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1. 发明申请

US20080045821A1 System for determining the concentration of an analyte 有权
标题翻译：用于确定分析物浓度的系统
公开(公告)号：US20080045821A1
公开(公告)日：2008-02-21
申请号：US11974477
申请日：2007-10-12
申请人： Mihailo Rebec , James Smous , Steven Brown , Hu-Wei Tan
发明人： Mihailo Rebec , James Smous , Steven Brown , Hu-Wei Tan
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/726 , G01N21/274 , G01N21/359 , G01N2201/067
摘要： A system for determining the concentration of an analyte in at least one body fluid in body tissue comprises an infrared light source, a body tissue interface, a detector, and a central processing unit. The body tissue interface is adapted to contact body tissue and to deliver light from the infrared light source to the contacted body tissue. The detector is adapted to receive spectral information corresponding to infrared light transmitted through the portion of body tissue being analyzed and to convert the received spectral information into an electrical signal indicative of the received spectral information. The central processing unit is adapted to compare the electrical signal to an algorithm built upon correlation with the analyte in body fluid, the algorithm adapted to convert the received spectral information into the concentration of the analyte in at least one body fluid.
摘要翻译：用于确定身体组织中的至少一种体液中的分析物的浓度的系统包括红外光源，身体组织界面，检测器和中央处理单元。身体组织界面适于接触身体组织并将红外光源的光传送到被接触的身体组织。检测器适于接收对应于通过被分析的身体组织部分透射的红外光的光谱信息，并将接收到的光谱信息转换为指示所接收的光谱信息的电信号。中央处理单元适于将电信号与建立在体液中与分析物相关的算法进行比较，该算法适于将接收到的光谱信息转换成至少一个体液中分析物的浓度。

2. 发明申请

US20080045820A1 Method for building an algorithm for converting spectral information 有权
标题翻译：用于构建用于转换光谱信息的算法的方法
公开(公告)号：US20080045820A1
公开(公告)日：2008-02-21
申请号：US11973790
申请日：2007-10-10
申请人： Mihailo Rebec , James Smous , Steven Brown , Hu-Wei Tan
发明人： Mihailo Rebec , James Smous , Steven Brown , Hu-Wei Tan
IPC分类号： A61B5/1455
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/726 , G01N21/274 , G01N21/359 , G01N2201/067
摘要： A system for determining the concentration of an analyte in at least one body fluid in body tissue comprises an infrared light source, a body tissue interface, a detector, and a central processing unit. The body tissue interface is adapted to contact body tissue and to deliver light from the infrared light source to the contacted body tissue. The detector is adapted to receive spectral information corresponding to infrared light transmitted through the portion of body tissue being analyzed and to convert the received spectral information into an electrical signal indicative of the received spectral information. The central processing unit is adapted to compare the electrical signal to an algorithm built upon correlation with the analyte in body fluid, the algorithm adapted to convert the received spectral information into the concentration of the analyte in at least one body fluid.
摘要翻译：用于确定身体组织中的至少一种体液中的分析物的浓度的系统包括红外光源，身体组织界面，检测器和中央处理单元。身体组织界面适于接触身体组织并将红外光源的光传送到被接触的身体组织。检测器适于接收对应于通过被分析的身体组织部分透射的红外光的光谱信息，并将接收到的光谱信息转换为指示所接收的光谱信息的电信号。中央处理单元适于将电信号与建立在体液中与分析物相关的算法进行比较，该算法适于将接收到的光谱信息转换成至少一个体液中分析物的浓度。

3. 发明申请

US20080059100A1 Method for correcting a spectral image for optical aberrations using software 失效
标题翻译：使用软件校正光学像差的光谱图像的方法
公开(公告)号：US20080059100A1
公开(公告)日：2008-03-06
申请号：US11894511
申请日：2007-08-21
申请人： James Smous , Mihailo Rebec , Michael Houlne
发明人： James Smous , Mihailo Rebec , Michael Houlne
IPC分类号： G06F19/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14556 , G01N21/6456 , G01N21/65 , G01N2021/6423
摘要： A spectral image is corrected for optical aberrations. Tissue is exposed to a high-intensity, narrow band of light. The narrow band of light is scattered by at least one analyte in the tissue. Raman signals are optically collected from the scattered light. The Raman signals are directed to a wavelength-separating device. The Raman signals are detected as a function of intensity and wavelength to create the spectral image. The spectral image is corrected for optical aberrations using a software algorithm to spatially reassign intensity. The software may be adapted to use a reference image to make dynamic corrections. Fluorescence signals may also be collected.
摘要翻译：对光学像差校正光谱图像。组织暴露于高强度，窄带光。窄带光被组织中的至少一种分析物散射。拉曼信号从散射光中被光学收集。拉曼信号被引导到波长分离装置。作为强度和波长的函数检测拉曼信号以产生光谱图像。使用软件算法对光学像差校正光谱图像以空间重新分配强度。该软件可以适于使用参考图像进行动态校正。也可以收集荧光信号。

4. 发明申请

US20080097240A1 Method of Determining the Concentration of an Analyte in a Body Fluid and System Therefor 有权
标题翻译：确定体液及其系统中分析物浓度的方法
公开(公告)号：US20080097240A1
公开(公告)日：2008-04-24
申请号：US11665118
申请日：2005-10-20
申请人： Mihailo Rebec , James Smous , Bryan Melle , Pamela Burson
发明人： Mihailo Rebec , James Smous , Bryan Melle , Pamela Burson
IPC分类号： A61B5/00
CPC分类号： A61B5/15134 , A61B5/150022 , A61B5/150068 , A61B5/150114 , A61B5/150358 , A61B5/150755 , A61B5/15136
摘要： A method of obtaining a body fluid sample for determining the concentration of an analyte in the body fluid sample comprises applying pressure to the skin of the user. The skin is stretched so as to create a tear in the skin such that the applied pressure causes the body fluid to flow from the tear. The body fluid flowing from the tear is collected. Disclosed is also a pressure member for applying pressure to and stretching skin in preparation for forming a tear in the skin.
摘要翻译：获得用于确定体液样品中分析物浓度的体液样品的方法包括向使用者的皮肤施加压力。皮肤被拉伸以在皮肤中产生撕裂，使得所施加的压力导致体液从泪液流出。收集从泪液流出的体液。还公开了用于对皮肤施加压力并拉伸皮肤以准备在皮肤中形成泪液的压力构件。

5. 发明申请

US20080051645A1 Non-invasive methods of using spectral information in determining analyte concentrations 失效
标题翻译：使用光谱信息确定分析物浓度的非侵入性方法
公开(公告)号：US20080051645A1
公开(公告)日：2008-02-28
申请号：US11894510
申请日：2007-08-21
申请人： Mihailo Rebec , Michael Houlne
发明人： Mihailo Rebec , Michael Houlne
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0059 , A61B5/14532 , A61B5/14546
摘要： A non-invasive method of determining the concentration of an analyte uses Raman or fluorescence spectral information. A high-intensity band of light is applied to one side of skin tissue. The high-intensity light enters the skin tissue and generates a Raman or fluorescence signal. A Raman-generating material or fluorescence-generating material is placed in a location nearest the other side of skin tissue. The Raman-generating or fluorescence-generating material is located generally opposite of the entry of the applied high-intensity light. The Raman or fluorescence signal is collected and the analyte concentration is determined using the collected Raman signal.
摘要翻译：确定分析物浓度的非侵入性方法使用拉曼或荧光光谱信息。将高强度光带施加到皮肤组织的一侧。高强度光进入皮肤组织并产生拉曼或荧光信号。将拉曼生成材料或荧光发生材料置于最接近皮肤组织另一侧的位置。拉曼生成或荧光发生材料大体上与施加的高强度光的入口相对。收集拉曼或荧光信号，并使用收集的拉曼信号确定分析物浓度。

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