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1. 再颁专利

USRE39390E1 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：USRE39390E1
公开(公告)日：2006-11-14
申请号：US10924334
申请日：2002-05-17
申请人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27/327
摘要： There is provided a cholesterol sensor with high-accuracy and excellent response, whose object to be measured is whole blood, where plasma with which is obtained by filtering out hemocytes therein filtered in blood can rapidly reach an electrode system. In a biosensor where plasma with which is obtained by filtering out hemocytes therein filtered with by a filter is sucked into a sample solution supply pathway due to capillarity, there are formed: a first pressing part for holding a primary side portion of the filter from the bottom; a second pressing part for holding a secondary side portion of the filter from the top and the bottom; a third pressing part for holding the central portion of the filter from the top; and a void for surrounding the filter between the second pressing part and third pressing part.
摘要翻译：提供了具有高精度和优异反应的胆固醇传感器，其测量对象为全血，等离子体<？delete-start id =“DEL-S-00001”date =“20061114”？>与<？delete -end id =“DEL-S-00001”？> <？insert-start id =“INS-S-00001”date =“20061114”？>通过过滤出<？insert-end id =“INS- S-00001“？>血细胞<？delete-start id =”DEL-S-00002“date =”20061114“？>其中过滤的<？delete-end id =”DEL-S-00002“？> 在血液中开始id =“INS-S-00002”date =“20061114”？> <？insert-end id =“INS-S-00002”？>可以快速到达电极系统。在等离子体<？delete-start id =“DEL-S-00003”date =“20061114”？>与<？delete-end id =“DEL-S-00003”？> <？insert-start id = 通过滤出<？insert-end id =“INS-S-00003”？>血细胞<？delete-start id =“DEL-S-00004”获得的“INS-S-00003”date =“20061114”？ “date =”20061114“？>用<？delete-end id =”DEL-S-00004“？> <？insert-start id =”INS-S-00004“date =”20061114“？> ？insert-end id =“INS-S-00004”？>由于毛细作用，将过滤器吸入样品溶液供给路径，形成有：从底部保持过滤器的初级侧部的第一按压部，用于从顶部和底部保持过滤器的次级侧部分的第二按压部分; 用于从顶部保持过滤器的中心部分的第三按压部分; 以及用于围绕第二按压部和第三按压部之间的过滤器的空隙。

2. 发明授权

US07056425B2 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US07056425B2
公开(公告)日：2006-06-06
申请号：US10469522
申请日：2002-11-12
申请人： Miwa Hasegawa , Tomohiro Yamamoto , Shin Ikeda , Toshihiko Yoshioka
发明人： Miwa Hasegawa , Tomohiro Yamamoto , Shin Ikeda , Toshihiko Yoshioka
IPC分类号： G01N27/327
CPC分类号： G01N33/5438 , C12Q1/001
摘要： To provide an improved biosensor which allows easy addition of whole blood to the sensor and rapid supply of the added whole blood to a filter even in the case of collecting blood by fingertip centesis for measurement, a second air aperture is provided in a sample solution supply pathway including an electrode system and a reaction layer and communicating with a first air aperture on the terminal end side.
摘要翻译：为了提供一种改进的生物传感器，即使在用于测量的指尖中心收集血液的情况下，也可以容易地将全血添加到传感器中并将添加的全血快速供应到过滤器，在样品溶液供应中提供第二空气孔路径，其包括电极系统和反应层，并且与终端侧的第一空气孔连通。

3. 发明授权

US06977032B2 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06977032B2
公开(公告)日：2005-12-20
申请号：US10472075
申请日：2002-11-12
申请人： Miwa Hasegawa , Tomohiro Yamamoto , Shin Ikeda , Toshihiko Yoshioka
发明人： Miwa Hasegawa , Tomohiro Yamamoto , Shin Ikeda , Toshihiko Yoshioka
IPC分类号： C12Q1/00 , G01N33/49 , G01N27/327
CPC分类号： G01N27/3272 , C12Q1/001 , G01N33/491
摘要： A biosensor including an insulating base plate, an electrode system, a cover for covering the insulating base plate, at least one reaction layer, a sample solution supply pathway communicating with an air aperture at a terminal end side, a sample solution supply part and a filter provided between the sample solution supply pathway and the sample solution supply part to filter hemocytes, an end face and a top face of a primary portion of the filter are exposed and the sample solution supply part is provided adjacently to the primary side portion so as to provide an improved biosensor which allows easy addition of whole blood to the sensor and rapid supply of the added whole blood to a filter even in the case of collecting blood by fingertip centesis for measurement.
摘要翻译：一种生物传感器，包括绝缘基板，电极系统，用于覆盖绝缘基板的盖，至少一个反应层，与终端侧的空气孔连通的样品溶液供给路径，样品溶液供给部和提供在样品溶液供应通道和样品溶液供应部分之间以过滤血细胞的过滤器，暴露过滤器的主要部分的端面和顶面，并且将样品溶液供应部分设置成与初级侧部分相邻，以便提供改进的生物传感器，其允许容易地将全血添加到传感器，并且即使在通过指尖中心收集血液用于测量的情况下将添加的全血快速供应到过滤器。

4. 发明申请

US20050072670A1 Biosensor 审中-公开
标题翻译：生物传感器
公开(公告)号：US20050072670A1
公开(公告)日：2005-04-07
申请号：US10478283
申请日：2002-12-27
申请人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： C12Q1/00 , C12Q1/60 , G01N27/403 , G01N33/487 , G01N33/49 , G01N27/26
CPC分类号： C12Q1/001 , C12Q1/006 , C12Q1/60 , G01N27/3272
摘要： In order to provide a biosensor with high accuracy and excellent response where plasma obtained by filtration of blood rapidly arrives at an electrode system, in a biosensor comprising: an insulating base plate; an electrode system having a working electrode and a counter electrode which are provided on the base plate; a reaction layer including at least oxidoreductase and an electron mediator; a sample solution supply pathway which includes the electrode system and the reaction layer and has an inlet and an air aperture; a sample solution supply part for introducing a sample solution, which is in position apart from the sample solution supply pathway; and a first filter which is disposed between the sample solution supply pathway and the sample solution supply part for filtering the sample solution, where the filtrate filtered with the first filter is supplied into the sample solution supply pathway due to capillary action, the direction in which the sample solution passes through the first filter and the direction in which the filtrate passes through the sample solution supply pathway are made cross at right angles.
摘要翻译：为了提供具有高精度和优异响应的生物传感器，其中通过过滤血液获得的血液迅速到达电极系统，在生物传感器中包括：绝缘基板; 具有设置在基板上的工作电极和对置电极的电极系统; 至少包含氧化还原酶和电子介体的反应层; 包括电极系统和反应层并具有入口和空气孔的样品溶液供应路径; 用于引入样品溶液的样品溶液供应部件，其处于离样品溶液供给路径的位置; 以及第一过滤器，其设置在样品溶液供给路径和样品溶液供给部之间，用于过滤样品溶液，其中用第一过滤器过滤的滤液由于毛细作用而被供给到样品溶液供给通道中，其中样品溶液通过第一过滤器，滤液通过样品溶液供应通道的方向被成直角交叉。

5. 发明授权

US06706232B2 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06706232B2
公开(公告)日：2004-03-16
申请号：US10363589
申请日：2003-03-04
申请人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/001
摘要： There is provided a cholesterol sensor with high-accuracy and excellent response, whose object to be measured is whole blood, where plasma with hemocytes therein filtered can rapidly reach an electrode system. In a biosensor where plasma with hemocytes therein filtered with a filter is sucked into a sample solution supply pathway due to capillarity, there are formed: a first pressing part for holding a primary side portion of the filter from the bottom; a second pressing part for holding a secondary side portion of the filter from the top and the bottom; a third pressing part for holding the central portion of the filter from the top; and a void for surrounding the filter between the second pressing part and third pressing part.
摘要翻译：提供了具有高精度和优异反应的胆固醇传感器，其被测量对象是全血，其中血细胞在其中被过滤的血浆可以快速地达到电极系统。在生物传感器中，其中用过滤器过滤血细胞的血浆由于毛细作用而被吸入样品溶液供应通道中，形成有：从底部保持过滤器的初级侧部分的第一按压部分; 用于从顶部和底部保持过滤器的次级侧部分的第二按压部分; 用于从顶部保持过滤器的中心部分的第三按压部分; 以及用于围绕第二按压部和第三按压部之间的过滤器的空隙。

6. 发明授权

US06821410B2 Biosensor and method of substrate quantification 失效
标题翻译：生物传感器和底物定量方法
公开(公告)号：US06821410B2
公开(公告)日：2004-11-23
申请号：US10084937
申请日：2002-03-01
申请人： Motokazu Watanabe , Miwa Hasegawa , Tomohiro Yamamoto , Toshihiko Yoshioka , Shiro Nankai
发明人： Motokazu Watanabe , Miwa Hasegawa , Tomohiro Yamamoto , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/26 , C12Q1/005 , C12Q1/44 , C12Q1/60
摘要： Disclosed is a highly responsive biosensor comprising a cholesterol-oxidizing enzyme and cholesterol esterase. The biosensor comprises: an electrically insulating base plate; an electrode system including a working electrode and a counter electrode formed on the base plate; a cover member joined with the base plate to define a sample supply pathway through which a sample solution is introduced from a sample supply port to the electrode system, the sample supply pathway being formed between the cover member and the base plate; and a reagent layer formed in the sample supply pathway, wherein the reagent layer contains a cholesterol-oxidizing enzyme, cholesterol esterase, an electron mediator, and a buffer having a buffering capacity in an acidic pH range.
摘要翻译：公开了一种高反应性生物传感器，其包含胆固醇氧化酶和胆固醇酯酶。生物传感器包括：电绝缘基板; 电极系统，包括形成在所述基板上的工作电极和对电极; 覆盖部件，其与所述基板接合，以限定样品供给路径，通过所述样品供给路径将样品溶液从样品供给口引入所述电极系统，所述样品供给路径形成在所述盖部件和所述基板之间; 以及在试样供给路径上形成的试剂层，其中，所述试剂层含有胆固醇 - 氧化酶，胆固醇酯酶，电子介体和在酸性pH范围内具有缓冲能力的缓冲液。

7. 发明授权

US06547954B2 Biosensor and method for quantitating biochemical substrate using the same 有权
标题翻译：生物传感器和使用其生物化学底物的定量方法
公开(公告)号：US06547954B2
公开(公告)日：2003-04-15
申请号：US09232320
申请日：1999-01-18
申请人： Shin Ikeda , Tomohiro Yamamoto , Toshihiko Yoshioka , Shiro Nankai , Shigeki Joko , Junko Iwata
发明人： Shin Ikeda , Tomohiro Yamamoto , Toshihiko Yoshioka , Shiro Nankai , Shigeki Joko , Junko Iwata
IPC分类号： G01N27327
CPC分类号： C12Q1/004 , Y10S435/817
摘要： A biosensor includes: an insulating substrate; an electrode system formed on the insulating substrate which has a working electrode and a counter electrode; and a reaction layer formed on the insulating substrate which contains an oxidoreductase and an electron acceptor. The electron acceptor is ferricinium ion derived from ferrocene electrolyte.
摘要翻译：生物传感器包括：绝缘基板; 形成在具有工作电极和对电极的绝缘基板上的电极系统; 以及形成在包含氧化还原酶和电子受体的绝缘基板上的反应层。电子受体是衍生自二茂铁电解质的三价铁离子。

8. 发明授权

US5922188A Biosensor and method for quantitating biochemical substrate using the same 失效
公开(公告)号：US5922188A
公开(公告)日：1999-07-13
申请号：US812602
申请日：1997-03-07
申请人： Shin Ikeda , Tomohiro Yamamoto , Toshihiko Yoshioka , Shiro Nankai , Shigeki Joko , Junko Iwata
发明人： Shin Ikeda , Tomohiro Yamamoto , Toshihiko Yoshioka , Shiro Nankai , Shigeki Joko , Junko Iwata
IPC分类号： C12Q1/00 , G01N27/26
CPC分类号： C12Q1/004 , Y10S435/817
摘要： A biosensor includes: an insulating substrate; an electrode system formed on the insulating substrate which has a working electrode and a counter electrode; and a reaction layer formed on the insulating substrate which contains an oxidoreductase and an electron acceptor. The electron acceptor is ferricinium ion derived from ferrocene electrolyte.

9. 发明授权

US06214612B1 Cholesterol sensor containing electrodes, cholesterol dehydrogenase, nicotinamide adenine dinucleotide and oxidized electron mediator 失效
标题翻译：胆固醇传感器含有电极，胆固醇脱氢酶，烟酰胺腺嘌呤二核苷酸和氧化电子介体
公开(公告)号：US06214612B1
公开(公告)日：2001-04-10
申请号：US08806801
申请日：1997-03-03
申请人： Tomohiro Yamamoto , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai , Junko Iwata
发明人： Tomohiro Yamamoto , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai , Junko Iwata
IPC分类号： C12M134
CPC分类号： C12Q1/005 , Y10S435/817
摘要： A cholesterol sensor for quantitative determination of cholesterol is provided containing an electrode system and a reaction reagent system. The electrode system contains a measuring electrode such as a carbon electrode and a counter electrode, and the reaction reagent system contains cholesterol dehydrogenase, nicotinamide adenine dinucleotide and an oxidized electron mediator. Electron mediators include ferricyanide, 1,2-naphthoquinone-4-sulfonate, 2,6-dichlorophenol indophenol, dimethylbenzoquinone, 1-methoxy-5-methylphenazinium sulfate, methylene blue, gallocyanine, thionine, phenazine methosulfate and Meldola's blue. Diaphorase, cholesterol esterase and a surfactant may also be present. The electrode system is on an insulating base plate, and the base plate has a covering member containing a groove that is a sample supplying channel which extends from an end of the base plate to the electrode system. A reaction layer containing the reagent system in dry form and a layer of a hydrophilic polymer is provided on the base plate or the covering member, or on both the electrode system and covering member so as to be exposed to the sample supplying channel. During operation, the electron mediator is reduced in conjunction with oxidation of cholesterol in a sample by cholesterol dehydrogenase, and an amount of current required to electrochemically re-oxidize the electron mediator is directly proportional to a quantity of cholesterol present in the sample.
摘要翻译：提供了用于定量测定胆固醇的胆固醇传感器，其包含电极系统和反应试剂系统。电极系统含有碳电极和对电极等测定电极，反应试剂系统含有胆固醇脱氢酶，烟酰胺腺嘌呤二核苷酸和氧化电子介体。电子介体包括铁氰化物，1,2-萘醌-4-磺酸盐，2,6-二氯苯酚靛酚，二甲基苯并醌，1-甲氧基-5-甲基吩嗪鎓硫酸盐，亚甲基蓝，花青素，硫堇，吩嗪甲硫酸盐和梅尔多拉蓝。也可以存在心律变性酶，胆固醇酯酶和表面活性剂。电极系统在绝缘基板上，基板具有包含作为从基板的端部延伸到电极系统的样品供给路径的槽的覆盖部件。含有干式试剂体系和亲水性聚合物层的反应层设置在基板或覆盖部件上，或电极系统和覆盖部件上，以暴露于样品供应通道。在操作期间，电子介体与胆固醇脱氢酶在样品中的胆固醇氧化一起被还原，并且电化学再氧化电子介体所需的电流量与样品中存在的胆固醇量成正比。

10. 发明授权

US5759445A Lipid-dispersed solution and process for producing the same 失效
标题翻译：脂质分散溶液及其制备方法
公开(公告)号：US5759445A
公开(公告)日：1998-06-02
申请号：US641765
申请日：1996-05-02
申请人： Tomohiro Yamamoto , Toshihiko Yoshioka , Shiro Nankai
发明人： Tomohiro Yamamoto , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N33/92 , G01N33/96 , B01J13/00 , C12Q1/60
CPC分类号： G01N33/96 , G01N33/92 , G01N2800/044 , Y10S516/928 , Y10T436/104165
摘要： There is disclosed an aqueous dispersed solution as a standard solution for determining lipid levels, having a dispersion form and a particle size, which are similar to those of serum lipids. A lipid-dispersed solution is obtained by evaporating an organic solvent from a mixture prepared by adding cholesterol, a phospholipid, a bile acid or bile acid salt, and a neutral lipid and/or a cholesterol ester in the organic solvent, swelling the resultant thin-film like mixture with water or buffer heated at a temperature higher than a phase transition temperature of the lecithin, and then dispersing the solution by a physical shear force. There can be easily obtained a solution having a cholesterol concentration of about less than 1,000 mg/dl, which is extremely stable and can be stored for a long period of time.
摘要翻译：公开了水分散溶液作为用于测定脂质水平的标准溶液，具有与血清脂质相似的分散体形式和粒径。通过将有机溶剂从通过在有机溶剂中加入胆固醇，磷脂，胆汁酸或胆汁酸盐和中性脂质和/或胆固醇酯制备的混合物蒸发而获得脂质分散溶液，将所得薄片在与高于卵磷脂相变温度的温度下加热的水或缓冲液混合，然后通过物理剪切力分散溶液。可以容易地获得胆固醇浓度大约小于1,000mg / dl的溶液，其极为稳定并且可以长期储存。

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