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1. 发明授权

US5310902A Alkylenediamine derivatives 失效
标题翻译：烷二胺衍生物
公开(公告)号：US5310902A
公开(公告)日：1994-05-10
申请号：US741590
申请日：1991-08-07
申请人： Mitsuo Masaki , Masaru Satoh , Naoya Moritoh , Koichi Hashimoto , Toshiro Kamishiro , Haruhiko Shinozaki
发明人： Mitsuo Masaki , Masaru Satoh , Naoya Moritoh , Koichi Hashimoto , Toshiro Kamishiro , Haruhiko Shinozaki
IPC分类号： C07D295/13 , C07D223/00 , C07D211/26
CPC分类号： C07D295/13
摘要： Novel alkylenediamine derivatives effectively employable glutamate blockers have the formula (I) or (II): ##STR1## wherein each of R.sup.1 and R.sup.6 is an aliphatic hydrocarbon group, an alicyclic hydrocarbon group, an aryl group, or an aralkyl group; each of R.sup.2 and R.sup.7 is an aliphatic hydrocarbon group, an alkoxy group, an aliphatic hydrocarbon group containing an ester bonding, an aliphatic hydrocarbon group containing an ether bonding, or an aryloxy group; each of R.sup.3, R.sup.4, R.sup.5 R.sup.8, R.sup.9 and R.sup.10 is hydrogen, an alkyl group, an alkoxy group, an acyloxy group, an aryl group, an aralkyl group, hydroxyl, a hydroxylalkyl group, halogen, nitrile, nitro, amino, carbamoyl or alkoxycarbonyl; and each of m and n is an integer of 0-3 (m+n does not exceed 3); k is an integer of 1-4; each of p and i is an integer of 2-13; and each of q and j is an integer of 4-7.
摘要翻译：新型亚烷基二胺衍生物有效地可用的谷氨酸盐阻滞剂具有式（I）或（II）：其中R 1和R 6各自为脂族烃基，脂环族烃基，芳基，或芳烷基; R 2和R 7各自为脂族烃基，烷氧基，含酯键的脂族烃基，含有醚键的脂族烃基或芳氧基; R 3，R 4，R 5，R 9和R 10各自为氢，烷基，烷氧基，酰氧基，芳基，芳烷基，羟基，羟基烷基，卤素，腈，硝基，氨基，氨基甲酰基或烷氧基羰基; 并且m和n分别为0-3的整数（m + n不超过3）; k是1-4的整数; p和i中的每一个是2-13的整数; 并且q和j中的每一个是4-7的整数。

2. 发明授权

US5070196A Alkylenediamine derivatives 失效
标题翻译：烷二胺衍生物
公开(公告)号：US5070196A
公开(公告)日：1991-12-03
申请号：US562422
申请日：1990-08-01
申请人： Mitsuo Masaki , Masaru Satoh , Naoya Moritoh , Koichi Hashimoto , Toshiro Kamishiro , Haruhiko Shinozaki
发明人： Mitsuo Masaki , Masaru Satoh , Naoya Moritoh , Koichi Hashimoto , Toshiro Kamishiro , Haruhiko Shinozaki
IPC分类号： C07D295/13
CPC分类号： C07D295/13
摘要： Novel alkylenediamine derivatives effectively employable as glutamate blockers have the formula (I) or (II): ##STR1## wherein each of R.sup.1 and R.sup.6 is an aliphatic hydrocarbon group, an alicyclic hydrocarbon group, an aryl group, or an aralkyl group; each of R.sup.2 and R.sup.7 is an aliphatic hydrocarbon group, an alkoxy group, an aliphatic hydrocarbon group containing an ester bonding, an aliphatic hydrocarbon group containing an ether bonding, or an aryloxy group; each of R.sup.3, R.sup.4, R.sup.5, R.sup.8, R.sup.9 and R.sup.10 is hydrogen, an alkyl group, an alkoxy group, an acyloxy group, an aryl group, an aralkyl group, hydroxyl, a hydroxylalkyl group, halogen, nitrile, nitro, amino, carbamoyl or alkoxycarbonyl; and each of m and n is an integer of 0-3 (m+n does not exceed 3); k is an integer of 1-4; each of p and i is an integer of 2-13; and each of q and j is an integer of 4-7.
摘要翻译：作为谷氨酸盐阻滞剂有效利用的新型亚烷基二胺衍生物具有式（I）或（II）：其中R 1和R 6各自为脂族烃基，脂环族烃基，芳基基团或芳烷基; R 2和R 7各自为脂族烃基，烷氧基，含酯键的脂族烃基，含有醚键的脂族烃基或芳氧基; R 3，R 4，R 5，R 8，R 9和R 10各自为氢，烷基，烷氧基，酰氧基，芳基，芳烷基，羟基，羟烷基，卤素，腈，硝基，氨基，氨基甲酰基或烷氧基羰基; 并且m和n分别为0-3的整数（m + n不超过3）; k是1-4的整数; p和i中的每一个是2-13的整数; 并且q和j中的每一个是4-7的整数。

3. 发明授权

US5250546A Amino-alcohol derivatives and processes for their preparation 失效
标题翻译：氨基醇衍生物及其制备方法
公开(公告)号：US5250546A
公开(公告)日：1993-10-05
申请号：US551037
申请日：1990-07-11
申请人： Mitsuo Masaki , Haruhiko Shinozaki , Masaru Satoh , Naoya Moritoh , Koichi Hashimoto , Toshiro Kamishiro
发明人： Mitsuo Masaki , Haruhiko Shinozaki , Masaru Satoh , Naoya Moritoh , Koichi Hashimoto , Toshiro Kamishiro
IPC分类号： C07D295/13 , A61K31/445
CPC分类号： C07D295/13
摘要： Amino-alcohol derivatives of the formula, ##STR1## where R.sub.1 is a straight or branched alkyl group having 3 to 8 carbon atoms, R.sub.2 and R.sub.3 are each a lower alkyl group, or R.sub.2 and R.sub.3 form a 5- to 7-membered ring together with the adjacent nitrogen atom which may have an oxygen atom attached thereto, R.sub.4 is a hydrogen atom or a lower alkyl group, R.sub.5 is a hydrogen atom or a lower alkyl group, X is a hydrogen or halogen atom or a lower alkyl or lower alkoxy group, and n is an integer of 2 or 3, and acid addition salts thereof, are effectively useful as medicines and agricultural chemicals. Processes are also disclosed for preparing such compounds.
摘要翻译：其中R1是具有3至8个碳原子的直链或支链烷基，R2和R3各自为低级烷基，或R2和R3形成5-至7-元环的下式的氨基醇衍生物，与可能具有氧原子的相邻氮原子一起，R4是氢原子或低级烷基，R5是氢原子或低级烷基，X是氢或卤素原子或低级烷基或低级烷基烷氧基，n为2或3的整数，其酸加成盐可有效用作药物和农药。还公开了制备这些化合物的方法。

4. 发明授权

US4764617A Quinaldinamide derivatives 失效
标题翻译：喹哪啶衍生物
公开(公告)号：US4764617A
公开(公告)日：1988-08-16
申请号：US895938
申请日：1986-08-13
申请人： Mitsuo Masaki , Haruhiko Shinozaki , Masaru Satoh , Naoya Moritoh , Koichi Hashimoto , Toshiro Kamishiro
发明人： Mitsuo Masaki , Haruhiko Shinozaki , Masaru Satoh , Naoya Moritoh , Koichi Hashimoto , Toshiro Kamishiro
IPC分类号： C07D295/12 , A01N43/42 , A61K31/47 , A61K31/55 , A61P25/00 , C07C67/00 , C07C209/00 , C07C209/40 , C07C209/60 , C07C211/27 , C07C213/00 , C07C225/16 , C07C239/00 , C07C251/48 , C07D20060101 , C07D215/48 , C07D215/52 , C07D217/00 , C07D295/10 , C07D401/06 , C07D401/12
CPC分类号： C07D215/48 , Y10S514/906
摘要： A novel quinaldinamide derivative having the formula: ##STR1## wherein each of R.sup.1 and R.sup.2 independently represents a lower alkyl group or R.sup.1 and R.sup.2 are combined together with the adjacent nitrogen atom to form a 5-7 membered ring; and X represents the hydrogen atom, a lower alkyl group or a lower alkoxy group, and its acid-addition salt, which show prominent central muscle relaxant effect, namely rigidity relieving effect on anemic decerebrated rigidity.

5. 发明授权

US4644063A 1,3-oxazolidine-2-one derivatives 失效
标题翻译： 1,3-恶唑烷-2-酮衍生物
公开(公告)号：US4644063A
公开(公告)日：1987-02-17
申请号：US739059
申请日：1985-05-29
申请人： Mituo Masaki , Haruhiko Shinozaki , Masaru Satoh , Naoya Moritoh , Koichi Hashimoto , Toshiro Kamishiro
发明人： Mituo Masaki , Haruhiko Shinozaki , Masaru Satoh , Naoya Moritoh , Koichi Hashimoto , Toshiro Kamishiro
IPC分类号： C07D413/06 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/445 , A61K31/55 , A61P21/00 , A61P21/02 , A61P25/00 , A61P25/08 , C07D263/20 , C07D263/22 , C07D263/24 , C07D405/00
CPC分类号： C07D263/20 , C07D263/22
摘要： 1,3-Oxazolidine-one derivatives of the following formula ##STR1## where R is straight or branched alkyl of C.sub.3 -C.sub.8, X is hydrogen, halogen, lower alkyl or lower alkoxy and n is 4, 5 or 6, or their acid addition salts are effective for medicinal and agricultural use.
摘要翻译：其中R是C 3 -C 8的直链或支链烷基，X是氢，卤素，低级烷基或低级烷氧基，n是4,5或6，或它们的酸加成盐对药用和农业有效。

6. 发明授权

US4891433A Process for the preparation of dibenzothiepin derivative 失效
标题翻译：二苯并噻吩衍生物的制备方法
公开(公告)号：US4891433A
公开(公告)日：1990-01-02
申请号：US102981
申请日：1987-09-30
申请人： Mitsuo Masaki , Hiromitsu Takeda , Naoya Moritoh , Toshihiro Takahashi
发明人： Mitsuo Masaki , Hiromitsu Takeda , Naoya Moritoh , Toshihiro Takahashi
IPC分类号： C07C323/62 , C07D337/14
CPC分类号： C07C323/62 , C07D337/14
摘要： A novel process for the preparation of 2-(10,11-dihydro-10-oxodibenzo[b, f]thiepin-2-yl)propionic acid which shows high anti-inflammatory and analgetic action is disclosed. The process starts from a propiophenone derivative having the formula (II): ##STR1## wherein R.sup.1 is hydrogen or a lower alkyl group, which is once converted into a haloacetal compound via a halo-ketone compound, and then converted into the desired dibenzothiepin derivative through a combination of rearrangement, hydrolysis and ring closure in variable sequences.
摘要翻译：公开了一种制备显示出高抗炎和止痛作用的2-（10,11-二氢-10-氧代二苯并[b，f]硫杂-2-基）丙酸的新方法。该方法从具有式（II）的苯丙酮衍生物开始：其中R1是氢或低级烷基，其通过卤代酮化合物一度转化为卤代缩醛化合物，然后转化为通过可变序列的重排，水解和闭环的组合，所需的二苯并噻吩衍生物。

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