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1. 发明授权

US06673904B2 Stem cell growth factor-like polypeptides 失效
标题翻译：干细胞生长因子样多肽
公开(公告)号：US06673904B2
公开(公告)日：2004-01-06
申请号：US09912935
申请日：2001-07-24
申请人： Mitsuo Nishikawa , Ivan Labat , Radoje T. Drmanac , Y. Tom Tang , Cheng-Chi Chao , Nancy Mize , John Childs
发明人： Mitsuo Nishikawa , Ivan Labat , Radoje T. Drmanac , Y. Tom Tang , Cheng-Chi Chao , Nancy Mize , John Childs
IPC分类号： A61K3800
CPC分类号： C07K14/475 , A61K38/00 , A61K2039/53 , Y10S435/81 , Y10S435/975
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human and mouse secreted stem cell growth factor-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries prepared from mouse bone marrow and human fetal liver spleen, ovary, adult brain, lung tumor, spinal cord, cervix, ovary, endothelial cells, umbilical cord, placental, lymphocyte, lung fibroblast, fetal brain, and testis. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译：本发明提供由对应于新型人和小鼠分泌的干细胞生长因子样多肽的这种多核苷酸和突变体或其变体编码的新型多核苷酸和多肽。这些多核苷酸包括从小鼠骨髓和人胎肝脾，卵巢，成人脑，肺肿瘤，脊髓，子宫颈，卵巢，内皮细胞，脐带，胎盘，淋巴细胞，肺成纤维细胞，胎儿中制备的cDNA文库中分离的核酸序列大脑和睾丸。本发明的其它方面包括含有用于产生新的人分泌的干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。

2. 发明申请

US20080241207A1 Methods and materials relating to novel stem cell growth factor-like polypeptides and polynucleotides 审中-公开
标题翻译：与新型干细胞生长因子样多肽和多核苷酸相关的方法和材料
公开(公告)号：US20080241207A1
公开(公告)日：2008-10-02
申请号：US11985996
申请日：2007-11-19
申请人： Y. Tom Tang , Ivan Labat , Radoje T. Drmanac , Nancy Mize , Mitsuo Nishikawa , Cheng-Chi Chao
发明人： Y. Tom Tang , Ivan Labat , Radoje T. Drmanac , Nancy Mize , Mitsuo Nishikawa , Cheng-Chi Chao
IPC分类号： A61L27/54 , C12Q1/68 , C07K16/22 , C12N5/02 , G01N33/53 , C40B40/08 , A61P43/00 , A61K35/12 , A61K38/18 , A61K31/711 , C12N5/00 , C12N5/22
CPC分类号： C07K14/475 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K16/00 , C07K2319/00 , C12N9/16 , C12N9/6432 , C12Y304/21006 , Y10S435/81 , Y10S435/975
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). Other aspects of the invention include vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译：本发明提供由对应于新的人类干细胞生长因子样蛋白质的这种多核苷酸及其突变体或变体编码的新型多核苷酸和多肽。这些多核苷酸包含从人胎儿皮肤（Hyseq克隆鉴定号15375176），成年脾（Hyseq克隆鉴定号14856094）和人内皮细胞的人睾丸细胞（Hyseq克隆鉴定号2880984和2881695）的cDNA文库中分离的核酸序列（Hyseq克隆鉴定号13804756,13687487,13804756）。本发明的其它方面包括含有生产新型人类干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。

3. 发明授权

US06824973B2 Method of promoting stem cell proliferation or survival by contacting a cell with a stem cell factor-like polypeptide 失效
标题翻译：通过使细胞与干细胞因子样多肽接触来促进干细胞增殖或存活的方法
公开(公告)号：US06824973B2
公开(公告)日：2004-11-30
申请号：US09894912
申请日：2001-06-28
申请人： Y. Tom Tang , Ivan Labat , Radoje T. Drmanac , Nancy Mize , Mitsuo Nishikawa , Cheng-Chi Chao
发明人： Y. Tom Tang , Ivan Labat , Radoje T. Drmanac , Nancy Mize , Mitsuo Nishikawa , Cheng-Chi Chao
IPC分类号： C12Q100
CPC分类号： C07K14/475 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K16/00 , C07K2319/00 , C12N9/16 , C12N9/6432 , C12Y304/21006 , Y10S435/81 , Y10S435/975
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). Other aspects of the invention include vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译：本发明提供由对应于新的人类干细胞生长因子样蛋白质的这种多核苷酸及其突变体或变体编码的新型多核苷酸和多肽。这些多核苷酸包含从人胎儿皮肤（Hyseq克隆鉴定号15375176），成年脾（Hyseq克隆鉴定号14856094）和人内皮细胞的人睾丸细胞（Hyseq克隆鉴定号2880984和2881695）的cDNA文库中分离的核酸序列（Hyseq克隆鉴定号13804756,13687487,13804756）。本发明的其它方面包括含有生产新型人类干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。

4. 发明申请

US20080241882A1 Methods and materials relating to novel stem cell growth factor-like polypeptides and polynucleotides 审中-公开
标题翻译：与新型干细胞生长因子样多肽和多核苷酸相关的方法和材料
公开(公告)号：US20080241882A1
公开(公告)日：2008-10-02
申请号：US11985824
申请日：2007-11-16
申请人： Y. Tom Tang , Ivan Labat , Radoje T. Drmanac , Nancy Mize , Mitsuo Nishikawa , Cheng-Chi Chao
发明人： Y. Tom Tang , Ivan Labat , Radoje T. Drmanac , Nancy Mize , Mitsuo Nishikawa , Cheng-Chi Chao
IPC分类号： C12P21/00 , C07H21/04 , C12N15/63 , C12N5/06
CPC分类号： C07K14/475 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K16/00 , C07K2319/00 , C12N9/16 , C12N9/6432 , C12Y304/21006 , Y10S435/81 , Y10S435/975
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). Other aspects of the invention include vectors containing processes fro producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译：本发明提供由对应于新的人类干细胞生长因子样蛋白质的这种多核苷酸及其突变体或变体编码的新型多核苷酸和多肽。这些多核苷酸包含从人胎儿皮肤（Hyseq克隆鉴定号15375176），成年脾（Hyseq克隆鉴定号14856094）和人内皮细胞的人睾丸细胞（Hyseq克隆鉴定号2880984和2881695）的cDNA文库中分离的核酸序列（Hyseq克隆鉴定号13804756,13687487,13804756）。本发明的其它方面包括含有产生新型人干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。

5. 发明授权

US07319141B2 Stem cell growth factor-like polypeptides 失效
标题翻译：干细胞生长因子样多肽
公开(公告)号：US07319141B2
公开(公告)日：2008-01-15
申请号：US10968674
申请日：2004-10-19
申请人： Y. Tom Tang , Ivan Labat , Radoje T. Drmanac , Nancy K. Mize , Mitsuo Nishikawa , Cheng-Chi Chao
发明人： Y. Tom Tang , Ivan Labat , Radoje T. Drmanac , Nancy K. Mize , Mitsuo Nishikawa , Cheng-Chi Chao
IPC分类号： C07K14/475 , C07H21/04
CPC分类号： C07K14/475 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K16/00 , C07K2319/00 , C12N9/16 , C12N9/6432 , C12Y304/21006 , Y10S435/81 , Y10S435/975
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). Other aspects of the invention include vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译：本发明提供由对应于新的人类干细胞生长因子样蛋白质的这种多核苷酸及其突变体或变体编码的新型多核苷酸和多肽。这些多核苷酸包含从人胎儿皮肤（Hyseq克隆鉴定号15375176），成年脾（Hyseq克隆鉴定号14856094）和人内皮细胞的人睾丸细胞（Hyseq克隆鉴定号2880984和2881695）的cDNA文库中分离的核酸序列（Hyseq克隆鉴定号13804756,13687487,13804756）。本发明的其它方面包括含有生产新型人类干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。

6. 发明申请

US20080227200A1 Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell and hematopoietic progenitor cell, and DNA coding for the same 审中-公开
标题翻译：具有支持造血干细胞和造血祖细胞的增殖或存活的活性的多肽和编码其的DNA
公开(公告)号：US20080227200A1
公开(公告)日：2008-09-18
申请号：US11986709
申请日：2007-11-26
申请人： Radoje T. Drmanac , Ivan Labat , Y. Tom Tang , Juhi Lee , Birgit Stache-Crain , Mitsuo Nishikawa
发明人： Radoje T. Drmanac , Ivan Labat , Y. Tom Tang , Juhi Lee , Birgit Stache-Crain , Mitsuo Nishikawa
IPC分类号： C12N5/06 , C12N15/11 , C07K14/00 , C07K16/18 , C12N15/00
CPC分类号： C12N5/0647 , A61K38/00 , C07K14/475
摘要： A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between cells which support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells and cells which do not support the proliferation or survival. Proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is supported by using stromal cells in which the isolated gene is expressed or a gene product of the isolated gene.
摘要翻译：通过比较支持造血干细胞或造血祖细胞的增殖或存活的细胞之间的表达基因和不支持增殖的细胞，分离编码具有支持造血干细胞或造血祖细胞增殖或存活的活性的多肽的基因或生存。通过使用分离的基因表达的基质细胞或分离的基因的基因产物来支持造血干细胞或造血祖细胞的增殖或存活。

7. 发明申请

US20050059073A1 Method and materials relating to novel stem cell growth factor-like polypeptides and polynucleotides 失效
标题翻译：与新型干细胞生长因子样多肽和多核苷酸相关的方法和材料
公开(公告)号：US20050059073A1
公开(公告)日：2005-03-17
申请号：US10968674
申请日：2004-10-19
申请人： Y. Tang , Ivan Labat , Radoje Drmanac , Nancy Mize , Mitsuo Nishikawa , Cheng-Chi Chao
发明人： Y. Tang , Ivan Labat , Radoje Drmanac , Nancy Mize , Mitsuo Nishikawa , Cheng-Chi Chao
IPC分类号： A61K38/00 , A61K48/00 , C07K14/475 , C07K16/00 , C12N5/08 , C12N9/16 , C12N9/64 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/475 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K16/00 , C07K2319/00 , C12N9/16 , C12N9/6432 , C12Y304/21006 , Y10S435/81 , Y10S435/975
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). Other aspects of the invention include vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译：本发明提供由对应于新的人类干细胞生长因子样蛋白质的这种多核苷酸及其突变体或变体编码的新型多核苷酸和多肽。这些多核苷酸包含从人胎儿皮肤（Hyseq克隆鉴定号15375176），成年脾（Hyseq克隆鉴定号14856094）和人内皮细胞的人睾丸细胞（Hyseq克隆鉴定号2880984和2881695）的cDNA文库中分离的核酸序列（Hyseq克隆鉴定号13804756,13687487,13804756）。本发明的其它方面包括含有生产新型人类干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。

8. 发明授权

US07320880B2 Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell and hematopoietic progenitor cell, and DNA coding for the same 失效
标题翻译：具有支持造血干细胞和造血祖细胞的增殖或存活的活性的多肽和编码其的DNA
公开(公告)号：US07320880B2
公开(公告)日：2008-01-22
申请号：US10478926
申请日：2002-06-11
申请人： Mitsuo Nishikawa , Radoje T. Drmanac , Ivan Lobal , Y. Tom Tang , Juhi Lee , Birgit Stache-Crain
发明人： Mitsuo Nishikawa , Radoje T. Drmanac , Ivan Lobal , Y. Tom Tang , Juhi Lee , Birgit Stache-Crain
IPC分类号： C07H21/04 , C07K14/475 , C12N5/00 , C12N1/00 , C12P21/02
CPC分类号： C12N5/0647 , A61K38/00 , C07K14/475
摘要： A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between cells which support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells which do not support the proliferation or survival. Proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is supported by using stromal cells in which the isolated gene is expressed or a gene product of the isolated gene.
摘要翻译：通过比较支持不支持增殖或存活的造血干细胞或造血祖细胞的增殖或存活的细胞之间的表达基因，分离编码具有支持造血干细胞或造血祖细胞的增殖或存活活性的多肽的基因。通过使用分离的基因表达的基质细胞或分离的基因的基因产物来支持造血干细胞或造血祖细胞的增殖或存活。

9. 发明授权

US07439332B2 Polypeptide having an activity to support proliferation or survival of hematopoietic stem or progenitor cells 失效
标题翻译：具有支持造血干细胞或祖细胞增殖或存活的活性的多肽
公开(公告)号：US07439332B2
公开(公告)日：2008-10-21
申请号：US10512109
申请日：2003-04-25
申请人： Mitsuo Nishikawa
发明人： Mitsuo Nishikawa
IPC分类号： C07K14/475 , C07H21/04
CPC分类号： C07K14/47
摘要： A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between cells which support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells and cells which do not support the proliferation or survival. Proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is supported by using stromal cells in which the isolated gene is expressed or a gene product of the isolated gene.
摘要翻译：通过比较支持造血干细胞或造血祖细胞的增殖或存活的细胞之间的表达基因和不支持增殖的细胞，分离编码具有支持造血干细胞或造血祖细胞增殖或存活的活性的多肽的基因或生存。通过使用分离的基因表达的基质细胞或分离的基因的基因产物来支持造血干细胞或造血祖细胞的增殖或存活。

10. 发明授权

US4156443A Binding lace for an automatic binder 失效
标题翻译：绑带花边用于自动捆扎
公开(公告)号：US4156443A
公开(公告)日：1979-05-29
申请号：US826519
申请日：1977-08-22
申请人： Mitsuo Nishikawa , Hideo Hosaka , Jun Maemori
发明人： Mitsuo Nishikawa , Hideo Hosaka , Jun Maemori
IPC分类号： B65B13/06 , B65D63/10 , B65D63/12 , D07B1/02 , B21F9/02
CPC分类号： B65D63/12 , B65B13/06 , B65D63/10 , D07B5/006 , Y10T428/2929
摘要： A binding lace for a novel automatic binder developed by the present inventors is disclosed. The binding lace is continuously thrusted from only one side of the binding lace into a lace guide positioned around an object to be bound and then travels while sliding along the lace guide without buckling to form loops of several turns overlapping each other. During travelling, the binding lace is sent in the lace guide without standing still, due to the properties of an outer portion and a core portion of the binding lace, while the binding lace always expands elastically outwardly in radial direction of the lace guide due to the larger rigidity and tensile stress of the core portion to hold a looped configuration with the loops having substantially the same diameter as the lace guide. After travelling stops, the binding lace is capable of holding the same diameter of the loops and a tip portion of the binding lace is held in the neighborhood of the overlap of the loops. The binding lace is pulled back to wind around the material to be bound. It has sufficient friction and elasticity in the outer portion of the binding lace, so that the tip portion of the binding lace is held by the bound material and at least one loop of the lace. In addition, the binding lace exerts a large tightening force by the core portion thereof, sufficient for binding a bundle of electric wires and gives a stable binding condition for a long time due to the outer portion thereof.
摘要翻译：公开了一种由本发明人开发的新型自动粘合剂的装订花边。束缚花边从装订花边的仅一侧连续地推入围绕待绑定的物体定位的花边导向器，然后在沿着花边导向器滑动的同时行进而不弯曲以形成彼此重叠的若干圈的环。在行进过程中，由于绑带花边的外部部分和芯部的特性，装订花边总是沿着花边导轨的径向方向弹性向外延伸，因此由于由于芯部分的较大的刚性和拉伸应力保持环形结构，其中环具有与花边导轨基本相同的直径。在行进停止之后，装订花边能够保持相同的环的直径，并且装订花边的顶端部分保持在环的重叠附近。绑定的蕾丝被拉回来围绕要绑定的材料。它在装订花边的外部具有足够的摩擦和弹性，使得装订花边的顶端部分被装订材料和花边的至少一个环保持。此外，装订花边通过其芯部施加大的紧固力，足以捆绑一束电线，并由于其外部部分而长时间地产生稳定的装订条件。

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