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1. 发明授权

US07501262B2 Promoters and gene expression method by using the promoters 有权
标题翻译：启动子和使用启动子的基因表达方法
公开(公告)号：US07501262B2
公开(公告)日：2009-03-10
申请号：US11599475
申请日：2006-11-15
申请人： Moon-Hee Sung , Seung-Goo Lee , Seung-Pyo Hong , Hwa-Jung Seo
发明人： Moon-Hee Sung , Seung-Goo Lee , Seung-Pyo Hong , Hwa-Jung Seo
IPC分类号： C12P21/00 , C12N1/21 , C12N15/70 , C12N15/74 , C07H21/04
CPC分类号： C07K14/32 , C12N15/70 , C12N15/75
摘要： To provide a promoter, a recombinant DNA, a gene expression vector, an expression vector, and a transformant, which are capable of expressing a gene without inducing gene expression with an inducer; and a method for producing a protein and a kit therefor, which can be operated easily and performed inexpensively by convenient and inexpensive steps. An isolated DNA having the nucleotide sequence of SEQ ID NO: 1 or 2 of Sequence Listing or a fragment thereof, wherein the isolated DNA exhibits a constitutive promoter activity in Escherichia coli or a bacterium belonging to the genus Bacillus; an isolated DNA having a nucleotide sequence of a nucleic acid capable of hybridizing to the above DNA, wherein the isolated DNA exhibits a constitutive promoter activity in Escherichia coli or a bacterium belonging to the genus Bacillus; a recombinant DNA comprising the above DNA and a foreign gene, wherein the foreign gene is operably located; a gene expression vector, at least comprising the above DNA; an expression vector comprising the recombinant DNA; a transformant having the above recombinant DNA, or the above expression vector; a method for producing a protein, characterized by culturing the above transformant, and collecting a protein from the resulting culture; and a kit for producing a protein, at least comprising the above DNA, or the above gene expression vector.
摘要翻译：提供能够表达基因而不诱导基因表达的启动子，重组DNA，基因表达载体，表达载体和转化体; 以及用于制备蛋白质及其试剂盒的方法，其可以容易地操作并且通过方便和便宜的步骤廉价地进行。具有序列表的SEQ ID NO：1或2的核苷酸序列或其片段的分离的DNA，其中所述分离的DNA在大肠杆菌或属于芽孢杆菌属的细菌中显示组成型启动子活性; 具有能够与上述DNA杂交的核酸的核苷酸序列的分离的DNA，其中所述分离的DNA在大肠杆菌或属于芽孢杆菌属的细菌中显示出组成型启动子活性; 包含上述DNA和外来基因的重组DNA，其中所述外源基因可操作地定位; 至少包含上述DNA的基因表达载体; 包含重组DNA的表达载体; 具有上述重组DNA的转化体或上述表达载体; 一种生产蛋白质的方法，其特征在于培养上述转化体，并从得到的培养物中收集蛋白质; 以及用于生产至少包含上述DNA或上述基因表达载体的蛋白质的试剂盒。

2. 发明申请

US20070128696A1 Novel promoters and gene expression method by using the promoters 有权
标题翻译：通过使用启动子的新型启动子和基因表达方法
公开(公告)号：US20070128696A1
公开(公告)日：2007-06-07
申请号：US11599475
申请日：2006-11-15
申请人： Moon-Hee Sung , Seung-Goo Lee , Seung-Pyo Hong , Hwa-Jung Seo
发明人： Moon-Hee Sung , Seung-Goo Lee , Seung-Pyo Hong , Hwa-Jung Seo
IPC分类号： C12P21/06 , C12N15/74 , C12N1/21 , C07H21/04
CPC分类号： C07K14/32 , C12N15/70 , C12N15/75
摘要： To provide a promoter, a recombinant DNA, a gene expression vector, an expression vector, and a transformant, which are capable of expressing a gene without inducing gene expression with an inducer; and a method for producing a protein and a kit therefor, which can be operated easily and performed inexpensively by convenient and inexpensive steps. An isolated DNA having the nucleotide sequence of SEQ ID NO: 1 or 2 of Sequence Listing or a fragment thereof, wherein the isolated DNA exhibits a constitutive promoter activity in Escherichia coli or a bacterium belonging to the genus Bacillus; an isolated DNA having a nucleotide sequence of a nucleic acid capable of hybridizing to the above DNA, wherein the isolated DNA exhibits a constitutive promoter activity in Escherichia coli or a bacterium belonging to the genus Bacillus; a recombinant DNA comprising the above DNA and a foreign gene, wherein the foreign gene is operably located; a gene expression vector, at least comprising the above DNA; an expression vector comprising the recombinant DNA; a transformant having the above recombinant DNA, or the above expression vector; a method for producing a protein, characterized by culturing the above transformant, and collecting a protein from the resulting culture; and a kit for producing a protein, at least comprising the above DNA, or the above gene expression vector.
摘要翻译：提供能够表达基因而不诱导基因表达的启动子，重组DNA，基因表达载体，表达载体和转化体; 以及用于制备蛋白质及其试剂盒的方法，其可以容易地操作并且通过方便和便宜的步骤廉价地进行。具有序列表的SEQ ID NO：1或2的核苷酸序列或其片段的分离的DNA，其中所述分离的DNA在大肠杆菌或属于芽孢杆菌属的细菌中显示组成型启动子活性; 具有能够与上述DNA杂交的核酸的核苷酸序列的分离的DNA，其中所述分离的DNA在大肠杆菌或属于芽孢杆菌属的细菌中显示出组成型启动子活性; 包含上述DNA和外来基因的重组DNA，其中所述外源基因可操作地定位; 至少包含上述DNA的基因表达载体; 包含重组DNA的表达载体; 具有上述重组DNA的转化体或上述表达载体; 一种生产蛋白质的方法，其特征在于培养上述转化体，并从得到的培养物中收集蛋白质; 以及用于生产至少包含上述DNA或上述基因表达载体的蛋白质的试剂盒。

3. 发明授权

US07183077B2 Promoters and gene expression method by using the promoters 有权
标题翻译：启动子和使用启动子的基因表达方法
公开(公告)号：US07183077B2
公开(公告)日：2007-02-27
申请号：US10258482
申请日：2001-04-26
申请人： Moon-Hee Sung , Seung-Goo Lee , Seung-Pyo Hong , Hwa-Jung Seo
发明人： Moon-Hee Sung , Seung-Goo Lee , Seung-Pyo Hong , Hwa-Jung Seo
IPC分类号： C12P21/00 , C12N1/21 , C12N15/70 , C12N15/74 , C07H21/04
CPC分类号： C07K14/32 , C12N15/70 , C12N15/75
摘要： To provide a promoter, a recombinant DNA, a gene expression vector, an expression vector, and a transformant, which are capable of expressing a gene without inducing gene expression with an inducer; and a method for producing a protein and a kit therefor, which can be operated easily and performed inexpensively by convenient and inexpensive steps. An isolated DNA having the nucleotide sequence of SEQ ID NO: 1 or 2 of Sequence Listing or a fragment thereof, wherein the isolated DNA exhibits a constitutive promoter activity in Escherichia coli or a bacterium belonging to the genus Bacillus; an isolated DNA having a nucleotide sequence of a nucleic acid capable of hybridizing to the above DNA, wherein the isolated DNA exhibits a constitutive promoter activity in Escherichia coli or a bacterium belonging to the genus Bacillus; a recombinant DNA comprising the above DNA and a foreign gene, wherein the foreign gene is operably located; a gene expression vector, at least comprising the above DNA; an expression vector comprising the recombinant DNA; a transformant having the above recombinant DNA, or the above expression vector; a method for producing a protein, characterized by culturing the above transformant, and collecting a protein from the resulting culture; and a kit for producing a protein, at least comprising the above DNA, or the above gene expression vector.
摘要翻译：提供能够表达基因而不诱导基因表达的启动子，重组DNA，基因表达载体，表达载体和转化体; 以及用于制备蛋白质及其试剂盒的方法，其可以容易地操作并且通过方便和便宜的步骤廉价地进行。具有序列表的SEQ ID NO：1或2的核苷酸序列或其片段的分离的DNA，其中所述分离的DNA在大肠杆菌或属于芽孢杆菌属的细菌中显示组成型启动子活性; 具有能够与上述DNA杂交的核酸的核苷酸序列的分离的DNA，其中所述分离的DNA在大肠杆菌或属于芽孢杆菌属的细菌中显示出组成型启动子活性; 包含上述DNA和外来基因的重组DNA，其中所述外源基因可操作地定位; 至少包含上述DNA的基因表达载体; 包含重组DNA的表达载体; 具有上述重组DNA的转化体或上述表达载体; 一种生产蛋白质的方法，其特征在于培养上述转化体，并从得到的培养物中收集蛋白质; 以及用于生产至少包含上述DNA或上述基因表达载体的蛋白质的试剂盒。

4. 发明授权

US06967087B1 Obligately symbiotic thermophile symbiobacterium toebii SC-1 producing thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase and a method for screening its relative bacteria 失效
标题翻译：共生共生嗜热菌共生菌toebii SC-1产生热稳定性L-酪氨酸苯酚裂解酶和L-色氨酸吲哚裂解酶及其相对细菌筛选方法
公开(公告)号：US06967087B1
公开(公告)日：2005-11-22
申请号：US10220174
申请日：2000-07-14
申请人： Moon-Hee Sung , Seung-Goo Lee , Sung-Keun Rhee , Seung-Pyo Hong , Dae-Joong Kang , Su-Mi Kim , Chul-Joong Kim , Jin-Woo Bae , Che Ok Jeon , Joong-Jae Kim , Kwang Kim , Jae Jun Song
发明人： Moon-Hee Sung , Seung-Goo Lee , Sung-Keun Rhee , Seung-Pyo Hong , Dae-Joong Kang , Su-Mi Kim , Chul-Joong Kim , Jin-Woo Bae , Che Ok Jeon , Joong-Jae Kim , Kwang Kim , Jae Jun Song
IPC分类号： G01N33/569 , C12N1/20 , C12N9/88 , C12P13/22 , C12Q1/06 , C12R1/01 , G01N21/77 , C12P39/00 , C12Q1/12
CPC分类号： C12R1/01 , C12N9/88 , C12P13/227
摘要： The present invention relates to a novel obligately symbiotic thermophile Symbiobacterium toebii SC-1(Accession NO: KCTC 0685BP), and a thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase produced by Symbiobacterium toebii SC-1. The present invention also relates to a pure culture method of Symbiobacterium toebii SC-1, a method of growth measurement for Symbiobacterium toebu SC-1 and its relative symbiotic bacteria showing low-growth yield using nitrate respiration, and a screening method of relative symbiotic strains of Symbiobacterium toebii SC-1 from the environment using a specific antibody to it. Therefore, the thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase produced by Symbiobacterium toebii SC-1 in this invention can provide more stable catalysts in enzymatic biotransformation processes which enzymatically produce valuable medico-amino acids 3,4-dehydroxy-L-phenylalanine (L-DOPA) and L-tryptophan.
摘要翻译：本发明涉及一种新型的共生共生嗜热ile ile i i i i i i i i））i i i i i i i i i i i i i i i i i。。。。。。。。。。。。。。。。。。。。本发明还涉及使用硝酸盐呼吸的共生杆菌SC-1的纯培养方法，使用硝酸盐呼吸显示低生长量的共生杆菌SC-1及其相对共生菌的生长测定方法以及相对共生菌株的筛选方法的来自环境的共表达杆菌SC-1使用特异性抗体。因此，在本发明中由共生杆菌（Toibii）SC-1产生的热稳定性L-酪氨酸苯酚裂解酶和L-色氨酸吲哚裂解酶可以在酶生物转化过程中提供更稳定的催化剂，其中酶促产生有价值的羟基 - 氨基酸3,4-脱羟基 - L-苯丙氨酸（L-DOPA）和L-色氨酸。

5. 发明授权

US07323328B2 Obligately symbiotic thermophile Symbiobacterium toebii SC-1 producing thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase 有权
标题翻译：共生共生嗜热菌共培养杆菌SC-1产生热稳定性L-酪氨酸苯酚裂解酶和L-色氨酸吲哚裂解酶
公开(公告)号：US07323328B2
公开(公告)日：2008-01-29
申请号：US11186559
申请日：2005-07-21
申请人： Moon-Hee Sung , Seung-Goo Lee , Sung-Keun Rhee , Seung-Pyo Hong , Dae-Joong Kang , Su-Mi Kim , Chul-Joong Kim , Jin-Woo Bae , Che Ok Jeon , Joong-Jae Kim , Kwang Kim , Jae Jun Song
发明人： Moon-Hee Sung , Seung-Goo Lee , Sung-Keun Rhee , Seung-Pyo Hong , Dae-Joong Kang , Su-Mi Kim , Chul-Joong Kim , Jin-Woo Bae , Che Ok Jeon , Joong-Jae Kim , Kwang Kim , Jae Jun Song
IPC分类号： C12N1/20 , C12N9/88 , C12P39/00
CPC分类号： C12R1/01 , C12N9/88 , C12P13/227
摘要： The present invention relates to a novel obligately symbiotic thermophile Symbiobacterium toebii SC-1 (Accession NO: KCTC 0685BP), and a thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase produced by Symbiobacterium toebii SC-1. The present invention also relates to a pure culture method of Symbiobacterium toebii SC-1, a method of growth measurement for Symbiobacterium toebii SC-1 and its relative symbiotic bacteria showing low-growth yield using nitrate respiration, and a screening method of relative symbiotic strains of Symbiobacterium toebii SC-1 from the environment using a specific antibody to it. Therefore, the thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase produced by Symbiobacterium toebii SC-1 in this invention can provide more stable catalysts in enzymatic biotransformation processes which enzymatically produce valuable medico-amino acids 3,4-dehydroxy-L-phenylalanine (L-DOPA) and L-tryptophan.
摘要翻译：本发明涉及一种新型的共生共生嗜热ile ile i i i i i i i i））i i i i i i i i i i i i i i i i i。。。。。。。。。。。。。。。。。。。。本发明还涉及使用硝酸盐呼吸的共生杆菌SC-1的纯培养方法，使用硝酸盐呼吸显示低生长产量的共生杆菌SC-1及其相对共生菌的生长方法，以及相对共生菌株的筛选方法的来自环境的共表达杆菌SC-1使用特异性抗体。因此，在本发明中由共生杆菌（Toibii）SC-1产生的热稳定性L-酪氨酸苯酚裂解酶和L-色氨酸吲哚裂解酶可以在酶生物转化过程中提供更稳定的催化剂，其中酶促产生有价值的羟基 - 氨基酸3,4-脱羟基 - L-苯丙氨酸（L-DOPA）和L-色氨酸。

6. 发明申请

US20050255090A1 Obligately symbiotic thermophile Symbiobacterium toebii SC-1 producing thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase 有权
标题翻译：共生共生嗜热菌共培养杆菌SC-1产生热稳定性L-酪氨酸苯酚裂解酶和L-色氨酸吲哚裂解酶
公开(公告)号：US20050255090A1
公开(公告)日：2005-11-17
申请号：US11186559
申请日：2005-07-21
申请人： Moon-Hee Sung , Seung-Goo Lee , Sung-Keun Rhee , Seung-Pyo Hong , Dae-Joong Kang , Su-Mi Kim , Chul-Joong Kim , Jin-Woo Bae , Che Jeon , Joong-Jae Kim , Kwang Kim , Jae Song
发明人： Moon-Hee Sung , Seung-Goo Lee , Sung-Keun Rhee , Seung-Pyo Hong , Dae-Joong Kang , Su-Mi Kim , Chul-Joong Kim , Jin-Woo Bae , Che Jeon , Joong-Jae Kim , Kwang Kim , Jae Song
IPC分类号： G01N33/569 , C12N1/20 , C12N9/88 , C12P13/22 , C12Q1/06 , C12R1/01 , G01N21/77 , A61K45/00
CPC分类号： C12R1/01 , C12N9/88 , C12P13/227
摘要： The present invention relates to a novel obligately symbiotic thermophile Symbiobacterium toebii SC-1 (Accession NO: KCTC 0685BP), and a thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase produced by Symbiobacterium toebii SC-1. The present invention also relates to a pure culture method of Symbiobacterium toebii SC-1, a method of growth measurement for Symbiobacterium toebii SC-1 and its relative symbiotic bacteria showing low-growth yield using nitrate respiration, and a screening method of relative symbiotic strains of Symbiobacterium toebii SC-1 from the environment using a specific antibody to it. Therefore, the thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase produced by Symbiobacterium toebii SC-1 in this invention can provide more stable catalysts in enzymatic biotransformation processes which enzymatically produce valuable medico-amino acids 3,4-dehydroxy-L-phenylalanine (L-DOPA) and L-tryptophan.
摘要翻译：本发明涉及一种新型的共生共生嗜热ile ile i i i i i i i i））i i i i i i i i i i i i i i i i i。。。。。。。。。。。。。。。。。。。。本发明还涉及使用硝酸盐呼吸的共生杆菌SC-1的纯培养方法，使用硝酸盐呼吸显示低生长产量的共生杆菌SC-1及其相对共生菌的生长方法，以及相对共生菌株的筛选方法的来自环境的共表达杆菌SC-1使用特异性抗体。因此，在本发明中由共生杆菌（Toibii）SC-1产生的热稳定性L-酪氨酸苯酚裂解酶和L-色氨酸吲哚裂解酶可以在酶生物转化过程中提供更稳定的催化剂，其中酶促产生有价值的羟基 - 氨基酸3,4-脱羟基 - L-苯丙氨酸（L-DOPA）和L-色氨酸。

7. 发明申请

US20090186804A1 ANTICOAGULANT AND COMPOSITION FOR PREVENTING THROMBUS CONTAINING POLY-GAMMA-GLUTAMIC ACID 审中-公开
标题翻译：用于预防含有多糖 - 谷氨酸的含沙门氏菌的抗凝血剂和组合物
公开(公告)号：US20090186804A1
公开(公告)日：2009-07-23
申请号：US12159561
申请日：2006-12-22
申请人： Moon-Hee Sung , Chung Park , Seung-Pyo Hong , Haryoung Poo , Tae-Woo Kim
发明人： Moon-Hee Sung , Chung Park , Seung-Pyo Hong , Haryoung Poo , Tae-Woo Kim
IPC分类号： A61K38/00 , A61P7/02
CPC分类号： A61K31/74 , A23L33/175 , A61K9/0095
摘要： The present invention relates to an anticoagulant and a composition for preventing thrombus formation, which contain poly-gamma-glutamic acid (PGA) as an active ingredient. The inventive PGA is a water-soluble, anionic, biodegradable and edible amino acid polymer material, which has an anticoagulant effect of preventing thrombi from being accumulated in blood vessels, shows an excellent sustained-release effect and is harmless to the human body. Thus, it is useful as a high-value-added anticoagulant and a food or beverage composition for preventing thrombus formation.
摘要翻译：本发明涉及含有聚-γ-谷氨酸（PGA）作为活性成分的用于预防血栓形成的抗凝血剂和组合物。本发明的PGA是一种水溶性，阴离子，可生物降解和可食用的氨基酸聚合物材料，其具有防止血栓在血管中积聚的抗凝作用，显示出优异的持续释放作用并对人体无害。因此，作为高附加值抗凝剂和用于预防血栓形成的食品或饮料组合物是有用的。

8. 发明授权

US09228190B2 Vector for constitutive high-level expression containing REPe mutant gene 有权
标题翻译：含有REPe突变基因的组成型高水平表达载体
公开(公告)号：US09228190B2
公开(公告)日：2016-01-05
申请号：US13143918
申请日：2010-01-07
申请人： Moon-Hee Sung , Seung Pyo Hong , A Ri Jang
发明人： Moon-Hee Sung , Seung Pyo Hong , A Ri Jang
IPC分类号： C12N15/00 , C12P21/06 , C12N1/20 , C12N15/70 , C07K14/195 , C12N15/74
CPC分类号： C12N15/70 , C07K14/195 , C12N15/746
摘要： A vector for constitutively expressing a high level of a target protein, and more particularly a RepE mutant protein containing a deletion of 21 amino acids in the C-terminal region of a RepE protein and a vector for constitutively expressing a high level of a target protein, which comprises a gene encoding the mutant protein. The constitutive high-level expression vector can stably express a high level of a target protein. Also, the surface expression vector can express a target protein on the surface of recombinant microorganisms while constitutively expressing a high level of the target protein, and thus will be useful for construction of an antigen for vaccines.
摘要翻译：用于组成型表达高水平靶蛋白的载体，更具体地，在RepE蛋白的C-末端区域中含有21个氨基酸缺失的RepE突变蛋白和用于组成型表达高水平靶蛋白的载体，其包含编码突变蛋白的基因。组成型高水平表达载体可稳定表达高水平的靶蛋白。此外，表面表达载体可以在重组微生物的表面上表达靶蛋白，同时组成型表达高水平的靶蛋白，因此可用于构建疫苗抗原。

9. 发明申请

US20060140971A1 Cell surface expression vector of sars virus antigen and microorganisms transformed thereby 审中-公开
标题翻译： sars病毒抗原和微生物转化的细胞表面表达载体
公开(公告)号：US20060140971A1
公开(公告)日：2006-06-29
申请号：US10559631
申请日：2004-06-04
申请人： Moon-Hee Sung , Chul-Joong Kim , Chang-Min Jung , Seung-Pyo Hong , Jong Su Lee , Jae Choi , Kwang Kim , Kuroda Shunichi , Ha Ryoung Poo
发明人： Moon-Hee Sung , Chul-Joong Kim , Chang-Min Jung , Seung-Pyo Hong , Jong Su Lee , Jae Choi , Kwang Kim , Kuroda Shunichi , Ha Ryoung Poo
IPC分类号： A61K39/02 , C12N1/21 , C12N15/74 , C07K14/165
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/523 , C07K2319/00 , C12N9/93 , C12N15/74 , C12N2710/20022 , C12N2770/20022 , Y02A50/476
摘要： The present invention relates to a surface expression vector of SARS coronavirus antigen containing a gene encoding an antigen of SARS inducing coronavirus and any one or two or more of genes pgsB, pgsC and pgsA encoding poly-gamma-glutamic acid synthase complex, a microorganism transformed by the surface expression vector, and a SARS vaccine comprising the microorganism. According to the present invention, it is possible to economically produce a vaccine for prevention and treatment of SARS using a recombinant strain expressing an SARS coronavirus antigen on their surface.
摘要翻译：本发明涉及SARS冠状病毒抗原的表达表达载体，其含有编码SARS诱导冠状病毒抗原的基因和编码聚-γ-谷氨酸合酶复合物的pgsB，pgsC和pgsA基因中的一种或两种以上的基因，微生物转化通过表面表达载体和包含该微生物的SARS疫苗。根据本发明，可以在表面上使用表达SARS冠状病毒抗原的重组菌株经济地制备用于预防和治疗SARS的疫苗。

10. 发明授权

US07871816B2 Vector for anti-HPV vaccine and transformed microorganism by the vector 有权
标题翻译：载体用于抗HPV疫苗和转化的微生物载体
公开(公告)号：US07871816B2
公开(公告)日：2011-01-18
申请号：US11939546
申请日：2007-11-13
申请人： Moon-Hee Sung , Ha Ryoung Poo , Jong Soo Lee , Chang Min Jung , Seung Pyo Hong , Chul-Joong Kim , Sue-nie Park , Hyun-mi Pyo
发明人： Moon-Hee Sung , Ha Ryoung Poo , Jong Soo Lee , Chang Min Jung , Seung Pyo Hong , Chul-Joong Kim , Sue-nie Park , Hyun-mi Pyo
IPC分类号： C12N1/20 , C12N15/00
CPC分类号： C07K14/005 , A61K39/0011 , A61K2039/523 , C12N7/00 , C12N2710/20022 , C12N2730/10122 , C12N2830/008
摘要： Expression vectors that can efficiently produce virion capsid protein, tumor-associated protein of human papillomavirus on a microbial surface. Bacterial strains harboring such surface display vectors, and the use of the bacterial strains or their extracts or purified products as complex vaccines, are also described. The surface display vectors contain one or more than two genes selected from among pgsB, pgsC and pgsA, encoding a poly-χ-glutamic acid synthetase complex (pgsBCA) of a Bacillus sp. strain, and genes that encode virion capsid proteins, tumor-associated proteins of human papillomavirus. Methods for preparing the foregoing vectors, vaccines and transformed microorganisms are also described.
摘要翻译：可以有效地产生病毒体衣壳蛋白，人乳头瘤病毒的肿瘤相关蛋白在微生物表面上的表达载体。还描述了携带这种表面显示载体的细菌菌株，以及细菌菌株或其提取物或纯化产物作为复合疫苗的用途。表面显示载体含有选自pgsB，pgsC和pgsA中的一种或多于两种的基因，编码芽孢杆菌属的多χ-谷氨酸合成酶复合物（pgsBCA）。菌株和编码病毒载体衣壳蛋白，人乳头瘤病毒的肿瘤相关蛋白的基因。还描述了制备前述载体，疫苗和转化的微生物的方法。

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