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1. 发明授权

US06413533B1 Method for chemoprevention of prostate cancer 失效
公开(公告)号：US06413533B1
公开(公告)日：2002-07-02
申请号：US09531472
申请日：2000-03-20
申请人： Mitchell S. Steiner , Sharan Raghow
发明人： Mitchell S. Steiner , Sharan Raghow
IPC分类号： A61F1300
CPC分类号： A61K45/06 , A61K31/00 , A61K31/015 , A61K31/138 , A61K31/4535 , A61K31/565 , Y10S514/938 , Y10S514/944 , Y10S514/965
摘要： This invention provides the chemoprevention of prostate cancer and, more particularly, to a method of preventing prostate carcinogenesis comprising the steps of administering to a human subject having a precancerous precursor of prostate adenocarcinoma, a pharmaceutical preparation comprising a chemopreventive agent to prevent, prevent recurrence of, suppress or inhibit prostate carcinogenesis. The present invention provides a safe and effective method for suppressing or inhibiting latent prostate cancer and is particularly useful for treating subjects having elevated risk of developing prostate cancer, for example, those having benign prostatic hyperplasia, prostate intraepithelial neoplasia (PIN), or an abnormally high level of circulating prostate specific antibody (PSA), or who have a family history of prostate cancer.

2. 发明授权

US07524866B2 Prevention and treatment of androgen—deprivation induced osteoporosis 失效
标题翻译：预防和治疗雄激素剥夺诱导的骨质疏松症
公开(公告)号：US07524866B2
公开(公告)日：2009-04-28
申请号：US10778334
申请日：2004-02-17
申请人： Mitchell S. Steiner , Sharan Raghow , Karen A. Veverka
发明人： Mitchell S. Steiner , Sharan Raghow , Karen A. Veverka
IPC分类号： A61K31/445 , A61K31/38 , A61K31/135
CPC分类号： A61K31/138
摘要： This invention provides: 1) a method of treating androgen-deprivation induced osteoporosis and/or bone fractures and/or loss of Bone Mineral Density (BMD) in a male subject suffering from prostate cancer; 2) a method of preventing androgen-deprivation induced osteoporosis and/or bone fractures and/or loss of Bone Mineral Density (BMD) in a male subject suffering from prostate cancer; 3) a method of suppressing or inhibiting androgen-deprivation induced osteoporosis and/or bone fractures and/or loss of BMD in a male subject suffering from prostate cancer; and 4) a method of reducing the risk of developing androgen-deprivation induced osteoporosis and/or bone fractures and/or loss of BMD in a male subject suffering from prostate cancer, by administering to the subject a pharmaceutical composition comprising an anti-estrogen agent and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or any combination thereof.
摘要翻译：本发明提供：1）在患有前列腺癌的男性受试者中治疗雄激素剥夺诱导的骨质疏松症和/或骨折和/或骨矿物质密度（BMD）丧失的方法; 2）在患有前列腺癌的男性受试者中预防雄激素剥夺诱导的骨质疏松症和/或骨折和/或骨矿物质密度（BMD）丧失的方法; 3）在患有前列腺癌的男性受试者中抑制或抑制雄激素剥夺诱导的骨质疏松症和/或骨折和/或BMD损失的方法; 和4）通过向受试者施用包含抗雌激素剂的药物组合物，降低在患有前列腺癌的男性受试者中发展雄激素剥夺诱导的骨质疏松症和/或骨折和/或BMD损失的风险的方法和/或其类似物，衍生物，异构体，代谢产物，药学上可接受的盐，药物产品，水合物，N-氧化物或其任何组合。

3. 发明授权

US06632447B1 Method for chemoprevention of prostate cancer 失效
标题翻译：化学预防前列腺癌的方法
公开(公告)号：US06632447B1
公开(公告)日：2003-10-14
申请号：US09707766
申请日：2000-11-08
申请人： Mitchell S. Steiner , Sharan Raghow
发明人： Mitchell S. Steiner , Sharan Raghow
IPC分类号： A61F1300
CPC分类号： A61K45/06 , A61K31/00 , A61K31/015 , A61K31/138 , A61K31/4535 , A61K31/565 , Y10S514/938 , Y10S514/965
摘要： This invention relates to the chemoprevention of prostate cancer and, more particularly, to a method of suppressing or inhibiting latent prostate cancer comprising administering to a mammalian subject a chemopreventive agent and analogs and metabolites thereof. The chemopreventive agent prevents, prevents recurrence of, suppresses or inhibit prostate carcinogenesis; and treats prostate cancer.
摘要翻译：本发明涉及前列腺癌的化学预防，更具体地说涉及一种抑制或抑制潜伏性前列腺癌的方法，包括向哺乳动物受试者施用化学预防剂及其类似物和代谢物。化学预防剂防止，预防复发，抑制或抑制前列腺癌发生; 并治疗前列腺癌

4. 发明授权

US06413535B1 Method for chemoprevention of prostate cancer 失效
公开(公告)号：US06413535B1
公开(公告)日：2002-07-02
申请号：US09660197
申请日：2000-09-12
申请人： Mitchell S. Steiner , Sharan Raghow
发明人： Mitchell S. Steiner , Sharan Raghow
IPC分类号： A61F1300
CPC分类号： A61K31/00 , A61K31/015 , A61K31/138 , A61K31/4535 , A61K31/565 , A61K45/06 , Y10S514/938 , Y10S514/944 , Y10S514/965
摘要： This invention provides the chemoprevention of prostate cancer and, more particularly, to a method of preventing prostate carcinogenesis comprising the steps of administering to a human subject having a precancerous precursor of prostate adenocarcinoma, a pharmaceutical preparation comprising a chemopreventive agent to prevent, prevent recurrence of, suppress or inhibit prostate carcinogenesis. The present invention provides a safe and effective method for suppressing or inhibiting latent prostate cancer and is particularly useful for treating subjects having elevated risk of developing prostate cancer, for example, those having benign prostatic hyperplasia, prostate intraepithelial neoplasia (PIN), or an abnormally high level of circulating prostate specific antibody (PSA), or who have a family history of prostate cancer.

5. 发明授权

US06413534B1 Method for chemoprevention of prostate cancer 失效
标题翻译：化学预防前列腺癌的方法
公开(公告)号：US06413534B1
公开(公告)日：2002-07-02
申请号：US09660184
申请日：2000-09-12
申请人： Mitchell S. Steiner , Sharan Raghow
发明人： Mitchell S. Steiner , Sharan Raghow
IPC分类号： A61F1300
CPC分类号： A61K31/00 , A61K31/015 , A61K31/138 , A61K31/4535 , A61K31/565 , A61K45/06 , Y10S514/938 , Y10S514/944 , Y10S514/965
摘要： This invention provides the chemoprevention of prostate cancer and, more particularly, to a method of preventing prostate carcinogenesis comprising the steps of administering to a human subject having a precancerous precursor of prostate adenocarcinoma, a pharmaceutical preparation comprising a chemopreventive agent to prevent, prevent recurrence of, suppress or inhibit prostate carcinogenesis. The present invention provides a safe and effective method for suppressing or inhibiting latent prostate cancer and is particularly useful for treating subjects having elevated risk of developing prostate cancer, for example, those having benign prostatic hyperplasia, prostate intraepithelial neoplasia (PIN), or an abnormally high level of circulating prostate specific antibody (PSA), or who have a family history of prostate cancer.
摘要翻译：本发明提供了前列腺癌的化学预防，更具体地，涉及一种预防前列腺癌发生的方法，其包括以下步骤：向具有前列腺腺癌前癌前体的人类受试者施用包含化学预防剂的药物制剂，以预防，预防复发，抑制或抑制前列腺癌发生。本发明提供了一种用于抑制或抑制潜伏性前列腺癌的安全有效的方法，并且特别可用于治疗具有升高的前列腺癌风险的受试者，例如具有良性前列腺增生，前列腺上皮内瘤变（PIN）或异常高水平的循环前列腺特异性抗体（PSA），或具有前列腺癌家族史的患者。

6. 发明授权

US06410043B1 Method for chemoprevention of prostate cancer 失效
公开(公告)号：US06410043B1
公开(公告)日：2002-06-25
申请号：US09660191
申请日：2000-09-12
申请人： Mitchell S. Steiner , Sharan Raghow
发明人： Mitchell S. Steiner , Sharan Raghow
IPC分类号： A61F1300
CPC分类号： A61K31/00 , A61K31/015 , A61K31/138 , A61K31/4535 , A61K31/565 , A61K45/06 , Y10S514/938 , Y10S514/944 , Y10S514/965
摘要： This invention provides the chemoprevention of prostate cancer and, more particularly, to a method of preventing prostate carcinogenesis comprising the steps of administering to a human subject having a precancerous precursor of prostate adenocarcinoma, a pharmaceutical preparation comprising a chemopreventive agent to prevent, prevent recurrence of, suppress or inhibit prostate carcinogenesis. The present invention provides a safe and effective method for suppressing or inhibiting latent prostate cancer and is particularly useful for treating subjects having elevated risk of developing prostate cancer, for example, those having benign prostatic hyperplasia, prostate intraepithelial neoplasia (PIN), or an abnormally high level of circulating prostate specific antibody (PSA), or who have a family history of prostate cancer.

7. 发明申请

US20060270641A1 Method for chemoprevention of prostate cancer 审中-公开
标题翻译：化学预防前列腺癌的方法
公开(公告)号：US20060270641A1
公开(公告)日：2006-11-30
申请号：US11140255
申请日：2005-05-31
申请人： Mitchell Steiner , Sharan Raghow
发明人： Mitchell Steiner , Sharan Raghow
IPC分类号： A61K31/56 , A61K31/453 , A61K31/138
CPC分类号： A61K31/138 , A61K31/453 , A61K31/56
摘要： This invention relates to the chemoprevention of prostate cancer and, more particularly, to a method of suppressing or inhibiting latent prostate cancer comprising administering to a mammalian subject a chemopreventive agent, for example raloxifene, or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, ester, or N-oxide, or mixtures thereof. The chemopreventive agent prevents, prevents recurrence of, suppresses or inhibits prostate carcinogenesis and treats prostate cancer.
摘要翻译：本发明涉及前列腺癌的化学预防，更具体地，涉及一种抑制或抑制潜伏性前列腺癌的方法，包括向哺乳动物受试者施用化学预防药物，例如雷洛昔芬或其类似物，衍生物，异构体，代谢物，药学上可接受的盐，酯或N-氧化物，或其混合物。化学预防剂防止，预防复发，抑制或抑制前列腺癌发生和治疗前列腺癌。

8. 发明申请

US20060287400A1 Method for treatment and chemoprevention of prostate cancer 审中-公开
标题翻译：前列腺癌的治疗和化学预防方法
公开(公告)号：US20060287400A1
公开(公告)日：2006-12-21
申请号：US11132425
申请日：2005-05-19
申请人： Mitchell Steiner , Sharan Raghow
发明人： Mitchell Steiner , Sharan Raghow
IPC分类号： A61K31/138 , A61K31/05 , A61K31/02
CPC分类号： A61K45/06 , A61K31/00 , A61K31/015 , A61K31/02 , A61K31/05 , A61K31/138 , A61K31/4535 , A61K31/565
摘要： This invention relates to the treatment and prevention of prostate cancer More particularly, the present invention provides 1) methods of preventing prostate carcinogenesis in a subject; 2) methods of preventing the recurrence of, suppressing, inhibiting or reducing the incidence of prostate carcinogenesis in a subject, 3) methods of treating a subject with prostate cancer; 4) methods of suppressing, inhibiting or reducing the incidence of prostate cancer in a subject; 5) methods of treating a subject with pre-malignant lesions of prostate cancer, and 6) methods of suppressing, inhibiting or reducing the incidence of pre-malignant lesions of prostate cancer in a subject by administering to the subject a compound of formula (I) or an analog or metabolite thereof, its N-oxide, ester, pharmaceutically acceptable salt, hydrate, or any combination thereof as described herein. The present invention provides a safe and effective method for suppressing or inhibiting prostate cancer, e.g. latent prostate cancer, and is particularly useful for treating subjects having an elevated risk of developing prostate cancer, for example, those having benign prostatic hyperplasia, prostate intraepithelial neoplasia (PIN), or an abnormally high level of circulating prostate specific antibody (PSA), or having a family history of prostate cancer.
摘要翻译：本发明涉及治疗和预防前列腺癌。更具体地，本发明提供1）预防受试者中前列腺癌发生的方法; 2）预防受试者的前列腺癌发生发生的复发，抑制，抑制或降低的方法，3）用前列腺癌治疗受试者的方法; 4）抑制或抑制受试者前列腺癌发病率的方法; 5）治疗患有前列腺癌的恶性前病变的受试者的方法，以及6）通过向受试者施用式（I）的化合物来抑制，抑制或降低患者前列腺癌的恶性前病变发病率的方法）或其类似物或代谢物，其N-氧化物，酯，药学上可接受的盐，水合物或其任何组合。本发明提供了一种安全有效的抑制或抑制前列腺癌的方法，例如，潜伏性前列腺癌，并且特别可用于治疗具有升高的前列腺癌风险的受试者，例如具有良性前列腺增生，前列腺上皮内瘤变（PIN）或异常高水平的循环前列腺特异性抗体（PSA）的受试者，或具有前列腺癌的家族史。

9. 发明申请

US20050080143A1 Treatment of androgen-deprivation induced osteoporosis 审中-公开
标题翻译：雄激素剥夺诱导的骨质疏松症的治疗
公开(公告)号：US20050080143A1
公开(公告)日：2005-04-14
申请号：US10944465
申请日：2004-09-20
申请人： Mitchell Steiner , Karen Veverka , Sharan Raghow
发明人： Mitchell Steiner , Karen Veverka , Sharan Raghow
IPC分类号： A61K31/138
CPC分类号： A61K31/135 , A61K9/0014 , A61K9/0019 , A61K9/0021 , A61K9/0024 , A61K9/0053 , A61K31/138
摘要： The present invention provides methods for reducing the incidence of, inhibiting, suppressing, reducing the incidence of, and treating androgen-deprivation induced osteoporosis, bone fractures and/or loss of bone mineral density (BMD) in men having prostate cancer, comprising administering to a male human subject having prostate cancer a toremifene and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or any combination thereof. The present invention also provides methods of treating, preventing, suppressing, inhibiting, or reducing the incidence of hot flashes, gynecomastia, and/or hair loss in male humans having prostate cancer, comprising same.
摘要翻译：本发明提供了减少在具有前列腺癌的男性中发生，抑制，抑制，降低发生和治疗雄激素剥夺诱导的骨质疏松症，骨折和/或骨矿物质密度（BMD）丧失的方法，包括给予具有前列腺癌托泊米芬和/或其类似物，衍生物，异构体，代谢物，药学上可接受的盐，药物产品，水合物，N-氧化物或其任何组合的男性受试者。本发明还提供了治疗，预防，抑制或抑制具有前列腺癌的男性人群中的潮热，男子女性发育和/或脱发的发生的方法。

10. 发明申请

US20070197664A1 Prevention and treatment of androgen-deprivation induced osteoporosis 审中-公开
标题翻译：预防和治疗雄激素剥夺诱导的骨质疏松症
公开(公告)号：US20070197664A1
公开(公告)日：2007-08-23
申请号：US11656566
申请日：2007-01-23
申请人： Mitchell Steiner , Sharan Raghow , Karen Veverka
发明人： Mitchell Steiner , Sharan Raghow , Karen Veverka
IPC分类号： A61K31/135
CPC分类号： A61K31/138 , A61K31/135
摘要： This invention provides a method of treatment, prevention, suppression, inhibition, or reduction of risk of developing androgen-deprivation induced skeletal-related events (SRE), such as pathologic fractures, surgery to bone, radiation to bone, spinal cord compression, change in antineoplastic therapy, including changes in hormonal therapy, new bone metastases, bone loss, or a combination thereof in men suffering from prostate cancer, comprising administering to a male subject suffering from prostate cancer a selective estrogen receptor modulator (SERM) and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or any combination thereof.
摘要翻译：本发明提供了治疗，预防，抑制，抑制或降低发展中的雄激素剥夺诱导的骨骼相关事件（SRE）的风险的方法，例如病理性骨折，骨骼手术，对骨骼的放射，脊髓压迫，变化包括对患有前列腺癌的男性的激素治疗，新骨转移，骨丢失或其组合的改变，包括对患有前列腺癌的男性受试者施用选择性雌激素受体调节剂（SERM）和/或其类似物，衍生物，异构体，代谢物，药学上可接受的盐，药物产品，水合物，N-氧化物或其任何组合。

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