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    • 7. 发明授权
    • 1-Oxadethiacepham compounds
    • 1-氧杂十八胺化合物
    • US4443598A
    • 1984-04-17
    • US374862
    • 1982-05-04
    • Mitsuru YoshiokaUyeo ShoichiroYoshio HamashimaIkuo KikkawaTeruji TsujiWataru Nagata
    • Mitsuru YoshiokaUyeo ShoichiroYoshio HamashimaIkuo KikkawaTeruji TsujiWataru Nagata
    • C07D498/04C07D505/00
    • C07D505/00
    • Intermediates for preparing an antibacterial 1-dethia-1-oxacephalosporins which are represented by the following formula: ##STR1## wherein R is a monovalent group (minus the carbonyl) from an acyl derived from a carboxylic or carbonic acid;Y.sup.1 is a divalent group of the following formula: ##STR2## wherein COB is carboxy or protected carboxy;X is hydrogen or a nucleophilic group; andZ is a leaving groupare prepared from a compound of the following formula: ##STR3## wherein R and Y.sup.1 are as defined above by the action of an acid. The new compounds of this invention shown by the following formula: ##STR4## wherein A is amino or substituted amino;E is hydrogen or methoxy; andY is a divalent group of the following formula: ##STR5## in which COB, X, and Z are as defined above are convertible into other compounds of the same formula by applying conventional methods in .beta.-lactam chemistry.
    • 用于制备由下式表示的抗菌1-脱氧-1-氧杂头孢菌素的中间体:其中R是衍生自羧酸或碳酸的酰基的一价基团(减去羰基); Y1是下式的二价基团:其中COB是羧基或被保护的羧基; X是氢或亲核基团; 并且Z是离去基团由下式的化合物制备:其中R和Y1如上所定义,通过酸的作用。 本发明的新化合物由下式表示:其中A是氨基或取代的氨基; E是氢或甲氧基; 并且Y是下式的二价基团:其中COB,X和Z如上定义的 + TR 可通过在β-内酰胺化学中应用常规方法转化为相同式的其它化合物。