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1. 发明授权

US11278666B2 Medication infusion device 有权
公开(公告)号：US11278666B2
公开(公告)日：2022-03-22
申请号：US16686186
申请日：2019-11-17
申请人： Min Wei
发明人： Min Wei
IPC分类号： A61M5/00 , A61M5/142 , A61M5/145 , A61M5/168 , A61M5/158
摘要： A medication infusion device includes a medication container containing liquid medication; an infusion needle; and a reciprocating pump having a pump chamber. The liquid medication is withdrawn from the medication container into the pump chamber during suction operation of the reciprocating pump, and the liquid medication is dispensed out of the pump chamber through the infusion needle during dispensing operation of the reciprocating pump. There are also mechanisms preventing liquid from flowing through the infusion needle during suction operation of the reciprocating pump and preventing liquid from flowing back into the medication container during dispensing operation of the reciprocating pump. The medication infusion device may further include a microcontroller to control medication infusion volume and rate.

2. 发明授权

US10692590B2 Method for conducting adaptive clinical trial with drug delivery device 有权
公开(公告)号：US10692590B2
公开(公告)日：2020-06-23
申请号：US15471035
申请日：2017-03-28
申请人： Min Wei
发明人： Min Wei
IPC分类号： G16H10/20 , G06F19/00
摘要： The method set out herein involves conducting adaptive clinical trial to develop parenteral therapeutic product with variable dose drug delivery devices. The method comprises using a variable dose drug delivery device to respond modifications during the adaptive clinical trial, wherein the variable dose drug delivery device is able to deliver more than one dose level and is for delivering fluid formulation. Other methods set out herein involve using a variable dose drug delivery device equipped with radio frequency identification (RFID) or near field communication (NFC) technology to improve patient adherence to drug administration in the adaptive clinical trial.

3. 发明申请

US20200179612A1 Drug Delivery Device 审中-公开
公开(公告)号：US20200179612A1
公开(公告)日：2020-06-11
申请号：US16699002
申请日：2019-11-28
申请人： Min Wei
发明人： Min Wei
IPC分类号： A61M5/32 , A61M5/315
摘要： A drug delivery device comprises a medication container containing medication for delivery and a detachable unit having an electronic circuit with a microprocessor. The electronic circuit is open and non-operational when the detachable component is assembled on the drug delivery device; and the electronic circuit is closed and operational when the detachable component is detached from the drug delivery device. The detachment of the detachable unit is an essential step to operate the drug delivery device. The detachable unit can be an activation protection cap or a needle shield remover for an autoinjector device. Alternatively, the detachable unit can be a needle shield remover for a pre-filled syringe.

4. 发明授权

US10300203B2 Priming mechanism for automatic injection device 有权
公开(公告)号：US10300203B2
公开(公告)日：2019-05-28
申请号：US15665519
申请日：2017-08-01
申请人： Min Wei
发明人： Min Wei
IPC分类号： A61M5/315 , A61M5/31 , A61M5/20
摘要： A priming mechanism for operating an automatic injection apparatus to ensure medication contents are properly delivered prior to a needled syringe of the apparatus being injected. The priming mechanism includes a push rod to move plunger(s) within the syringe; a releasable support including bendable supporting arms, which limiting motion of the syringe relative to an upper housing body before and during priming; and a recess element inside the lower housing body to release said bendable arm to allow motion of the syringe relative to the upper housing body in distal direction after priming. In one form, the priming mechanism is used for removing air bubble before injection to ensure delivering correct dose. In another form, the priming mechanism is used to mix different contents in a dual chamber syringe before injection.

5. 发明申请

US20180250474A1 Syringe Type Medication Delivery Device 审中-公开
公开(公告)号：US20180250474A1
公开(公告)日：2018-09-06
申请号：US15910156
申请日：2018-03-02
申请人： Min Wei
发明人： Min Wei
IPC分类号： A61M5/315 , A61M5/31
CPC分类号： A61M5/31505 , A61M5/3129 , A61M5/3137 , A61M5/3146 , A61M5/31515 , A61M5/31586 , A61M2005/3109 , A61M2005/3123 , A61M2005/3139 , A61M2005/31508
摘要： A pre-filled syringe for sterile medication fluid injection includes a syringe barrel with rotationally symmetric cylindrical bore, having a distal end and a proximal end; a syringe piston with rotationally symmetric external shape; a backstop mounted at the proximal end of the syringe barrel with an opening that is rotationally asymmetric about the axis through the syringe barrel; a push rod to move the syringe piston inside the syringe barrel, wherein at least one portion of the push rod is rotationally asymmetric about the axis through the syringe barrel, and upon rotation, the rotationally asymmetric portion of the push rod is aligned with the rotationally asymmetric opening of the backstop; and a seal component to cover the distal end of the syringe barrel.

6. 发明授权

US10049189B2 Method for developing parenteral therapeutic product with drug delivery device through clinical trial 有权
公开(公告)号：US10049189B2
公开(公告)日：2018-08-14
申请号：US14859296
申请日：2015-09-19
申请人： Min Wei
发明人： Min Wei
IPC分类号： G06Q10/00 , G06Q50/00 , G06F19/00 , G16H10/20 , A61M5/142 , A61M5/145 , A61M5/20 , A61M5/24 , A61M5/315
摘要： The method set out herein involves conducting clinical trial to develop parenteral therapeutic product with drug delivery device. The method comprises conducting a dose-finding clinical study using a variable dose drug delivery device to evaluate multiple clinical doses, wherein the variable dose drug delivery device is automatic, portable and for user self-administration. During the dose-finding clinical study, both the performance of the drug and the performance of the variable dose drug delivery device are evaluated.

7. 发明申请

US20170300665A1 Method For Conducting Adaptive Clinical Trial With Drug Delivery Device 审中-公开
公开(公告)号：US20170300665A1
公开(公告)日：2017-10-19
申请号：US15471035
申请日：2017-03-28
申请人： Min Wei
发明人： Min Wei
IPC分类号： G06F19/00
CPC分类号： G16H10/20 , G06F19/3456
摘要： The method set out herein involves conducting adaptive clinical trial to develop parenteral therapeutic product with variable dose drug delivery devices. The method comprises using a variable dose drug delivery device to respond modifications during the adaptive clinical trial, wherein the variable dose drug delivery device is able to deliver more than one dose level and is for delivering fluid formulation. Other methods set out herein involve using a variable dose drug delivery device equipped with radio frequency identification (RFID) or near field communication (NFC) technology to improve patient adherence to drug administration in the adaptive clinical trial.

8. 发明授权

US09762283B2 Method and apparatus for antenna calibration 有权
公开(公告)号：US09762283B2
公开(公告)日：2017-09-12
申请号：US14427026
申请日：2012-09-13
申请人： Jia Chen , Youping Su , Min Wei
发明人： Jia Chen , Youping Su , Min Wei
IPC分类号： H04B1/48 , H04B1/56 , H04B7/04 , H01Q3/26 , H04B17/12 , H04B17/14 , H04B17/21
CPC分类号： H04B1/48 , H01Q3/267 , H04B1/56 , H04B7/04 , H04B17/12 , H04B17/14 , H04B17/21
摘要： Method and apparatus for antenna calibration have been disclosed. A radio unit (510) is provided. The radio unit (510) may comprise: a plurality of transmit/receive (TX/RX) paths; a plurality of radio frequency (RF) ports (512) connected with the plurality of TX/RX paths; and a coupling unit (516), coupled with the plurality of TX/RX paths and configured to inject an uplink (UL) calibration signal (550) into at least one of the plurality of TX/RX paths and extract a downlink (DL) calibration signal (540) from at least one of the plurality of TX/RX paths. A normal TX/RX path may be reused both for antenna calibration and antenna supervision. Thus, a low cost hardware solution for antenna calibration is provided. An AIR base station (500) comprising such radio unit (510) is also provided.

9. 发明申请

US20170080159A1 Medication Delivery Device 审中-公开
公开(公告)号：US20170080159A1
公开(公告)日：2017-03-23
申请号：US15126658
申请日：2015-04-08
申请人： Min Wei
发明人： Min Wei
IPC分类号： A61M5/315 , A61M5/32 , A61M5/31 , A61M5/20
摘要： A mechanical device for assisting medication injection is provided herein comprising a connector having a distal end and a proximal end; a piston rod locked in said connector before medication injection; a spring configured to bias said piston rod distally; a releasable restraining means configured to releasably restrain said piston rod in a locked state against said biasing of said spring, wherein, upon release of said releasable restraining means, said piston rod moves distally under force of said spring; an activation means configured to release said releasable restraining means; and a mounting means for mounting a syringe at said distal end of said connector.

10. 发明授权

US09029167B2 Preparation of an optical PH sensor based on fluorescein and 1-heptanesulfonic acid sodium Co-intercalated layered double hydroxide 有权
标题翻译：基于荧光素和1-庚磺酸钠共插层式双氢氧化物制备光学PH传感器
公开(公告)号：US09029167B2
公开(公告)日：2015-05-12
申请号：US13520694
申请日：2010-03-12
申请人： Min Wei , Wenying Shi , Jun Lu , Xue Duan
发明人： Min Wei , Wenying Shi , Jun Lu , Xue Duan
IPC分类号： G01N21/76 , G01N31/22
CPC分类号： G01N31/221
摘要： This invention relates to the field of preparation technology of optical pH sensor by co-intercalated fluorescein and 1-heptanesulfonic acid sodium into layered double hydroxide. The sensor is composed by conductive materials and the surface LDH films by co-interacted FLU and HES. The synthesis method is: first: synthesis of LDH colloid suspension, subsequently, the FLU and HES co-intercalated LDH colloid solution was prepared following the ion-exchange method, then the thin film of FLU-HES/LDH was spreaded on the surface of the conductive material by electrophoretic deposition, and the oriental pH sensor was synthesized. The advantages of the present invention is: first, the LDH matrix provides chromophore molecules with a confined and stable environment; the novel electrophoretic deposition strategy in this work provides a method for precise control of thickness (ranging from nanometers to micrometers), and the oriental pH sensor show good pH responsive.
摘要翻译：本发明涉及通过共插入荧光素和1-庚烷磺酸钠的光学pH传感器的制备技术领域到层状双氢氧化物中。传感器由导电材料和表面LDH膜共同相互作用的FLU和HES组成。合成方法是：首先合成LDH胶体悬浮液，随后用离子交换法制备FLU和HES共插入LDH胶体溶液，然后将FLU-HES / LDH薄膜铺展在通过电泳沉积导电材料和东方pH传感器。本发明的优点是：首先，LDH基体为发色团分子提供约束和稳定的环境; 该工作中的新型电泳沉积策略提供了一种精确控制厚度（范围从纳米到微米）的方法，东方pH传感器显示出良好的pH响应。

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