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1. 发明申请

US20120003321A1 Crosslinked Dextran Composite Magnetic Microparticles and Preparation Process and Using Method Thereof 审中-公开
标题翻译：交联葡聚糖复合磁性微粒及其制备方法及其使用方法
公开(公告)号：US20120003321A1
公开(公告)日：2012-01-05
申请号：US13142159
申请日：2008-12-29
申请人： Mingli Peng , Yanhong Liu , Yali Cui , Chao Chen , Ke Li
发明人： Mingli Peng , Yanhong Liu , Yali Cui , Chao Chen , Ke Li
IPC分类号： A61K9/14 , A61K31/513 , A61K31/337 , A61K31/7068 , A61K31/437 , A61K31/4375 , A61K31/704 , A61K38/14 , B82Y5/00
CPC分类号： A61K9/0009 , A61K9/0019 , A61K9/1611 , A61K9/1652 , H01F1/083
摘要： The present invention relates to crosslinked dextran magnetic composite microparticles and a preparation process and a using method thereof. The composite microparticles comprise magnetic nanoparticles and dextran with crosslinked structure, wherein the magnetic nanoparticles are dispersed in the dextran with crosslinked structure. The process for preparing the composite microparticles comprises: preparing a dextran solution; synthesizing dextran magnetic composite microparticles; and synthesizing the crosslinked dextran magnetic composite microparticles. The using method of composite microparticles comprises: preparing crosslinked dextran magnetic composite microparticles loaded with anti-cancer drug; and adding a sustained-releasing solution thereto.
摘要翻译：本发明涉及交联葡聚糖磁性复合微粒及其制备方法及其应用方法。复合微粒包括具有交联结构的磁性纳米颗粒和葡聚糖，其中磁性纳米颗粒分散在具有交联结构的葡聚糖中。制备复合微粒的方法包括：制备葡聚糖溶液; 合成葡聚糖磁复合微粒; 并合成交联的葡聚糖磁性复合微粒。复合微粒的使用方法包括：制备负载抗癌药物的交联葡聚糖磁复合微粒; 并向其中加入缓释溶液。

2. 发明申请

US20120121717A1 DRUG-LOADED POLYSACCHARIDE-COATED GOLDMAG PARTICLES (DPGPs) AND ITS SYNTHESIS METHOD 审中-公开
标题翻译：药物加载多糖包裹的金黄色颗粒（DPGPs）及其合成方法
公开(公告)号：US20120121717A1
公开(公告)日：2012-05-17
申请号：US13142820
申请日：2008-12-30
申请人： Xu Chao , Yali Cui , Mingli Peng , Chao Chen , Xiaofang Xin , Ke Li , Wenli Hui
发明人： Xu Chao , Yali Cui , Mingli Peng , Chao Chen , Xiaofang Xin , Ke Li , Wenli Hui
IPC分类号： A61K9/14 , B05D3/00 , A61P31/00 , A61K31/704 , A61P35/00
CPC分类号： A61K9/1652 , A61K9/5094 , A61K31/704 , A61K49/183 , B82Y25/00 , H01F1/0054 , H01F1/061
摘要： The invention relates to Polysaccharide-coated GoldMag particles (DPGPs) and the method of its synthesis, which characterized GoldMag particles as a core and natural or synthetic biodegradable polysaccharide such as dextran, cyclodextrin and derivatives as shell. DPGPs are synthesized by mixing Polysaccharide-coated GoldMag particles (DPGPs) with drug through physical bond. The preparation of the drug-loaded composite particles include: preparing the polysaccharide-coated GoldMag particles and then loading the drug on the polysaccharide-coated GoldMag particles. The drug-loading process is carried out through directly mixing the polysaccharide-coated GoldMag particles with the drug solution by the shaker. That means the polysaccharide-coated GoldMag particles load the drug through affinity adsorption.
摘要翻译：本发明涉及多糖包被的GoldMag颗粒（DPGP）及其合成方法，其特征在于以GoldMag颗粒为核心，以天然或合成的可生物降解多糖如葡聚糖，环糊精和衍生物为壳。 DPGPs通过物理粘合剂将多糖包被的GoldMag颗粒（DPGPs）与药物混合来合成。负载药物的复合颗粒的制备包括：制备多糖包被的GoldMag颗粒，然后将药物装载在多糖包被的GoldMag颗粒上。药物加载过程通过将振荡器与药物溶液直接混合，将多糖包被的GoldMag颗粒直接混合来进行。这意味着多糖包被的GoldMag颗粒通过亲和吸附装载药物。

3. 发明授权

US08409544B2 Preparation method of ferroferric oxide magnetic nanospheres 有权
标题翻译：二氧化铁磁纳米球的制备方法
公开(公告)号：US08409544B2
公开(公告)日：2013-04-02
申请号：US13142167
申请日：2008-12-31
申请人： Mingli Peng , Caiquan Zhang , Yali Cui , Chao Chen , Jinghui Zeng
发明人： Mingli Peng , Caiquan Zhang , Yali Cui , Chao Chen , Jinghui Zeng
IPC分类号： C01G49/02
CPC分类号： H01F1/0045 , B82Y25/00 , B82Y30/00 , C01G49/08 , C01P2004/32 , C01P2004/64 , C01P2006/42
摘要： Disclosed is a process of preparing magnetite nanoparticles, comprising the following steps: 1) preparing a ferric salt mixed system, wherein a soluble ferric salt is dissolved in glycol at ambient temperature, and then urea and polyethylene glycol are added and mixed homogeneously to obtain the trivalent iron salt mixed system, the mass ratio of glycol to the trivalent iron salt being 15:1 to 60:1, glycol to urea being 20:1 to 100:1, and glycol to polyethylene glycol being 20:1 to 100:1; 2) reacting, wherein the trivalent iron salt mixed system is transferred into a reaction autoclave, sealed and placed into a heating device to react at a temperature of 200 to 300° C. for 8 to 72 hours; and 3) washing, wherein after the reaction system is naturally cooled down to ambient temperature, the product is taken out, and washed with anhydrous ethanol and water in turn to obtain the magnetite nanoparticles. The soluble iron salt includes ferric chloride, ferric sulfate, ferric acetate and ferric nitrate. The obtained nanospheres exhibit a uniform distribution of the particle diameter with a good dispersity in water. The nanospheres have superparamagnetism, and their particle diameter can be controlled by varying the reaction time as desired.
摘要翻译：公开了一种制备磁铁矿纳米颗粒的方法，包括以下步骤：1）制备铁盐混合体系，其中可溶性铁盐在环境温度下溶于二醇，然后加入尿素和聚乙二醇并均匀混合，得到三价铁盐混合体系，二醇与三价铁盐的质量比为15:1至60:1，二醇与尿素的比例为20:1至100:1，二醇与聚乙二醇的比例为20:1至100:1 ; 2）反应，其中将三价铁盐混合体系转移到反应釜中，密封并置于加热装置中，在200-300℃的温度下反应8至72小时; 和3）洗涤，其中在反应体系自然冷却至环境温度后，取出产物，依次用无水乙醇和水洗涤，得到磁铁矿纳米颗粒。可溶性铁盐包括氯化铁，硫酸铁，醋酸铁和硝酸铁。得到的纳米球表现出均匀的粒径分布，在水中具有良好的分散性。纳米球具有超顺磁性，并且可通过根据需要改变反应时间来控制它们的粒径。

4. 发明申请

US20110318261A1 Preparation Method of Ferroferric Oxide Magnetic Nanospheres 有权
标题翻译：铁氧体磁性纳米球的制备方法
公开(公告)号：US20110318261A1
公开(公告)日：2011-12-29
申请号：US13142167
申请日：2008-12-31
申请人： Mingli Peng , Caiquan Zhang , Yali Cui , Chao Chen , Jinghui Zeng
发明人： Mingli Peng , Caiquan Zhang , Yali Cui , Chao Chen , Jinghui Zeng
IPC分类号： C01G49/08 , B82Y40/00
CPC分类号： H01F1/0045 , B82Y25/00 , B82Y30/00 , C01G49/08 , C01P2004/32 , C01P2004/64 , C01P2006/42
摘要： Disclosed is a process of preparing magnetite nanoparticles, comprising the following steps: 1) preparing a ferric salt mixed system, wherein a soluble ferric salt is dissolved in glycol at ambient temperature, and then urea and polyethylene glycol are added and mixed homogeneously to obtain the trivalent iron salt mixed system, the mass ratio of glycol to the trivalent iron salt being 15:1 to 60:1, glycol to urea being 20:1 to 100:1, and glycol to polyethylene glycol being 20:1 to 100:1; 2) reacting, wherein the trivalent iron salt mixed system is transferred into a reaction autoclave, sealed and placed into a heating device to react at a temperature of 200 to 300° C. for 8 to 72 hours; and 3) washing, wherein after the reaction system is naturally cooled down to ambient temperature, the product is taken out, and washed with anhydrous ethanol and water in turn to obtain the magnetite nanoparticles. The soluble iron salt includes ferric chloride, ferric sulfate, ferric acetate and ferric nitrate. The obtained nanospheres exhibit a uniform distribution of the particle diameter with a good dispersity in water. The nanospheres have superparamagnetism, and their particle diameter can be controlled by varying the reaction time as desired.
摘要翻译：公开了一种制备磁铁矿纳米颗粒的方法，包括以下步骤：1）制备铁盐混合体系，其中可溶性铁盐在环境温度下溶于二醇，然后加入尿素和聚乙二醇并均匀混合，得到三价铁盐混合体系，二醇与三价铁盐的质量比为15:1至60:1，二醇与尿素的比例为20:1至100:1，二醇与聚乙二醇的比例为20:1至100:1 ; 2）反应，其中将三价铁盐混合体系转移到反应釜中，密封并置于加热装置中，在200-300℃的温度下反应8至72小时; 和3）洗涤，其中在反应体系自然冷却至环境温度后，取出产物，依次用无水乙醇和水洗涤，得到磁铁矿纳米颗粒。可溶性铁盐包括氯化铁，硫酸铁，醋酸铁和硝酸铁。得到的纳米球表现出均匀的粒径分布，在水中具有良好的分散性。纳米球具有超顺磁性，并且可通过根据需要改变反应时间来控制它们的粒径。

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