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1. 发明授权

US10112212B1 Droplet ejection using focused acoustic radiation having a plurality of frequency ranges 有权
公开(公告)号：US10112212B1
公开(公告)日：2018-10-30
申请号：US10821311
申请日：2004-04-08
申请人： Richard G. Stearns , Mitchell W. Mutz , Richard N. Ellson
发明人： Richard G. Stearns , Mitchell W. Mutz , Richard N. Ellson
IPC分类号： B05D1/02 , B05D5/00 , B05D7/00 , B28B19/00 , B29B15/10 , C23C18/00 , C23C20/00 , C23C28/00
摘要： Devices and methods are provided for ejecting a droplet from a reservoir using focused acoustic radiation having a plurality of nonsimultaneous and discrete frequency ranges. Such frequency ranges may be used to control droplet volume and/or velocity. Optionally, satellite fluid ejection from the reservoir is suppressed.

2. 发明申请

US20120006106A1 ACOUSTIC ASSESSMENT OF CHARACTERISTICS OF A FLUID RELEVANT TO ACOUSTIC EJECTION 有权
标题翻译：与流体相关的流体特性的声学评估
公开(公告)号：US20120006106A1
公开(公告)日：2012-01-12
申请号：US12983803
申请日：2011-01-03
申请人： Richard N. Ellson , Mitchell W. Mutz , Shehrzad Ahmed Qureshi , Richard G. Stearns
发明人： Richard N. Ellson , Mitchell W. Mutz , Shehrzad Ahmed Qureshi , Richard G. Stearns
IPC分类号： G01N29/024
CPC分类号： G01N29/4418 , B01J2219/00362 , B01J2219/00702 , B01L3/0268 , B01L2200/143 , B01L2300/0819 , B01L2300/0829 , B01L2300/1888 , B01L2400/0436 , B01L2400/0439 , B41J2/14008 , C40B60/14 , G01F23/296 , G01F23/2968 , G01N29/02 , G01N29/024 , G01N29/22 , G01N29/222 , G01N29/28 , G01N29/4427 , G01N29/46 , G01N35/1016 , G01N2035/00158 , G01N2291/02818 , G01N2291/02836 , G01N2291/02881 , G01N2291/2695
摘要： Methods are provided for analyzing characteristics of fluids in the context of an acoustic ejection system. Such a system has a controller, an acoustic radiation generator, and a coupling medium coupling the radiation to a reservoir holding fluid. The methods can use acoustic radiation to both perturb a surface of the fluid in the reservoir and analyze the effect of the perturbation. The methods may use information about prior fluids. The methods of the invention can determine physical characteristics such as speed of sound and viscosity. The methods also include ways to determine a level of acoustic energy suitable to eject a droplet. Preferably the methods are executed automatically under control of programming of a controller of an acoustic ejection system.
摘要翻译：提供了用于在声弹射系统的上下文中分析流体特性的方法。这种系统具有控制器，声辐射发生器和将辐射耦合到储存器保持流体的耦合介质。这些方法可以使用声辐射来扰乱储层中的流体表面并分析扰动的影响。这些方法可以使用关于现有流体的信息。本发明的方法可以确定诸如声速和粘度的物理特性。所述方法还包括确定适于喷射液滴的声能水平的方法。优选地，这种方法在声学弹射系统的控制器的编程的控制下自动执行。

3. 发明授权

US07354141B2 Acoustic assessment of characteristics of a fluid relevant to acoustic ejection 有权
标题翻译：与声弹出相关的流体特性的声学评估
公开(公告)号：US07354141B2
公开(公告)日：2008-04-08
申请号：US11048285
申请日：2005-01-31
申请人： Richard N. Ellson , Mitchell W. Mutz , Shehrzad Ahmed Qureshi , Richard G. Stearns
发明人： Richard N. Ellson , Mitchell W. Mutz , Shehrzad Ahmed Qureshi , Richard G. Stearns
IPC分类号： B41J2/02 , B41J2/135
CPC分类号： G01N29/4418 , B01J2219/00362 , B01J2219/00702 , B01L3/0268 , B01L2200/143 , B01L2300/0819 , B01L2300/0829 , B01L2300/1888 , B01L2400/0436 , B01L2400/0439 , B41J2/14008 , C40B60/14 , G01F23/296 , G01F23/2968 , G01N29/02 , G01N29/024 , G01N29/22 , G01N29/222 , G01N29/28 , G01N29/4427 , G01N29/46 , G01N35/1016 , G01N2035/00158 , G01N2291/02818 , G01N2291/02836 , G01N2291/02881 , G01N2291/2695
摘要： Methods are provided for analyzing characteristics of fluids in the context of an acoustic ejection system. Such a system has a controller, an acoustic radiation generator, and a coupling medium coupling the radiation to a reservoir holding fluid. The methods can use acoustic radiation to both perturb a surface of the fluid in the reservoir and analyze the effect of the perturbation. The methods may use information about prior fluids. The methods of the invention can determine physical characteristics such as speed of sound and viscosity. The methods also include ways to determine a level of acoustic energy suitable to eject a droplet. Preferably the methods are executed automatically under control of programming of a controller of an acoustic ejection system.
摘要翻译：提供了用于在声弹射系统的上下文中分析流体特性的方法。这种系统具有控制器，声辐射发生器和将辐射耦合到储存器保持流体的耦合介质。这些方法可以使用声辐射来扰乱储层中的流体表面并分析扰动的影响。这些方法可以使用关于现有流体的信息。本发明的方法可以确定诸如声速和粘度的物理特性。所述方法还包括确定适于喷射液滴的声能水平的方法。优选地，这种方法在声学弹射系统的控制器的编程的控制下自动执行。

4. 发明申请

US20080173077A1 Acoustic assessment of characteristics of a fluid relevant to acoustic ejection 有权
公开(公告)号：US20080173077A1
公开(公告)日：2008-07-24
申请号：US12079173
申请日：2008-03-24
申请人： Richard N. Ellson , Mitchell W. Mutz , Shehrzad Ahmed Qureshi , Richard G. Stearns
发明人： Richard N. Ellson , Mitchell W. Mutz , Shehrzad Ahmed Qureshi , Richard G. Stearns
IPC分类号： G01N29/024
CPC分类号： G01N29/4418 , B01J2219/00362 , B01J2219/00702 , B01L3/0268 , B01L2200/143 , B01L2300/0819 , B01L2300/0829 , B01L2300/1888 , B01L2400/0436 , B01L2400/0439 , B41J2/14008 , C40B60/14 , G01F23/296 , G01F23/2968 , G01N29/02 , G01N29/024 , G01N29/22 , G01N29/222 , G01N29/28 , G01N29/4427 , G01N29/46 , G01N35/1016 , G01N2035/00158 , G01N2291/02818 , G01N2291/02836 , G01N2291/02881 , G01N2291/2695
摘要： Methods are provided for analyzing characteristics of fluids in the context of an acoustic ejection system. Such a system has a controller, an acoustic radiation generator, and a coupling medium coupling the radiation to a reservoir holding fluid. The methods can use acoustic radiation to both perturb a surface of the fluid in the reservoir and analyze the effect of the perturbation. The methods may use information about prior fluids. The methods of the invention can determine physical characteristics such as speed of sound and viscosity. The methods also include ways to determine a level of acoustic energy suitable to eject a droplet. Preferably the methods are executed automatically under control of programming of a controller of an acoustic ejection system.

5. 发明授权

US06808934B2 High-throughput biomolecular crystallization and biomolecular crystal screening 有权
标题翻译：高通量生物分子结晶和生物分子晶体筛选
公开(公告)号：US06808934B2
公开(公告)日：2004-10-26
申请号：US10055245
申请日：2002-01-22
申请人： Mitchell W. Mutz , Richard N. Ellson , Richard G. Stearns
发明人： Mitchell W. Mutz , Richard N. Ellson , Richard G. Stearns
IPC分类号： G01N110
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00351 , B01J2219/0036 , B01J2219/00362 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00756 , B01L3/5085 , B01L3/50853 , B01L2400/0433 , B05B17/0607 , B05B17/0615 , B41J2/14008 , C07B2200/11 , C07K1/306 , C30B7/00 , C30B29/58 , C40B40/06 , C40B40/10 , C40B60/14 , Y10T436/25 , Y10T436/2575
摘要： The present invention provides a method for the acoustic ejection of fluid droplets from fluid-containing reservoirs to form arrays suitable for high-throughput combinatorial crystallization experiments. Such arrays may utilize very small fluid volumes, in the order of picoliters. The method is especially suited to preparing combinatorial libraries useful in developing techniques for crystallizing biomacromolecules, such as proteins. The small volumes conserve macromolecules that may be costly and rare, and permit the testing of a large number of experimental crystallization conditions for a given amount of a macromolecule. The time required for the experiments may be very short due to the small volumes. The invention is conducive to forming high-density microarrays of small volume crystallization experiments. Acoustic detection of crystals in situ, and distinction between biomacromolecular and non-biomacromolecular crystals, are also taught.
摘要翻译：本发明提供了一种用于从含液体储存器弹出流体液滴以形成适于高通量组合结晶实验的阵列的方法。这样的阵列可以利用非常小的流体体积，按照皮升级的顺序。该方法特别适用于制备用于开发生物大分子如蛋白质结晶技术的组合文库。小体积保存可能是昂贵和罕见的大分子，并且允许对于给定量的大分子测试大量的实验结晶条件。由于体积小，实验所需的时间可能非常短。本发明有利于形成小体积结晶实验的高密度微阵列。还教导了原位晶体的声学检测，以及生物大分子和非生物大分子晶体的区别。

6. 发明授权

US06416164B1 Acoustic ejection of fluids using large F-number focusing elements 有权
标题翻译：使用大的F数量聚焦元件的流体声弹射
公开(公告)号：US06416164B1
公开(公告)日：2002-07-09
申请号：US09910690
申请日：2001-07-20
申请人： Richard G. Stearns , Richard N. Ellson
发明人： Richard G. Stearns , Richard N. Ellson
IPC分类号： B41J204
CPC分类号： B41J2/14008
摘要： The present invention provides a method and device for the acoustic ejection of fluid droplets from fluid-containing reservoirs using focusing means having an F-number greater than approximately 2. The droplets are ejected toward designated sites on a substrate surface for deposition thereon. In one embodiment, the device is comprised of: a plurality of reservoirs each adapted to contain a fluid; an ejector comprising a means for generating acoustic radiation and a large F-numbered means for focusing the acoustic radiation at a focal point near the fluid surface in each of the reservoirs; and a means for positioning the ejector in acoustically coupled relationship to each of the reservoirs. The invention is useful in a number of contexts, particularly in the preparation of biomolecular arrays.
摘要翻译：本发明提供一种用于使用具有大于约2的F数的聚焦装置从含有流体的储存器弹出流体液滴的方法和装置。液滴朝向衬底表面上的指定位置喷射以沉积在其上。在一个实施例中，该装置包括：多个储存器，每个储存器适于容纳流体; 喷射器，其包括用于产生声辐射的装置和用于将声辐射聚焦在每个储存器中的流体表面附近的焦点处的大的F编号装置; 以及用于将喷射器定位成与每个储存器的声耦合关系的装置。本发明在许多上下文中是有用的，特别是在生物分子阵列的制备中。

7. 发明申请

US20110166797A1 ACOUSTIC DETERMINATION OF PROPERTIES OF RESERVOIRS AND OF FLUIDS CONTAINED THEREIN 审中-公开
标题翻译：储层和含有流体的性质的声学确定
公开(公告)号：US20110166797A1
公开(公告)日：2011-07-07
申请号：US12834786
申请日：2010-07-12
申请人： Richard N. Ellson , Richard G. Stearns
发明人： Richard N. Ellson , Richard G. Stearns
IPC分类号： G01N29/02 , G06F19/00 , G01K11/22
CPC分类号： B01L3/0268 , B01J2219/00362 , B01J2219/00702 , B01L2200/143 , B01L2300/0819 , B01L2400/0436 , B01L2400/0439 , C40B60/14 , G01F23/296 , G01F23/2968 , G01N29/02 , G01N29/22 , G01N29/222 , G01N29/28 , G01N35/1016 , G01N2035/00158 , G01N2291/02818 , G01N2291/02836 , G01N2291/02881 , G01N2291/2695
摘要： The invention provides devices and methods for acoustically determining the properties of the contents of one or more reservoirs in a plurality of reservoirs. Each reservoir is adapted to contain a fluid. An acoustic radiation generator can be positioned in acoustic coupling relationship to each of the reservoirs. Acoustic radiation generated by the acoustic radiation generator is transmitted through each reservoir to an analyzer. The analyzer is capable of analyzing a characteristic of the transmitted acoustic radiation and optionally correlating the characteristic to a property of the reservoirs' contents. Properties that may be determined include volume, temperature, and composition. The invention is particularly suited to determining the properties of the contents of a plurality of reservoirs to allow for accuracy and control over the dispensing of fluids therefrom.
摘要翻译：本发明提供用于声学确定多个储存器中的一个或多个储存器的内容物的性质的装置和方法。每个储存器适于容纳流体。声辐射发生器可以定位成与每个储存器的声耦合关系。由声辐射发生器产生的声辐射通过每个储存器传送到分析器。分析仪能够分析所发射的声辐射的特性，并且可选地将特征与储层内容物性相关联。可以确定的属性包括体积，温度和组成。本发明特别适合于确定多个储存器的内容物的性质，以允许精确度和控制从其中分配流体。

8. 发明申请

US20090007676A1 ACOUSTIC DETERMINATION OF PROPERTIES OF RESERVOIRS AND OF FLUIDS CONTAINED THEREIN 有权
标题翻译：储层和含有流体的性质的声学确定
公开(公告)号：US20090007676A1
公开(公告)日：2009-01-08
申请号：US12187122
申请日：2008-08-06
申请人： Richard N. Ellson , Richard G. Stearns
发明人： Richard N. Ellson , Richard G. Stearns
IPC分类号： G01N29/024
CPC分类号： B01L3/0268 , B01J2219/00362 , B01J2219/00702 , B01L2200/143 , B01L2300/0819 , B01L2400/0436 , B01L2400/0439 , C40B60/14 , G01F23/296 , G01F23/2968 , G01N29/02 , G01N29/22 , G01N29/222 , G01N29/28 , G01N35/1016 , G01N2035/00158 , G01N2291/02818 , G01N2291/02836 , G01N2291/02881 , G01N2291/2695
摘要： The invention provides devices and methods for acoustically determining the properties of the contents of one or more reservoirs in a plurality of reservoirs. Each reservoir is adapted to contain a fluid. An acoustic radiation generator can be positioned in acoustic coupling relationship to each of the reservoirs. Acoustic radiation generated by the acoustic radiation generator is transmitted through each reservoir to an analyzer. The analyzer is capable of analyzing a characteristic of the transmitted acoustic radiation and optionally correlating the characteristic to a property of the reservoirs' contents. Properties that may be determined include volume, temperature, and composition. The invention is particularly suited to determining the properties of the contents of a plurality of reservoirs to allow for accuracy and control over the dispensing of fluids therefrom.
摘要翻译：本发明提供用于声学确定多个储存器中的一个或多个储存器的内容物的性质的装置和方法。每个储存器适于容纳流体。声辐射发生器可以定位成与每个储存器的声耦合关系。由声辐射发生器产生的声辐射通过每个储存器传送到分析器。分析仪能够分析所发射的声辐射的特性，并且可选地将特征与储层内容物性相关联。可以确定的属性包括体积，温度和组成。本发明特别适合于确定多个储存器的内容物的性质，以允许精确度和控制从其中分配流体。

9. 发明授权

US07784331B2 Acoustic determination of properties of reservoirs and of fluids contained therein 有权
标题翻译：储存器及其中所含流体的性质的声学测定
公开(公告)号：US07784331B2
公开(公告)日：2010-08-31
申请号：US12187122
申请日：2008-08-06
申请人： Richard N. Ellson , Richard G. Stearns
发明人： Richard N. Ellson , Richard G. Stearns
IPC分类号： G01N29/07
CPC分类号： B01L3/0268 , B01J2219/00362 , B01J2219/00702 , B01L2200/143 , B01L2300/0819 , B01L2400/0436 , B01L2400/0439 , C40B60/14 , G01F23/296 , G01F23/2968 , G01N29/02 , G01N29/22 , G01N29/222 , G01N29/28 , G01N35/1016 , G01N2035/00158 , G01N2291/02818 , G01N2291/02836 , G01N2291/02881 , G01N2291/2695
摘要： The invention provides devices and methods for acoustically determining the properties of the contents of one or more reservoirs in a plurality of reservoirs. Each reservoir is adapted to contain a fluid. An acoustic radiation generator can be positioned in acoustic coupling relationship to each of the reservoirs. Acoustic radiation generated by the acoustic radiation generator is transmitted through each reservoir to an analyzer. The analyzer is capable of analyzing a characteristic of the transmitted acoustic radiation and optionally correlating the characteristic to a property of the reservoirs' contents. Properties that may be determined include volume, temperature, and composition. The invention is particularly suited to determining the properties of the contents of a plurality of reservoirs to allow for accuracy and control over the dispensing of fluids therefrom.
摘要翻译：本发明提供用于声学确定多个储存器中的一个或多个储存器的内容物的性质的装置和方法。每个储存器适于容纳流体。声辐射发生器可以定位成与每个储存器的声耦合关系。由声辐射发生器产生的声辐射通过每个储存器传送到分析器。分析仪能够分析所发射的声辐射的特性，并且可选地将特征与储层内容物性相关联。可以确定的属性包括体积，温度和组成。本发明特别适合于确定多个储存器的内容物的性质，以允许精确度和控制从其中分配流体。

10. 发明授权

US07454958B2 Acoustic determination of properties of reservoirs and of fluids contained therein 有权
标题翻译：储存器及其中所含流体的性质的声学测定
公开(公告)号：US07454958B2
公开(公告)日：2008-11-25
申请号：US10946141
申请日：2004-09-20
申请人： Richard N. Ellson , Richard G. Stearns
发明人： Richard N. Ellson , Richard G. Stearns
IPC分类号： G01N29/02 , G01N29/22 , G01N29/36
CPC分类号： G01F23/296 , B01J2219/00362 , B01J2219/00702 , B01L3/0268 , B01L2200/143 , B01L2300/0819 , B01L2400/0436 , B01L2400/0439 , C40B60/14 , G01F23/2968 , G01N29/02 , G01N29/22 , G01N29/222 , G01N29/28 , G01N35/1016 , G01N2035/00158 , G01N2291/02818 , G01N2291/02836 , G01N2291/02881 , G01N2291/2695
摘要： The invention provides devices and methods for acoustically determining the properties of the contents of one or more reservoirs in a plurality of reservoirs. Each reservoir is adapted to contain a fluid. An acoustic radiation generator can be positioned in acoustic coupling relationship to each of the reservoirs. Acoustic radiation generated by the acoustic radiation generator is transmitted through each reservoir to an analyzer. The analyzer is capable of analyzing a characteristic of the transmitted acoustic radiation and optionally correlating the characteristic to a property of the reservoirs' contents. Properties that may be determined include volume, temperature, and composition. The invention is particularly suited to determining the properties of the contents of a plurality of reservoirs to allow for accuracy and control over the dispensing of fluids therefrom.
摘要翻译：本发明提供用于声学确定多个储存器中的一个或多个储存器的内容物的性质的装置和方法。每个储存器适于容纳流体。声辐射发生器可以定位成与每个储存器的声耦合关系。由声辐射发生器产生的声辐射通过每个储存器传送到分析器。分析仪能够分析所发射的声辐射的特性，并且可选地将特征与储层内容物性相关联。可能确定的属性包括体积，温度和组成。本发明特别适合于确定多个储存器的内容物的性质，以允许精确度和控制从其中分配流体。

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