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1. 发明授权

US5147941A Denture adhesive 失效
标题翻译：假牙胶
公开(公告)号：US5147941A
公开(公告)日：1992-09-15
申请号：US786638
申请日：1991-11-01
申请人： Mohammed Tazi , Robert B. Login , Krystyna Plochocka , Rama K. Haldar , Balgopal Gangadharan , William E. Prosise
发明人： Mohammed Tazi , Robert B. Login , Krystyna Plochocka , Rama K. Haldar , Balgopal Gangadharan , William E. Prosise
IPC分类号： A61K6/00 , C08F220/06
CPC分类号： A61K6/0026 , C08F220/06
摘要： According to this invention, there is provided a denture adhesive which is a mixed partial salt of a copolymer of maleic anhydride and acrylic acid (or methacrylic acid), optionally including a C.sub.1 -C.sub.4 alkyl vinyl ether, having a weight average molecular weight of about 30,000 to 400,000, preferably about 50,000 to 350,000. The copolymer comprises about 10 to 70 mole percent, preferably 20 to 60 mole percent, of maleic anhydride, about 30 to 90 mole percent, preferably 40 to 80 percent, of acrylic acid (or methacrylic acid), and 0 to 25 mole percent of a C.sub.1 -C.sub.4 alkyl vinyl ether.
摘要翻译：根据本发明，提供了一种义齿粘合剂，其是马来酸酐和丙烯酸（或甲基丙烯酸）的共聚物的混合的部分盐，其任选地包括C 1 -C 4烷基乙烯基醚，其重均分子量为约 30,000至400,000，优选约50,000至350,000。共聚物包含约10至70摩尔％，优选20至60摩尔％的马来酸酐，约30至90摩尔％，优选40至80重量％的丙烯酸（或甲基丙烯酸）和0至25摩尔％ C1-C4烷基乙烯基醚。

2. 发明授权

US5037924A Denture adhesive 失效
标题翻译：假牙胶
公开(公告)号：US5037924A
公开(公告)日：1991-08-06
申请号：US557356
申请日：1990-07-25
申请人： Mohammed Tazi , Robert B. Login , Yoon T. Kwak , Balgopal Gangadharan , Rama K. Haldar
发明人： Mohammed Tazi , Robert B. Login , Yoon T. Kwak , Balgopal Gangadharan , Rama K. Haldar
IPC分类号： A61K6/00 , C08F222/06
CPC分类号： A61K6/0026 , C08F222/06
摘要： According to this invention, there is provided a denture adhesive which is a mixed partial salt of a terpolymer of maleic anhydride, (MA) a C.sub.1 -C.sub.4 alkyl vinyl ether (AVE) and isobutylene (IB) vinyl ether, having a weight average molecular weight of about 30,000 to 400,000, preferably about 50,000 to 350,000. The terpolymer has its components in the molar ratio of MA:AVE:IB of about 1:0.4-0.9:0.1-0.6, preferably about 1:0.5-0.8-0.2-0.5.
摘要翻译：根据本发明，提供了一种义齿粘合剂，其是马来酸酐，（MA），C 1 -C 4烷基乙烯基醚（AVE）和异丁烯（IB）乙烯基醚的三元共聚物的混合部分盐，其重均分子量重量约30,000至400,000，优选约50,000至350,000。三元共聚物的组分摩尔比为约1:0.4-0.9:0.1-0.6，优选约1:0.5-0.8-0.2-0.5的MA:AVE:BB。

3. 发明授权

US5262171A Pharmaceutical tablet with PVP having enhanced drug dissolution rate 失效
标题翻译：具有PVP的药物片剂具有增强的药物溶解速率
公开(公告)号：US5262171A
公开(公告)日：1993-11-16
申请号：US796999
申请日：1991-11-25
申请人： Robert B. Login , Mohammed Tazi , Jui-Chang Chuang , Rama K. Haldar , Dinesh Jaiswal , Chi-San Wu
发明人： Robert B. Login , Mohammed Tazi , Jui-Chang Chuang , Rama K. Haldar , Dinesh Jaiswal , Chi-San Wu
IPC分类号： A61K9/20 , A61K47/32 , C08F4/34 , C08F126/10
CPC分类号： A61K9/2027 , Y10S514/96 , Y10S526/915 , Y10S526/936
摘要： A pharmaceutical tablet is provided herein having an effective dissolution rate. The tablet contains a pharmaceutically-active ingredient and a substantially linear, i.e. non-crosslinked K-30 to K-120 PVP as a binding agent. The PVP used herein is made by an initiated polymerization process in which vinyl pyrrolidone monomer is polymerized in the presence of an initiator which produces a linear PVP polymerization, i.e. is a poor hydrogen abstractor of PVP polymer backbones, which would produce a disadvantageous crosslinked PVP product. Suitable initiators include low energy peroxyester free radical initiators, such as t-amylperoxy pivalate, an azo initiator, or a redox initiator which can perform at low temperatures.Preferably the residual initiator level in the PVP is reduced to less than 500 ppm, thereby further precluding the possibility of crosslinking of the PVP polymer during the shelf-life of the tablet.
摘要翻译：本文提供了具有有效溶解速率的药片。片剂含有药物活性成分和基本上线性的，即非交联的K-30至K-120 PVP作为结合剂。本文使用的PVP通过引发聚合方法制备，其中乙烯基吡咯烷酮单体在产生线性PVP聚合的引发剂存在下聚合，即是PVP聚合物主链的不良氢提取物，其将产生不利的交联PVP产物。合适的引发剂包括低能过氧酯自由基引发剂，例如可在低温下进行的新戊酸叔戊基过氧化物，偶氮引发剂或氧化还原引发剂。优选地，PVP中的残余引发剂水平降低到小于500ppm，从而进一步排除了在片剂保质期间PVP聚合物交联的可能性。

4. 发明授权

US5066709A Bioadhesive composition 失效
标题翻译：生物粘合剂组合物
公开(公告)号：US5066709A
公开(公告)日：1991-11-19
申请号：US585326
申请日：1990-09-20
申请人： Ratan K. Chaudhuri , Rama K. Haldar , Balgopal Gangadharan
发明人： Ratan K. Chaudhuri , Rama K. Haldar , Balgopal Gangadharan
IPC分类号： A61C13/23 , A61K6/00 , A61L24/06 , C08F16/16 , C08F20/02 , C08F20/52 , C08F216/16 , C08F222/06 , C08F222/38 , C09J11/00 , C09J125/00 , C09J125/08 , C09J129/00 , C09J129/10 , C09J135/00
CPC分类号： A61L24/06
摘要： This invention relates to superior bioadhesive compositions having time extended adhesive properties comprising a non-toxic carrier and a polymer having between about 45 and about 70 weight % of units having the structure ##STR1## between about 50 and about 30 weight % of units having the structure ##STR2## and 2 to 7 weight % of an amine salt containing a lactam functionally derived from A and/or B, wherein R is hydrogen, alkoxy, phenyl, carboxy or --N lactam having from 3 to 6 carbon atoms; R.sub.1 is C.sub.1 to C.sub.6 alkylene and R.sub.2 is C.sub.2 to C.sub.4 alkylene; said copolymer having a number average molecular weight of about 40,000 to about 500,000 and a relatively small particle size. The invention also relates to the method of synthesizing and using the above composition.
摘要翻译：本发明涉及具有时间延长的粘合剂性质的优异的生物粘合剂组合物，其包含无毒载体和具有约45至约70重量％的具有结构“IMAGE”A的单元的聚合物。约50至约30重量％的单元具有结构 B.和/或 C.和2至7重量％的含有功能性衍生自A和/或B的内酰胺的胺盐，其中R是氢，烷氧基，苯基，羧基或 - 具有3至6个碳原子的N内酰胺; R1是C1-C6亚烷基，R2是C2-C4亚烷基; 所述共聚物的数均分子量为约40,000至约500,000，并且具有相对小的粒度。本发明还涉及合成和使用上述组合物的方法。

5. 发明授权

US5055046A Bioadhesive composition 失效
标题翻译：生物粘合剂组合物
公开(公告)号：US5055046A
公开(公告)日：1991-10-08
申请号：US681590
申请日：1991-04-08
申请人： Ratan K. Chaudhuri , Rama K. Haldar , Balgopal Gangadharan
发明人： Ratan K. Chaudhuri , Rama K. Haldar , Balgopal Gangadharan
IPC分类号： A61C13/23 , A61K6/00 , A61L24/06
CPC分类号： A61L24/06
摘要： This invention relates to superior bioadhesive compositions having time extended adhesive properties comprising a non-toxic carrier and a polymer having between about 45 and about 70 weight % of units having the structure ##STR1## between about 50 and about 30 weight % of units having the structure ##STR2## and 2 and 7 weight % of an amine salt containing a lactam functionality derived from A and/or B, wherein R is hydrogen, alkoxy, phenyl, carboxyl or --N lactam having from 3 to 6 carbon atoms; R.sub.1 is C.sub.1 to C.sub.6 alkylene and R.sub.2 is C.sub.2 to C.sub.4 alkylene; said copolymer having a number average molecular weight of about 40,000 to about 500,000 and a relatively small particle size. The invention also relates to the method of synthesizing and using the above composition.
摘要翻译：本发明涉及具有时间延长的粘合剂性质的优异的生物粘合剂组合物，其包含无毒载体和具有约45至约70重量％的具有结构“IMAGE”A的单元的聚合物。约50至约30重量％的单元具有结构 B.和/或 C.和2和7重量％的含有衍生自A和/或B的内酰胺官能团的胺盐，其中R是氢，烷氧基，苯基，羧基或 - 具有3至6个碳原子的N内酰胺; R1是C1-C6亚烷基，R2是C2-C4亚烷基; 所述共聚物的数均分子量为约40,000至约500,000，并且具有相对小的粒度。本发明还涉及合成和使用上述组合物的方法。

6. 发明授权

US4910247A Adhesive composition 失效
标题翻译：粘合剂组合物
公开(公告)号：US4910247A
公开(公告)日：1990-03-20
申请号：US329036
申请日：1989-03-27
申请人： Rama K. Haldar , Balgopal Gangadharan , Ratan K. Chaudhuri
发明人： Rama K. Haldar , Balgopal Gangadharan , Ratan K. Chaudhuri
IPC分类号： A61K6/00 , A61L24/06 , C08K5/098 , C09J107/00 , C09J129/00 , C09J129/10 , C09J133/02 , C09J135/08
CPC分类号： C08K5/098 , A61L24/06 , C09J129/10 , A61L2400/14
摘要： A composition containing an adhesive suitable for affixing dentures or ostomy devices to a mucous membrane, which adhesive is a mixture composed of(a) 75-25 wt. % of a blend comprising a divalent calcium salt and a monovalent sodium salt of a lower alkyl vinyl ether/maleic acid copolymer wherein the concentration of Ca is between about 10 and 15 wt. % of the blend; Na is between about 1.5 and about 4 wt. % of the blend and --COOH is between about 9 and about 25 wt. % of the blend;(b) 0-10 wt. % of a lower alkyl vinyl ether/maleic acid auxiliary metal salt wherein said metal is divalent magnesium and/or monovalent potassium and wherein said auxiliary metal represents between about 1.5 and about 15 wt. % of said auxiliary metal salt compound and(c) 25-75 wt. % of a stearic acid metal salt wherein said metal salt is magnesium stearate containing from 0% to about 75% sodium stearate.The invention also relates to the use of said composition as an adhesive used in association with mucous membranes.
摘要翻译：一种含有适于将假牙或造口术装置粘贴到粘膜上的粘合剂的组合物，该粘合剂是由（a）75-25wt。％的包含二价钙盐和低级烷基乙烯基醚/马来酸共聚物的一价钠盐的共混物，其中Ca的浓度为约10至15wt。％的混合物; Na为约1.5至约4wt。共混物和-COOH的％为约9至约25重量％。％的混合物; （b）0-10wt。％的低级烷基乙烯基醚/马来酸辅助金属盐，其中所述金属是二价镁和/或一价钾，并且其中所述辅助金属占约1.5至约15wt。％的所述辅助金属盐化合物和（c）25-75wt。％的硬脂酸金属盐，其中所述金属盐是含有0％至约75％硬脂酸钠的硬脂酸镁。本发明还涉及所述组合物作为与粘膜缔合使用的粘合剂的用途。

7. 发明授权

US5093031A Surface active lactams 失效
标题翻译：表面活性内酰胺
公开(公告)号：US5093031A
公开(公告)日：1992-03-03
申请号：US257596
申请日：1988-10-14
申请人： Robert B. Login , Ratan K. Chaudhuri , Rama K. Haldar , Mohamed M. Hashem , Michael W. Helioff , David J. Tracy
发明人： Robert B. Login , Ratan K. Chaudhuri , Rama K. Haldar , Mohamed M. Hashem , Michael W. Helioff , David J. Tracy
IPC分类号： A01N25/04 , A01N25/14 , B01F17/16 , C07D499/00 , C11D1/58 , C11D3/32
CPC分类号： C11D3/32 , A01N25/04 , A01N25/14 , C07D499/00 , C11D1/58
摘要： The invention relates to properties and uses of N-hydrocarbon substituted lactams, particularly N-alkyl substituted lactams having the formula ##STR1## wherein R' is a hydrophobic radical such as linear or branched chain alkyl group containing from 8 to 27 carbon atoms, most preferably micelle forming pyrrolidones having 12 to 16 carbon atoms in the R' group. The invention particularly relates to the uses of the N-hydrocarbon substituted lactams which involve surfactant properties, such as solubility, wetting, viscosity building, emulsifying and/or complexing properties.
摘要翻译：本发明涉及N-烃取代的内酰胺，特别是具有式“IMAGE”的N-烷基取代的内酰胺的性质和用途，其中R'是疏水性基团，例如含有8至27个碳原子的直链或支链烷基，大多数优选在R'基团中形成具有12至16个碳原子的吡咯烷酮。本发明特别涉及涉及表面活性剂性质的N-烃取代的内酰胺的用途，例如溶解度，润湿性，粘度建立，乳化和/或络合性质。

8. 发明授权

US5294644A Surface active lactams 失效
标题翻译：表面活性内酰胺
公开(公告)号：US5294644A
公开(公告)日：1994-03-15
申请号：US654359
申请日：1991-02-12
申请人： Robert B. Login , Ratan K. Chaudhuri , Rama K. Haldar , Mohamed M. Hashem , Michael W. Helioff , David J. Tracy
发明人： Robert B. Login , Ratan K. Chaudhuri , Rama K. Haldar , Mohamed M. Hashem , Michael W. Helioff , David J. Tracy
IPC分类号： A01N25/04 , A01N25/14 , A61K8/49 , A61Q5/02 , A61Q13/00 , A61Q17/02 , B01F17/28 , C02F1/68 , C07D207/26 , C07D207/267 , C07D211/76 , C07D223/10 , C07D499/00 , C09D9/00 , C09G1/00 , C11D1/58 , C11D3/28 , C11D3/32 , B01F17/78 , H01N37/00
CPC分类号： C11D3/32 , A01N25/04 , A01N25/14 , A61K8/4913 , C02F1/683 , C07D207/267 , C07D211/76 , C07D223/10 , C07D499/00 , C09D9/00 , C09G1/00 , C11D1/58 , C11D3/28 , A61Q13/00 , A61Q17/005 , A61Q17/02 , A61Q5/02 , Y10S516/07
摘要： The invention relates to properties and uses of N-hydrocarbon substituted lactams, particularly N-alkyl substituted lactams having the formula ##STR1## wherein R' is a hydrophobic radical such as linear or branched chain alkyl group containing from 8 to 27 carbon atoms, most preferably micelle forming pyrrolidones having 12 to 16 carbon atoms in the R' group. The invention particularly relates to the uses of the N-hydrocarbon substituted lactams which involve surfactant properties, such as solubility, wetting, viscosity building, emulsifying and/or complexing properties.
摘要翻译：本发明涉及N-烃取代的内酰胺，特别是具有式（*化学结构*）A的N-烷基取代的内酰胺的性质和用途，其中R'是疏水基团，例如含有8至27的直链或支链烷基碳原子，最优选在R'基团中具有12至16个碳原子的胶束形成吡咯烷酮。本发明特别涉及涉及表面活性剂性质的N-烃取代的内酰胺的用途，例如溶解度，润湿性，粘度建立，乳化和/或络合性质。

9. 发明授权

US5252611A Controlled release tablets including strongly swellable, moderately crosslinked polyvinylpyrrolidone 失效
标题翻译：控释片，包括强溶胀，中等交联的聚乙烯吡咯烷酮
公开(公告)号：US5252611A
公开(公告)日：1993-10-12
申请号：US915500
申请日：1992-07-20
申请人： Jenn S. Shih , Jui-Chang Chuang , Rama K. Haldar
发明人： Jenn S. Shih , Jui-Chang Chuang , Rama K. Haldar
IPC分类号： A61K9/20 , C08F2/18 , A61K47/32
CPC分类号： A61K9/2027
摘要： What is described herein is a controlled release, drug-delivery composition which comprises a strongly swellable, moderately crosslinked polyvinylpyrrolidone polymer in the form of fine white powders having a defined aqueous gel volume and Brookfield viscosity which is prepared by precipitation polymerization in the presence of a prescribed amount of crosslinking agent, and an effective amount of a pharmaceutical medicament.
摘要翻译：本文描述的是控释药物递送组合物，其包含具有限定的水凝胶体积和布氏粘度的细白色粉末形式的强溶胀，中等交联的聚乙烯吡咯烷酮聚合物，其通过在存在下沉淀聚合制备规定量的交联剂和有效量的药物。

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