人类视觉的颜色感觉的模拟,优选在近红外区域,代替其它非侵入式近红外检测方法中使用的分光光度计和窄带光源。 使用多个检测器单元,每个检测器单元覆盖检测到的光谱的宽且重叠的区域,并行色彩感知和比色法。 这些改进主要涉及改善信号对背景(或噪声)比,使得数据流得到改善。 这些改进使用一致的采样,使用具有足够速度的询问系统来对来自不同采样部分或滤波器组的不同数据流进行比较,以允许测试动脉血,并使用具有光谱结构的滤波器。 在某些情况下,神经网络用于分析,允许系统学习。 还描述了用于背景辨别的新颖方法。
    • 7. 发明授权
    • Non-spectrophotometric measurement of analyte concentrations and optical
properties of objects
    • 非分光光度法测量物体的分析物浓度和光学性质
    • US5818044A
    • 1998-10-06
    • US383293
    • 1995-02-02
    • Lester SodicksonMyron J. Block
    • Lester SodicksonMyron J. Block
    • G01N33/49A61B5/00A61B5/145A61B5/1455G01N21/27G01N21/31G01N21/35G01N21/47G01N21/64G01N33/487
    • A61B5/1455A61B5/14532A61B5/14546A61B5/6826A61B5/6838G01N21/31G01N21/359G01N21/4795G01N2021/3137
    • Improvement methods and apparatus for determination of optical properties of objects have been developed. The apparatus and methods of the invention provide an analog of color perception of human vision, preferably in the near infrared region, replacing spectrophotometers and narrow band sources used in other non-invasive near infrared detection methods. A plurality of detector units are used, each covering a broad and overlapping region of the detected spectrum, paralleling color perception and colorimetry. The improvements are primarily concerned with improving the signal-to-background (or noise) ratio such that the data stream is improved. These improvements use congruent sampling, comparison of different data streams from different sample portions or filter sets, using an interrogation system with sufficient speed to allow testing of arterial blood, and using a filter with a spectral structure. In some circumstances, a neural net is used for analysis, allowing the system to learn. A novel method for background discrimination is also described.
    • 已经开发了用于确定物体光学特性的改进方法和装置。 本发明的装置和方法提供人类视觉的颜色感觉的模拟,优选在近红外区域,代替其它非侵入式近红外检测方法中使用的分光光度计和窄带光源。 使用多个检测器单元,每个检测器单元覆盖检测到的光谱的宽且重叠的区域,并行色彩感知和比色法。 这些改进主要涉及改善信号对背景(或噪声)比,使得数据流得到改善。 这些改进使用一致的采样,使用具有足够速度的询问系统来对来自不同采样部分或滤波器组的不同数据流进行比较,以允许测试动脉血,并使用具有光谱结构的滤波器。 在某些情况下,神经网络用于分析,允许系统学习。 还描述了用于背景辨别的新颖方法。
    • 10. 发明授权
    • Immunoassay system
    • 免疫测定系统
    • US6008057A
    • 1999-12-28
    • US406380
    • 1995-03-17
    • Thomas R. GlassMyron J. Block
    • Thomas R. GlassMyron J. Block
    • G01N33/542G01N33/543G01N33/557G01N33/53
    • G01N33/54373G01N33/542Y10S435/973Y10S436/80Y10S436/805
    • Disclosed is a method of assaying, in assay apparatus, for at least the ligand intended to be used to assay analyte in a sample, with which analyte the ligand will specifically bind. The method provides a product in which a ligand is labeled with a detectable tag and is immobilized on an appropriate substrate. An assay is made to measure the immobilized, labeled ligand by detecting the tag labeling the latter. The product can then be used to assay for the analyte by contacting the latter so as to form a complex. The extent and rate of specific binding of the analyte in the complex is identifiable, either by competition assay or sandwich assay as a rate of change, so the relative proportions of analyte and ligand are readily determinable.
    • 公开了一种在测定装置中至少测定用于测定样品中的分析物的配体的方法,配体将与其配体将特异性结合。 该方法提供了其中配体用可检测标签标记并固定在合适的底物上的产物。 通过检测标记后者的标签来测定固定的标记的配体。 然后可以将该产物用于通过与后者接触来测定分析物以便形成复合物。 通过竞争测定或夹心测定作为变化率,分析物在复合物中的特异性结合的程度和速率是可识别的,因此分析物和配体的相对比例容易确定。