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1. 发明授权

US07067514B2 Pyrimidine compounds 有权
公开(公告)号：US07067514B2
公开(公告)日：2006-06-27
申请号：US10656671
申请日：2003-09-05
申请人： Mitsunori Ono , Shijie Zhang , Teresa Przewloka , Keizo Koya , Elena Kostik , Yuniko Wada , Lijun Sun , Weiwen Ying
发明人： Mitsunori Ono , Shijie Zhang , Teresa Przewloka , Keizo Koya , Elena Kostik , Yuniko Wada , Lijun Sun , Weiwen Ying
IPC分类号： A61K31/506 , A61P3/10 , A61P17/06 , A61P19/02 , A61P25/28
CPC分类号： C07D239/48 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/541 , C07D401/12 , C07D401/14 , C07D403/12
摘要： This invention features pyrimidine compounds of formula (I): R1 is aryl, or heteroaryl; each of R2 and R4, independently, is Rc, halogen, nitro, cyano, isothionitro, SRc, or ORc; or R2 and R4, taken together, is carbonyl; R3 is Rc, alkenyl, alkynyl, ORc, OC(O)Rc, SO2Rc, S(O)Rc, S(O2)NRcRd, SRc, NRcRd, NRcCORd, NRcC(O)ORd, NRcC(O)NRcRd, NRcSO2Rd, CORc, C(O)ORc, or C(O)NRcRd; R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is O, S, S(O), S(O2), or NRc; Y is a covalent bond, CH2, C(O), C═N—Rc, C═N—ORc, C═N—SRc, O, S, S(O), S(O2), or NRc; Z is N or CH; one of U and V is N, and the other is CRc; and W is O, S, S(O), S(O2), NRc, or NC(O)Rc; in which each of Ra and Rb, independently, is H, alkyl, aryl, heteroaryl; and each of Rc and Rd, independently, is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl.

2. 发明申请

US20060025409A1 Pyrimidine compounds 失效
公开(公告)号：US20060025409A1
公开(公告)日：2006-02-02
申请号：US11193001
申请日：2005-07-29
申请人： Mitsunori Ono , Shijie Zhang , Teresa Przewloka , Keizo Koya , Elena Kostik , Yuniko Wada , Lijun Sun , Weiwen Ying
发明人： Mitsunori Ono , Shijie Zhang , Teresa Przewloka , Keizo Koya , Elena Kostik , Yuniko Wada , Lijun Sun , Weiwen Ying
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/53 , A61K31/506
CPC分类号： C07D239/48 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/541 , C07D401/12 , C07D401/14 , C07D403/12
摘要： This invention features pyrimidine compounds of formula (I): R1 is aryl, or heteroaryl; each of R2 and R4, independently, is Rc, halogen, nitro, cyano, isothionitro, SRc, or ORc; or R2 and R4, taken together, is carbonyl; R3 is Rc, alkenyl, alkynyl, ORc, OC(O)Rc, SO2Rc, S(O)Rc, S(O2)NRcRd, SRc, NRcRd, NRcCORd, NRcC(O)ORd, NRcC(O)NRcRd; NRcSO2Rd, CORc, C(O)ORc, or C(O)NRcRd, R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is O, S, S(O), S(O2), or NRc; Y is a covalent bond, CH2, C(O), C═N—Rc, C═N—ORc, C═N—SRc, O, S, S(O), S(O2), or NRc; Z is N or CH; one of U and V is N, and the other is CRc; and W is O, S, S(O), S(O2), NRc, or NC(O)Rc; in which each of Ra and Rb, independently, is H, alkyl, aryl, heteroaryl; and each of Rc and Rd, independently, is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl.

3. 发明授权

US06693097B2 Pyrimidine compounds 有权
标题翻译：嘧啶化合物
公开(公告)号：US06693097B2
公开(公告)日：2004-02-17
申请号：US10000742
申请日：2001-11-30
申请人： Mitsunori Ono , Shijie Zhang , Teresa Przewloka , K. Koya , Elena Kostik , Yuniko Wada , Lijun Sun , Weiwen Ying
发明人： Mitsunori Ono , Shijie Zhang , Teresa Przewloka , K. Koya , Elena Kostik , Yuniko Wada , Lijun Sun , Weiwen Ying
IPC分类号： C07D41704
CPC分类号： C07D239/48 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/541 , C07D401/12 , C07D401/14 , C07D403/12
摘要： This invention features pyrimidine compounds of formula (I): aryl, or heteroaryl; each of R2 and R4, independently, is Rc, halogen, nitro, cyano, isothionitro, SRc, or ORc; or R2 and R4, taken together, is carbonyl; R3 is Rc, alkenyl, alkynyl, ORc, OC(O)Rc, SO2Rc, S(O)Rc, S(O2)NRcRd, SRc, NRcRd, NRcCORd, NRcC(O)ORd, NRcC(O)NRcRd, NRcSO2Rd, CORc, C(O)ORc, or C(O)NRcRd; R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is O, S, S(O), S(O2), or NRc; Y is a covalent bond, CH2, C(O), C═N—Rc, C═N—ORc, C═N—SRc, O, S, S(O), S(O2), or NRc; Z is N or CH; one of U and V is N, and the other is CRc; and W is O, S, S(O), S(O2), NRc, or NC(O)Rc; in which each of Ra and Rb, independently, is H, alkyl, aryl, heteroaryl; and each of Rc and Rd, independently, is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl.
摘要翻译：本发明的特征在于式（I）的嘧啶化合物：芳基或杂芳基; R 2和R 4各自独立地是R c，卤素，硝基，氰基，异硫代，SR c或OR c; 或R 2和R 4一起是羰基; R 3是R c，链烯基，炔基，OR c，OC（O）R c，SO 2 R c，S（O）R c，S（O 2）NR c NR c C（O）OR d，NR c C（O）NR c， R d，NR c，SO 2 R d，COR c，C（O）OR c或C（O）NR c R d; R5是H或烷基; n是0，1，2，3，4，5或6; X是O，S，S（O），S（O 2）或NR c; Y是共价键，CH 2，C（O），C = NR c，C = N-OR c，C = N-SR c，O，S，S（O））或NR ; Z是N或CH; U和V之一是N，另一个是CR ; 并且W是O，S，S（O），S（O 2），NR c或NC（O）R c; 其中R 1和R 2各自独立地是H，烷基，芳基，杂芳基; R c和R d各自独立地是H，烷基，芳基，杂芳基，环基，杂环基或烷基羰基。

4. 发明授权

US07465725B2 Pyrimidine compounds 失效
标题翻译：嘧啶化合物
公开(公告)号：US07465725B2
公开(公告)日：2008-12-16
申请号：US11193001
申请日：2005-07-29
申请人： Mitsunori Ono , Lijun Sun , Teresa Przewloka , Shijie Zhang , Elena Kostik , Weiwen Ying , Yumiko Wada , Keizo Koya
发明人： Mitsunori Ono , Lijun Sun , Teresa Przewloka , Shijie Zhang , Elena Kostik , Weiwen Ying , Yumiko Wada , Keizo Koya
IPC分类号： A61K31/506 , A61P17/06 , A61P19/02 , A61P25/28 , C07D401/04 , C07D405/04 , C07D413/04 , C07D417/04 , C07D239/24
CPC分类号： C07D239/48 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/541 , C07D401/12 , C07D401/14 , C07D403/12
摘要： This invention features pyrimidine compounds of formula (I): R1 is aryl, or heteroaryl; each of R2 and R4, independently, is Rc, halogen, nitro, cyano, isothionitro, SRc, or ORc; or R2 and R4, taken together, is carbonyl; R3 is Rc, alkenyl, alkynyl, ORc, OC(O)Rc, SO2Rc, S(O)Rc, S(O2)NRcRd, SRc, NRcRd, NRcCORd, NRcC(O)ORd, NRcC(O)NRcRd, NRcSO2Rd, CORc, C(O)ORc, or C(O)NRcRd; R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is O, S, S(O), S(O2), or NRc; Y is a covalent bond, CH2, C(O), C═N—Rc, C═N—ORc, C═N—SRc, O, S, S(O), S(O2), or NRc; Z is N or CH; one of U and V is N, and the other is CRc; and W is O, S, S(O), S(O2), NRc, or NC(O)Rc; in which each of Ra and Rb, independently, is H, alkyl, aryl, heteroaryl; and each of Rc and Rd, independently, is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl.
摘要翻译：本发明具有式（I）的嘧啶化合物：R1是芳基或杂芳基; R 2和R 4各自独立地是Rc，卤素，硝基，氰基，异硫脲，SRc或ORc; 或R 2和R 4一起是羰基; R3是Rc，烯基，炔基，ORc，OC（O）Rc，SO2Rc，S（O）Rc，S（O2）NRcRd，SRc，NRcRd，NRcCORd，NRcC（O）ORd，NRcC（O）NRcRd，NRcSO2Rd， CORc，C（O）ORc或C（O）NRcRd; R5是H或烷基; n是0，1，2，3，4，5或6; X是O，S，S（O），S（O 2）或NR c; Y是共价键，CH2，C（O），C-N-Rc，C-N-ORc，C-N-SRc，O，S，S（O），S（O 2）或NRc; Z是N或CH; U和V之一是N，另一个是CRc; 并且W是O，S，S（O），S（O 2），NR c或NC（O）R c; 其中R a和R b各自独立地为H，烷基，芳基，杂芳基; R c和R d各自独立地为H，烷基，芳基，杂芳基，环基，杂环基或烷基羰基。

5. 发明授权

US08318790B2 Triazole compounds that modulate HSP90 activity 有权
公开(公告)号：US08318790B2
公开(公告)日：2012-11-27
申请号：US11807201
申请日：2007-05-25
申请人： Weiwen Ying , David James , Shijie Zhang , Junghyun Chae , Teresa Przewloka , Howard P. Ng , Hao Li , Zachary Demko , Dinesh U. Chimmanamada , Chi-wan Lee , Zhenjian Du , Kevin Foley , Minghu Song , Lijun Sun , Keizo Koya , Dan Zhou , Shuzhen Qin
发明人： Weiwen Ying , David James , Shijie Zhang , Junghyun Chae , Teresa Przewloka , Howard P. Ng , Hao Li , Zachary Demko , Dinesh U. Chimmanamada , Chi-wan Lee , Zhenjian Du , Kevin Foley , Minghu Song , Lijun Sun , Keizo Koya , Dan Zhou , Shuzhen Qin
IPC分类号： A61K31/4196 , A61P35/00 , C07D249/12
CPC分类号： C07D417/04 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/10 , C07D405/14 , C07D409/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

6. 发明申请

US20080090887A1 Triazole compounds that modulate HSP90 activity 有权
公开(公告)号：US20080090887A1
公开(公告)日：2008-04-17
申请号：US11807201
申请日：2007-05-25
申请人： Weiwen Ying , David James , Shijie Zhang , Junghyun Chae , Teresa Przewloka , Howard Ng , Hao Li , Zachary Demko , Dinesh Chimmanamada , Chi-wan Lee , Zhenjian Du , Kevin Foley , Minghu Song , Lijun Sun , Keizo Koya , Dan Zhou , Shuzhen Qin
发明人： Weiwen Ying , David James , Shijie Zhang , Junghyun Chae , Teresa Przewloka , Howard Ng , Hao Li , Zachary Demko , Dinesh Chimmanamada , Chi-wan Lee , Zhenjian Du , Kevin Foley , Minghu Song , Lijun Sun , Keizo Koya , Dan Zhou , Shuzhen Qin
IPC分类号： A61K31/4196 , A61P35/00 , C07D249/12
CPC分类号： C07D417/04 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/10 , C07D405/14 , C07D409/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

7. 发明申请

US20120122869A1 TRIZAOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY 有权
标题翻译：调节HSP90活性的TRIZAOLE化合物
公开(公告)号：US20120122869A1
公开(公告)日：2012-05-17
申请号：US13350296
申请日：2012-01-13
申请人： Weiwen Ying , David James , Shijie Zhang , Junghyun Chae , Teresa Przewloka , Howard P. Ng , Hao Li , Zachary Demko , Dinesh U. Chimmanamada , Chi-wan Lee , Zhenjian Du , Kevin Foley , Minghu Song , Lijun Sun , Keizo Koya , Dan Zhou , Shuzhen Qin
发明人： Weiwen Ying , David James , Shijie Zhang , Junghyun Chae , Teresa Przewloka , Howard P. Ng , Hao Li , Zachary Demko , Dinesh U. Chimmanamada , Chi-wan Lee , Zhenjian Du , Kevin Foley , Minghu Song , Lijun Sun , Keizo Koya , Dan Zhou , Shuzhen Qin
IPC分类号： A61K31/5377 , A61K31/4196 , A61P35/00 , C07D403/00 , A61K31/4709 , C07D249/12 , C07D413/10
CPC分类号： C07D417/04 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/10 , C07D405/14 , C07D409/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译：本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物，或包含这种化合物的组合物。

8. 发明申请

US20050203119A1 Dihydropyridine compounds for treating or preventing metabolic disorders 审中-公开
标题翻译：用于治疗或预防代谢紊乱的二氢吡啶化合物
公开(公告)号：US20050203119A1
公开(公告)日：2005-09-15
申请号：US10939252
申请日：2004-09-10
申请人： Mitsunori Ono , Yumiko Wada , Lijun Sun , Shoujun Chen , Teresa Przewloka , Shijie Zhang , Christopher Borella , Keizo Koya , Kevin Foley , Zhi-Qiang Xia , Hao Li , Dan Zhou
发明人： Mitsunori Ono , Yumiko Wada , Lijun Sun , Shoujun Chen , Teresa Przewloka , Shijie Zhang , Christopher Borella , Keizo Koya , Kevin Foley , Zhi-Qiang Xia , Hao Li , Dan Zhou
IPC分类号： A61K31/47 , A61K31/4741 , A61K31/4743 , A61K31/4745 , C07D215/54 , C07D221/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D471/02 , C07D491/02 , C07D491/04 , C07D498/02
CPC分类号： C04B35/632 , C07D215/54 , C07D221/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D491/04
摘要： This invention relates to dihydropyridine compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein A2, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, and m are defined herein, and compositions comprising such compounds. The invention also relates to methods of preventing or treating metabolic disorders, such as diabetes mellitus, and conditions and complications associated with diabetes mellitus, comprising administering to a subject in need thereof a compound of formula (1) or a composition comprising such a compound. The invention further relates to kits comprising a compound of formula (I).
摘要翻译：本发明涉及式（I）的二氢吡啶化合物：或其药学上可接受的盐，溶剂化物，包合物或前药，其中A 2，R 12，R 12， R 13，R 14，R 15，R 16，R 17，R 13， 18，R 19，R 20，R 21，R 22和m被定义和包含这些化合物的组合物。本发明还涉及预防或治疗诸如糖尿病的代谢性疾病以及与糖尿病相关的病症和并发症的方法，其包括向有需要的受试者施用式（1）化合物或包含这种化合物的组合物。本发明还涉及包含式（I）化合物的试剂盒。

9. 发明授权

US08901308B2 Triazole compounds that modulate Hsp90 activity 有权
标题翻译：调节Hsp90活性的三唑化合物
公开(公告)号：US08901308B2
公开(公告)日：2014-12-02
申请号：US13550324
申请日：2012-07-16
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
IPC分类号： C07D401/04 , C07D405/04 , C07D417/04 , C07D413/04 , C07D403/04 , C07D403/10 , C07D249/08 , C07D473/00 , C07D249/12 , C07D409/04 , C07D473/34
CPC分类号： C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译：本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物，或包含这种化合物的组合物。

10. 发明申请

US20060167070A1 Triazole compounds that modulate Hsp90 activity 有权
公开(公告)号：US20060167070A1
公开(公告)日：2006-07-27
申请号：US11282119
申请日：2005-11-17
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard Ng , Kevin Foley , Zhenjian Du , James Barsoum
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard Ng , Kevin Foley , Zhenjian Du , James Barsoum
IPC分类号： A61K31/4196 , C07D403/02 , C07D249/12 , C07D249/08
CPC分类号： C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

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