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1. 发明授权

US08614289B2 Processes for the manufacture of macrocyclic depsipeptides and new intermediates 失效
标题翻译：用于制备大环脱肽和新中间体的方法
公开(公告)号：US08614289B2
公开(公告)日：2013-12-24
申请号：US13449937
申请日：2012-04-18
申请人： Murat Acemoglu , Heribert Hellstern , Felix Kollmer , John Lopez , Robert Schreiber , Christian Sprecher , Hans Stettler
发明人： Murat Acemoglu , Heribert Hellstern , Felix Kollmer , John Lopez , Robert Schreiber , Christian Sprecher , Hans Stettler
IPC分类号： A61K38/12 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , A61K38/00
CPC分类号： C07K11/02 , A61K38/00 , C07K7/06 , C07K11/00
摘要： The invention relates to a method or process for the chemical manufacture of depsipeptides of the formula I, wherein the symbols have the meaning defined in the description, to new intermediates and their manufacture, as well as related invention embodiments.
摘要翻译：本发明涉及用于化学制备式I的缩酚酸肽的方法或方法，其中符号具有在描述中定义的含义，新的中间体及其制备以及相关的发明实施方案。

2. 发明申请

US20140080995A1 Processes for the Manufacture of Macrocyclic Depsipeptides and New Intermediates 审中-公开
标题翻译：制备大环肽和新型中间体的方法
公开(公告)号：US20140080995A1
公开(公告)日：2014-03-20
申请号：US14082315
申请日：2013-11-18
申请人： Murat Acemoglu , Heribert Hellstern , Felix Kollmer , John Lopez , Robert Schreiber , Christian Sprecher , Hans Stettler
发明人： Murat Acemoglu , Heribert Hellstern , Felix Kollmer , John Lopez , Robert Schreiber , Christian Sprecher , Hans Stettler
IPC分类号： C07K11/02 , C07K11/00
CPC分类号： C07K11/02 , A61K38/00 , C07K7/06 , C07K11/00
摘要： The invention relates to a method or process for the chemical manufacture of depsipeptides of the formula I, wherein the symbols have the meaning defined in the description, to new intermediates and their manufacture, as well as related invention embodiments.
摘要翻译：本发明涉及用于化学制备式I的缩酚酸肽的方法或方法，其中符号具有在描述中定义的含义，新的中间体及其制备以及相关的发明实施方案。

3. 发明授权

US09278997B2 Processes for the manufacture of macrocyclic depsipeptides and new intermediates 有权
公开(公告)号：US09278997B2
公开(公告)日：2016-03-08
申请号：US14082315
申请日：2013-11-18
申请人： Murat Acemoglu , Heribert Hellstern , Felix Kollmer , John Lopez , Robert Schreiber , Christian Sprecher , Hans Stettler
发明人： Murat Acemoglu , Heribert Hellstern , Felix Kollmer , John Lopez , Robert Schreiber , Christian Sprecher , Hans Stettler
IPC分类号： A61K38/12 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , C07K11/02 , C07K7/06 , C07K11/00 , A61K38/00
CPC分类号： C07K11/02 , A61K38/00 , C07K7/06 , C07K11/00
摘要： The invention relates to a method or process for the chemical manufacture of depsipeptides of the formula I, wherein the symbols have the meaning defined in the description, to new intermediates and their manufacture, as well as related invention embodiments.

4. 发明申请

US20170020832A1 PHARMACEUTICAL FORMULATIONS OF NAPROXEN FOR SOFT GEL ENCAPSULATION AND COMBINATIONS THEREOF 审中-公开
标题翻译：用于软胶囊封装及其组合的纳豆酮药物制剂
公开(公告)号：US20170020832A1
公开(公告)日：2017-01-26
申请号：US15285968
申请日：2016-10-05
申请人： John Lopez , Peter Draper , Sankalp Vashishtha , Nancy Klassen , Christina Armstrong
发明人： John Lopez , Peter Draper , Sankalp Vashishtha , Nancy Klassen , Christina Armstrong
IPC分类号： A61K31/192 , A61K9/00 , A61K9/48
CPC分类号： A61K31/192 , A61K9/0053 , A61K9/48 , A61K9/4833 , A61K9/4858 , A61K9/4866 , A61K45/06 , A61K2300/00
摘要： This invention relates to a naproxen formulation suitable for encapsulation into a soft gel dosage unit by increasing the stability, concentration, and bioavailability of naproxen. Fill formulations of the invention may include other active pharmaceutical ingredients and combinations of two or more active pharmaceutical ingredients. This invention also provides for adjusting pH values of fill formulations without additional process steps. A process for increasing the achievable concentration of an active NSAID pharmaceutical ingredient, such as naproxen, relative to fill composition for dosage units is also provided. The highly concentrated formulation of this invention permits a reduction in the fill volume or dosage unit size, or an increase in concentration of the active pharmaceutical ingredient per dosage form. The invention also relates to a formulation of optimal stability suitable for supporting a fill composition compatible with the soft gel dosage unit.
摘要翻译：本发明涉及一种适于通过增加萘普生的稳定性，浓度和生物利用度来包囊入软凝胶剂量单位的萘普生制剂。本发明的填充制剂可以包括其它活性药物成分和两种或更多种活性药物成分的组合。本发明还提供了在没有附加工艺步骤的情况下调节填充制剂的pH值。还提供了相对于剂量单位的填充组合物增加活性NSAID药物成分（例如萘普生）可实现浓度的方法。本发明的高度浓缩的制剂允许每剂量形式的活性药物成分的填充体积或剂量单位大小的减少或活性药物成分的浓度增加。本发明还涉及适合于支持与软凝胶剂量单位相容的填充组合物的最佳稳定性的制剂。

5. 发明授权

US08722928B2 Stable and non-precipitating aqueous compositions containing the potassium salt of (S)-(+)-abscisic acid, and methods of their preparation and use 有权
标题翻译：含有（S） - （+） - 脱落酸的钾盐的稳定和非沉淀含水组合物及其制备和使用方法
公开(公告)号：US08722928B2
公开(公告)日：2014-05-13
申请号：US13447715
申请日：2012-04-16
申请人： Daniel F. Heiman , Bala Devisetty , Peter D. Petracek , Xiaozhong Liu , John Lopez , Derek D. Woolard , Yueh Wang , Gregory D. Venburg , Prem Warrior
发明人： Daniel F. Heiman , Bala Devisetty , Peter D. Petracek , Xiaozhong Liu , John Lopez , Derek D. Woolard , Yueh Wang , Gregory D. Venburg , Prem Warrior
IPC分类号： C07C63/06 , A01N31/08
CPC分类号： A01N25/22 , A01N37/42 , A01N2300/00 , A01N25/30
摘要： The present invention generally relates to aqueous compositions containing salts of (S)-(+)-abscisic acid, the surfactant Atlox™ 4913, and the color stabilizers sodium citrate and sodium acetate, methods of their preparation, and methods of their agricultural use.
摘要翻译：本发明一般涉及含有（S） - （+） - 脱落酸，表面活性剂Atlox TM 4913和颜色稳定剂柠檬酸钠和乙酸钠的盐的水性组合物，其制备方法及其农业方法。

6. 发明授权

US08635144B2 Confidential block trading system and method 有权
标题翻译：机密块交易系统和方法
公开(公告)号：US08635144B2
公开(公告)日：2014-01-21
申请号：US12692147
申请日：2010-01-22
申请人： Henri Waelbroeck , Fred J. Federspiel , John Lopez
发明人： Henri Waelbroeck , Fred J. Federspiel , John Lopez
IPC分类号： G06Q40/00
CPC分类号： G06Q40/00 , G06Q40/04 , G06Q40/06
摘要： Methods and systems for facilitating trading of securities, preferred methods comprising receiving a first buy or sell order from a first user; calculating a block price range; determining that said first order is reasonably priced; transmitting to a second user a notification that a reasonably priced order is present, but without notifying said second user of the side; receiving a second order from said second user, wherein said second order is a contra to said first order and nearly matches but does not cross said first order; transmitting a contra order notification to said second user after said second order is received, said contra order notification indicating that a nearly matching contra order is active; receiving a third order from said second user, said third order being a contra to said first order and crossing said first order; and executing a trade comprising said first order and said third order.
摘要翻译：用于促进证券交易的方法和系统，优选方法包括从第一用户接收第一买/卖订单; 计算块价格范围; 确定所述第一订单的价格是合理的; 向第二用户传送价格合理的订单存在但不通知所述第二用户的通知; 从所述第二用户接收第二顺序，其中所述第二顺序与所述第一顺序相反，并且几乎匹配但不跨越所述第一顺序; 在接收到所述第二次订单之后，向所述第二用户发送拒绝订单通知，所述反向订单通知指示几乎匹配的反对订单是活动的; 从所述第二用户接收第三命令，所述第三命令与所述第一命令相反，并且越过所述第一命令; 以及执行包括所述第一顺序和所述第三顺序的交易。

7. 发明申请

US20120330682A1 SYSTEMS AND METHODS FOR NATIONAL REGISTRY DATA COLLECTION AS PATIENT CARE IS CONDUCTED 有权
标题翻译：国家注册数据收集系统和方法作为患者护理被引导
公开(公告)号：US20120330682A1
公开(公告)日：2012-12-27
申请号：US13535157
申请日：2012-06-27
申请人： John Lopez , Michelle Fennessy , Susan Zelisko , Corey Sartain
发明人： John Lopez , Michelle Fennessy , Susan Zelisko , Corey Sartain
IPC分类号： G06Q50/24
CPC分类号： G06Q50/24 , G06F19/00 , G06F19/324 , G06Q10/063 , G16H10/20 , G16H10/60
摘要： A user interface is provided that requests clinical note data from a healthcare provider as a patient is being seen by the healthcare provider. The clinical note data requested includes data needed to populate one or more variables of one or more national registries and data needed to populate a clinical note medical record of an existing electronic medical records system. The clinical note data entered by the healthcare provider for the patient is received from the user interface. Automatically and at substantially the same time, the entered clinical note data needed to populate a clinical note medical record of an existing EMR system for the patient is stored in the existing EMR system, and the entered clinical note data needed to populate one or more variables for the patient for the one or more national registries is stored in a database.
摘要翻译：提供了一种用户界面，当医疗保健提供者正在看病人时，提供从医疗保健提供者请求临床票据数据的用户界面。所要求的临床注释数据包括填写一个或多个国家注册管理机构的一个或多个变量所需的数据和填写现有电子病历系统的临床笔记医疗记录所需的数据。医疗保健提供者为患者输入的临床笔记数据从用户界面接收。自动和大体上相同的时间内，现有的EMR系统中存储了填写病人现有EMR系统的临床笔记医疗记录所需输入的临床注释数据，并且输入的临床注释数据需要填充一个或多个变量为一个或多个国家注册管理机构的患者存储在数据库中。

8. 发明申请

US20080300318A1 Cinnamaldehyde formulations and methods of use 审中-公开
标题翻译：肉桂醛配方及使用方法
公开(公告)号：US20080300318A1
公开(公告)日：2008-12-04
申请号：US12152788
申请日：2008-05-16
申请人： Yueh Wang , Bassam Shammo , Rebecca Dickenson , John Lopez , Judith Fugiel , Linda Rehberger , Prem Warrior
发明人： Yueh Wang , Bassam Shammo , Rebecca Dickenson , John Lopez , Judith Fugiel , Linda Rehberger , Prem Warrior
IPC分类号： A01N35/00 , A01P5/00
CPC分类号： A01N35/02 , A01N25/02 , A01N25/30 , A01N2300/00
摘要： The invention generally relates to various cinnamaldehyde (cinnamic aldehyde) formulations for protecting plants from nematodes and other pathogens. The invention provides specific formulations which do not require the use of chemical additives. These formulations have low phytotoxicity and low volatility. Also, methods of applying the formulations for agricultural use are disclosed.
摘要翻译：本发明一般涉及用于保护植物免受线虫和其它病原体的各种肉桂醛（肉桂醛）制剂。本发明提供了不需要使用化学添加剂的具体制剂。这些制剂的植物毒性低，挥发性低。此外，公开了施用农业用制剂的方法。

9. 发明授权

US08454982B2 Stable S-(+)-abscisic acid liquid and soluble granule formulations 有权
标题翻译：稳定的S - （+） - 脱落酸液体和可溶性颗粒制剂
公开(公告)号：US08454982B2
公开(公告)日：2013-06-04
申请号：US13469691
申请日：2012-05-11
申请人： Yueh Wang , Prem Warrior , Ahsan Lone , John Lopez , Bruce Baldi
发明人： Yueh Wang , Prem Warrior , Ahsan Lone , John Lopez , Bruce Baldi
IPC分类号： A61K8/02
CPC分类号： A01N37/42 , A01N25/12 , A01N25/22 , A01N43/12 , A01N43/90 , A01N45/02 , A01N47/36 , A01N2300/00
摘要： The present invention generally relates to stable S-(+)-abscisic acid liquid and soluble granule formulations and methods of making and using such formulations.
摘要翻译：本发明一般涉及稳定的S - （+） - 脱落酸液体和可溶性颗粒制剂以及制备和使用这些制剂的方法。

10. 发明申请

US20120220459A1 STABLE S-(+)-ABSCISIC ACID LIQUID AND SOLUBLE GRANULE FORMULATIONS 有权
标题翻译：稳定的S - （+） - 绝对酸液和可溶性颗粒配方
公开(公告)号：US20120220459A1
公开(公告)日：2012-08-30
申请号：US13469691
申请日：2012-05-11
申请人： Yueh Wang , Prem Warrior , Ahsan Lone , John Lopez , Bruce Baldi
发明人： Yueh Wang , Prem Warrior , Ahsan Lone , John Lopez , Bruce Baldi
IPC分类号： A01N43/90 , B29B9/06 , A01N47/36 , A01P21/00 , A01N37/42 , A01N43/12
CPC分类号： A01N37/42 , A01N25/12 , A01N25/22 , A01N43/12 , A01N43/90 , A01N45/02 , A01N47/36 , A01N2300/00
摘要： The present invention generally relates to stable S-(+)-abscisic acid liquid and soluble granule formulations and methods of making and using such formulations.
摘要翻译：本发明一般涉及稳定的S - （+） - 脱落酸液体和可溶性颗粒制剂以及制备和使用这些制剂的方法。

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