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1. 发明授权

US4433152A Amidinopiperidine derivatives 失效
标题翻译：脒基哌啶衍生物
公开(公告)号：US4433152A
公开(公告)日：1984-02-21
申请号：US379714
申请日：1982-05-19
申请人： Mutsumi Muramatsu , Toshio Satoh , Hiroyasu Sekine , Atsushi Tendo , Yoshio Kikawa , Kaname Kondo
发明人： Mutsumi Muramatsu , Toshio Satoh , Hiroyasu Sekine , Atsushi Tendo , Yoshio Kikawa , Kaname Kondo
IPC分类号： C07D211/08 , C07D211/34 , C07D211/60 , C07D211/62 , C07D401/12 , C07D409/12
CPC分类号： C07D401/12 , C07D211/34 , C07D211/60 , C07D211/62 , C07D409/12
摘要： A compound of the formula, ##STR1## wherein R represents a hydrogen atom, a naphthyl, indanyl, tetrahydronaphthyl or pyridyl group, or a phenyl group which may have 1 to 3 substituents selected from the group consisting of a halogen atom, and an alkyl, alkenyl, alkoxy, alkanoyl, cyano, formyl, trifluoromethyl, phenyl, phenylalkyl, alkanoyl-amino, aminosulfonyl, carboxyl, alkoxycarbonyl, benzyloxycarbonyl, benzoylvinyl, phenylvinylcarbonyl, carboxyvinyl, and diphenyl-methyloxycarobnylvinyl group, A represents an oxygen or sulfur atom, and n represents an integer of 0 to 3, with the proviso that when n is an integer of 0, R must not be a hydrogen atom, or a pharmaceutically acceptable salt thereof is effectively useful for inhibiting a complement reaction, inflammation caused by an allergic reaction, and platelet aggregation.
摘要翻译：下式的化合物，其中R表示氢原子，萘基，茚满基，四氢萘基或吡啶基，或可具有1至3个选自卤素原子和烷基的烷基的苯基烯基，烷氧基，烷酰基，氰基，甲酰基，三氟甲基，苯基，苯基烷基，烷酰基 - 氨基，氨基磺酰基，羧基，烷氧基羰基，苄氧基羰基，苯甲酰基乙烯基，苯基乙烯基羰基，羧基乙烯基和二苯基甲氧基草酰乙烯基，A表示氧或硫原子， n表示0〜3的整数，条件是当n为0的整数时，R不能为氢原子，或其药学上可接受的盐可有效用于抑制补体反应，由过敏反应引起的炎症，和血小板聚集。

2. 发明授权

US4465851A Guanidinocyclohexanecarboxylic acid derivatives 失效
标题翻译：胍基环己烷羧酸衍生物
公开(公告)号：US4465851A
公开(公告)日：1984-08-14
申请号：US336707
申请日：1982-01-04
申请人： Mutsumi Muramatsu , Toshio Satoh , Hiroyasu Sekine , Atsushi Tendo
发明人： Mutsumi Muramatsu , Toshio Satoh , Hiroyasu Sekine , Atsushi Tendo
IPC分类号： C07D209/08 , C07D215/32 , C07D311/16 , C07D311/30 , C07C129/12
CPC分类号： C07D311/30 , C07D209/08 , C07D215/32 , C07D311/16 , Y10S514/826
摘要： A compound having the formula ##STR1## wherein R.sub.1 represents an indanyl, indolyl, quinolyl or chromonyl group, the group of the formula ##STR2## (in which R.sub.2 represents a halogen atom or a nitro group), or the group of the formula ##STR3## (in which R.sub.3 represents a halogen atom, or an alkyl, nitro, cyano, acetamino, aminosulfonyl, benzoyl, phenoxy or trifluoromethyl group, R.sub.4 represents a hydrogen or halogen atom, or an alkyl group, and R.sub.5 represents a hydrogen or halogen atom, or an alkyl group), or a pharmaceutically acceptable salt thereof. The compound is obtained by reacting 4-guanidinomethylcyclohexanecarboxylic acid or a reactive derivative thereof with a compound of the formula R.sub.1 --OH wherein R.sub.1 is the same as defined above, or a reactive derivative thereof.
摘要翻译：具有式“IMAGE”的化合物，其中R 1表示茚满基，吲哚基，喹啉基或苯并二氢吡喃基，式IMAMA（其中R 2表示卤素原子或硝基）图像（其中R3表示卤素原子，或烷基，硝基，氰基，乙酰氨基，氨基磺酰基，苯甲酰基，苯氧基或三氟甲基，R4表示氢或卤素原子或烷基，R5表示氢或卤素原子或烷基）或其药学上可接受的盐。该化合物通过4-胍基甲基环己烷羧酸或其反应性衍生物与式R 1 -OH的化合物反应而获得，其中R 1与上述定义相同，或其活性衍生物。

3. 发明授权

US4348410A Cyclohexane carboxylic acid derivatives 失效
标题翻译：环己烷羧酸衍生物
公开(公告)号：US4348410A
公开(公告)日：1982-09-07
申请号：US186849
申请日：1980-09-15
申请人： Mutsumi Muramatsu , Toshio Satoh , Yukio Yanagimoto , Tadami Shinuchi , Toshio Nakajima , Isao Nakajima
发明人： Mutsumi Muramatsu , Toshio Satoh , Yukio Yanagimoto , Tadami Shinuchi , Toshio Nakajima , Isao Nakajima
IPC分类号： C07D213/65 , A61K31/24 , A61K31/215 , C07C69/614 , C07C69/773
CPC分类号： C07D213/65 , Y10S514/926 , Y10S514/927
摘要： A compound of the formula: ##STR1## wherein R.sub.1 represents a vanilyl, napthyl, pyridyl or .alpha.-tocopheryl group, or a group of the formula, ##STR2## wherein R.sub.2 represents a hydrogen atom, a lower alkoxy, formyl, lower alkanoyl or phenyl group, or a group of the formula --(CH.sub.2).sub.n COOR.sub.3, wherein R.sub.3 represents a hydrogen atom, a lower alkyl, phenyl, benzyl, anisyl or lower alkoxycarbonylmethyl group, and n represents an integer of 0 to 2, or a pharmaceutically acceptable salt thereof is effective for use as an anti-ulcer agent.
摘要翻译：下式的化合物，其中R1表示香草基，萘基，吡啶基或α-生育酚基，或下式的基团，其中R 2表示氢原子，低级烷氧基，甲酰基，低级烷酰基或苯基或式 - （CH 2）n COOR 3的基团，其中R 3表示氢原子，低级烷基，苯基，苄基，茴香基或低级烷氧基羰基甲基，n表示0至2的整数，或药学上其可接受的盐可用作抗溃疡剂。

4. 发明申请

US20080117729A1 Optical Disc Apparatus and Laser Driving Method 审中-公开
标题翻译：光盘装置和激光驱动方法
公开(公告)号：US20080117729A1
公开(公告)日：2008-05-22
申请号：US11858159
申请日：2007-09-20
申请人： Toshio Satoh , Nobuo Nakai
发明人： Toshio Satoh , Nobuo Nakai
IPC分类号： G11B7/00
CPC分类号： G11B7/1263
摘要： A driving voltage of a laser diode provided in an optical disc apparatus is properly set based on an operating environment thereof to reduce unnecessary power consumption and heat generation. A temperature detector detects the temperature inside a pickup. A memory stores a value of the voltage to be supplied to a laser driver, the voltage corresponding to each of various operating environments. A controller refers to voltage values stored in the memory to set the voltage to be supplied to the laser driver based on a current operating environment. Operating environment parameters includes at least one of the temperature, operation mode, recording rate, and accumulated light emission time. The voltage value to be stored in the memory is a value of the voltage at which electric power consumed by the laser driver becomes smallest in the operating environment.
摘要翻译：基于其操作环境适当地设置设置在光盘装置中的激光二极管的驱动电压，以减少不必要的功率消耗和发热。温度检测器检测拾音器内部的温度。存储器存储要提供给激光驱动器的电压的值，对应于各种操作环境中的每一个的电压。控制器是指存储在存储器中的电压值，以基于当前的操作环境来设置要提供给激光驱动器的电压。操作环境参数包括温度，操作模式，记录速率和累积发光时间中的至少一个。要存储在存储器中的电压值是在操作环境中由激光驱动器消耗的电力变得最小的电压的值。

5. 发明授权

US5910499A Antiallergic agent having an anti-oxidant action 失效
标题翻译：具有抗氧化作用的抗过敏剂
公开(公告)号：US5910499A
公开(公告)日：1999-06-08
申请号：US40494
申请日：1998-03-18
申请人： Toshio Satoh , Tetsuo Ebata , Yasuo Kosaka
发明人： Toshio Satoh , Tetsuo Ebata , Yasuo Kosaka
IPC分类号： C07D295/08 , A61K31/495 , A61P11/00 , A61P37/08 , A61P43/00 , C07D295/092 , C07D295/088
CPC分类号： C07D295/088
摘要： An antiallergic agent having leucotriene production inhibiting action and antihistaminic action, which can be orally administered is provided; the antiallergic agent comprises a hydroquinone derivative of general formula ##STR1## (wherein n represents an integer of 2-10).
摘要翻译：提供了可以口服给药的具有白三烯产生抑制作用和抗组胺作用的抗过敏剂。抗过敏剂包含通式（其中n表示2-10的整数）的氢醌衍生物。

6. 发明授权

US5416242A Hydroquinone derivative 失效
标题翻译：对苯二酚衍生物
公开(公告)号：US5416242A
公开(公告)日：1995-05-16
申请号：US283713
申请日：1994-08-01
申请人： Toshio Satoh , Hitoshi Matsumoto , Yasunori Niiro
发明人： Toshio Satoh , Hitoshi Matsumoto , Yasunori Niiro
IPC分类号： C07C43/23 , C07C43/205
CPC分类号： C07C43/23
摘要： Novel hydroquinone derivatives of the formulae (I) and (II), ##STR1## wherein R.sup.1 is an alkyl group having 7 to 11 carbon atoms, ##STR2## wherein each of R.sup.2 to R.sup.5 is independently a hydrogen atom, a lower alkyl group or a lower alkoxy group provided that at least one of R.sup.2 to R.sup.5 is a lower alkyl group or a lower alkoxy group, and R.sup.6 is an alkyl group having a carbon chain of at least 2 carbon atoms. as compounds having antioxidant activity and tumor incidence inhibiting activity, and an antioxidant and a tumor incidence inhibitor containing, as an active ingredient, a hydroquinone derivative of the formula (III), ##STR3## wherein each of R.sup.7 to R.sup.10 is independently a hydrogen atom, a lower alkyl group or a lower alkoxy group, and R.sup.11 is an alkyl group having a carbon chain of at least 2 carbon atoms, and/or a salt thereof.
摘要翻译：式（I）和（II）的新型氢醌衍生物，其中R1是具有7-11个碳原子的烷基，其中R2至R5各自独立地为氢原子低级烷基或低级烷氧基，条件是R 2至R 5中的至少一个为低级烷基或低级烷氧基，R 6为具有至少2个碳原子的碳链的烷基。作为具有抗氧化活性和肿瘤发生抑制活性的化合物，以及含有式（III）的氢醌衍生物作为活性成分的抗氧化剂和肿瘤发生抑制剂，其中R7至R10各自独立地为氢原子，低级烷基或低级烷氧基，R11为碳原子数为2以上的烷基，和/或其盐。

7. 发明授权

US5051406A Pharmaceutical composition using albumin as a carrier and process for producing the same 失效
标题翻译：使用白蛋白作为载体的药物组合物及其制备方法
公开(公告)号：US5051406A
公开(公告)日：1991-09-24
申请号：US620394
申请日：1990-11-30
申请人： Toshio Satoh
发明人： Toshio Satoh
IPC分类号： A61K9/14 , A61K47/42 , A61K47/48
CPC分类号： A61K9/146 , A61K47/42 , A61K47/48284
摘要： The pharmaceutical composition of the present invention is a pharmaceutical composition of high drug content containing 1-200 parts by weight of a drug having a protein binding property and 100 parts by weight of albumin.This pharmaceutical composition is produced by stirring the drug and albumin of the above proportions at a high speed in an aqueous solvent and then removing the solvent by distillation, and has effects of alleviating the side effect of the drug used therein and also of improving the absorption, light stability, etc. of the drug.

8. 发明授权

US5004742A Benzothiazine-1,1-dioxide derivatives 失效
标题翻译：苯并噻嗪-1,1-二氧化物衍生物
公开(公告)号：US5004742A
公开(公告)日：1991-04-02
申请号：US392899
申请日：1989-08-14
申请人： Toshio Satoh , Yasunori Niiro , Hisao Kakegawa , Hitoshi Matsumoto
发明人： Toshio Satoh , Yasunori Niiro , Hisao Kakegawa , Hitoshi Matsumoto
IPC分类号： C12N9/99 , A61K31/54 , A61P29/00 , A61P37/08 , A61P43/00 , C07D279/02 , C07D417/12
CPC分类号： C07D417/12 , C07D279/02
摘要： The present invention relates to novel benzothiazine-1,1-dioxide derivatives. These benzothiazine-1,1-dioxide derivatives have a high hyaluronidase-inhibiting activity and accordingly can be used in drugs such as anti-inflammatory agent, anti-allergic agent and the like.

9. 发明授权

US06190694B1 Chitosan-containing soft capsule and process for producing the same 失效
标题翻译：含壳聚糖的软胶囊及其制备方法
公开(公告)号：US06190694B1
公开(公告)日：2001-02-20
申请号：US09416183
申请日：1999-10-11
申请人： Yutaka Mizushima , Yasuo Kosaka , Toshio Satoh
发明人： Yutaka Mizushima , Yasuo Kosaka , Toshio Satoh
IPC分类号： A61K948
CPC分类号： A61K9/4858
摘要： The present invention relates to a process for producing a chitosan-containing soft capsule. The process includes the steps of rendering chitosan a powder; adding the chitosan powder, powder comprising an organic acid and a salt thereof, and an emulsifier to an oil or fat; stirring the resultant mixture so as to suspend the powders, to thereby obtain a gel-like stock; and feeding the gel-like stock and a gelatin solution for coating into an automated encapsulation machine, to effect encapsulation of the stock with gelatin.
摘要翻译：本发明涉及含有壳聚糖的软胶囊的制造方法。该方法包括使壳聚糖成粉末的步骤; 将壳聚糖粉末，包含有机酸及其盐的粉末和乳化剂加入到油或脂肪中; 搅拌所得混合物以使粉末悬浮，从而获得凝胶状原料; 并将凝胶状原料和明胶溶液加入到自动封装机中，以明胶包封原料。

10. 发明授权

US5351225A Optical recording and reproducing apparatus having a plurality of light spots 失效
标题翻译：具有多个光点的光学记录和再现装置
公开(公告)号：US5351225A
公开(公告)日：1994-09-27
申请号：US877429
申请日：1992-05-01
申请人： Takashi Ishida , Shunji O'Hara , Kenzo Ishibashi , Toshio Satoh
发明人： Takashi Ishida , Shunji O'Hara , Kenzo Ishibashi , Toshio Satoh
IPC分类号： G11B7/09
CPC分类号： G11B7/0946
摘要： In an optical recording and reproducing apparatus which forms at least first and second light spots on a track of an optical recording medium to record, reproduce or erase information, a movable range of the second light spot is limited to less than one half of a track pitch, normal to the track, from the track to prevent tracks other than a target track from being miserased, misrecorded or misreproduced. When a deviation of the second light spot from the target track exceeds a predetermined amount, light emission of the second light spot is stopped to prevent a track other than the target track from being miserased, misrecorded or misreproduced. When the deviation of the second light spot from the target track exceeds the predetermined amount, the second light spot is returned to a neutral position to prevent a track other than the target track from being miserased, misrecorded or misreproduced.
摘要翻译：在光学记录和再现装置中，其至少在光学记录介质的轨道上形成第一和第二光斑以记录，再现或擦除信息，第二光斑的可移动范围被限制在小于轨道的一半从轨道正常的轨道，以防止目标轨道以外的轨迹被歪曲，误记或错误地产生。当第二光点与目标轨迹的偏差超过预定量时，停止第二光点的发光，以防止除了目标轨迹以外的轨迹被误导，误记或错误地产生。当第二光点与目标轨道的偏差超过预定量时，第二光点返回到中立位置，以防止目标轨道以外的轨迹被误导，误记或错误地产生。

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