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1. 发明申请

US20050154185A1 Vitronectin receptor antagonist pharmaceuticals 失效
标题翻译： Vitronectin受体拮抗剂药物
公开(公告)号：US20050154185A1
公开(公告)日：2005-07-14
申请号：US10770380
申请日：2004-02-02
申请人： Milind Rajopadhye , Thomas Harris , Edward Cheesman
发明人： Milind Rajopadhye , Thomas Harris , Edward Cheesman
IPC分类号： A61K49/00 , C07D401/12 , C07D401/14 , C07K5/02 , C07K5/06 , C07K5/078 , C07K5/12 , C07D471/02 , C07D487/02
CPC分类号： C07D401/14 , A61K49/0002 , C07D401/12 , C07K5/0205 , C07K5/0215 , C07K5/06139 , C07K5/06191
摘要： The present invention describes novel compounds of the formula: (Q)d-Ln-Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present invention also provides novel compounds useful for monitoring therapeutic angiogenesis treatment and destruction of new angiogenic vasculature. The present invention also provides novel compounds useful for imaging atherosclerosis, restenosis, cardiac ischemia, and myocardial reperfusion injury. The present invention also provides novel compounds useful for the treatment of rheumatoid arthritis. The pharmaceuticals are comprised of a targeting moiety that binds to a receptor that is upregulated during angiogenesis, an optional linking group, and a therapeutically effective radioisotope or diagnostically effective imageable moiety. The imageable moiety is a gamma ray or positron emitting radioisotope, a magnetic resonance imaging contrast agent, an X-ray contrast agent, or an ultrasound contrast agent.
摘要翻译：本发明描述了新的下式化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？>（Q）对于癌症的诊断和治疗有用的<？in-line-formula description =“在线公式”end =“tail”？>，肿瘤成像方法患者，以及在患者中治疗癌症的方法。本发明还提供了可用于监测治疗性血管生成治疗和破坏新的血管生成脉管系统的新型化合物。本发明还提供了用于成像动脉粥样硬化，再狭窄，心脏缺血和心肌再灌注损伤的新型化合物。本发明还提供了可用于治疗类风湿性关节炎的新化合物。药物由与血管发生期间上调的受体结合的靶向部分，任选的连接基团和治疗有效的放射性同位素或诊断上有效的可成像部分组成。可成像部分是伽马射线或正电子发射放射性同位素，磁共振成像造影剂，X射线造影剂或超声造影剂。

2. 发明申请

US20060003926A1 PHARMACEUTICALS FOR THE IMAGING OF ANGIOGENIC DISORDERS 失效
标题翻译：用于成像发生疾病的药物
公开(公告)号：US20060003926A1
公开(公告)日：2006-01-05
申请号：US10622246
申请日：2003-07-18
申请人： Milind Rajopadhye , D. Edwards , John Barrett , Alan Carpenter , Thomas Harris , Stuart Heminway , Shuang Liu , Singh Prahlad
发明人： Milind Rajopadhye , D. Edwards , John Barrett , Alan Carpenter , Thomas Harris , Stuart Heminway , Shuang Liu , Singh Prahlad
IPC分类号： A61K38/12 , C07K7/64
CPC分类号： C07D401/14 , A61K38/00 , A61K45/06 , A61K49/0002 , A61K49/227 , A61K51/082 , A61K51/088 , C07D401/12 , C07K7/06 , C07K7/08 , C07K7/64
摘要： The present invention describes novel compounds of the formula: (Q)d-Ln-Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present invention also provides novel compounds useful for monitoring therapeutic angiogenesis treatment and destruction of new angiogenic vasculature. The pharmaceuticals are comprised of a targeting moiety that binds to a receptor that is upregulated during angiogenesis, an optional linking group, and a therapeutically effective radioisotope or diagnostically effective imageable moiety. The imageable moiety is a gamma ray or positron emitting radioisotope, a magnetic resonance imaging contrast agent, an X-ray contrast agent, or an ultrasound contrast agent.
摘要翻译：本发明描述了新的下式化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？>（Q）对于癌症的诊断和治疗有用的<？in-line-formula description =“在线公式”end =“tail”？>，肿瘤成像方法患者，以及在患者中治疗癌症的方法。本发明还提供了可用于监测治疗性血管生成治疗和破坏新的血管生成脉管系统的新型化合物。药物由与血管发生期间上调的受体结合的靶向部分，任选的连接基团和治疗有效的放射性同位素或诊断上有效的可成像部分组成。可成像部分是伽马射线或正电子发射放射性同位素，磁共振成像造影剂，X射线造影剂或超声造影剂。

3. 发明申请

US20120102887A1 Machine Generated Wrap Data 有权
标题翻译：机器生成的包装数据
公开(公告)号：US20120102887A1
公开(公告)日：2012-05-03
申请号：US13284528
申请日：2011-10-28
申请人： Patrick R. Lancaster, III , Michael Mitchell , Thomas Harris , Robert D. Janes, SR.
发明人： Patrick R. Lancaster, III , Michael Mitchell , Thomas Harris , Robert D. Janes, SR.
IPC分类号： B65B11/00 , G01N3/02
CPC分类号： B65B57/18 , B65B11/025 , B65B11/045 , B65B2011/002 , B65B2210/18 , B65B2210/20
摘要： A method for generating data with a wrapping machine during wrapping of a load includes measuring a length of packaging material dispensed during wrapping of the load with a sensing assembly on the wrapping machine. The method further includes obtaining a value indicative of a weight of the packaging material per unit of length and determining a weight of the packaging material dispensed on the wrapped load based on the measured length and the obtained value without removing the packaging material from the load. The determined weight of the packaging material is displayed on a display device.
摘要翻译：用于在缠绕负载期间用包装机产生数据的方法包括测量在包裹机器处的传感组件的负载包裹期间分配的包装材料的长度。该方法还包括获得指示每单位长度的包装材料的重量的值，并且基于所测量的长度和所获得的值确定分配在包裹的负载上的包装材料的重量，而不从包装材料中取出负载。包装材料的确定重量显示在显示装置上。

4. 发明申请

US20090178374A1 ELECTRONIC CONTROL OF METERED FILM DISPENSING IN A WRAPPING APPARATUS 有权
标题翻译：在包装装置中计量膜分配的电子控制
公开(公告)号：US20090178374A1
公开(公告)日：2009-07-16
申请号：US12349929
申请日：2009-01-07
申请人： Patrick R. Lancaster, III , Robert D. Janes, SR. , Michael Mitchell , Thomas Harris , Richard L. Johnson
发明人： Patrick R. Lancaster, III , Robert D. Janes, SR. , Michael Mitchell , Thomas Harris , Richard L. Johnson
IPC分类号： B65B53/00 , B65B11/04 , G06F17/00
CPC分类号： B65B59/02 , B65B11/025 , B65B11/04 , B65B11/045 , B65B41/16 , B65B57/04 , B65B2011/002 , B65B2210/18 , B65B2210/20
摘要： An apparatus for wrapping a load may include a film dispenser for dispensing a film web including a film dispensing drive. The apparatus may also include a rotational drive system for providing relative rotation between the load and the dispenser during a wrapping cycle. The apparatus may further include a controller configured to operatively couple the film dispensing drive and the rotational drive system such that, for any portion of a revolution of the film dispenser relative to the load during the wrapping cycle, the film dispenser dispenses a selected length of the film web corresponding to the portion of the revolution.
摘要翻译：用于包装负载的装置可以包括用于分配包括胶片分配驱动器的胶片幅的胶片分配器。该装置还可以包括旋转驱动系统，用于在卷绕循环期间在负载和分配器之间提供相对旋转。该装置还可以包括控制器，该控制器被配置为可操作地耦合胶片分配驱动器和旋转驱动系统，使得对于胶片分配器相对于包装循环期间的负载的转动的任何部分，胶片分配器分配选定长度的电影卷对应于革命的一部分。

5. 发明申请

US20070142217A1 Regeneration of ionic liquid catalyst by hydrogenation using metal and acid 有权
标题翻译：使用金属和酸通过氢化再生离子液体催化剂
公开(公告)号：US20070142217A1
公开(公告)日：2007-06-21
申请号：US11316629
申请日：2005-12-20
申请人： Saleh Elomari , Thomas Harris
发明人： Saleh Elomari , Thomas Harris
IPC分类号： B01J27/125 , B01J27/06 , B01J31/00
CPC分类号： B01J27/32 , B01J27/125 , B01J31/0278 , B01J31/0284 , B01J31/0287 , B01J31/0288 , B01J31/40 , C07C2/862 , Y02P20/584
摘要： A process for regenerating a used acidic ionic liquid catalyst which has been deactivated by conjunct polymers comprising combining the used catalyst, a metal and a Broensted acid which acts a source of hydrogen in a reaction zone under hydrogenation conditions for a time sufficient to hydrogenate at least a portion of the conjunct polymer is disclosed. An embodiment of a process for regenerating a used acidic ionic liquid catalyst which has been deactivated by conjunct polymers comprising the steps of combining the used ionic liquid catalyst, a metal and HCl in a reaction zone under hydrogenation conditions for a time sufficient to hydrogenate at least a portion of the conjunct polymer; removing reaction product from the reaction zone; mixing the removed reaction product with a hydrocarbon solvent in which the hydrogenated conjunct polymers are soluble; allowing the mixture to separate into two phases, a lighter phase which contains the hydrogenated conjunct polymers and a heavier phase which contains a regenerated ionic liquid catalyst; and recovering at least a portion of the heavier phase is also disclosed.
摘要翻译：一种再生使用的酸性离子液体催化剂的方法，其已经通过结合聚合物失活，包括将氢化条件下的反应区中使用的催化剂，金属和作为氢源的布朗斯台德酸组合至少足以氢化至少公开了一部分结合聚合物。用于再生已使用的结合聚合物失活的酸性离子液体催化剂的方法的一个实施方案包括以下步骤：在氢化条件下将反应区中使用的离子液体催化剂，金属和HCl组合至少足以氢化至少结合聚合物的一部分; 从反应区除去反应产物; 将除去的反应产物与其中氢化结合聚合物可溶的烃溶剂混合; 允许混合物分离成两相，其中较轻的相含有氢化结合聚合物和较重相，其含有再生离子液体催化剂; 并且还公开了至少一部分较重相的回收。

6. 发明申请

US20060142626A1 Alkylated aromatic compositions, zeolite catalyst compositions and processes for making the same 有权
公开(公告)号：US20060142626A1
公开(公告)日：2006-06-29
申请号：US11355770
申请日：2006-02-15
申请人： Curt Campbell , Thomas Harris , Pierre Tequi , Jean-Louis Le Coent
发明人： Curt Campbell , Thomas Harris , Pierre Tequi , Jean-Louis Le Coent
IPC分类号： C07C15/00 , C07C2/68
CPC分类号： C07C15/107 , B01J29/084 , B01J29/18 , B01J29/80 , B01J29/90 , B01J35/1038 , B01J35/1061 , B01J35/1066 , B01J35/108 , B01J38/56 , B01J2229/42 , C07C2/66 , C07C303/06 , Y02P20/584 , C07C309/31
摘要： The present invention is directed to novel alkylated aromatic compositions, zeolite catalyst compositions and processes for making the same. The catalyst compositions comprise zeolite Y and mordenite zeolite having a controlled macropore structure. The present invention is also directed to the preparation of the catalyst compositions and their use in the preparation of novel alkylated aromatic compositions. The catalyst compositions of the present invention exhibit reduced deactivation rates during the alkylation process, thereby increasing the life of the catalysts.

7. 发明申请

US20060064042A1 Isometric system, method and apparatus 审中-公开
公开(公告)号：US20060064042A1
公开(公告)日：2006-03-23
申请号：US11198399
申请日：2005-08-08
申请人： Michael Smyser , Ronald Wiley , Thomas Harris
发明人： Michael Smyser , Ronald Wiley , Thomas Harris
IPC分类号： A61B5/103 , A61B5/117 , A61B5/22 , G01L3/24 , A63B21/00
CPC分类号： A63B21/0023 , A61B5/225 , A61B5/6825 , A61B2560/0406 , A63B24/00 , A63B2220/53 , A63B2225/20 , G06F19/3481
摘要： System, method and apparatus for carrying out isometric exercises for either diagnostic purposes or therapeutic purposes. When employed in a diagnostic mode, the instrument is programmed to carry out standardized diagnostic regimens and during such regimens provides both visual and aural cues, carries out mathematical computations of force values and provides recordation of diagnostic data in archival memory. When employed in a therapeutic mode the apparatus may only be programmed within mandated therapeutic parameter limitations. During therapeutic trials, the user is visually and aurally cued throughout the test sequence and the therapeutic data evolved during the regimen is recorded and recoverable from archival memory.

8. 发明申请

US20050203322A1 ZEOLITE Y ALKYLATION CATALYSTS 有权
标题翻译：沸石Y烷基化催化剂
公开(公告)号：US20050203322A1
公开(公告)日：2005-09-15
申请号：US10800047
申请日：2004-03-12
申请人： Thomas Harris , Curt Campbell , Paul Marcantonio , Pierre Tequi , Jean-Louis Le Coent
发明人： Thomas Harris , Curt Campbell , Paul Marcantonio , Pierre Tequi , Jean-Louis Le Coent
IPC分类号： B01J29/08 , A61K31/513 , A61K31/7048 , B01J29/04 , B01J29/18 , B01J35/10 , B01J37/00 , C07B61/00 , C07C2/12 , C07C2/66 , C07C2/68 , C07C5/00 , C07C15/107 , C07C303/06 , C07C309/31
CPC分类号： B01J37/0009 , B01J29/084 , B01J35/1038 , B01J35/1066 , B01J2229/42 , C07C2/66 , C07C303/06 , C07C309/31 , C07C309/58 , C07C2529/06 , C10M159/24 , C10M2219/046 , C07C15/107 , C10N2210/02
摘要： The present invention is directed to a zeolite Y catalyst having a controlled macropore structure. The present invention is also directed to a zeolite Y catalyst composite and a process for preparing the catalyst composite. The catalyst composite exhibits reduced deactivation rates during the alkylation process, thereby increasing the life of the catalyst. The present invention is also directed to processes for the preparation of carbonated, overbased aromatic sulfonates, which processes comprise alkylation, carbonation of aromatic hydrocarbons with one or more olefins.
摘要翻译：本发明涉及具有受控大孔结构的沸石Y催化剂。本发明还涉及沸石Y催化剂复合材料和制备催化剂复合材料的方法。催化剂复合物在烷基化过程中表现出降低的失活速率，从而增加催化剂的寿命。本发明还涉及制备碳酸化的高碱性芳族磺酸盐的方法，该方法包括芳族烃与一种或多种烯烃的烷基化，碳酸化。

9. 发明授权

US09725195B2 Electronic control of metered film dispensing in a wrapping apparatus 有权
公开(公告)号：US09725195B2
公开(公告)日：2017-08-08
申请号：US12349929
申请日：2009-01-07
申请人： Patrick R. Lancaster, III , Robert D. Janes, Sr. , Michael Mitchell , Thomas Harris , Richard L. Johnson
发明人： Patrick R. Lancaster, III , Robert D. Janes, Sr. , Michael Mitchell , Thomas Harris , Richard L. Johnson
IPC分类号： B65B11/02 , B65B11/04 , B65B11/00
CPC分类号： B65B59/02 , B65B11/025 , B65B11/04 , B65B11/045 , B65B41/16 , B65B57/04 , B65B2011/002 , B65B2210/18 , B65B2210/20
摘要： An apparatus for wrapping a load may include a film dispenser for dispensing a film web including a film dispensing drive. The apparatus may also include a rotational drive system for providing relative rotation between the load and the dispenser during a wrapping cycle. The apparatus may further include a controller configured to operatively couple the film dispensing drive and the rotational drive system such that, for any portion of a revolution of the film dispenser relative to the load during the wrapping cycle, the film dispenser dispenses a selected length of the film web corresponding to the portion of the revolution.

10. 发明申请

US20120260792A1 PRODUCTS AND METHODS FOR BALLISTIC DAMAGE MITIGATION AND BLAST DAMAGE SUPPRESSION 审中-公开
标题翻译：用于弹丸损伤缓解和BLAST损伤抑制的产品和方法
公开(公告)号：US20120260792A1
公开(公告)日：2012-10-18
申请号：US13280080
申请日：2011-10-24
申请人： Ronald Grossman , Thomas Harris
发明人： Ronald Grossman , Thomas Harris
IPC分类号： F41H5/04 , E04F13/00 , B32B43/00
CPC分类号： F41H5/0478
摘要： This invention is directed to energy absorbing or dissipating composite materials used to reduce structural damage from explosive blast energy and ballistic projectiles, either separately or in combination, and to methods of employing such materials. More particularly, this invention is directed to a blast damage suppression and/or ballistic shielding material comprising at least three independent layers; a layer comprising fiber based panels; a spray foam coating material and a coating layer comprising an elasto-plastic material.
摘要翻译：本发明涉及能量吸收或消散复合材料，其用于单独地或组合地减少爆炸能量和弹道射弹的结构损伤，以及采用这种材料的方法。更具体地说，本发明涉及包含至少三个独立层的爆炸破坏抑制和/或弹道屏蔽材料; 包括基于纤维的面板的层; 喷涂泡沫涂料和包含弹性塑料材料的涂层。

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