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1. 发明授权

US09962331B2 Composition containing horse chestnut extract 有权
公开(公告)号：US09962331B2
公开(公告)日：2018-05-08
申请号：US10832713
申请日：2004-04-26
申请人： Min-Young Kim , Byung-Young Park , Chang-Hee Moon , Eun-Kyu Park , Kyoung-Mi Kim
发明人： Min-Young Kim , Byung-Young Park , Chang-Hee Moon , Eun-Kyu Park , Kyoung-Mi Kim
IPC分类号： A61K9/00 , A61K9/20 , A61K36/77 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/42
CPC分类号： A61K9/0014 , A61K9/0019 , A61K9/2059 , A61K36/77 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/42
摘要： The present invention relates to a composition containing Horse chestnut extract that inhibits angiogenesis and matrix metalloproteinase activity. The Horse chestnut extract of the present invention inhibits angiogenesis and activity of matrix metalloproteinase, so that it can be applied to treat and prevent disease related to angiogenesis and/or matrix metalloproteinase.

2. 发明授权

US07485327B2 Composition comprising Melissa leaf extract for anti-angiogenic and matrix metalloproteinase inhibitory activity 有权
标题翻译：组合物，其包含用于抗血管生成和基质金属蛋白酶抑制活性的Melissa叶提取物
公开(公告)号：US07485327B2
公开(公告)日：2009-02-03
申请号：US10460951
申请日：2003-06-12
申请人： Min-Young Kim , Byung-Young Park , Chang-Hee Moon , Eun-Kyu Park , Kyoung-Mi Kim
发明人： Min-Young Kim , Byung-Young Park , Chang-Hee Moon , Eun-Kyu Park , Kyoung-Mi Kim
IPC分类号： A61K36/00
CPC分类号： A61K36/31 , A23L33/105 , A61K8/97 , A61K36/53 , A61K45/06 , A61K2800/782 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： The present invention relates to a composition comprising Melissa leaf extract that inhibits angiogenesis and matrix metalloproteinase activity. The Melissa leaf extract of the present invention inhibits angiogenesis and activity of matrix metalloproteinase, so that it can be applied to treat or prevent diseases related to angiogenesis and matrix metalloproteinase. The composition of the present invention comprising Melissa leaf extract may also comprise more than one component of the other anti-angiogenic, anti-cancer, anti-inflammatory and anti-aging components. This particular composition comprising Melissa leaf extract can be used for pharmaceutical, dietetic and/or cosmetic purposes.
摘要翻译：本发明涉及包含抑制血管生成和基质金属蛋白酶活性的梅利莎叶提取物的组合物。本发明的梅利莎叶提取物抑制血管发生和基质金属蛋白酶的活性，因此可用于治疗或预防与血管生成和基质金属蛋白酶相关的疾病。包含梅利莎叶提取物的本发明的组合物还可以包含多于一种其它抗血管生成，抗癌，抗炎和抗衰老成分的组分。包含Melissa叶提取物的这种特定组合物可用于药物，饮食和/或美容目的。

3. 发明授权

US07572831B2 Composition containing chalcone 有权
标题翻译：含查耳酮的组合物
公开(公告)号：US07572831B2
公开(公告)日：2009-08-11
申请号：US10838853
申请日：2004-05-03
申请人： Min-Young Kim , Byung-Young Park , Kyoung-Mi Kim , Nack-Do Sung , Pyung-Keun Myung
发明人： Min-Young Kim , Byung-Young Park , Kyoung-Mi Kim , Nack-Do Sung , Pyung-Keun Myung
IPC分类号： A61K31/235 , A61K31/12
CPC分类号： A61K31/12 , A61K31/03
摘要： The present invention provides an MMP-inhibitory composition comprising chalcone or its derivatives. They inhibit the MMPs in collagenase subfamily as well as those in gelatinase subfamily. The MMP inhibitory activity of chalcone derivatives was similar to or greater than that of parent compound, chalcone. Chalcone or its derivatives of the present invention inhibit activity of matrix metalloproteinase, so that it can be applied to treat and prevent diseases related to matrix metalloproteinase.
摘要翻译：本发明提供含有查耳酮或其衍生物的MMP抑制组合物。它们抑制胶原酶亚族中的MMP以及明胶酶亚家族中的MMPs。查耳酮衍生物的MMP抑制活性与母体化合物查耳酮相似或更大。本发明的查耳酮或其衍生物抑制基质金属蛋白酶的活性，因此可用于治疗和预防与基质金属蛋白酶相关的疾病。

4. 发明申请

US20060002915A1 Pharmaceutical composition comprising arginine deiminase for inhibiting angiogenesis 失效
标题翻译：包含用于抑制血管发生的精氨酸脱亚氨酶的药物组合物
公开(公告)号：US20060002915A1
公开(公告)日：2006-01-05
申请号：US11159428
申请日：2005-06-20
申请人： Bon-Hong Min , Myung-Ok Park , Min-Young Kim , Byung-Young Park , Boe-Gwun Chun , Sang-Wook Kang , Chang-Hee Moon
发明人： Bon-Hong Min , Myung-Ok Park , Min-Young Kim , Byung-Young Park , Boe-Gwun Chun , Sang-Wook Kang , Chang-Hee Moon
IPC分类号： A61K48/00 , A61K38/48
CPC分类号： A61K38/50 , C12Y305/03006
摘要： The present invention relates to a pharmaceutical composition for inhibiting angiogenesis which comprises arginine deiminase as an active ingredient, where the arginine deiminase, obtained from Mycoplasma arginini or prepared by a genetic recombination technique, may be conjugated to an activated polymer to lower its immunogenecity and increase its life time. The pharmaceutical composition of the present invention exhibits an excellent inhibitory activity against angiogenesis.
摘要翻译：本发明涉及一种抑制血管发生的药物组合物，其包含精氨酸脱亚氨酶作为活性成分，其中由支原体支原体获得或通过遗传重组技术制备的精氨酸脱亚胺酶可与活化的聚合物缀合以降低其免疫原性并增加它的生活时间。本发明的药物组合物显示出优异的血管生成抑制活性。

5. 发明授权

US07413735B2 Pharmaceutical composition comprising arginine deiminase for inhibiting angiogenesis 失效
标题翻译：包含用于抑制血管发生的精氨酸脱亚氨酶的药物组合物
公开(公告)号：US07413735B2
公开(公告)日：2008-08-19
申请号：US11159428
申请日：2005-06-20
申请人： Bon-Hong Min , Myung-Ok Park , Min-Young Kim , Byung-Young Park , Boe-Gwun Chun , Sang-Wook Kang , Chang-Hee Moon
发明人： Bon-Hong Min , Myung-Ok Park , Min-Young Kim , Byung-Young Park , Boe-Gwun Chun , Sang-Wook Kang , Chang-Hee Moon
IPC分类号： A61K38/00 , A61K39/02 , C12N9/88 , C12N9/06 , C12N15/70 , C12P21/06 , C12Q1/34 , C07H21/04
CPC分类号： A61K38/50 , C12Y305/03006
摘要： The present invention relates to a pharmaceutical composition for inhibiting angiogenesis which comprises arginine deiminase as an active ingredient, where the arginine deiminase, obtained from Mycoplasma arginini or prepared by a genetic recombination technique, may be conjugated to an activated polymer to lower its immunogenecity and increase its life time. The pharmaceutical composition of the present invention exhibits an excellent inhibitory activity against angiogenesis.
摘要翻译：本发明涉及一种抑制血管发生的药物组合物，其包含精氨酸脱亚氨酶作为活性成分，其中由支原体支原体获得或通过遗传重组技术制备的精氨酸脱亚胺酶可与活化的聚合物缀合以降低其免疫原性并增加它的生活时间。本发明的药物组合物显示出优异的血管生成抑制活性。

6. 发明授权

US4825211A Warning device for vehicles against an approaching objects 失效
标题翻译：车辆对接近物体的警告装置
公开(公告)号：US4825211A
公开(公告)日：1989-04-25
申请号：US108590
申请日：1987-10-14
申请人： Byung-Young Park
发明人： Byung-Young Park
IPC分类号： B60Q1/52 , G01S17/93 , G08G1/00
CPC分类号： G01S17/936 , B60Q9/008
摘要： A warning device for use on a vehicle for sensing an approaching object when the vehicle is moving backward. The device produces a first signal when the object is in remote proximity of the vehicle and at least a second signal when the object is in close proximity of the vehicle. The device has a circuit for emitting intermittent infrared light when the vehicle is moving backward and a circuit for receiving the infrared light reflected from the object. The circuit for receiving produces a receive signal indicative of the received infrared light. The device further has an output of the circuit for receiving connected to two inverting inputs of both first and second differential amplifiers, inverting inputs of the first and second differential amplifiers being connected by a first and second variable resistors, respectively, to an applied voltage. First and second outputs of the first and second differential amplifiers, respectively, are connected to first and second inputs of an AND gate. An output of the AND gate is connected to a circuit for producing the second signal and the output of the first differential amplifier is connected to a circuit for producing the first signal.
摘要翻译：一种在车辆向后移动时用于感测接近物体的警告装置。当物体远离车辆时，该设备产生第一信号，并且当物体处于车辆附近时，至少产生第二信号。该装置具有用于当车辆向后移动时发出间歇性红外线的电路和用于接收从物体反射的红外线的电路。用于接收的电路产生指示所接收的红外光的接收信号。该装置还具有用于接收的电路的输出，连接到第一和第二差分放大器的两个反相输入，第一和第二差分放大器的反相输入分别由第一和第二可变电阻器连接到施加的电压。第一和第二差分放大器的第一和第二输出分别连接到与门的第一和第二输入端。与门的输出连接到用于产生第二信号的电路，并且第一差分放大器的输出连接到用于产生第一信号的电路。

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