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1. 发明授权

US6104940A Electrode probe and body fluid examination equipment including the same 有权
标题翻译：电极探针和体液检查设备包括相同
公开(公告)号：US6104940A
公开(公告)日：2000-08-15
申请号：US326350
申请日：1999-06-04
申请人： Motokazu Watanabe , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Motokazu Watanabe , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27/30 , A61B5/00 , A61B5/145 , A61B5/1486 , A61B5/15 , A61B5/157 , A61B5/05
CPC分类号： A61B5/1486 , A61B5/6848
摘要： Disclosed is an electrode probe and a body fluid examination equipment enabling examination of a trace amount of body fluid. The electrode probe comprises an insulating needle member, a working electrode lead disposed in the needle member, a working electrode whose lead is protruding outside from the needle member, a counter electrode disposed on the surface of the needle member, a lead connected to the counter electrode, and a reagent layer disposed in contact with or in the vicinity of the working and counter electrodes of the electrode system. When a trace amount of body fluid leaking on the skin surface is brought into contact with the reagent layer, the reagent layer dissolves which results in electron transfer whereby information about the concentration of analyte in the body fluid can be obtained from the electrode system.
摘要翻译：公开了能够检测微量体液的电极探针和体液检查装置。电极探针包括绝缘针构件，设置在针构件中的工作电极引线，其引线从针构件向外突出的工作电极，设置在针构件表面上的对电极，连接到计数器的引线电极和设置成与电极系统的工作电极和对电极接触或附近的试剂层。当皮肤表面泄漏的微量体液与试剂层接触时，试剂层溶解，导致电子转移，从而可以从电极系统获得关于体液中分析物浓度的信息。

2. 发明授权

US07005048B1 Glucose sensor 有权
标题翻译：葡萄糖传感器
公开(公告)号：US07005048B1
公开(公告)日：2006-02-28
申请号：US09807692
申请日：2000-10-02
申请人： Motokazu Watanabe , Keiko Yugawa , Toshihiko Yoshioka , Shiro Nankai , Junko Nakayama , Shoji Miyazaki , Hideyuki Baba
发明人： Motokazu Watanabe , Keiko Yugawa , Toshihiko Yoshioka , Shiro Nankai , Junko Nakayama , Shoji Miyazaki , Hideyuki Baba
IPC分类号： G01N27/327
CPC分类号： C12Q1/006
摘要： The present invention provides a high-performance glucose sensor having excellent storage stability and an improved response characteristic. This sensor comprises: an electrically insulating base plate; an electrode system including at least a working electrode and a counter electrode formed on the base plate; and a reaction layer containing at least pyrrolo-quinoline quinone dependent glucose dehydrogenase, formed in contact with or in the vicinity of the electrode system, and the reaction layer contains at least one kind of additive selected from the group consisting of gluconic acid and salts thereof.
摘要翻译：本发明提供一种具有优异的储存稳定性和改善的响应特性的高性能葡萄糖传感器。该传感器包括：电绝缘基板; 电极系统，其至少包括形成在所述基板上的工作电极和对电极; 和至少含有与电极体系接触或附近形成的吡咯并喹啉醌依赖型葡萄糖脱氢酶的反应层，反应层含有选自葡萄糖酸及其盐的至少一种添加剂。

3. 发明授权

US06383819B1 Method for determining cholesterol and sensor applicable to the same 有权
标题翻译：胆固醇和传感器的测定方法
公开(公告)号：US06383819B1
公开(公告)日：2002-05-07
申请号：US09492979
申请日：2000-01-27
申请人： Motokazu Watanabe , Toshihiko Yoshioka , Shiro Nankai
发明人： Motokazu Watanabe , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N33543
CPC分类号： G01N27/3272 , G01N33/92 , G01N2800/044 , G01N2800/52 , Y10S435/803 , Y10S435/814 , Y10S435/817 , Y10S435/962 , Y10S435/973 , Y10S436/806 , Y10S436/815 , Y10S436/824 , Y10S436/825 , Y10T436/25375 , Y10T436/255
摘要： The present disclosure relates to a method for determining cholesterol in low density lipoprotein comprising the steps of (a) measuring total cholesterol level in a sample containing at least high density lipoprotein, low density lipoprotein, very low density lipoprotein and chylomicron, and (b) measuring cholesterol levels in the high density lipoprotein, very low density lipoprotein and chylomicron in the sample, wherein the cholesterol level in the low density lipoprotein is determined by subtracting a value obtained in step (b) from a value obtained in step (a). The present invention enables concurrent determination of cholesterol level in low density lipoprotein and total cholesterol level, facilitating acquisition of two types of biological information at a time.
摘要翻译：本公开涉及一种用于测定低密度脂蛋白胆固醇的方法，包括以下步骤：（a）测量含有至少高密度脂蛋白，低密度脂蛋白，极低密度脂蛋白和乳糜微粒的样品中的总胆固醇水平，和（b）测量样品中高密度脂蛋白，极低密度脂蛋白和乳糜微粒中的胆固醇水平，其中通过从步骤（a）中获得的值减去步骤（b）中获得的值来确定低密度脂蛋白中的胆固醇水平。本发明能够同时测定低密度脂蛋白和总胆固醇水平的胆固醇水平，便于一次获取两种生物信息。

4. 发明申请

US20050072670A1 Biosensor 审中-公开
标题翻译：生物传感器
公开(公告)号：US20050072670A1
公开(公告)日：2005-04-07
申请号：US10478283
申请日：2002-12-27
申请人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： C12Q1/00 , C12Q1/60 , G01N27/403 , G01N33/487 , G01N33/49 , G01N27/26
CPC分类号： C12Q1/001 , C12Q1/006 , C12Q1/60 , G01N27/3272
摘要： In order to provide a biosensor with high accuracy and excellent response where plasma obtained by filtration of blood rapidly arrives at an electrode system, in a biosensor comprising: an insulating base plate; an electrode system having a working electrode and a counter electrode which are provided on the base plate; a reaction layer including at least oxidoreductase and an electron mediator; a sample solution supply pathway which includes the electrode system and the reaction layer and has an inlet and an air aperture; a sample solution supply part for introducing a sample solution, which is in position apart from the sample solution supply pathway; and a first filter which is disposed between the sample solution supply pathway and the sample solution supply part for filtering the sample solution, where the filtrate filtered with the first filter is supplied into the sample solution supply pathway due to capillary action, the direction in which the sample solution passes through the first filter and the direction in which the filtrate passes through the sample solution supply pathway are made cross at right angles.
摘要翻译：为了提供具有高精度和优异响应的生物传感器，其中通过过滤血液获得的血液迅速到达电极系统，在生物传感器中包括：绝缘基板; 具有设置在基板上的工作电极和对置电极的电极系统; 至少包含氧化还原酶和电子介体的反应层; 包括电极系统和反应层并具有入口和空气孔的样品溶液供应路径; 用于引入样品溶液的样品溶液供应部件，其处于离样品溶液供给路径的位置; 以及第一过滤器，其设置在样品溶液供给路径和样品溶液供给部之间，用于过滤样品溶液，其中用第一过滤器过滤的滤液由于毛细作用而被供给到样品溶液供给通道中，其中样品溶液通过第一过滤器，滤液通过样品溶液供应通道的方向被成直角交叉。

5. 发明授权

US06706232B2 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06706232B2
公开(公告)日：2004-03-16
申请号：US10363589
申请日：2003-03-04
申请人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/001
摘要： There is provided a cholesterol sensor with high-accuracy and excellent response, whose object to be measured is whole blood, where plasma with hemocytes therein filtered can rapidly reach an electrode system. In a biosensor where plasma with hemocytes therein filtered with a filter is sucked into a sample solution supply pathway due to capillarity, there are formed: a first pressing part for holding a primary side portion of the filter from the bottom; a second pressing part for holding a secondary side portion of the filter from the top and the bottom; a third pressing part for holding the central portion of the filter from the top; and a void for surrounding the filter between the second pressing part and third pressing part.
摘要翻译：提供了具有高精度和优异反应的胆固醇传感器，其被测量对象是全血，其中血细胞在其中被过滤的血浆可以快速地达到电极系统。在生物传感器中，其中用过滤器过滤血细胞的血浆由于毛细作用而被吸入样品溶液供应通道中，形成有：从底部保持过滤器的初级侧部分的第一按压部分; 用于从顶部和底部保持过滤器的次级侧部分的第二按压部分; 用于从顶部保持过滤器的中心部分的第三按压部分; 以及用于围绕第二按压部和第三按压部之间的过滤器的空隙。

6. 发明授权

US06416641B1 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US06416641B1
公开(公告)日：2002-07-09
申请号：US09328511
申请日：1999-06-09
申请人： Shin Ikeda , Motokazu Watanabe , Toshihiko Yoshioka , Shiro Nankai
发明人： Shin Ikeda , Motokazu Watanabe , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/001
摘要： The present invention relates to a biosensor comprising a working electrode base plate 11, a counter electrode base plate 14 and a reagent layer containing at least an enzyme and an electron mediator, wherein a working electrode 12 disposed on the working electrode base plate and a counter electrode 15 disposed on the counter electrode base plate are positioned so as to mutually face and a terminal of a measuring device can be brought in contact with terminals 13, 16 of both electrodes from through-holes 25, 24. Such a biosensor can produce highly reliable and accurate measuring results with only a small amount of a sample.
摘要翻译：本发明涉及一种生物传感器，其包括工作电极基板11，对电极基板14和至少含有酶和电子介体的试剂层，其中设置在工作电极底板上的工作电极12和反电极配置在对置电极基板上的电极15被定位成相互面对，并且测量装置的端子可以从通孔25,24与两个电极的端子13,16接触。这种生物传感器可以高度生产可靠和准确的测量结果，只有少量的样品。

7. 发明授权

US06762062B2 Method of determining cholesterol and sensor applicable to the same 失效
标题翻译：测定胆固醇和传感器的方法适用于此
公开(公告)号：US06762062B2
公开(公告)日：2004-07-13
申请号：US09961930
申请日：2001-09-24
申请人： Motokazu Watanabe , Toshihiko Yoshioka , Shiro Nankai
发明人： Motokazu Watanabe , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N3353
CPC分类号： G01N27/3272 , G01N33/92 , G01N2800/044 , G01N2800/52 , Y10S435/803 , Y10S435/814 , Y10S435/817 , Y10S435/962 , Y10S435/973 , Y10S436/806 , Y10S436/815 , Y10S436/824 , Y10S436/825 , Y10T436/25375 , Y10T436/255
摘要： The present disclosure relates to a method for determining cholesterol in low density lipoprotein comprising the steps of (a) measuring total cholesterol level in a sample containing at least high density lipoprotein, low density lipoprotein, very low density lipoprotein and chylomicron, and (b) measuring cholesterol levels in the high density lipoprotein, very low density lipoprotein and chylomicron in the sample, wherein the cholesterol level in the low density lipoprotein is determined by subtracting a value obtained in the step (b) from a value obtained in the step (a). The present invention enables concurrent determination of cholesterol level in low density lipoprotein and total cholesterol level, facilitating acquisition of two types of biological information at a time.
摘要翻译：本公开涉及一种用于测定低密度脂蛋白胆固醇的方法，包括以下步骤：（a）测量含有至少高密度脂蛋白，低密度脂蛋白，极低密度脂蛋白和乳糜微粒的样品中的总胆固醇水平，和（b）测量样品中高密度脂蛋白，极低密度脂蛋白和乳糜微粒中的胆固醇水平，其中通过从步骤（a）中获得的值减去步骤（b）中获得的值来确定低密度脂蛋白中的胆固醇水平）。本发明能够同时测定低密度脂蛋白和总胆固醇水平的胆固醇水平，便于一次获取两种生物信息。

8. 发明授权

US06699382B2 Method for analyzing a biological sample 有权
标题翻译：分析生物样品的方法
公开(公告)号：US06699382B2
公开(公告)日：2004-03-02
申请号：US10235451
申请日：2002-09-04
申请人： Toshihiko Yoshioka , Shin Ikeda , Motokazu Watanabe , Shiro Nankai
发明人： Toshihiko Yoshioka , Shin Ikeda , Motokazu Watanabe , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/001
摘要： A biosensor enabling accurate measurement of the concentration of a substrate contained in a trace amount of a sample solution is disclosed. The electrochemical analysis element in accordance with the present invention which should be included in the biosensor comprises a sensor body having a hollow space which space is open at its both ends, an electrode system having a working electrode and a counter electrode, a reagent segment containing an enzyme, wherein the electrode system and the reagent segment are disposed on an inner wall of the hollow space.
摘要翻译：公开了能够精确测量微量样品溶液中所含的基板的浓度的生物传感器。应包括在生物传感器中的根据本发明的电化学分析元件包括具有中空空间的传感器本体，其两端开放空间，具有工作电极和对电极的电极系统，含有酶，其中电极系统和试剂段设置在中空空间的内壁上。

9. 再颁专利

USRE39390E1 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：USRE39390E1
公开(公告)日：2006-11-14
申请号：US10924334
申请日：2002-05-17
申请人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27/327
摘要： There is provided a cholesterol sensor with high-accuracy and excellent response, whose object to be measured is whole blood, where plasma with which is obtained by filtering out hemocytes therein filtered in blood can rapidly reach an electrode system. In a biosensor where plasma with which is obtained by filtering out hemocytes therein filtered with by a filter is sucked into a sample solution supply pathway due to capillarity, there are formed: a first pressing part for holding a primary side portion of the filter from the bottom; a second pressing part for holding a secondary side portion of the filter from the top and the bottom; a third pressing part for holding the central portion of the filter from the top; and a void for surrounding the filter between the second pressing part and third pressing part.
摘要翻译：提供了具有高精度和优异反应的胆固醇传感器，其测量对象为全血，等离子体<？delete-start id =“DEL-S-00001”date =“20061114”？>与<？delete -end id =“DEL-S-00001”？> <？insert-start id =“INS-S-00001”date =“20061114”？>通过过滤出<？insert-end id =“INS- S-00001“？>血细胞<？delete-start id =”DEL-S-00002“date =”20061114“？>其中过滤的<？delete-end id =”DEL-S-00002“？> 在血液中开始id =“INS-S-00002”date =“20061114”？> <？insert-end id =“INS-S-00002”？>可以快速到达电极系统。在等离子体<？delete-start id =“DEL-S-00003”date =“20061114”？>与<？delete-end id =“DEL-S-00003”？> <？insert-start id = 通过滤出<？insert-end id =“INS-S-00003”？>血细胞<？delete-start id =“DEL-S-00004”获得的“INS-S-00003”date =“20061114”？ “date =”20061114“？>用<？delete-end id =”DEL-S-00004“？> <？insert-start id =”INS-S-00004“date =”20061114“？> ？insert-end id =“INS-S-00004”？>由于毛细作用，将过滤器吸入样品溶液供给路径，形成有：从底部保持过滤器的初级侧部的第一按压部，用于从顶部和底部保持过滤器的次级侧部分的第二按压部分; 用于从顶部保持过滤器的中心部分的第三按压部分; 以及用于围绕第二按压部和第三按压部之间的过滤器的空隙。

10. 发明授权

US06821410B2 Biosensor and method of substrate quantification 失效
标题翻译：生物传感器和底物定量方法
公开(公告)号：US06821410B2
公开(公告)日：2004-11-23
申请号：US10084937
申请日：2002-03-01
申请人： Motokazu Watanabe , Miwa Hasegawa , Tomohiro Yamamoto , Toshihiko Yoshioka , Shiro Nankai
发明人： Motokazu Watanabe , Miwa Hasegawa , Tomohiro Yamamoto , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/26 , C12Q1/005 , C12Q1/44 , C12Q1/60
摘要： Disclosed is a highly responsive biosensor comprising a cholesterol-oxidizing enzyme and cholesterol esterase. The biosensor comprises: an electrically insulating base plate; an electrode system including a working electrode and a counter electrode formed on the base plate; a cover member joined with the base plate to define a sample supply pathway through which a sample solution is introduced from a sample supply port to the electrode system, the sample supply pathway being formed between the cover member and the base plate; and a reagent layer formed in the sample supply pathway, wherein the reagent layer contains a cholesterol-oxidizing enzyme, cholesterol esterase, an electron mediator, and a buffer having a buffering capacity in an acidic pH range.
摘要翻译：公开了一种高反应性生物传感器，其包含胆固醇氧化酶和胆固醇酯酶。生物传感器包括：电绝缘基板; 电极系统，包括形成在所述基板上的工作电极和对电极; 覆盖部件，其与所述基板接合，以限定样品供给路径，通过所述样品供给路径将样品溶液从样品供给口引入所述电极系统，所述样品供给路径形成在所述盖部件和所述基板之间; 以及在试样供给路径上形成的试剂层，其中，所述试剂层含有胆固醇 - 氧化酶，胆固醇酯酶，电子介体和在酸性pH范围内具有缓冲能力的缓冲液。

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