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1. 发明申请

US20060151185A1 Automatic cell cultivation apparatus utilizing autoclave sterilization and method for using the same 有权
标题翻译：使用高压灭菌器的自动细胞培养装置及其使用方法
公开(公告)号：US20060151185A1
公开(公告)日：2006-07-13
申请号：US11257950
申请日：2005-10-25
申请人： Mutsumi Takagi , Katsumi Nakashima , Toshihisa Doi , Takamasa Ogata
发明人： Mutsumi Takagi , Katsumi Nakashima , Toshihisa Doi , Takamasa Ogata
IPC分类号： A01B63/111
CPC分类号： A61L2/07 , C12M23/50 , C12M37/00 , C12M41/48 , Y10S435/809
摘要： To present an automatic cell cultivation apparatus capable of sterilizing completely including a cold storage unit and a normal temperature storage unit, without causing cross contamination, in used of cell cultivation of plural subjects. An automatic cell cultivation apparatus comprising an operation unit 11 for operating to cultivate cells of subjects, incubator units 14 for cultivating the cells, a cold storage unit 16 for storing reagents necessary for cultivation, a normal temperature storage unit 17 for storing culture tools, an inlet-outlet unit 15 for taking in and out reagents and culture tools, and a steam supply unit 22 for autoclave sterilization, in which the incubator units 14, the cold storage unit 16, the normal temperature storage unit 17, and the inlet-outlet unit 15 communicate with the operation unit 11, and have sealing doors 18a to 18d leading to the operation unit 11, filters 20a and 20b for cleaning and sterilizing the air stream supplied in the operation unit 11 are provided, and sealing doors 30a and 30b are provided between the filter units and the operation unit 11. By selecting the sealing doors 18a to 18d and opening and closing, sterilizing steam from the steam supply unit 22 is supplied into any of the sterilization required units, operation unit 11, and the incubator units 14, the cold storage unit 16, the normal temperature storage unit 17, and the inlet-outlet unit 15, communicating with the operation unit 11.
摘要翻译：为了呈现能够完全包括冷藏单元和常温储存单元的自动细胞培养装置，而不会引起交叉污染，用于多个受试者的细胞培养。一种自动细胞培养装置，包括用于培养受试者细胞的操作单元11，用于培养细胞的培养单元14，用于培养培养所需的试剂的冷藏单元16，用于储存培养工具的常温储存单元17，用于取出和取出试剂和培养工具的入口出口单元15和用于高压灭菌的蒸汽供应单元22，其中培养箱单元14，冷藏单元16，常温储存单元17和入口插座单元15与操作单元11通信，并且具有通向操作单元11的密封门18a至18d，设置用于清洁和消毒供应在操作单元11中的空气流的过滤器20a和20b，并且密封门 30a和30b设置在过滤器单元和操作单元11之间。通过选择密封门18a至18d并打开和关闭，来自蒸汽供应单元22的灭菌蒸汽被供应到任何灭菌要求的单元，操作单元11和孵化器单元14，冷藏单元16，常温存储单元17和入口出口单元15与操作单元11连通。

2. 发明授权

US07883887B2 Automatic cell cultivation apparatus utilizing autoclave sterilization and method for using the same 有权
标题翻译：使用高压灭菌器的自动细胞培养装置及其使用方法
公开(公告)号：US07883887B2
公开(公告)日：2011-02-08
申请号：US11257950
申请日：2005-10-25
申请人： Mutsumi Takagi , Katsumi Nakashima , Toshihisa Doi , Takamasa Ogata
发明人： Mutsumi Takagi , Katsumi Nakashima , Toshihisa Doi , Takamasa Ogata
IPC分类号： C12M1/00 , C12M3/00 , A61L2/08 , A61L2/00
CPC分类号： A61L2/07 , C12M23/50 , C12M37/00 , C12M41/48 , Y10S435/809
摘要： To present an automatic cell cultivation apparatus capable of sterilizing completely including a cold storage unit and a normal temperature storage unit, without causing cross contamination, in used of cell cultivation of plural subjects. An automatic cell cultivation apparatus comprising an operation unit 11 for operating to cultivate cells of subjects, incubator units 14 for cultivating the cells, a cold storage unit 16 for storing reagents necessary for cultivation, a normal temperature storage unit 17 for storing culture tools, an inlet-outlet unit 15 for taking in and out reagents and culture tools, and a steam supply unit 22 for autoclave sterilization, in which the incubator units 14, the cold storage unit 16, the normal temperature storage unit 17, and the inlet-outlet unit 15 communicate with the operation unit 11, and have sealing doors 18a to 18d leading to the operation unit 11, filters 20a and 20b for cleaning and sterilizing the air stream supplied in the operation unit 11 are provided, and sealing doors 30a and 30b are provided between the filter units and the operation unit 11. By selecting the sealing doors 18a to 18d and opening and closing, sterilizing steam from the steam supply unit 22 is supplied into any of the sterilization required units, operation unit 11, and the incubator units 14, the cold storage unit 16, the normal temperature storage unit 17, and the inlet-outlet unit 15, communicating with the operation unit 11.
摘要翻译：为了呈现能够完全包括冷藏单元和常温储存单元的自动细胞培养装置，而不会引起交叉污染，用于多个受试者的细胞培养。一种自动细胞培养装置，包括用于培养受试者细胞的操作单元11，用于培养细胞的培养单元14，用于培养培养所需的试剂的冷藏单元16，用于储存培养工具的常温储存单元17，用于取出和取出试剂和培养工具的入口 - 出口单元15和用于高压灭菌的蒸汽供应单元22，其中培养箱单元14，冷藏单元16，常温储存单元17和入口单元15与操作单元11连通，并且具有通向操作单元11的密封门18a至18d，设置用于清洁和消毒在操作单元11中供应的空气流的过滤器20a和20b，并且密封门30a和30b是设置在过滤器单元和操作单元11之间。通过选择密封门18a至18d并打开和关闭来自蒸汽供应单元22的蒸汽灭菌，与操作单元11和培养箱单元14，冷藏单元16，常温存储单元17和入口出口单元15中的任一个进行通信。

3. 发明授权

US07816128B2 Automatic cell cultivation apparatus having a multijoint robot 有权
标题翻译：具有多关节机器人的自动细胞培养装置
公开(公告)号：US07816128B2
公开(公告)日：2010-10-19
申请号：US11287965
申请日：2005-11-28
申请人： Katsumi Nakashima , Toshihisa Doi , Yohichi Nakamura
发明人： Katsumi Nakashima , Toshihisa Doi , Yohichi Nakamura
IPC分类号： C12M1/00 , C12M3/00
CPC分类号： C12M23/50 , C12M41/48 , Y10S483/901 , Y10T74/2036
摘要： An automatic cell cultivation apparatus is provided which is capable of conveying the culture container, exchanging the culture medium, and operating other jobs promptly by a robot. The automatic cell cultivation apparatus has a cultivation apparatus main body for cultivating cells in a culture container, and the cultivation apparatus main body is equipped with one or more incubator accommodating the culture container, a chemical suction machine for sucking chemicals in the culture container, and a multijoint robot for conveying the culture container, the multijoint robot having functions of conveying the culture container, detaching and attaching the lid of the culture container, and inclining the container when sucking chemicals in the culture container, so that cell cultivation operations can be promptly carried out by only one robot.
摘要翻译：提供一种自动细胞培养装置，其能够输送培养容器，交换培养基，并且由机器人迅速地进行其他作业。自动细胞培养装置具有栽培培养容器中培养细胞的培养装置主体，培养装置主体装有容纳培养容器的一个或多个培养箱，用于在培养容器中吸取化学物质的化学吸引机，以及用于输送培养容器的多关节机器人，具有输送培养容器的功能的多关节机器人，分离和附着培养容器的盖子，以及在将化学品吸入培养容器时倾斜容器，从而可以及时地进行细胞培养操作仅由一个机器人执行。

4. 发明申请

US20060115889A1 Automatic cell cultivation apparatus having a multijoint robot 有权
标题翻译：具有多关节机器人的自动细胞培养装置
公开(公告)号：US20060115889A1
公开(公告)日：2006-06-01
申请号：US11287965
申请日：2005-11-28
申请人： Katsumi Nakashima , Toshihisa Doi , Yohichi Nakamura
发明人： Katsumi Nakashima , Toshihisa Doi , Yohichi Nakamura
IPC分类号： C12M1/36
CPC分类号： C12M23/50 , C12M41/48 , Y10S483/901 , Y10T74/2036
摘要： An automatic cell cultivation apparatus is provided which is capable of conveying the culture container, exchanging the culture medium, and operating other jobs promptly by a robot. The automatic cell cultivation apparatus has a cultivation apparatus main body for cultivating cells in a culture container, and the cultivation apparatus main body is equipped with one or more incubator accommodating the culture container, a chemical suction machine for sucking chemicals in the culture container, and a multijoint robot for conveying the culture container, the multijoint robot having functions of conveying the culture container, detaching and attaching the lid of the culture container, and inclining the container when sucking chemicals in the culture container, so that cell cultivation operations can be promptly carried out by only one robot.
摘要翻译：提供一种自动细胞培养装置，其能够输送培养容器，交换培养基，并且由机器人迅速地进行其他作业。自动细胞培养装置具有栽培培养容器中培养细胞的培养装置主体，培养装置主体装有容纳培养容器的一个或多个培养箱，用于在培养容器中吸取化学物质的化学吸引机，以及用于输送培养容器的多关节机器人，具有输送培养容器的功能的多关节机器人，分离和附着培养容器的盖子，以及在将化学品吸入培养容器时倾斜容器，从而可以及时地进行细胞培养操作仅由一个机器人执行。

5. 发明授权

US08265371B2 Method for evaluating cell detachment, method of detaching cultured cell, apparatus for evaluating cell detachment and automated cell culture apparatus 有权
标题翻译：评估细胞分离的方法，分离培养细胞的方法，评价细胞分离的装置和自动细胞培养装置
公开(公告)号：US08265371B2
公开(公告)日：2012-09-11
申请号：US12296528
申请日：2007-04-12
申请人： Osamu Ohji , Toshihisa Doi
发明人： Osamu Ohji , Toshihisa Doi
IPC分类号： G06K9/00
CPC分类号： G01N33/5005 , C12M33/00 , C12M41/46
摘要： A novel method for evaluating cell detachment which can be used in passage operation and the like in culture of adhesive cells; a method of detaching a cultured cell utilizing the same; an apparatus for evaluating cell detachment for carrying out the aforementioned method for evaluating cell detachment; and an automated cell culture apparatus in which the apparatus is used are provided.
摘要翻译：一种用于评价细胞分离的新方法，其可用于粘附细胞培养中的通过操作等; 使用该培养细胞分离培养细胞的方法; 用于评价细胞分离以进行上述评价细胞分离的方法的装置; 提供使用该装置的自动细胞培养装置。

6. 发明申请

US20090304257A1 Method for Evaluating Cell Detachment, Method of Detaching Cultured Cell, Apparatus for Evaluating Cell Detachment and Automated Cell Culture Apparatus 有权
标题翻译：评估细胞分离方法，分离培养细胞的方法，评估细胞分离和自动细胞培养装置
公开(公告)号：US20090304257A1
公开(公告)日：2009-12-10
申请号：US12296528
申请日：2007-04-12
申请人： Osamu Ohjo , Toshihisa Doi
发明人： Osamu Ohjo , Toshihisa Doi
IPC分类号： G06K9/00 , C12M3/00
CPC分类号： G01N33/5005 , C12M33/00 , C12M41/46
摘要： A novel method for evaluating cell detachment which can be used in passage operation and the like in culture of adhesive cells; a method of detaching a cultured cell utilizing the same; an apparatus for evaluating cell detachment for carrying out the aforementioned method for evaluating cell detachment; and an automated cell culture apparatus in which the apparatus is used are provided.A first image is taken by imaging a certain position in a culture vessel; a second image is taken by imaging the certain position again after taking the first image and also after allowing the culture liquid in the culture vessel to flow; and the cell detachment from the culture vessel is evaluated based on a cell area ratio A, a cell area ratio B, and a common area ratio C following determination of the common area ratio C for a section where the cell is present in both the first image and the second image based on the cell area ratio A for a section where the cell is present in the first image, and the cell area ratio B for a section where the cell is present in the second image.
摘要翻译：一种用于评价细胞分离的新方法，其可用于粘附细胞培养中的通过操作等; 使用该培养细胞分离培养细胞的方法; 用于评价细胞分离以进行上述评价细胞分离的方法的装置; 提供使用该装置的自动细胞培养装置。通过在培养容器中成像某一位置来拍摄第一图像; 在拍摄第一图像之后，并且在允许培养容器中的培养液体流动之后，通过对特定位置进行成像而拍摄第二图像; 并且在确定细胞存在于两个第一个细胞中的部分的共同面积比C之后，基于细胞面积比A，细胞面积比率B和公共面积比率C来评估细胞与培养容器的分离基于单元存在于第一图像中的单元的单元面积比A以及单元存在于第二图像中的单元的单元面积比率B的图像和第二图像。

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