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1. 发明授权

US06451044B1 Method and apparatus for heating inflammed tissue 失效
公开(公告)号：US06451044B1
公开(公告)日：2002-09-17
申请号：US09473919
申请日：1999-12-28
申请人： Morteza Naghavi , Bujin Guo , Birendra Lal , S. Ward Casscells, III , James T. Willerson
发明人： Morteza Naghavi , Bujin Guo , Birendra Lal , S. Ward Casscells, III , James T. Willerson
IPC分类号： A61N100
CPC分类号： A61F2/86 , A61B2017/22001 , A61F2007/0088 , A61N5/0601 , A61N7/02
摘要： The present invention relates to methods for treating inflammation in body tissues. More specifically, certain disclosed methods relate to selectively inducing apoptosis in inflammatory immune cells by heating cells for a sufficient time and at a sufficient temperature to induce programmed cell death. The disclosed stents can be placed in contact with the inflammatory cells and heated under controlled conditions. The disclosed apparatus and methods are particularly suitable for treating athersclerotic plaques.

2. 发明授权

US07603166B2 Method and apparatus for detection of vulnerable atherosclerotic plaque 有权
标题翻译：用于检测易受损的动脉粥样硬化斑块的方法和装置
公开(公告)号：US07603166B2
公开(公告)日：2009-10-13
申请号：US10640570
申请日：2003-08-12
申请人： S. Ward Casscells, III , James T. Willerson , Morteza Naghavi , Bujin Guo
发明人： S. Ward Casscells, III , James T. Willerson , Morteza Naghavi , Bujin Guo
IPC分类号： A61B5/00
CPC分类号： A61B5/01 , A61B1/04 , A61B5/0507 , A61B5/14539 , A61B5/1459 , A61B5/6853
摘要： Methods for the detection of inflammation associated with vulnerable atherosclerotic plaque to prevent heart attack and stroke are disclosed. The methods are also applicable to detection of infection, cancer, wounds or auto-immune disease in the body. Certain embodiments of the new methods provide a way of predicting the level of vulnerability of an atherosclerotic plaque to rupture or thrombus formation by assessing via fiber optic NIR spectrophotometry the status of two or more parameters associated with inflamed atherosclerotic plaque in a vessel of a living patient. From these measurements such conditions as low pH, hypoxia, low glucose, oxidative stress or compounds abundant in vulnerable plaque such as oxidized LDL cholesterol and oxidized metabolites of NO, significant active macrophage population, thin plaque cap, as well as senescence and/or apoptosis of smooth muscle or endothelial cells are determined with the assistance of a suitably programmed microprocessor. By considering together the status of some or all of these conditions with respect to successive sites along a vessel wall, particular plaques which are at significant risk of rupturing or thrombosing can be distinguished from “normal” vessel wall and from “intermediate” and relatively stable or “lower risk” plaques. Sites having more of the indicator conditions would be considered most in need of prompt intervention, and certain combinations of parameter levels would be suggestive of relatively stable plaque.Also disclosed is a multi-parameter catheter and analytical processing assembly for use in the methods.
摘要翻译：公开了用于检测与脆弱动脉粥样硬化斑块相关的炎症以预防心脏病发作和中风的方法。该方法也适用于体内感染，癌症，伤口或自身免疫疾病的检测。新方法的某些实施方案提供了一种预测动脉粥样硬化斑块破裂或血栓形成的脆弱程度的方法，其通过光纤NIR分光光度法评估与活体患者的血管中发炎的动脉粥样硬化斑块相关的两个或多个参数的状态。从这些测量结果可以看出，低pH，低氧，低葡萄糖，氧化应激或脆弱斑块中丰富的化合物如氧化低密度脂蛋白胆固醇和氧化代谢物NO，显着的活性巨噬细胞群体，薄斑块帽以及衰老和/或细胞凋亡在适当编程的微处理器的帮助下测定平滑肌或内皮细胞。通过一起考虑沿着血管壁的连续部位的某些或所有这些状况的状况，具有显着的破裂或血栓形成风险的特定斑块可以与“正常”血管壁和“中间体”和相对稳定的区别或“较低风险”斑块。具有更多指标条件的部位将被认为最需要及时干预，参数水平的某些组合将提示相对稳定的斑块。还公开了一种用于该方法的多参数导管和分析处理组件。

3. 发明授权

US07426409B2 Method and apparatus for detecting vulnerable atherosclerotic plaque 有权
标题翻译：检测易受损的动脉粥样硬化斑块的方法和装置
公开(公告)号：US07426409B2
公开(公告)日：2008-09-16
申请号：US10212860
申请日：2002-08-05
申请人： S. Ward Casscells, III , James T. Willerson , Morteza Naghavi , Bujin Guo
发明人： S. Ward Casscells, III , James T. Willerson , Morteza Naghavi , Bujin Guo
IPC分类号： A61B1/00 , A61B1/04 , A61B6/00
CPC分类号： A61B5/415 , A61B5/0071 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/015 , A61B5/02007 , A61B5/418 , A61B5/6853
摘要： Methods and devices are disclosed for detecting vulnerable atherosclerotic plaque, or plaque at risk of reducing blood flow in a vessel, by identifying a region of elevated temperature along a living vessel wall. The disclosure that human atherosclerotic plaque with measurable temperature heterogeneity has the morphological characteristics of plaque that is likely to ulcerate provides a new and sensitive technique for detecting and treating these dangerous plaques before myocardial infarction and its consequences occur. The disclosed methods are advantageous over conventional plaque detection techniques because they are capable of differentiating between those plaques that are at great risk of rupture, fissure, or ulceration, and consequent thrombosis and occlusion of the artery, and those that are not presently at risk. Infrared heat-sensing catheters useful for identifying potentially fatal arterial plaques in patients with disease of the coronary or other arteries are also described. In some embodiments a coherent infrared fiber optic bundle is employed to radially and longitudinally explore a luminal wall to identify inflamed, heat-producing, atherosclerotic plaque. Certain other methods and devices are disclosed which are particularly suited for non-invasively identifying and then monitoring the progression or amelioration of an inflamed plaque in a patient, and for monitoring for onset of inflammation in an implanted arteriovenous graft. Also disclosed are thermocouple basket catheters and thermistor basket catheters which are also capable of detecting temperature heterogeneity along a vessel wall.
摘要翻译：公开了用于通过识别沿着活体壁的高温区域来检测易受伤害的动脉粥样硬化斑块或具有降低血管中血流风险的斑块的方法和装置。具有可测量的温度异质性的人类动脉粥样硬化斑块具有可能溃疡的斑块的形态特征的揭示提供了在心肌梗塞之前检测和治疗这些危险斑块及其后果的新的和灵敏的技术。所公开的方法相对于常规斑块检测技术是有利的，因为它们能够区分那些具有破裂，裂隙或溃疡的巨大危险以及由此导致的动脉血栓形成和闭塞以及目前尚不存在风险的那些斑块。还描述了可用于识别患有冠状动脉或其他动脉疾病的患者中的潜在致命动脉斑块的红外热感测导管。在一些实施例中，使用相干红外光纤束来径向和纵向地探查管腔壁以识别发炎的，发热的动脉粥样硬化斑块。公开了某些其它的方法和装置，其特别适用于非侵入性地识别并随后监测患者中发炎斑块的进展或改善，以及用于监测植入的动静脉移植物中发炎的发生。还公开了也能够沿着血管壁检测温度异质性的热电偶篮导管和热敏电阻篮导管。

4. 发明授权

US06763261B2 Method and apparatus for detecting vulnerable atherosclerotic plaque 有权
标题翻译：检测易受损的动脉粥样硬化斑块的方法和装置
公开(公告)号：US06763261B2
公开(公告)日：2004-07-13
申请号：US10033731
申请日：2001-12-26
申请人： S. Ward Casscells, III , James T. Willerson , Morteza Naghavi , Bujin Guo
发明人： S. Ward Casscells, III , James T. Willerson , Morteza Naghavi , Bujin Guo
IPC分类号： A61B500
CPC分类号： A61B5/6885 , A61B5/0071 , A61B5/0075 , A61B5/0077 , A61B5/0086 , A61B5/01 , A61B5/015 , A61B5/02007 , A61B5/0507 , A61B5/413 , A61B5/415 , A61B5/418 , A61B5/6853 , A61B5/6858 , A61B8/12 , A61B8/445 , A61B8/5223 , A61B8/5238 , A61B2017/00084 , A61B2017/22001 , A61B2560/0223
摘要： Methods and devices are disclosed for detecting vulnerable atherosclerotic plaque, or plaque at risk of reducing blood flow in a vessel, by a identifying a region of elevated temperature along a living vessel wall. The disclosure that human atherosclerotic plaque with measurable temperature heterogeneity has the morphological characteristics of plaque that is likely to ulcerate provides a new and sensitive technique for detecting and treating these dangerous plaques before myocardial infarction and its consequences occur. The disclosed methods are advantageous over conventional plaque detection techniques because they are capable of differentiating between those plaques that are at great risk of rupture, fissure, or ulceration, and consequent thrombosis and occlusion of the artery and those that are not presently at risk. Infrared heat-sensing catheters useful for identifying potentially fatal arterial plaques in patients with disease of the coronary or other arteries are also described. In some embodiments a coherent infrared fiber optic bundle is employed to radially and longitudinally explore a luminal wall to identify inflamed, heat-producing, atherosclerotic plaque. Certain other methods and devices are disclosed which are particularly suited for non-invasively identifying and then monitoring the progression or amelioration of an inflamed plaque in a patient, and for monitoring for onset of inflammation in an implanted arteriovenous graft. Also disclosed are thermocouple basket catheters and thermistor basket catheters which are also capable of detecting temperature heterogeneity along a vessel wall.
摘要翻译：公开了用于通过识别沿着活体壁的高温区域来检测易受伤害的动脉粥样硬化斑块或具有减少血管中血流风险的斑块的方法和装置。具有可测量的温度异质性的人类动脉粥样硬化斑块具有可能溃疡的斑块的形态特征的揭示提供了在心肌梗塞之前检测和治疗这些危险斑块及其后果的新的和灵敏的技术。所公开的方法相对于常规斑块检测技术是有利的，因为它们能够区分那些具有破裂，裂隙或溃疡的巨大风险的斑块，以及由此导致的动脉血栓形成和闭塞以及目前尚不存在风险的那些斑块。还描述了可用于识别患有冠状动脉或其他动脉疾病的患者中的潜在致命动脉斑块的红外热感测导管。在一些实施例中，使用相干红外光纤束来径向和纵向地探查管腔壁以识别发炎的，发热的动脉粥样硬化斑块。公开了某些其它的方法和装置，其特别适用于非侵入性地识别并随后监测患者中发炎斑块的进展或改善，以及用于监测植入的动静脉移植物中发炎的发生。还公开了也能够沿着血管壁检测温度异质性的热电偶篮导管和热敏电阻篮导管。

5. 发明授权

US06615071B1 Method and apparatus for detecting vulnerable atherosclerotic plaque 有权
标题翻译：检测易受损的动脉粥样硬化斑块的方法和装置
公开(公告)号：US06615071B1
公开(公告)日：2003-09-02
申请号：US09340089
申请日：1999-06-25
申请人： S. Ward Casscells, III , James T. Willerson , Morteza Naghavi , Bujin Guo
发明人： S. Ward Casscells, III , James T. Willerson , Morteza Naghavi , Bujin Guo
IPC分类号： A61B500
CPC分类号： A61B5/01 , A61B5/0066 , A61B5/0071 , A61B5/0075 , A61B5/0086 , A61B5/015 , A61B5/02007 , A61B5/0507 , A61B5/415 , A61B5/418 , A61B5/6853 , A61B2017/00084 , A61B2017/22001
摘要： Methods and devices are disclosed for detecting vulnerable atherosclerotic plaque, or plaque at risk of reducing blood flow in a vessel, by identifying a region of elevated temperature along a living vessel wall. The disclosure that human atherosclerotic plaque with measurable temperature heterogeneity has the morphological characteristics of plaque that is likely to ulcerate provides a new and sensitive technique for detecting and treating these dangerous plaques before myocardial infarction and its consequences occur. The disclosed methods are advantageous over conventional plaque detection techniques because they are capable of differentiating between those plaques that are at great risk of rupture, fissure, or ulceration, and consequent thrombosis and occlusion of the artery, and those that are not presently at risk. Infrared heat-sensing catheters useful for identifying potentially fatal arterial plaques in patients with disease of the coronary or other arteries are also described. In some embodiments a coherent infrared fiber optic bundle is employed to radially and longitudinally explore a luminal wall to identify inflamed, heat-producing, atherosclerotic plaque. Certain other methods and devices are disclosed which are particularly suited for non-invasively identifying and then monitoring the progression or amelioration of an inflamed plaque in a patient, and for monitoring for onset of inflammation in an implanted arteriovenous graft. Also disclosed are thermocouple basket catheters and thermistor basket catheters which are also capable of detecting temperature heterogeneity along a vessel wall.
摘要翻译：公开了用于通过识别沿着活体壁的高温区域来检测易受伤害的动脉粥样硬化斑块或具有降低血管中血流风险的斑块的方法和装置。具有可测量的温度异质性的人类动脉粥样硬化斑块具有可能溃疡的斑块的形态特征的揭示提供了在心肌梗塞之前检测和治疗这些危险斑块及其后果的新的和灵敏的技术。所公开的方法相对于常规斑块检测技术是有利的，因为它们能够区分那些具有破裂，裂隙或溃疡的巨大危险以及由此导致的动脉血栓形成和闭塞以及目前尚不存在风险的那些斑块。还描述了可用于识别患有冠状动脉或其他动脉疾病的患者中的潜在致命动脉斑块的红外热感测导管。在一些实施例中，使用相干红外光纤束来径向和纵向地探查管腔壁以识别发炎的，发热的动脉粥样硬化斑块。公开了某些其它的方法和装置，其特别适用于非侵入性地识别并随后监测患者中发炎斑块的进展或改善，以及用于监测植入的动静脉移植物中发炎的发生。还公开了也能够沿着血管壁检测温度异质性的热电偶篮导管和热敏电阻篮导管。

6. 发明授权

US06950063B2 Intraluminal MRI probe 有权
标题翻译：腔内MRI探针
公开(公告)号：US06950063B2
公开(公告)日：2005-09-27
申请号：US10188788
申请日：2002-07-03
申请人： Krzysztof Nesteruk , Jaroslaw Wosik , Leiming P. Xie , James T. Willerson , Samuel Ward Casscells , Morteza Naghavi
发明人： Krzysztof Nesteruk , Jaroslaw Wosik , Leiming P. Xie , James T. Willerson , Samuel Ward Casscells , Morteza Naghavi
IPC分类号： G01R33/28 , G01R3/327 , A61B5/05
CPC分类号： G01R33/285
摘要： The present invention relates to an intraluminal magnetic resonance imaging (MRI) probe which may be used for intraluminal MRI. The present invention is sized sufficiently small to be inserted into a patient intraluminally. The probe of the present invention comprises a substrate having a dielectric constant in the range of 1-1000, and first and second conducting layers on each side of the dielectric. The present invention is configured to result in a distributed capacitance.
摘要翻译：本发明涉及可用于管腔内MRI的管腔内磁共振成像（MRI）探针。本发明的尺寸足够小以便内插入患者。本发明的探针包括介电常数在1-1000范围内的衬底，以及电介质每侧的第一和第二导电层。本发明被配置成产生分布电容。

7. 发明申请

US20120178065A1 Advanced Button Application for Individual Self-Activating and Monitored Control System in Weight Loss Program 审中-公开
标题翻译：个体自主激活和监控控制系统减肥计划的高级按钮应用
公开(公告)号：US20120178065A1
公开(公告)日：2012-07-12
申请号：US13346804
申请日：2012-01-10
申请人： Morteza Naghavi , Albert Andrew Yen , Haider Ali Hassan , David S. Panthagani , Gregory L. Hennig , Mortaza Mark Naghavi , Susan Michelle Spiering , Timothy Allen Brinkley
发明人： Morteza Naghavi , Albert Andrew Yen , Haider Ali Hassan , David S. Panthagani , Gregory L. Hennig , Mortaza Mark Naghavi , Susan Michelle Spiering , Timothy Allen Brinkley
IPC分类号： G09B19/00
CPC分类号： G09B19/0092 , G16H20/60
摘要： A mobile programmable device and method providing aural, visual or mechanical stimulus in a program for facilitating weight loss or maintenance. The device may be a mobile phone programmed with a downloadable mobile application. The application program may be modified as a result of user behavior or responses to the application. Thus the application can provide a personalized aid in weight loss control. The application may also provide a link for the user to live coaching assistance, support text messaging or email.
摘要翻译：一种在程序中提供听觉，视觉或机械刺激以便于减肥或维护的移动可编程设备和方法。该设备可以是用可下载的移动应用程序编程的移动电话。应用程序可能会因用户行为或应用程序的响应而被修改。因此，该应用可以在减肥控制中提供个性化的辅助。应用程序还可以为用户提供直接辅导辅助，支持短信或电子邮件的链接。

8. 发明申请

US20120177623A1 Compositions for Boosting Metabolism, Assisting Weight Loss, and Promoting Cardiovascular Health 有权
标题翻译：促进代谢，协助减肥和促进心血管健康的组合
公开(公告)号：US20120177623A1
公开(公告)日：2012-07-12
申请号：US13346792
申请日：2012-01-10
申请人： Morteza Naghavi , Albert Andrew Yen , Mortaza Mark Naghavi , Mojtaba Frank Naghavi , Susan Michelle Splering
发明人： Morteza Naghavi , Albert Andrew Yen , Mortaza Mark Naghavi , Mojtaba Frank Naghavi , Susan Michelle Splering
IPC分类号： A61K36/82 , A61P3/00 , A61P9/00 , A61K31/122
CPC分类号： A61K36/82 , A61K31/05 , A61K31/122 , A61K31/592 , A61K31/714 , A61K33/24 , A61K36/704 , A61K36/77 , A61K2300/00
摘要： This invention relates to orally ingested compositions for boosting metabolic rate and reducing or controlling levels of cholesterol and triglycerides and improving cardiovascular function, thus preferably assisting with weight loss and promoting cardiovascular health when administered to mammals, including humans.
摘要翻译：本发明涉及用于促进代谢率和降低或控制胆固醇和甘油三酯水平并改善心血管功能的口服摄取组合物，因此优选在给予哺乳动物（包括人）时协助体重减轻和促进心血管健康。

9. 发明申请

US20120065514A1 Cardiohealth Methods and Apparatus 审中-公开
标题翻译：心脏健康方法与装置
公开(公告)号：US20120065514A1
公开(公告)日：2012-03-15
申请号：US13142548
申请日：2009-12-25
申请人： Morteza Naghavi , Albert Andrew Yen , Harvey S. Hecht , Haider Ali Hassan , David S. Panthagani
发明人： Morteza Naghavi , Albert Andrew Yen , Harvey S. Hecht , Haider Ali Hassan , David S. Panthagani
IPC分类号： A61B8/06 , A61B5/021 , A61B5/0285 , A61B5/02
CPC分类号： A61B5/02055 , A61B5/015 , A61B5/02125 , A61B5/022 , A61B5/0402 , A61B5/0537 , A61B5/14546 , A61B5/1455 , A61B5/6824 , A61B5/6826 , A61B5/6838 , A61B5/6841 , A61B5/7275 , A61B2560/0431 , A61B2560/0437 , A61B2562/0271 , G01K13/002 , G16H50/20 , G16H50/30
摘要： Methods and apparatus for improving measurements of cardiovascular health status in a given individual are provided. The comprehensive assessment of cardiovascular health includes at least two components: risk factor assessment based on epidemiologic studies and functional status of the individual. Structural studies of the individual can also be included in the comprehensive assessment of cardiovascular health. The invention aims to improve detection, treatment, devices, and administration of cardiovascular risk assessment.
摘要翻译：提供了用于改善给定个体心血管健康状况测量的方法和装置。心血管健康综合评估至少包括两个部分：基于流行病学研究的风险因素评估和个体功能状态。个人的结构研究也可以纳入心血管健康综合评估。本发明旨在改善心血管风险评估的检测，治疗，设备和管理。

10. 发明申请

US20110270051A1 Cardiovascular Disease Screening Method and Apparatus 审中-公开
标题翻译：心血管疾病筛查方法与装置
公开(公告)号：US20110270051A1
公开(公告)日：2011-11-03
申请号：US13099606
申请日：2011-05-03
申请人： Morteza Naghavi , Albert Andrew Yen , Haider Ali Hassan , David S. Panthagani
发明人： Morteza Naghavi , Albert Andrew Yen , Haider Ali Hassan , David S. Panthagani
IPC分类号： A61B5/00
CPC分类号： A61B5/0205 , A61B5/02007 , A61B5/02028 , A61B5/02108 , A61B5/022 , A61B5/029 , A61B5/0402 , A61B5/0535 , A61B5/145 , A61B5/7275 , A61B8/0883 , A61B8/0891 , A61B8/485 , G16H40/63 , G16H50/20 , G16H50/30
摘要： The disclosure teaches non-invasive, inexpensive and reproducible tests that provide improved measurement of risk assessment by measurement of the following parameters of a subject. The disclosure includes intima-media thickness, augmentation index, arterial wall elasticity, central arterial pressure, electrocardiogram impedance, cardiograph blood pressure measurement, ankle-brachial index, 3D (three dimensional) plaque volume, vessel wall volume, and diameter waveform pattern characterization. Further, the disclosure teaches that satisfactory measurement of risk assessment may be achieved by conducting any four of the aforementioned tests.
摘要翻译：该公开内容教导了非侵入性，廉价和可再现的测试，其通过测量受试者的以下参数来提供对风险评估的改进的测量。该公开内容包括内膜 - 中膜厚度，增大指数，动脉壁弹性，中心动脉压，心电图阻抗，心电图血压测量，踝肱指数，3D（三维）斑块体积，血管壁体积和直径波形图表征。此外，该公开内容教导了可以通过进行上述任何四个测试来实现令人满意的风险评估测量。

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