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1. 发明申请

US20090211907A1 Separation Medium for Biochemical Analysis 审中-公开
标题翻译：分离培养基用于生物化学分析
公开(公告)号：US20090211907A1
公开(公告)日：2009-08-27
申请号：US11884993
申请日：2006-02-24
申请人： Mitsutoshi Masuda , Kazuko Matsumoto , Rika Iwaura , Yoshinori Yamaguchi , Toshimi Shimizu
发明人： Mitsutoshi Masuda , Kazuko Matsumoto , Rika Iwaura , Yoshinori Yamaguchi , Toshimi Shimizu
IPC分类号： B01D57/02 , G01N27/26
CPC分类号： B01D57/02 , C07K1/26 , C07K1/28 , G01N27/44747
摘要： The invention provides a novel packing composition for separation and/or analysis which permits easy capillary replacement; a process for the production of the packing composition; a method for filling a capillary with the packing composition; and electrophoretic methods (such as capillary electrophoresis) with the same. The invention relates to a packing composition for electrophoretic separation and/or analysis which contains a long self-assembly produced by dissolving a low-molecular-weight amphiphilic compound having a hydrophobic moiety and a hydrophilic moiety in water under heating and then cooling the resulting solution; a process for the production of the packing composition; a method of separation and/or analysis with the composition; and so on.
摘要翻译：本发明提供了用于分离和/或分析的新型包装组合物，其允许容易的毛细管置换; 一种生产包装组合物的方法; 用填充组合物填充毛细管的方法; 和电泳方法（如毛细管电泳）相同。本发明涉及一种用于电泳分离和/或分析的包装组合物，其包含通过在加热下将具有疏水部分和亲水部分的低分子量两亲性化合物溶解在水中，然后冷却所得溶液而产生的长自组装 ; 一种生产包装组合物的方法; 用该组合物分离和/或分析的方法; 等等。

2. 发明授权

US06897326B2 Asymmetrical bicipital lipid and tubular aggregate formed by using the same 失效
标题翻译：通过使用相同的形式形成不对称的脂质和管状聚集体
公开(公告)号：US06897326B2
公开(公告)日：2005-05-24
申请号：US10475700
申请日：2002-02-01
申请人： Mitsutoshi Masuda , Toshimi Shimizu
发明人： Mitsutoshi Masuda , Toshimi Shimizu
IPC分类号： C07H5/04 , C07H13/06 , C07C231/00
CPC分类号： C07H5/04
摘要： The present invention is a stable, nanometer scale micro-tubular aggregated material of an asymmetric double-headed lipid represented by the general formula R—NHCO—(CH2)n—COOH (I) (in the formula, R represents an aldopyranose radical from which the terminal reducing hydroxyl group is excluded and n is from six to twenty). The external diameter of the micro-tubular aggregated material is 10-300 nm, and the length is 0.3-10 μm. The micro-tubular aggregated material can be manufactured by dispersing the asymmetric double-headed lipid described above in water at pH of two to eight, next heating to 80-100° C. to dissolve it and then gradually cooling the aqueous solution obtained.
摘要翻译：本发明是由通式<？in-line-formula description =“In-Line Formulas”end =“lead”→> R-（式2）所示的不对称双头脂质的稳定的纳米级微管聚集物， NHCO-（CH 2 CH 2）n -COOH（I）<βin-line-formula description =“In-line Formulas”end =“tail”？>（in 式中，R表示不具有末端还原羟基的醛吡喃基，n为6〜20）。微管聚集材料的外径为10-300nm，长度为0.3-10μm。微管状聚集体可以通过将上述不对称双头脂质分散在pH为2〜8的水中，接着加热至80-100℃，使其溶解，然后逐渐冷却所得水溶液。

3. 发明授权

US5876748A Fibrous microtube of oligoglycine compound 失效
标题翻译：纤维微管的低聚糖化合物
公开(公告)号：US5876748A
公开(公告)日：1999-03-02
申请号：US916375
申请日：1997-08-22
申请人： Toshimi Shimizu , Masaki Kogiso , Mitsutoshi Masuda
发明人： Toshimi Shimizu , Masaki Kogiso , Mitsutoshi Masuda
IPC分类号： A61L27/00 , C07C233/47 , C07C235/74 , C07K1/113 , C07K5/00 , C07K7/00 , C08G69/10 , D01F4/00 , D01F6/00 , D01F9/00 , D06M23/12 , C07C233/04
CPC分类号： C08G69/10 , C07C235/74
摘要： A lipid represented by the following formula:MO--(CO--CH.sub.2 --NH).sub.p --CO--(CH.sub.2).sub.n --CO--(NH--CH.sub.2 --CO).sub.q --OMwherein M represents a hydrogen atom or an alkali metal, n is an integer of 6-18 and p and q each represent an integer of at least 1 with the proviso that a total of p and q is not greater than 6. When an aqueous solution of an alkali metal salt of the lipid is allowed to stand for 2-3 weeks, a fibrous microtube including a tubular body having a diameter of 1-3 .mu.m and a plurality of spherical vesicles contained within the tubular body and having a diameter of 0.1-3 .mu.m is formed.
摘要翻译：由下式表示的脂质：MO-（CO-CH 2 -NH）p -CO-（CH 2）n -CO-（NH-CH 2 -CO）q-OM，其中M表示氢原子或碱金属，n为 6-18的整数，p和q各自表示至少为1的整数，条件是p和q的总和不大于6.当使脂质的碱金属盐的水溶液静置 2-3周，形成包含直径为1-3μm的管状体和包含在管状体内且直径为0.1-3μm的多个球状小泡的纤维状微管。

4. 发明授权

US5705635A Method for the preparation of ultrafine fibrous assembly having twisted morphology 失效
标题翻译：制备具有扭曲形态的超细纤维组合物的方法
公开(公告)号：US5705635A
公开(公告)日：1998-01-06
申请号：US752437
申请日：1996-11-14
申请人： Toshimi Shimizu , Mitsutoshi Masuda
发明人： Toshimi Shimizu , Mitsutoshi Masuda
IPC分类号： C07H13/04 , C07H1/00 , C09K3/00 , C07H5/04
CPC分类号： C07H1/00
摘要： When a saturated aqueous solution of a bolaform glycolipid represented by the general formula G--NH--CO--(CH.sub.2).sub.n --CO--NH--G, in which G is a residue derived from a D- or L-glucopyranose by excepting the reduced-terminal hydroxyl group and the subscript n is 10, 12 or 14, at a high temperature, e.g., 90 .degree. C. or higher, is cooled at a controlled rate of 0.5 .degree. C./minute or lower, crystallite growth of the precipitates proceeds to form an ultrafine fibrous assembly of up to several hundreds .mu.m length having a twisted fibrous morphology of right- or left-hand screw. The twisted fibrous assembly thus obtained has usefulness as a functional material in the field of fine chemicals and in the fields of electronic and information technologies.
摘要翻译：当由通式G-NH-CO-（CH2）n-CO-NH-G表示的bolaform糖脂的饱和水溶液，其中G是衍生自D-或L-吡喃葡萄糖的残基，末端羟基和下标n为10,12或14，在高温例如90℃或更高温度下以0.5℃/分钟或更低的受控速率冷却，析出物的微晶生长进行以形成长达数百μm长度的超细纤维组合物，其具有右旋或左旋螺杆的扭曲的纤维形态。由此获得的扭曲纤维组合物作为精细化学品领域和电子和信息技术领域的功能材料是有用的。

5. 发明授权

US06632497B2 Hollow fibrous organic nanotube and method for producing the same 失效
标题翻译：中空纤维状有机纳米管及其制造方法
公开(公告)号：US06632497B2
公开(公告)日：2003-10-14
申请号：US09939841
申请日：2001-08-28
申请人： Toshimi Shimizu , George John , Mitsutoshi Masuda
发明人： Toshimi Shimizu , George John , Mitsutoshi Masuda
IPC分类号： B29C3516
CPC分类号： B82Y30/00 , C07H15/04 , D01D5/24 , D01F9/00 , Y10S977/734 , Y10S977/896 , Y10T428/139 , Y10T428/2918
摘要： The invention provides a novel hollow fibrous organic nanotube comprising an O-glycoside type glycolipid having an aldose residue as the glycosyl group and a group represented by the general formula: wherein R is an unsaturated straight-chain hydrocarbon group having 12 to 18 carbon atoms, as the aglycon. The nanotube structure can be obtained by gradually cooling a saturated aqueous solution of the starting material down to room temperature where the solution is kept standing for days or for weeks to cause spontaneous formation of hollow tubes as precipitates.
摘要翻译：本发明提供一种新型的中空纤维状有机纳米管，其包含具有醛糖残基作为糖基的O-糖苷型糖脂和由通式表示的基团：其中R是具有12至18个碳原子的不饱和直链烃基，作为aglycon。纳米管结构可以通过将起始材料的饱和水溶液逐渐冷却至室温而获得，其中溶液保持静置数天或数周以引起中空管作为沉淀物的自发形成。

6. 发明授权

US6030640A Oligoglycine compound, fibrous microtube of oligoglycine compound and process of producing fibrous microtube 失效
标题翻译：寡聚糖化合物，低聚糖化合物的纤维状微管和生产纤维状微管的方法
公开(公告)号：US6030640A
公开(公告)日：2000-02-29
申请号：US184631
申请日：1998-11-03
申请人： Toshimi Shimizu , Masaki Kogiso , Mitsutoshi Masuda
发明人： Toshimi Shimizu , Masaki Kogiso , Mitsutoshi Masuda
IPC分类号： A61L27/00 , C07C233/47 , C07C235/74 , C07K1/113 , C07K5/00 , C07K7/00 , C08G69/10 , D01F4/00 , D01F6/00 , D01F9/00 , D06M23/12 , C07C233/04 , C08G69/26
CPC分类号： C08G69/10 , C07C235/74
摘要： A lipid represented by the following formula:MO--(CO--CH.sub.2 --NH).sub.p --CO--(CH.sub.2).sub.n --CO--(NH--CH.sub.2 --CO).sub.q --OMwherein M represents a hydrogen atom or an alkali metal, n is an integer of 6-18 and p and q each represent an integer of at least 1 with the proviso that a total of p and q is not greater than 6. When an aqueous solution of an alkali metal salt of the lipid is allowed to stand for 2-3 weeks, a fibrous microtube including a tubular body having a diameter of 1-3 .mu.m and a plurality of spherical vesicles contained within the tubular body and having a diameter of 0.1-3 .mu.m is formed.
摘要翻译：由下式表示的脂质：MO-（CO-CH 2 -NH）p -CO-（CH 2）n -CO-（NH-CH 2 -CO）q-OM其中M表示氢原子或碱金属，n 是6-18的整数，p和q各自表示至少为1的整数，条件是p和q的总数不大于6.当脂质的碱金属盐的水溶液被允许放置2-3周，形成包含直径为1-3μm的管状体的纤维状微管和容纳在管状体内且直径为0.1〜3μm的多个球状小泡。

7. 发明授权

US5578664A Methods of solubilizing iodine in aqueous medium and aqueous antiseptic composition containing iodine 失效
标题翻译：在含水介质中溶解碘的方法和含有碘的含水防腐组合物
公开(公告)号：US5578664A
公开(公告)日：1996-11-26
申请号：US524041
申请日：1995-09-06
申请人： Mitsutoshi Masuda , Yukimichi Nakao , Toshimi Shimizu
发明人： Mitsutoshi Masuda , Yukimichi Nakao , Toshimi Shimizu
IPC分类号： C01B7/13 , A01N59/12 , C01B7/14 , C08F12/00 , C08F12/22 , C08K3/02 , C08L25/18
CPC分类号： C01B7/14 , A01N59/12
摘要： A method of solubilizing iodine in an aqueous medium is disclosed, which includes mixing the aqueous medium with iodine together with a polystyrene derivative having the recurring units of the formula ##STR1## wherein R represents an alkylene group having 1-4 carbon atoms and n is an integer of 2-20. An antiseptic composition includes an aqueous medium, the above polystryene derivative, and iodine dissolved in the aqueous medium.
摘要翻译：公开了将碘溶解在水性介质中的方法，其包括将水性介质与碘一起与具有1-4个碳原子的公式的重复单元的聚苯乙烯衍生物混合，并且n是2-20的整数。防腐剂组合物包括水性介质，上述聚苯衍生物和溶解在水性介质中的碘。

8. 发明授权

US09018156B2 Organic nanotube having hydrophobized inner surface, and encapsulated medicinal agent prepared using the nanotube 有权
标题翻译：具有疏水化内表面的有机纳米管和使用纳米管制备的包封的药剂
公开(公告)号：US09018156B2
公开(公告)日：2015-04-28
申请号：US14116182
申请日：2012-03-30
申请人： Naohiro Kameta , Wuxiao Ding , Mitsutoshi Masuda , Hiroyuki Minamikawa , Momoyo Wada , Toshimi Shimizu
发明人： Naohiro Kameta , Wuxiao Ding , Mitsutoshi Masuda , Hiroyuki Minamikawa , Momoyo Wada , Toshimi Shimizu
IPC分类号： A61K9/00 , B82Y40/00 , A61K47/48 , C07K1/113 , B82Y5/00 , B82Y30/00
CPC分类号： A61K9/0092 , A61K47/6925 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C07K1/1136
摘要： Provided is an organic nanotube having a hydrophobized inner surface, formed by molecules including an asymmetric bipolar lipid molecule represented by the following General Formula (1) and a derivative thereof represented by the following General Formula (2), wherein the organic nanotube has a hydrophilized outer surface and a hydrophobized inner surface of a hollow cylinder and is formed by binary self-assembly, the organic nanotube encapsulates a hydrophobic guest in the hollow cylinder, has a function of refolding a denatured protein, and has a function of sustainably-releasing a hydrophobic drug according to the change in hydrophobicity of the inner surface of the tube or external stimulus, In Formulas (1) and (2), wherein the same symbols have the same meanings, G is a 1-glucopyranosyl group or 2-glucopyranosyl group, and n is an integer of 12 to 22. Particularly, an asymmetric bipolar lipid molecule and an ester thereof respectively represented by general formulae (1) and (2) wherein n is an integer of 18 to 22, both of Z1 and Z2 are single bonds, Y is Gly, m(s) is the same or different integer of 3 to 6, X is OH, and R is a methoxy group, an ethoxy group, or a benzyloxy group are novel substances, and can form a carboxylic acid based asymmetric nanotube by single component self-assembly or binary self-assembly.
摘要翻译：本发明提供一种具有疏水化内表面的有机纳米管，其由包含由以下通式（1）表示的不对称双相脂质分子及其通式（2）所示的衍生物的分子形成，其中有机纳米管具有亲水化外表面和中空圆筒的疏水化内表面，并且通过二元自组装形成，有机纳米管在中空圆柱体中包封疏水性客体，具有重折叠变性蛋白质的功能，并且具有可持续释放的功能根据管内表面或外部刺激物的疏水性变化的疏水性药物，在式（1）和（2）中，其中相同的符号具有相同的含义，G是1-吡喃葡萄糖基或2-吡喃葡萄糖基，n为12〜22的整数。特别地，分别由通式（1）和（2）表示的不对称双相脂质分子及其酯 erein n为18〜22的整数，Z1和Z2均为单键，Y为Gly，m（s）为3〜6的相同或不同的整数，X为OH，R为甲氧基，乙氧基或苄氧基是新物质，可以通过单组分自组装或二元自组装形成羧酸类不对称纳米管。

9. 发明授权

US07202228B2 Hydrogelation agents 失效
标题翻译：水凝胶剂
公开(公告)号：US07202228B2
公开(公告)日：2007-04-10
申请号：US10415730
申请日：2002-03-15
申请人： Toshimi Shimizu , Rika Iwamura , Mitsutoshi Masuda
发明人： Toshimi Shimizu , Rika Iwamura , Mitsutoshi Masuda
IPC分类号： A61K48/00 , C07H21/04
CPC分类号： C07H19/10 , C07H21/04
摘要： A gelatinizer is provided having a component which promises to have biological compatibility, which can easily be mass-produced by a simple method, and which can solidify a large amount of water or aqueous solution when only a very small weight of it is used.This invention is a hydrogelatinizer represented by the general formula: R-An where A, which may be identical or different, are respectively nucleotides, n is 2 or 3, and R is a hydrocarbon chain (when n is 2, R is bivalent, and when n is 3, R is trivalent), said hydrocarbon being bonded to a phosphoric acid part of said nucleotides.
摘要翻译：提供了一种具有承诺具有生物相容性的成分的胶凝剂，其可以通过简单的方法容易地批量生产，并且当仅使用非常小的重量时，其可以固化大量的水或水溶液。

10. 发明授权

US5910565A Oligoglycine compound, fibrous microtube of oligoglycine compound and process of producing fibrous microtube 失效
标题翻译：寡聚糖化合物，低聚糖化合物的纤维状微管和生产纤维状微管的方法
公开(公告)号：US5910565A
公开(公告)日：1999-06-08
申请号：US184632
申请日：1998-11-03
申请人： Toshimi Shimizu , Masaki Kogiso , Mitsutoshi Masuda
发明人： Toshimi Shimizu , Masaki Kogiso , Mitsutoshi Masuda
IPC分类号： A61L27/00 , C07C233/47 , C07C235/74 , C07K1/113 , C07K5/00 , C07K7/00 , C08G69/10 , D01F4/00 , D01F6/00 , D01F9/00 , D06M23/12 , C08G69/26
CPC分类号： C08G69/10 , C07C235/74
摘要： A lipid represented by the following formula:MO--(CO--CH.sub.2 --NH).sub.p --CO--(CH.sub.2).sub.n --CO--(NH--CH.sub.2 --CO).sub.q --OMwherein M represents a hydrogen atom or an alkali metal, n is an integer of 6-18 and p and q each represent an integer of at least 1 with the proviso that a total of p and q is not greater than 6. When an aqueous solution of an alkali metal salt of the lipid is allowed to stand for 2-3 weeks, a fibrous microtube including a tubular body having a diameter of 1-3 .mu.m and a plurality of spherical vesicles contained within the tubular body and having a diameter of 0.1-3 .mu.m is formed.
摘要翻译：由下式表示的脂质：MO-（CO-CH2-NH）对-CO-（CH2）n-CO-（NH-CH2-CO）q-OM，其中M表示氢原子或碱金属，n为 6-18的整数，p和q各自表示至少为1的整数，条件是p和q的总和不大于6.当使脂质的碱金属盐的水溶液静置 2-3周，形成包含直径为1-3μm的管状体和包含在管状体内且直径为0.1-3μm的多个球状小泡的纤维状微管。

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