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1. 发明授权

US08445649B2 Antibody and use thereof 有权
标题翻译：抗体及其用途
公开(公告)号：US08445649B2
公开(公告)日：2013-05-21
申请号：US12734359
申请日：2008-10-29
申请人： Minako Hoshi , Michio Sato , Shoji Ideno , Koji Naito , Satoshi Horie , Munehiro Noda , Hajime Horii
发明人： Minako Hoshi , Michio Sato , Shoji Ideno , Koji Naito , Satoshi Horie , Munehiro Noda , Hajime Horii
IPC分类号： C07K16/18 , C12P21/08
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2800/2821
摘要： An antibody provided by the present invention has a low reactivity with amyloid precursor proteins, and has a higher reactivity with amylospheroids than with amyloid β fibrils or monomeric amyloid β-proteins. According to the present invention, an antibody is provided that has a higher reactivity with amylospheroids than with amyloid precursor proteins, and has any one or more of the following properties: (i) a higher activity with amylospheroids than with amyloid β fibrils; (ii) a higher reactivity with amylospheroids than with monomeric amyloid β-proteins; and (iii) an activity of inhibiting neuronal cell death induced by amylospheroids.
摘要翻译：由本发明提供的抗体与淀粉样蛋白前体蛋白具有低反应性，并且与淀粉样蛋白β原纤维或单体淀粉样β-蛋白具有比淀粉样蛋白球体更高的反应性。根据本发明，提供了与淀粉样蛋白前体蛋白具有比淀粉样前体蛋白更高的反应性的抗体，并且具有以下特性中的任何一种或多种：（i）与淀粉样蛋白β原纤维相比，淀粉样蛋白球体的活性更高; （ii）与淀粉样β蛋白相比，淀粉样蛋白球体的反应性更高; 和（iii）抑制淀粉样蛋白球体诱导的神经元细胞死亡的活性。

2. 发明申请

US20100297662A1 ANTIBODY AND USE THEREOF 有权
标题翻译：抗体及其用途
公开(公告)号：US20100297662A1
公开(公告)日：2010-11-25
申请号：US12734359
申请日：2008-10-29
申请人： Minako Hoshi , Michio Sato , Shoji Ideno , Koji Naito , Satoshi Horie , Munehiro Noda , Hajime Horii
发明人： Minako Hoshi , Michio Sato , Shoji Ideno , Koji Naito , Satoshi Horie , Munehiro Noda , Hajime Horii
IPC分类号： G01N33/566 , C07K16/18 , C12M1/34 , C12N5/12 , C07H21/00 , C12N15/63
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2800/2821
摘要： An antibody provided by the present invention has a low reactivity with amyloid precursor proteins, and has a higher reactivity with amylospheroids than with amyloid β fibrils or monomeric amyloid β-proteins. According to the present invention, an antibody is provided that has a higher reactivity with amylospheroids than with amyloid precursor proteins, and has any one or more of the following properties: (i) a higher activity with amylospheroids than with amyloid β fibrils; (ii) a higher reactivity with amylospheroids than with monomeric amyloid β-proteins; and (iii) an activity of inhibiting neuronal cell death induced by amylospheroids.
摘要翻译：本发明提供的抗体与淀粉样蛋白前体蛋白的反应性低，与淀粉样蛋白和淀粉样蛋白相比具有比淀粉样蛋白球体更高的反应性。原纤维或单体淀粉样蛋白和蛋白质。根据本发明，提供了与淀粉样蛋白前体蛋白具有比淀粉样前体蛋白更高反应性的抗体，并且具有以下特性中的任何一种或多种：（i）与淀粉样蛋白相比具有更高的淀粉样蛋白球体活性; 原纤维（ii）与淀粉样蛋白和单糖淀粉样蛋白相比，与淀粉样蛋白球体的反应性更高; 和（iii）抑制淀粉样蛋白球体诱导的神经元细胞死亡的活性。

3. 发明授权

US5440018A Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same 失效
标题翻译：重组人血清白蛋白，其制备方法和含有其的药物制剂
公开(公告)号：US5440018A
公开(公告)日：1995-08-08
申请号：US36387
申请日：1993-03-24
申请人： Takao Ohmura , Akinori Sumi , Wataru Ohtani , Naoto Fuluhata , Kazuya Takeshima , Kaeko Kamide , Munehiro Noda , Masahide Kondo , Syoichi Ishikawa , Kazuhiro Oohara , Kazumasa Yokoyama
发明人： Takao Ohmura , Akinori Sumi , Wataru Ohtani , Naoto Fuluhata , Kazuya Takeshima , Kaeko Kamide , Munehiro Noda , Masahide Kondo , Syoichi Ishikawa , Kazuhiro Oohara , Kazumasa Yokoyama
IPC分类号： A61K38/00 , C07K1/14 , C07K14/765 , C12N15/14 , A61K38/38 , C07K1/16 , C07K1/36
CPC分类号： C07K14/765 , A61K38/00
摘要： Human serum albumin obtained by gene manipulation techniques can be purified by a combination of specified steps in which a culture supernatant obtained from a human serum albumin-producing host is subjected to ultrafiltration, heat treatment, acid treatment and another ultrafiltration, followed by subsequent treatments with a cation exchanger, a hydrophobic chromatography carrier and an anion exchanger, and by salting-out to thereby obtain a pure form of human serum albumin which contains substantially no proteinous and polysaccharide contaminants, which is formulated into a pharmaceutical preparation. This process makes it possible to effeciently purify recombinant human serum albumin and to provide substantially pure human serum albumin which does not contain producer host-related substances and other contaminants and is sufficiently free from coloration.
摘要翻译：通过基因操作技术获得的人血清白蛋白可以通过特定步骤的组合来纯化，其中将得自人血清白蛋白的宿主的培养上清液进行超滤，热处理，酸处理和另一次超滤，然后用阳离子交换剂，疏水性色谱载体和阴离子交换剂，并通过盐析，从而获得纯的形式的人血清白蛋白，其基本上不含有配制成药物制剂的蛋白质和多糖污染物。该方法使得可以有效地纯化重组人血清白蛋白并提供基本上纯的人血清白蛋白，其不含生产者宿主相关物质和其它污染物，并且没有着色。

4. 发明授权

US5986062A Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same 失效
标题翻译：重组人血清白蛋白，其制备方法和含有其的药物制剂
公开(公告)号：US5986062A
公开(公告)日：1999-11-16
申请号：US538471
申请日：1995-10-03
申请人： Takao Ohmura , Akinori Sumi , Wataru Ohtani , Naoto Furuhata , Kazuya Takeshima , Kaeko Kamide , Munehiro Noda , Masahide Kondo , Syoichi Ishikawa , Kazuhiro Oohara , Kazumasa Yokoyama , Nagatoshi Fujiwara
发明人： Takao Ohmura , Akinori Sumi , Wataru Ohtani , Naoto Furuhata , Kazuya Takeshima , Kaeko Kamide , Munehiro Noda , Masahide Kondo , Syoichi Ishikawa , Kazuhiro Oohara , Kazumasa Yokoyama , Nagatoshi Fujiwara
IPC分类号： A61K38/00 , C07K14/765
CPC分类号： C07K14/765 , A61K2039/545 , A61K38/00
摘要： Human serum albumin obtained by gene manipulation techniques can be purified by a combination of specified steps in which a culture supernatant obtained from a human serum albumin-producing host is subjected to ultrafiltration, heat treatment, acid treatment and another ultrafiltration, followed by subsequent treatments with a cation exchanger, a hydrophobic chromatography carrier and an anion exchanger, and by salting-out to thereby obtain a pure form of human serum albumin which contains substantially no proteinous and polysaccharide contaminants, which is formulated into a pharmaceutical preparation. The thus obtained human serum albumin can further be purified by treating recombinant human serum albumin with a hydrophobic chromatography carrier at pH of 2 to 5 and a salt concentration of 0.4 to 1 and exposing the carrier to a pH of 6 to 8 and a salt concentration of 0.01 to 0.3 M, or treating the culture supernatant with boric acid or a salt thereof at pH 8 to 11 for 1 to 10 hours and recovering the supernatant. This process makes it possible to effeciently purify recombinant human serum albumin and to provide substantially pure human serum albumin which does not contain producer host-related substances and other contaminants and is sufficiently free from coloration.
摘要翻译：通过基因操作技术获得的人血清白蛋白可以通过特定步骤的组合来纯化，其中将得自人血清白蛋白的宿主的培养上清液进行超滤，热处理，酸处理和另一次超滤，然后用阳离子交换剂，疏水性色谱载体和阴离子交换剂，并通过盐析，从而获得纯的形式的人血清白蛋白，其基本上不含有配制成药物制剂的蛋白质和多糖污染物。由此获得的人血清白蛋白可以进一步通过用pH为2至5和盐浓度为0.4至1的疏水色谱载体处理重组人血清白蛋白并将载体暴露于pH6至8和盐浓度为0.01〜0.3M，或用硼酸或其盐在pH8〜11处理培养上清1〜10小时，回收上清液。该方法使得可以有效地纯化重组人血清白蛋白并提供基本上纯的人血清白蛋白，其不含生产者宿主相关物质和其它污染物，并且没有着色。

5. 发明授权

US5521287A Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same 失效
公开(公告)号：US5521287A
公开(公告)日：1996-05-28
申请号：US202130
申请日：1994-02-25
申请人： Takao Ohmura , Akinori Sumi , Wataru Ohtani , Naoto Furuhata , Kazuya Takeshima , Kaeko Kamide , Munehiro Noda , Masahide Kondo , Syoichi Ishikawa , Kazuhiro Oohara , Kazumasa Yokoyama , Nagatoshi Fujiwara
发明人： Takao Ohmura , Akinori Sumi , Wataru Ohtani , Naoto Furuhata , Kazuya Takeshima , Kaeko Kamide , Munehiro Noda , Masahide Kondo , Syoichi Ishikawa , Kazuhiro Oohara , Kazumasa Yokoyama , Nagatoshi Fujiwara
IPC分类号： A61K38/00 , C07K14/765 , A61K38/38 , C07K1/16 , C07K1/36
CPC分类号： C07K14/765 , A61K2039/545 , A61K38/00
摘要： Human serum albumin obtained by gene manipulation techniques can be purified by a combination of specified steps in which a culture supernatant obtained from a human serum albumin-producing host is subjected to ultrafiltration, heat treatment, acid treatment and another ultrafiltration, followed by subsequent treatments with a cation exchanger, a hydrophobic chromatography carrier and an anion exchanger, and by salting-out to thereby obtain a pure form of human serum albumin which contains substantially no proteinous and polysaccharide contaminants, which is formulated into a pharmaceutical preparation. The thus obtained human serum albumin can further be purified by treating recombinant human serum albumin with a hydrophobic chromatography carrier at pH of 2 to 5 and a salt concentration of 0.4 to 1 and exposing the carrier to a pH of 6 to 8 and a salt concentration of 0.01 to 0.3 M, or treating the culture supernatant with boric acid or a salt thereof at pH 8 to 11 for 1 to 10 hours and recovering the supernatant. This process makes it possible to effeciently purify recombinant human serum albumin and to provide substantially pure human serum albumin which does not contain producer host-related substances and other contaminants and is sufficiently free from coloration.

6. 发明授权

US5219995A Plasma fraction purification 失效
$Plasma fraction purification$
标题翻译：血浆级分纯化
公开(公告)号：US5219995A
公开(公告)日：1993-06-15
申请号：US913590
申请日：1992-07-14
申请人： Steven W. Herring , Yahiro Uemura , Munehiro Noda , Kenneth T. Shitanishi
发明人： Steven W. Herring , Yahiro Uemura , Munehiro Noda , Kenneth T. Shitanishi
IPC分类号： A61K38/43 , C07K1/18 , C07K1/22 , C07K1/30 , C07K14/435 , C07K14/745 , C12N9/64 , C12N9/74
CPC分类号： C12N9/6429 , C07K14/745 , C12N9/6432 , C12Y304/21005 , C12Y304/21006
摘要： The present invention describes a process for activating Factor II to Factor II.sub.a by incubating Factor II in the presence of Factor V, Factor X.sub.a, phospholipids, and calcium ions. Each of the factors is prepared from a single impure protein fraction which includes Factors II, V and X. The Factor II, V and X purification procedure comprises the steps of DEAE ligand chromatography and precipitation by the addition of barium chloride. Factor V is recovered from the barium chloride supernatant, and Factors II and X are contained in the barium chloride precipitate. The barium chloride precipitate is dissolved in an aqueous solution and is applied to a chromatographic resin coupled with a ligand which binds Factor X and Factor II weakly or not at all. Factor II is recovered from the fraction, which remains unbound or weakly bound to the Factor X binding ligand. Factor X.sub.a is prepared by recovering Factor X from the ligand during the Factor II preparation procedure and activating the Factor X to Factor X.sub.a by specific proteolytic cleavage.
摘要翻译：本发明描述了通过在因子V，因子Xa，磷脂和钙离子的存在下孵育因子II来激活因子II至因子IIa的方法。因子II，V和X的纯化程序包括DEAE配体层析和加入氯化钡沉淀的步骤。因子V从氯化钡上清液中回收，因子II和X包含在氯化钡沉淀中。将氯化钡沉淀物溶解在水溶液中，并施加到与限制因子X和因子II的配体偶联的色谱树脂上或完全不结合。因子II从部分回收，其保持未结合或弱结合于因子X结合配体。因子Xa通过在因子II制备过程中从配体中回收因子X并通过特异性蛋白水解切割活化因子X至因子Xa来制备。

7. 发明授权

US07037879B2 Pest control method for grass family plants using endophytic bacteria, pest control material, and seed bound to the pest control material 有权
标题翻译：使用内生细菌，害虫防治材料和种子结合害虫防治材料的草本植物的害虫控制方法
公开(公告)号：US07037879B2
公开(公告)日：2006-05-02
申请号：US10139063
申请日：2002-05-02
申请人： Takahiro Imada , Naoya Hiruma , Tsuyoshi Isawa , Munehiro Noda , Yohsuke Kurihara , Madoka Kon
发明人： Takahiro Imada , Naoya Hiruma , Tsuyoshi Isawa , Munehiro Noda , Yohsuke Kurihara , Madoka Kon
IPC分类号： A01N63/00 , C12N1/20
CPC分类号： A01N63/00
摘要： The objective of the present invention is to confer pest resistance to plants of Poaceae without using any chemically synthesized pesticides. The pest resistance can be conferred to plants of Poaceae by isolating from a natural plant an endophytic bacterium capable of expressing pest resistance, artificially culturing the endophytic bacterium, and introducing the bacteria to a Poaceae plant of interest.
摘要翻译：本发明的目的是在不使用任何化学合成的农药的情况下赋予禾本科植物抗病虫害性。通过从天然植物中分离能够表达害虫抗性的内生细菌，人工培养内生细菌，并将细菌引入感兴趣的禾本科植物，可以将抗病性赋予禾本科植物。

8. 植物专利

USPP11428P Glyceria plant named `Gly-P` 失效
公开(公告)号：USPP11428P
公开(公告)日：2000-06-27
申请号：US938751
申请日：1997-09-26
申请人： Satoshi Shinozaki , Hiroyuki Sano , Naoya Hiruma , Takahiro Imada , Munehiro Noda , Fumiyoshi Akaike , Sachiko Yamashima , Madoka Kon
发明人： Satoshi Shinozaki , Hiroyuki Sano , Naoya Hiruma , Takahiro Imada , Munehiro Noda , Fumiyoshi Akaike , Sachiko Yamashima , Madoka Kon
摘要： The present invention relates to a variety obtained by selecting and cross-breeding those individuals producing the insect resistance substance peramine from Glyceria ischyroneura Steud. growing wild in various districts of Japan.

9. 发明授权

US07084331B2 Rice containing endophytic bacteria and method of producing it 失效
标题翻译：含有内生细菌的水稻及其生产方法
公开(公告)号：US07084331B2
公开(公告)日：2006-08-01
申请号：US10139665
申请日：2002-05-02
申请人： Tsuyoshi Isawa , Naoya Hiruma , Takahiro Imada , Munehiro Noda , Yohsuke Kurihara , Madoka Kon
发明人： Tsuyoshi Isawa , Naoya Hiruma , Takahiro Imada , Munehiro Noda , Yohsuke Kurihara , Madoka Kon
IPC分类号： A01H5/00 , C12N1/12 , C12N1/20 , C12N15/01
CPC分类号： A01H3/00
摘要： The present invention provides a rice plant that shows enhanced growth and increased seed production, which also enables reduction of the use of chemical fertilizers.In the present invention, a nitrogen-fixing endophytic bacterium is isolated from bacteria symbiotically inhabiting natural plants, the isolated endophytic bacterium is artificially proliferated and then artificially inoculated into rice plants, and thus, the nitrogen-fixing endophytic bacteria are allowed to infect to rice plants.
摘要翻译：本发明提供了一种显示出增强的生长和增加的种子生产的水稻植物，其还能够减少化学肥料的使用。在本发明中，固氮内生细菌从共生栖息天然植物的细菌中分离出来，分离的内生细菌被人工增殖，然后人工接种到水稻中，从而使固氮内生细菌感染到水稻植物。

10. 发明授权

US06617133B1 Process for purifying recombinant human serum albumin 有权
标题翻译：重组人血清白蛋白纯化方法
公开(公告)号：US06617133B1
公开(公告)日：2003-09-09
申请号：US09317214
申请日：1999-05-24
申请人： Munehiro Noda , Akinori Sumi , Takao Ohmura , Kazumasa Yokoyama
发明人： Munehiro Noda , Akinori Sumi , Takao Ohmura , Kazumasa Yokoyama
IPC分类号： C12P2100
CPC分类号： C07K14/765
摘要： The invention provides a process for purifying recombinant human serum albumin (rHSA) by heating a-culture medium containing rHSA and the rHSA-producing host cells, feeding said heated solution upwardly into a fluidized bed in which adsorbent particles are suspended to effect contacting with the adsorbent particles and then recovering the adsorbed fraction containing the rHSA, and a composition comprising rHSA which shows a A350/A280 ratio of below 0.015, when formulated into a 25% solution of said albumin.
摘要翻译：本发明提供了通过加热含有rHSA和产生rHSA的宿主细胞的培养基来纯化重组人血清白蛋白（rHSA）的方法，将所述加热溶液向上加入流化床中，其中吸附剂颗粒悬浮以实现与吸附剂颗粒，然后回收含有rHSA的吸附级分，以及包含rHSA的组合物，其在配制成所述白蛋白的25％溶液时显示A350 / A280比率低于0.015。

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