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1. 发明授权

US08313934B2 Reduction of the toxic effect of impurities from raw materials by extractive fermentation 有权
标题翻译：通过提取发酵降低原料中杂质的毒性作用
公开(公告)号：US08313934B2
公开(公告)日：2012-11-20
申请号：US12239562
申请日：2008-09-26
申请人： Monica Bhatia , Michael C. M. Cockrem , Stephen B. del Cardayre , Fernando A. Sanchez-Riera
发明人： Monica Bhatia , Michael C. M. Cockrem , Stephen B. del Cardayre , Fernando A. Sanchez-Riera
IPC分类号： C12P7/62
CPC分类号： C12P7/649 , Y02E50/13
摘要： There are provided bioproducts and methods of improving production of the bioproducts from engineered microbial cells, the methods comprising: providing a fermentation broth comprising a crude carbon source; inoculating said fermentation broth with said microbial cells; and incubating the inoculated fermentation broth; wherein said bioproduct is a hydrophobic solvent immiscible with said fermentation broth, and wherein a toxic side product present in said crude carbon source is soluble in said hydrophobic solvent. Also, provided are kits for practicing the methods of improving production of bioproducts.
摘要翻译：提供了改善来自工程微生物细胞的生物产物生产的生物产物和方法，所述方法包括：提供包含粗碳源的发酵液; 用所述微生物细胞接种所述发酵液; 并培养接种的发酵液; 其中所述生物产物是与所述发酵液不混溶的疏水性溶剂，并且其中存在于所述粗碳源中的有毒副产物可溶于所述疏水溶剂。此外，提供了用于实践改善生物产物生产方法的试剂盒。

2. 发明授权

US5210296A Recovery of lactate esters and lactic acid from fermentation broth 失效
标题翻译：从发酵液中回收乳酸酯和乳酸
公开(公告)号：US5210296A
公开(公告)日：1993-05-11
申请号：US718542
申请日：1991-06-20
申请人： Michael C. M. Cockrem , Pride D. Johnson
发明人： Michael C. M. Cockrem , Pride D. Johnson
IPC分类号： C07C67/08 , C12P7/56
CPC分类号： C12P7/56 , C07C67/08
摘要： The production of high purity lactate ester or lactic acid from a concentrated fermentation broth by continuous acidification in the presence of an alcohol diluent with sequential or simultaneous esterification, distillation off of high purity ester, and, if desired, hydrolysis of the ester to high purity lactic acid.
摘要翻译：在醇稀释剂存在下，通过连续或同时酯化，蒸馏掉高纯度酯，并且如果需要，将酯水解成高纯度，从浓缩的发酵液中生产高纯度乳酸酯或乳酸乳酸。

3. 发明授权

US5522995A Process for recovering organic acids from aqueous salt solutions 失效
标题翻译：从盐水溶液中回收有机酸的方法
公开(公告)号：US5522995A
公开(公告)日：1996-06-04
申请号：US395621
申请日：1995-02-28
申请人： Michael C. M. Cockrem
发明人： Michael C. M. Cockrem
IPC分类号： B01D61/02 , B01D61/04 , C07C51/42 , B01D61/12
CPC分类号： B01D61/025 , B01D61/04 , C07C51/42 , B01D2311/04
摘要： A crude aqueous mixture of basic salts of an organic acid, free organic acid, and impurities is mixed with carbon dioxide under pressure and applied to a membrane such as a reverse osmosis or other membrane with small pores while holding the mixture under pressure with well mixed carbon dioxide, such that the free organic acid preferentially permeates the membrane while the impurities and salts of the organic,acid are preferentially but not necessarily completely retained. In The preferred form of the invention a back pressure is maintained on the permeate side of the membrane that is a significant pressure but less than the pressure applied to the feed side. This allows higher levels of acidification to be achieved. This is necessary as many membranes are permeable to CO.sub.2 choices of membrane permeate side pressure, retentate side pressure, and permeate counter flow rate can be used to effect different levels of either purification or concentration or both.
摘要翻译：将有机酸，游离有机酸和杂质的碱性盐的粗水混合物在压力下与二氧化碳混合并施加到膜如反渗透或具有小孔的其它膜，同时将混合物保持在充分混合的压力下使得游离有机酸优先渗透膜，而有机酸的杂质和盐优先但不一定完全保留。在本发明的优选形式中，在膜的渗透侧保持背压，其是显着的压力但小于施加到进料侧的压力。这允许实现更高水平的酸化。这是必要的，因为许多膜可渗透CO 2选择膜渗透侧面压力，渗余物侧压力，并且渗透物反流速可用于实现不同水平的纯化或浓缩或两者。

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