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1. 发明授权

US08871509B2 Nanoparticle-based gene delivery systems 有权
标题翻译：基于纳米粒子的基因传递系统
公开(公告)号：US08871509B2
公开(公告)日：2014-10-28
申请号：US12809996
申请日：2010-03-18
申请人： Min Su Han , Kangseok Lee , Dong-Eun Kim
发明人： Min Su Han , Kangseok Lee , Dong-Eun Kim
IPC分类号： C12N5/00 , C12N5/02 , C07H21/02 , C12N15/11 , C12N15/87 , C12N15/113 , C12N15/89 , A61K47/48 , A61K31/713 , A61K31/7105
CPC分类号： C12N15/113 , A61K31/7105 , A61K31/713 , A61K47/6923 , C12N15/111 , C12N15/87 , C12N15/89 , C12N2310/11 , C12N2310/127 , C12N2310/14 , C12N2310/351 , C12N2310/51 , C12N2310/531 , C12N2320/32 , Y10S977/773
摘要： The present invention provides a gene delivery system containing nanoparticles. In more detail, the present invention provides a gene delivery system containing (a) a nanomaterial; (b) an oligonucleotide as an universal binding partner covalently linked to the surface of the nanomaterial; and (c) a cargo comprising (i) a complementary oligonucleotide containing a nucleotide sequence complementary to the universal binding partner as a binding counter-partner, and (ii) an inhibitory molecule having a nucleotide sequence complementary to a target gene of interest to be inhibited or an inducible molecule having a nucleotide sequence of a target gene of interest to be expressed. The present invention is a gene delivery system capable of feasibly deliver aptamer, siRNA, shRNA, miRNA, ribozyme, DNAzyme, PNA or gene as well as antisense oligonucleotide into the cells. In addition, the present invention is more efficient than the commercially available gene transfer reagent in respect to the degree of knockdown of target protein expression.
摘要翻译：本发明提供含有纳米颗粒的基因递送系统。更详细地，本发明提供了一种基因递送系统，其包含（a）纳米材料; （b）与纳米材料的表面共价连接的通用结合配偶体的寡核苷酸; （c）货物，其包含（i）含有与通用结合配偶体互补的核苷酸序列作为结合对配体的互补寡核苷酸，和（ii）具有与目的靶基因互补的核苷酸序列的抑制性分子，或具有待表达的靶基因的核苷酸序列的诱导型分子。本发明是能够将适体，siRNA，shRNA，miRNA，核酶，DNA酶，PNA或基因以及反义寡核苷酸可行地递送到细胞中的基因递送系统。此外，与靶蛋白质表达的敲低程度相比，本发明比市售的基因转移试剂更有效。

2. 发明申请

US20110229966A1 Nanoparticle-Based Gene Delivery Systems 有权
标题翻译：基于纳米粒子的基因递送系统
公开(公告)号：US20110229966A1
公开(公告)日：2011-09-22
申请号：US12809996
申请日：2010-03-18
申请人： Min Su Han , Kangseok Lee , Dong-Eun Kim
发明人： Min Su Han , Kangseok Lee , Dong-Eun Kim
IPC分类号： C12N5/00
CPC分类号： C12N15/113 , A61K31/7105 , A61K31/713 , A61K47/6923 , C12N15/111 , C12N15/87 , C12N15/89 , C12N2310/11 , C12N2310/127 , C12N2310/14 , C12N2310/351 , C12N2310/51 , C12N2310/531 , C12N2320/32 , Y10S977/773
摘要： The present invention provides a gene delivery system containing nanoparticles. In more detail, the present invention provides a gene delivery system containing (a) a nanomaterial; (b) an oligonucleotide as an universal binding partner covalently linked to the surface of the nanomaterial; and (c) a cargo comprising (i) a complementary oligonucleotide containing a nucleotide sequence complementary to the universal binding partner as a binding counter-partner, and (ii) an inhibitory molecule having a nucleotide sequence complementary to a target gene of interest to be inhibited or an inducible molecule having a nucleotide sequence of a target gene of interest to be expressed. The present invention is a gene delivery system capable of feasibly deliver aptamer, siRNA, shRNA, miRNA, ribozyme, DNAzyme, PNA or gene as well as antisense oligonucleotide into the cells. In addition, the present invention is more efficient than the commercially available gene transfer reagent in respect to the degree of knockdown of target protein expression.
摘要翻译：本发明提供含有纳米颗粒的基因递送系统。更详细地，本发明提供了一种基因递送系统，其包含（a）纳米材料; （b）与纳米材料的表面共价连接的通用结合配偶体的寡核苷酸; （c）货物，其包含（i）含有与通用结合配偶体互补的核苷酸序列作为结合对配体的互补寡核苷酸，和（ii）具有与目的靶基因互补的核苷酸序列的抑制性分子，或具有待表达的靶基因的核苷酸序列的诱导型分子。本发明是能够将适体，siRNA，shRNA，miRNA，核酶，DNA酶，PNA或基因以及反义寡核苷酸可行地递送到细胞中的基因递送系统。此外，与靶蛋白质表达的敲低程度相比，本发明比市售的基因转移试剂更有效。

3. 发明授权

US06445520B1 Method for detecting mechanical damage in a parking zone of a hard disk drive 失效
标题翻译：用于检测硬盘驱动器的停车区中的机械损坏的方法
公开(公告)号：US06445520B1
公开(公告)日：2002-09-03
申请号：US09732410
申请日：2000-12-06
申请人： Wonchoul Yang , Kangseok Lee , Haesung Kwon
发明人： Wonchoul Yang , Kangseok Lee , Haesung Kwon
IPC分类号： G11B502
CPC分类号： G11B5/012
摘要： A method for detecting an asperity in a non-data parking zone of a disk in a hard disk drive. The method includes the steps of moving the heads of the disk drive adjacent to the parking zones of the disks, and then detecting asperities in the parking zones with a thermal asperity detection circuit.
摘要翻译：一种用于检测硬盘驱动器中的盘的非数据停车区中的粗糙度的方法。该方法包括以下步骤：使盘驱动器的磁头移动到与磁盘的停车区相邻的位置，然后用热凹凸检测电路检测驻车区域的粗糙度。

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