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1. 发明授权

US07629362B2 2-pyridine carboxamide derivatives 有权
标题翻译： 2-吡啶甲酰胺衍生物
公开(公告)号：US07629362B2
公开(公告)日：2009-12-08
申请号：US10545424
申请日：2004-02-13
申请人： Morihiro Mitsuya , Makoto Bamba , Fumiko Sakai , Hitomi Watanabe , Yasuhiro Sasaki , Teruyuki Nishimura , Jun-ichi Eiki
发明人： Morihiro Mitsuya , Makoto Bamba , Fumiko Sakai , Hitomi Watanabe , Yasuhiro Sasaki , Teruyuki Nishimura , Jun-ichi Eiki
IPC分类号： A61K31/4436 , C07D417/14 , C07D401/14
CPC分类号： C07D471/04 , C07D417/14
摘要： The present invention relates to a compound which has a glucokinase-activating effect and is useful as a therapeutic agent for diabetes mellitus, being represented by a formula (I): [wherein X1 represents a nitrogen atom, sulfur atom, oxygen atom or the like; R1 represents a 6- to 10-membered aryl group, 5- to 7-membered heteroaryl group or the like; D represents an oxygen atom or sulfur atom; R2 and R3 are the same or different, each representing a hydrogen atom, lower alkyl group or the like; a formula (II) represents an optionally substituted 5- to 7-membered heteroaryl group or the like; a formula (III) represents a monocyclic or bicyclic heteroaryl group] or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及具有葡糖激酶活化作用并可用作糖尿病治疗剂的化合物，其由式（I）表示：[其中X1表示氮原子，硫原子，氧原子等 ; R1表示6-至10-元芳基，5-至7-元杂芳基等; D表示氧原子或硫原子; R2和R3相同或不同，各自表示氢原子，低级烷基等; 式（II）表示任选取代的5〜7元杂芳基等; 式（III）表示单环或双环杂芳基]或其药学上可接受的盐。

2. 发明授权

US08344003B2 2-pyridinecarboxamide derivatives 有权
标题翻译： 2-吡啶甲酰胺衍生物
公开(公告)号：US08344003B2
公开(公告)日：2013-01-01
申请号：US12604835
申请日：2009-10-23
申请人： Morihiro Mitsuya , Makoto Bamba , Fumiko Sakai , Hitomi Watanabe , Yasuhiro Sasaki , Teruyuki Nishimura , Jun-ichi Eiki
发明人： Morihiro Mitsuya , Makoto Bamba , Fumiko Sakai , Hitomi Watanabe , Yasuhiro Sasaki , Teruyuki Nishimura , Jun-ichi Eiki
IPC分类号： A61K31/4436 , C07D417/14 , C07D401/14
CPC分类号： C07D471/04 , C07D417/14
摘要： The present invention relates to a compound which has a glucokinase-activating effect and is useful as a therapeutic agent for diabetes mellitus, being represented by a formula (I): [wherein X1 represents a nitrogen atom, sulfur atom, oxygen atom or the like; R1 represents a 6- to 10-membered aryl group, 5- to 7-membered heteroaryl group or the like; D represents an oxygen atom or sulfur atom; R2 and R3 are the same or different, each representing a hydrogen atom, lower alkyl group or the like; a formula (II) represents an optionally substituted 5- to 7-membered heteroaryl group or the like; a formula (III) represents a monocyclic or bicyclic heteroaryl group] or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及具有葡糖激酶活化作用并可用作糖尿病治疗剂的化合物，其由式（I）表示：[其中X1表示氮原子，硫原子，氧原子等 ; R1表示6-至10-元芳基，5-至7-元杂芳基等; D表示氧原子或硫原子; R2和R3相同或不同，各自表示氢原子，低级烷基等; 式（II）表示任选取代的5〜7元杂芳基等; 式（III）表示单环或双环杂芳基]或其药学上可接受的盐。

3. 发明申请

US20100041660A1 NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES 有权
标题翻译：新型2-吡啶甲酰胺衍生物
公开(公告)号：US20100041660A1
公开(公告)日：2010-02-18
申请号：US12604835
申请日：2009-10-23
申请人： MORIHIRO MITSUYA , Makoto Bamba , Fumiko Sakai , Hitomi Watanabe , Yasuhiro Sasaki , Teruyuki Nishimura , Jun-ichi Eiki
发明人： MORIHIRO MITSUYA , Makoto Bamba , Fumiko Sakai , Hitomi Watanabe , Yasuhiro Sasaki , Teruyuki Nishimura , Jun-ichi Eiki
IPC分类号： A61K31/53 , C07D417/14 , A61K31/4436 , C07D401/14 , A61K31/444 , C07D513/02 , A61K31/4365 , C07D403/02 , A61K31/501 , A61K31/497 , A61P3/10 , A61K31/506 , C07D253/065
CPC分类号： C07D471/04 , C07D417/14
摘要： The present invention relates to a compound which has a glucokinase-activating effect and is useful as a therapeutic agent for diabetes mellitus, being represented by a formula (I): [wherein X1 represents a nitrogen atom, sulfur atom, oxygen atom or the like; R1 represents a 6- to 10-membered aryl group, 5- to 7-membered heteroaryl group or the like; D represents an oxygen atom or sulfur atom; R2 and R3 are the same or different, each representing a hydrogen atom, lower alkyl group or the like; a formula (II) represents an optionally substituted 5- to 7-membered heteroaryl group or the like; a formula (III) represents a monocyclic or bicyclic heteroaryl group] or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及具有葡糖激酶活化作用并可用作糖尿病治疗剂的化合物，其由式（I）表示：[其中X1表示氮原子，硫原子，氧原子等 ; R1表示6-至10-元芳基，5-至7-元杂芳基等; D表示氧原子或硫原子; R2和R3相同或不同，各自表示氢原子，低级烷基等; 式（II）表示任选取代的5〜7元杂芳基等; 式（III）表示单环或双环杂芳基]或其药学上可接受的盐。

4. 发明申请

US20060258701A1 Novel 2-pyridinecarboxamide derivatives 有权
标题翻译：新型2-吡啶甲酰胺衍生物
公开(公告)号：US20060258701A1
公开(公告)日：2006-11-16
申请号：US10545424
申请日：2004-02-13
申请人： Morihiro Mitsuya , Makoto Bamba , Fumio Sakai , Hitomi Watanabe , Yasuhiro Sasaki , Teruyuki Nishimura , Jun-ichi Eiki
发明人： Morihiro Mitsuya , Makoto Bamba , Fumio Sakai , Hitomi Watanabe , Yasuhiro Sasaki , Teruyuki Nishimura , Jun-ichi Eiki
IPC分类号： A61K31/4745 , A61K31/444 , A61K31/4439 , C07D498/02 , C07D417/14
CPC分类号： C07D471/04 , C07D417/14
摘要： The present invention relates to a compound which has a glucokinase-activating effect and is useful as a therapeutic agent for diabetes mellitus, being represented by a formula (I): [wherein X1 represents a nitrogen atom, sulfur atom, oxygen atom or the like; R1 represents a 6- to 10-membered aryl group, 5- to 7-membered heteroaryl group or the like; D represents an oxygen atom or sulfur atom; R and R3 are the same or different, each representing a hydrogen atom, lower alkyl group or the like; a formula (II) represents an optionally substituted 5- to 7-membered heteroaryl group or the like; a formula (III) represents a monocyclic or bicyclic heteroaryl group] or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及具有葡糖激酶活化作用并可用作糖尿病治疗剂的化合物，其由式（I）表示：其中X 1表示氮原子，硫原子，氧原子等; R 1表示6至10元芳基，5至7元杂芳基等; D表示氧原子或硫原子; R和R 3相同或不同，各自表示氢原子，低级烷基等; 式（II）表示任选取代的5〜7元杂芳基等; 式（III）表示单环或双环杂芳基]或其药学上可接受的盐。

5. 发明申请

US20080032996A1 Substituted Quinazoline or Pyridopyrimidine Derivative 失效
标题翻译：取代喹唑啉或吡啶并嘧啶衍生物
公开(公告)号：US20080032996A1
公开(公告)日：2008-02-07
申请号：US10593540
申请日：2005-03-23
申请人： Morihiro Mitsuya , Makoto Bamba , Yasuhiro Sasaki , Teruyuki Nishimura , Jun-ichi Eiki , Keisuke Arakawa
发明人： Morihiro Mitsuya , Makoto Bamba , Yasuhiro Sasaki , Teruyuki Nishimura , Jun-ichi Eiki , Keisuke Arakawa
IPC分类号： A61K31/519 , A61K31/517 , A61K38/28 , A61P3/04 , A61P3/10 , C07D403/12 , C07D413/12 , C07D417/14 , C07D471/04 , C07D513/04
CPC分类号： A61K31/513 , A61K31/517 , A61K31/519 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D513/04
摘要： The present invention provides a compound having a glucokinase activating action being useful for prevention or treatment of diabetes mellitus, etc. being represented by the formula (I): X is nitrogen atom, etc.; Y is oxygen atom, etc.; R1 is an optionally substituted five to six-membered heteroaryl group, etc.; R2 is hydrogen atom or fluorine atom; and ring A is a monocyclic or bicyclic heteroaryl group which may have a substituent represented by the formula (II)] or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供具有葡糖激酶活化作用的化合物，其可用于预防或治疗由式（I）表示的糖尿病等：X为氮原子等; Y是氧原子等; R 1是任选取代的五至六元杂芳基等; R 2是氢原子或氟原子; 环A是可以具有式（II）表示的取代基的单环或双环杂芳基]或其药学上可接受的盐。

6. 发明授权

US07687502B2 Substituted quinazoline or pyridopyrimidine derivative 失效
标题翻译：取代喹唑啉或吡啶并嘧啶衍生物
公开(公告)号：US07687502B2
公开(公告)日：2010-03-30
申请号：US10593540
申请日：2005-03-23
申请人： Morihiro Mitsuya , Makoto Bamba , Yasuhiro Sasaki , Teruyuki Nishimura , Jun-ichi Eiki , Keisuke Arakawa
发明人： Morihiro Mitsuya , Makoto Bamba , Yasuhiro Sasaki , Teruyuki Nishimura , Jun-ichi Eiki , Keisuke Arakawa
IPC分类号： A61K31/519 , A61K31/497 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/14 , C07D419/12 , A61P3/04 , A61P3/10 , C07D471/04 , C07D513/04
CPC分类号： A61K31/513 , A61K31/517 , A61K31/519 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D513/04
摘要： The present invention provides a compound having a glucokinase activating action being useful for prevention or treatment of diabetes mellitus, etc. being represented by the formula (I): X is nitrogen atom, etc.; Y is oxygen atom, etc.; R1 is an optionally substituted five to six-membered heteroaryl group, etc.; R2 is hydrogen atom or fluorine atom; and ring A is a monocyclic or bicyclic heteroaryl group which may have a substituent represented by the formula (II)] or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供具有葡糖激酶活化作用的化合物，其可用于预防或治疗由式（I）表示的糖尿病等：X为氮原子等; Y是氧原子等; R1是任选取代的五至六元杂芳基等; R2是氢原子或氟原子; 环A是可以具有式（II）表示的取代基的单环或双环杂芳基]或其药学上可接受的盐。

7. 发明申请

US20110212891A1 AZEPINONE DERIVATIVES 审中-公开
标题翻译： AZEPINONE衍生物
公开(公告)号：US20110212891A1
公开(公告)日：2011-09-01
申请号：US13126533
申请日：2009-10-26
申请人： Osamu Okamoto , Yasuhiro Sasaki , Hitomi Watanabe , Hideki Jona , Kevin D. Dykstra
发明人： Osamu Okamoto , Yasuhiro Sasaki , Hitomi Watanabe , Hideki Jona , Kevin D. Dykstra
IPC分类号： A61K38/12 , C07K5/00 , A61P3/10
CPC分类号： C07D223/16 , C07D401/12 , C07D417/12 , C07K5/06026
摘要： The present invention relates to a compound represented by formula (I): wherein R1 represents a hydrogen atom or the like; R2 and R3 represent a hydrogen atom or the like; R4 is a group represented by (II) R5 represents a phenyl group which may be substituted with a halogen or the like; m is an integer of from 1 to 3; and p is an integer of from 0 to 4; or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及由式（I）表示的化合物：其中R1表示氢原子等; R2和R3表示氢原子等; R4是由（II）表示的基团，R5表示可以被卤素等取代的苯基; m为1〜3的整数，且p为0至4的整数; 或其药学上可接受的盐。

8. 发明授权

US09137608B2 Actuator, piezoelectric actuator, electronic device, and method for attenuating vibration and converting vibration direction 有权
标题翻译：执行器，压电致动器，电子装置以及衰减振动和转动振动方向的方法
公开(公告)号：US09137608B2
公开(公告)日：2015-09-15
申请号：US13513953
申请日：2010-12-14
申请人： Masatake Takahashi , Yasuharu Onishi , Yasuhiro Sasaki , Shigeki Shinoda , Junichiro Mataga , Ukyo Mori , Jun Kuroda , Yukio Murata
发明人： Masatake Takahashi , Yasuharu Onishi , Yasuhiro Sasaki , Shigeki Shinoda , Junichiro Mataga , Ukyo Mori , Jun Kuroda , Yukio Murata
IPC分类号： H01L41/053 , H04R7/20 , H04R17/00
CPC分类号： H04R7/20 , H04R17/00
摘要： A viscoelastic body is interposed between a vibrating membrane vibrating in association with a piezoelectric vibrator composed of a piezoelectric element and a base and a support member supporting the vibrating membrane. The viscoelastic body attenuates vibration transmitted from the support member to the vibrating membrane and converts vibration of the vibrating membrane in the surface direction parallel to its main surfaces to vibration of the vibrating membrane in the direction nearly perpendicular to the surface direction. The vibrating membrane is annular with an opening at the center, and the base is joined to the vibrating membrane coaxially with opening.
摘要翻译：粘弹性体介于与由压电元件和基底构成的压电振动器相关联的振动膜和支撑振动膜的支撑构件之间。粘弹性体将从支撑构件传递到振动膜的振动衰减，并且使振动膜的与其主表面平行的表面方向的振动在振动膜的振动上沿着与表面方向大致垂直的方向发生振动。振动膜是中心具有开口的环形，基部与开口同轴地连接到振动膜。

9. 发明授权

US08891188B2 Breakdown prediction device, breakdown prediction method, and breakdown prediction program 有权
标题翻译：故障预测装置，故障预测方法和故障预测程序
公开(公告)号：US08891188B2
公开(公告)日：2014-11-18
申请号：US13574141
申请日：2011-01-20
申请人： Shigeru Kasai , Yasuhiro Sasaki , Hiroshi Sakai
发明人： Shigeru Kasai , Yasuhiro Sasaki , Hiroshi Sakai
IPC分类号： G11B27/36 , G11B20/10 , G11B20/18 , G11B19/04
CPC分类号： G11B20/10009 , G11B19/048 , G11B20/10027 , G11B20/10314 , G11B20/1816 , G11B27/36 , G11B2220/2516
摘要： A breakdown prediction device of the present invention includes: a vibration measurement unit that measures vibrations generated from a device being monitored; and a signal processing unit that performs breakdown prediction when a specific vibration is measured at the vibration measurement unit, a maximum vibration amplitude value of the vibration exceeding an upper limit vibration amplitude threshold, and a vibration amplitude value thereof being below a lower limit vibration amplitude threshold at a point in time when a specified time is reached from a point in time when the vibration exceeds the upper limit vibration amplitude threshold.
摘要翻译：本发明的故障预测装置包括：振动测量单元，其测量从被监视的设备产生的振动; 以及信号处理单元，其在所述振动测量单元处测量特定振动时执行击穿预测，所述振动的最大振动振幅值超过上限振幅阈值，并且其振动振幅值低于下限振幅在振动超过上限振幅阈值的时间点达到指定时间的时间点的阈值。

10. 发明授权

US08770591B2 Connector seal 有权
标题翻译：连接器密封
公开(公告)号：US08770591B2
公开(公告)日：2014-07-08
申请号：US12382102
申请日：2009-03-09
申请人： Yasuhiro Sasaki , Shigeru Tanaka , Osamu Sugiyama , Tohru Kurosawa , Hiroaki Yamagishi , Genki Murakoshi
发明人： Yasuhiro Sasaki , Shigeru Tanaka , Osamu Sugiyama , Tohru Kurosawa , Hiroaki Yamagishi , Genki Murakoshi
IPC分类号： F16L17/06 , H02G15/04 , F16L5/02
CPC分类号： H01R13/521
摘要： The present invention is to provide a connector seal allowing an accurate inspection of presence of an incorrectly formed bore in a terminal insertion bore of the connector seal. A connector seal includes a seal main body and a plurality of terminal insertion bores. Each terminal insertion bore has an upper membrane potion and a lower membrane portion, which are spaced one another and interconnected together with a lamella. Preferably, the terminal insertion bore has a membrane, which includes a substantially curved groove and a substantially curved lamella. Preferably, the terminal insertion bore has a membrane which includes a lamella, the lamella being oriented in a direction coincident with a diagonal line of a rectangular cross-section of a terminal so that corners of the terminal hit opposite ends of the lamella.
摘要翻译：本发明提供一种连接器密封件，其允许精确检查在连接器密封件的端子插入孔中存在不正确形成的孔。连接器密封件包括密封主体和多个端子插入孔。每个端子插入孔具有上隔膜部分和下膜部分，其彼此间隔开并与片层互连在一起。优选地，端子插入孔具有膜，其包括基本上弯曲的凹槽和基本上弯曲的薄片。优选地，端子插入孔具有包括薄片的薄膜，薄片沿着与端子的矩形横截面的对角线重合的方向定向，使得端子的拐角撞击薄片的相对端。

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