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1. 发明授权

US06218514B1 Antibodies specific for soluble truncated integrins 失效
标题翻译：特异于可溶性截短整合素的抗体
公开(公告)号：US06218514B1
公开(公告)日：2001-04-17
申请号：US09343062
申请日：1999-06-29
申请人： Mohit Trikha , Kenneth V. Honn
发明人： Mohit Trikha , Kenneth V. Honn
IPC分类号： A61K39395
CPC分类号： C07K14/82 , C07K14/70546
摘要： tr-&agr;IIb, a soluble, truncated integrin found to be exclusively expressed in tumor cells is provided. An additional truncated integrin, tr-&bgr;3, has also been found to be exclusively expressed in tumor cells. Diagnostic compositions including nucleic acid probes and antibodies and methods for detecting the presence of tr-&agr;IIb and tr-&bgr;3 to identify the presence of tumor cells in a sample are also provided.
摘要翻译： tr-αIIb是发现在肿瘤细胞中唯一表达的可溶性截短的整联蛋白。还发现另外的截短整合素tr-β3仅在肿瘤细胞中表达。还提供了包括核酸探针和抗体的诊断组合物和用于检测tr-αIIb和tr-β3的存在以鉴定样品中肿瘤细胞存在的方法。

2. 发明授权

US6046316A Nucleic acid encoding truncated integrins 失效
标题翻译：核酸编码截短的整合素
公开(公告)号：US6046316A
公开(公告)日：2000-04-04
申请号：US987418
申请日：1997-12-09
申请人： Mohit Trikha , Kenneth V. Honn
发明人： Mohit Trikha , Kenneth V. Honn
IPC分类号： C07K14/705 , C07K14/82 , C12N15/12
CPC分类号： C07K14/82 , C07K14/70546
摘要： tr-.alpha.llb, a soluble, truncated integrin found to be exclusively expressed in tumor cells is provided. An additional truncated integrin, tr-.beta.3, has also been found to be exclusively expressed in tumor cells. Diagnostic compositions including nucleic acid probes and antibodies and methods for detecting the presence of tr-.alpha.llb and tr-.beta.3 to identify the presence of tumor cells in a sample are also provided.
摘要翻译：提供了一种发现在肿瘤细胞中唯一表达的可溶性截短的整联蛋白tr-α11b。还发现另外的截短的整联蛋白tr-β3在肿瘤细胞中是唯一表达的。还提供了包括核酸探针和抗体的诊断组合物和用于检测tr-α11b和tr-β3的存在以鉴定样品中肿瘤细胞存在的方法。

3. 发明授权

US5234933A Cyclic hydroxamic acids 失效
标题翻译：循环羟基酸
公开(公告)号：US5234933A
公开(公告)日：1993-08-10
申请号：US785927
申请日：1991-10-31
申请人： Lawrence J. Marnett , Kenneth V. Honn , Carl R. Johnson , Yung-fa Chen , Katsu-ichi Shimoji
发明人： Lawrence J. Marnett , Kenneth V. Honn , Carl R. Johnson , Yung-fa Chen , Katsu-ichi Shimoji
IPC分类号： C07D211/94
CPC分类号： C07D211/94
摘要： Novel cyclic hydroxamic acids of the general formula: ##STR1## wherein ring A is 5- or 6-membered; R.sup.1, R.sup.2 and R.sup.3 each, ipendently, is hydrogen, C1-24 alkyl, C2-24 alkenyl or a group of the formula: ##STR2## wherein R.sup.4, R.sup.5, R.sup.7 and R.sup.8 each, independently is hydrogen,C1-4 alkyl, C1-4 alkoxy, trifluoromethyl, halogen or nitro; l is 1-3; m is 1-3; n is 1-3; k is 1-3;R.sup.6 and R.sup.9 each, independently is C1-24 alkylene or C2-24 alkenylene;With the proviso that, more than one of R.sup.1, R.sup.2 and R.sup.3 are not hydrogen at the same time; and the pharmaceutically acceptable salts thereof possesses an inhibitory activity against 12-lipoxygenase, and therefore, may be useful for treating and/or preventing inflammation, immune diseases, psoriasis, arteriosclerosis and/or ischaemic cardiovascular diseases and also for suppressing metastasis of cancer.
摘要翻译：新型环状异羟肟酸，其通式为：其中环A为5-或6-元; R1，R2和R3各自独立地是氢，C1-24烷基，C2-24链烯基或下式的基团：其中R4，R5，R7和R8各自独立地是氢，C1- 4烷基，C 1-4烷氧基，三氟甲基，卤素或硝基; l为1-3; m为1-3; n为1-3; k为1-3; R6和R9各自独立地为C1-24亚烷基或C2-24亚烯基; 条件是，R1，R2和R3中的一个以上不是同时为氢; 其药学上可接受的盐具有对12-脂肪氧合酶的抑制活性，因此可用于治疗和/或预防炎症，免疫疾病，牛皮癣，动脉硬化和/或缺血性心血管疾病，也可用于抑制癌转移。

4. 发明授权

US5292884A Cyclic hydroxamic acids 失效
标题翻译：环状异羟肟酸
公开(公告)号：US5292884A
公开(公告)日：1994-03-08
申请号：US959999
申请日：1992-10-13
申请人： Kenneth V. Honn , Carl R. Johnson , Yung-Fa Chen , Katsu-Ichi Shimoji , Lawrence J. Marnett
发明人： Kenneth V. Honn , Carl R. Johnson , Yung-Fa Chen , Katsu-Ichi Shimoji , Lawrence J. Marnett
IPC分类号： C07D211/94 , C07D211/40 , A61K31/445
CPC分类号： C07D211/94
摘要： This invention is related to a cyclic hydroxamic acid of the formula: ##STR1## wherein R.sup.1 is C.sub.1-24 alkyl and R.sup.2 is benzyl.
摘要翻译：本发明涉及下式的环状异羟肟酸：其中R 1是C 1-4烷基，R 2是苄基。

5. 发明授权

US5378607A Method for testing for the presence of metastatic tumor cells 失效
标题翻译：检测转移性肿瘤细胞存在的方法
公开(公告)号：US5378607A
公开(公告)日：1995-01-03
申请号：US737431
申请日：1991-07-29
申请人： Mohanathasan Chelladurai , Kenneth V. Honn , Daniel A. Walz
发明人： Mohanathasan Chelladurai , Kenneth V. Honn , Daniel A. Walz
IPC分类号： G01N33/574 , G01N33/53 , G01N33/86
CPC分类号： G01N33/57492 , G01N2333/31 , Y10S435/96 , Y10S436/813
摘要： A method of testing for the presence of tumor cells which are metastatic based upon the presence of Human Leukocyte Antigen (HLA) is described. In the test a protein which selectively binds the HLA is used to determine the presence of excess HLA which is a characteristic of the tumor cells. The preferred protein is a bacterial enterotoxin, preferably the enterotoxin A (SEA) produced by Staphylococcus aureus.
摘要翻译：描述了基于人白细胞抗原（HLA）的存在来测试转移的肿瘤细胞的存在的方法。在测试中，选择性结合HLA的蛋白质用于确定过量HLA的存在，其是肿瘤细胞的特征。优选的蛋白质是细菌肠毒素，优选由金黄色葡萄球菌产生的肠毒素A（SEA）。

6. 发明授权

US4950680A Method and compositions for inhibition of tumor cell induced platelet aggregation 失效
标题翻译：用于抑制肿瘤细胞诱导的血小板聚集的方法和组合物
公开(公告)号：US4950680A
公开(公告)日：1990-08-21
申请号：US661953
申请日：1984-10-17
申请人： John D. Taylor , Kenneth V. Honn
发明人： John D. Taylor , Kenneth V. Honn
IPC分类号： A61K31/275 , A61K31/44 , A61K31/55
CPC分类号： A61K31/55 , A61K31/275 , A61K31/44
摘要： Compositions and a method for inhibiting tumor cell induced platelet aggregation are described. Platelet aggregation by tumor cells is part of the metastatic cascade which is interrupted according to the present invention. The compounds include a mixture of at least two members of the group including a calcium channel blocker, a prostacyclin, a thromboxane synthase inhibitor and a phosphodiesterase inhibitor. All of the compounds utilized have an affect on calcium ion which controls platelet aggregation.
摘要翻译：描述了组合物和抑制肿瘤细胞诱导的血小板聚集的方法。肿瘤细胞的血小板聚集是根据本发明中断的转移级联的一部分。所述化合物包括至少两种成员的混合物，包括钙通道阻断剂，前列环素，血栓烷合成酶抑制剂和磷酸二酯酶抑制剂。所有使用的化合物都对钙离子有影响，从而控制血小板聚集。

7. 发明授权

US4906646A Method and composition for the treatment of tumors by administering a platinum coordination compound and a calcium channel blocker compound of the dihydropyridine class 失效
标题翻译：通过施用铂配位化合物和二氢吡啶类的钙通道阻断剂化合物来治疗肿瘤的方法和组合物
公开(公告)号：US4906646A
公开(公告)日：1990-03-06
申请号：US786321
申请日：1985-10-10
申请人： Kenneth V. Honn , John D. Taylor , James M. Onoda
发明人： Kenneth V. Honn , John D. Taylor , James M. Onoda
IPC分类号： A61K31/455 , A61K31/275 , A61K31/28 , A61K31/282 , A61K31/44 , A61K31/55 , A61K33/24 , A61P35/00 , C07D211/90
CPC分类号： A61K33/24 , A61K31/275 , A61K31/44 , A61K31/55
摘要： A method for the treatment of malignant tumors by co-administering a platinum coordination compound and a dihydropyridine class calcium channel blocker compound is described. The compounds are administered over a period of several days in at least two separate dosages of each compound so as to produce regression of the tumor in vitro and in vivo and inhibition of metastasis of the tumor in vivo.
摘要翻译：描述了通过共同施用铂配位化合物和二氢吡啶类钙通道阻断剂来治疗恶性肿瘤的方法。化合物在几天内以至少两种不同剂量的每种化合物施用，以便在体内和体内产生肿瘤的回归和体内肿瘤转移的抑制。

8. 发明授权

US5861268A Method for induction of tumor cell apoptosis with chemical inhibitors targeted to 12-lipoxygenase 失效
标题翻译：用靶向12-lipoxygenase的化学抑制剂诱导肿瘤细胞凋亡的方法
公开(公告)号：US5861268A
公开(公告)日：1999-01-19
申请号：US652369
申请日：1996-05-23
申请人： Dean G. Tang , Kenneth V. Honn
发明人： Dean G. Tang , Kenneth V. Honn
IPC分类号： C12Q1/26 , G01N33/50
CPC分类号： G01N33/5011 , C12Q1/26 , Y10S435/975
摘要： A method and test kit for determining tumor cell apoptosis by inhibition of 12-lipoxygenase is described. A method for selectively inducing tumor cell apoptosis by inhibiting 12-lipoxygenase is also described. The preferred compounds are selected from the group consisting of a cyclic hydroxamic acid; and an aryl aliphatic acid; nordihydro guaiaretic acid (NDGA) and N-benzyl-N-hydroxy-5-phenylpentanamide (BHPP).
摘要翻译：描述了通过抑制12-脂肪氧合酶确定肿瘤细胞凋亡的方法和测试试剂盒。还描述了通过抑制12-脂肪氧合酶选择性诱导肿瘤细胞凋亡的方法。优选的化合物选自环状异羟肟酸; 和芳基脂肪酸; 去甲二氢愈创木酸（NDGA）和N-苄基-N-羟基-5-苯基戊酰胺（BHPP）。

9. 发明授权

US5529934A Method for measuring blood procoagulant activity of human leukocyte antigens 失效
标题翻译：测定人白细胞抗原血液促凝血活性的方法
公开(公告)号：US5529934A
公开(公告)日：1996-06-25
申请号：US737441
申请日：1991-07-29
申请人： Mohanathasan Chelladurai , Kenneth V. Honn , Daniel A. Walz
发明人： Mohanathasan Chelladurai , Kenneth V. Honn , Daniel A. Walz
IPC分类号： A61K38/16 , A61K39/00 , A61M1/36 , C12Q1/00 , A01N37/18 , A61K39/085 , C07K1/00
CPC分类号： A61M1/3672 , A61K38/164 , A61K39/001 , A61K39/0011
摘要： Thromboembolic complications have been documented in cancer patients and mismatched organ transplant recipients. Procoagulants have been implicated in these processes and may play an additional role in tumor metastases. Two proteins displaying procoagulant activity, with molecular weights of 35,000 and 28,000 daltons, were isolated from human ovarian carcinoma extracts. The amino terminal sequence of the first 12 amino acids of the 35,000 dalton protein was determined to be IKEEHVIIQAEF. This sequence displays 100% homology to the major histocompatibility (MHC) antigen HLA-DR which exists as an heterodimer composed of a 35 kDa and 28 kDa protein. The procoagulant activity was further purified through immunoaffinity column chromatography involving a monoclonal antibody to HLA-DR. The immunoaffinity purified protein enhanced thrombin generation in recalcified normal plasma approximately 20-fold. HLA-DR procoagulant activity was completely abrogated by the addition of Staphylcoccal aureus enterotoxin A (SEA).
摘要翻译：血栓栓塞并发症已经在癌症患者和错配的器官移植受者中得到记录。促凝剂已经涉及这些过程，并且可能在肿瘤转移中起另外的作用。从人卵巢癌提取物中分离出两种显示促凝活性的蛋白质，分子量为35,000和28,000道尔顿。 35,000道尔顿蛋白的前12个氨基酸的氨基末端序列被确定为IKEEHVIIQAEF。该序列与作为由35kDa和28kDa蛋白质组成的异二聚体存在的主要组织相容性（MHC）抗原HLA-DR显示100％同源性。通过涉及HLA-DR的单克隆抗体的免疫亲和柱色谱进一步纯化促凝血活性。免疫亲和纯化蛋白增强了重新钙化正常血浆中凝血酶的产生约20倍。通过添加金黄色葡萄球菌肠毒素A（SEA），HLA-DR促凝血活性被完全消除。

10. 发明授权

US4690935A Inhibition of tumor growth and metastasis with calcium channel blocker compounds 失效
标题翻译：用钙通道阻滞剂化合物抑制肿瘤生长和转移
公开(公告)号：US4690935A
公开(公告)日：1987-09-01
申请号：US480704
申请日：1983-03-31
申请人： John D. Taylor , Kenneth V. Honn
发明人： John D. Taylor , Kenneth V. Honn
IPC分类号： A61K31/135 , A61K31/275 , A61K31/44 , A61K31/455 , A61K31/495 , A61K31/55 , A61P35/00 , C07D211/90 , A61K31/125
CPC分类号： A61K31/275 , A61K31/44 , A61K31/55
摘要： The use of calcium channel blocker compounds as antitumor and antimetastatic agents in mammals in vivo and in standard laboratory experimets with tumor cells in vitro is described. In particular the use of nimodipine (Bay e 9736) or nifedipine (Bay a 1040) and structurally related compounds as described.
摘要翻译：描述了钙通道阻滞剂化合物在体内在哺乳动物中的抗肿瘤和抗转移剂以及体外肿瘤细胞的标准实验室实验中的用途。特别是使用如所述的尼莫地平（Bay e 9736）或硝苯地平（Bay a 1040）和结构相关的化合物。

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