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1. 发明授权

US06795617B2 Optical device for generating pulsed light 有权
标题翻译：用于产生脉冲光的光学装置
公开(公告)号：US06795617B2
公开(公告)日：2004-09-21
申请号：US10426900
申请日：2003-04-30
申请人： Mihaela Dinu , Charles Kerbage , Xiang Liu , Francesco Quochi , Robert S. Windeler , Chunhui Xu
发明人： Mihaela Dinu , Charles Kerbage , Xiang Liu , Francesco Quochi , Robert S. Windeler , Chunhui Xu
IPC分类号： G02B626
CPC分类号： G02B6/266 , G02B6/02366 , G02B6/02376 , G02B6/0239
摘要： An optical device including a microstructured fiber pumped by an external pulsed-light source. In one embodiment, the microstructured fiber includes two waist regions functioning as a tunable attenuator and a wavelength shifter, respectively. Output wavelength of the optical device is selected by attenuating the pump light in the first waist region and then passing the light through the second waist region to shift the pump energy to a new spectral band. An optical device of the invention configured with two or more microstructured fibers generates two or more synchronized pulsed beams, each at a different characteristic wavelength. Certain embodiments of the invention provide an inexpensive, compact, energy-efficient multi-wavelength synchronized pulsed-light source.
摘要翻译：包括由外部脉冲光源泵浦的微结构纤维的光学装置。在一个实施例中，微结构纤维包括分别用作可调谐衰减器和波长移位器的两个腰部区域。通过衰减第一腰围区域中的泵浦光，然后使光通过第二腰区，将泵浦能量转移到新的光谱带，来选择光学装置的输出波长。配置有两个或多个微结构纤维的本发明的光学器件产生两个或更多个同步的脉冲束，每个具有不同的特征波长。本发明的某些实施例提供了一种廉价，紧凑，节能的多波长同步脉冲光源。

2. 发明授权

US06608952B2 Fiber apparatus and method for manipulating optical signals 有权
标题翻译：用于操纵光信号的光纤装置和方法
公开(公告)号：US06608952B2
公开(公告)日：2003-08-19
申请号：US09929989
申请日：2001-08-15
申请人： Benjamin John Eggleton , Arturo Hale , Charles Kerbage , Robert Scott Windeler
发明人： Benjamin John Eggleton , Arturo Hale , Charles Kerbage , Robert Scott Windeler
IPC分类号： G02B626
CPC分类号： G02B6/02376 , G02B6/02052 , G02B6/02366 , G02B6/02371 , G02B6/02385 , G02B6/0239 , G02F1/0115 , G02F1/0147 , G02F2202/32 , G02F2203/48
摘要： Embodiments of the invention include an optical fiber device such as a modulator, variable attenuator or tunable filter including an optical fiber having a core region, a cladding layer around the core region, and a controllable active material disposed in, e.g., capillaries or rings formed the cladding layer. The active materials include, e.g., electro-optic material, magneto-optic material, photorefractive material, thermo-optic material and/or materials such as laser dyes that provide tunable gain or loss. The application of, e.g., temperature, light or an electric or magnetic field varies optical properties of the active material, which, in turn, varies or affects the propagation properties of optical signals in the device. The optical device includes a tapered region that causes the core mode to spread into the cladding region and, simultaneously, allows the active material to be relatively close to the propagated modes, thus allowing interaction between the active material and the propagating modes.
摘要翻译：本发明的实施例包括诸如调制器，可变衰减器或可调谐滤波器的光纤器件，其包括具有芯区域的光纤，围绕芯区域的包层，以及设置在例如形成的毛细管或环的可控活性材料包层。活性材料包括例如电光材料，磁光材料，光折射材料，热光材料和/或诸如提供可调谐增益或损耗的激光染料的材料。例如温度，光或电场或磁场的应用改变了活性材料的光学性质，其又改变或影响装置中光信号的传播特性。光学器件包括使芯模扩展到包层区域并同时允许活性材料相对接近传播模式的锥形区域，从而允许活性材料与传播模式之间的相互作用。

3. 发明授权

US07440664B2 Microstructured optical waveguide for providing periodic and resonant structures 有权
标题翻译：用于提供周期性和谐振结构的微结构光波导
公开(公告)号：US07440664B2
公开(公告)日：2008-10-21
申请号：US10409227
申请日：2003-04-08
申请人： Benjamin J. Eggleton , Justin D. Ging , Arturo Hale , Charles Kerbage
发明人： Benjamin J. Eggleton , Justin D. Ging , Arturo Hale , Charles Kerbage
IPC分类号： G02B6/02
CPC分类号： G02B6/021 , G02B6/02204 , G02B6/02366 , G02B6/02376 , G02B6/02385 , G02B6/0239
摘要： A microstructured optical waveguide is formed to include a periodic sequence of “plugs” of optically active material within the inner cladding air tunnels. The plugs are utilized as a grating structure for generating resonant and periodic structures. The waveguide (in one embodiment, an optical fiber) is tunable by changing the spacing of the plugs (e.g., heating the structure, changing the pressure within the structure, etc.), or by modifying the initial spacing of the plugs during the formation of the microstructured optical waveguide (i.e., by modifying the “dipping frequency” of the waveguide into a reservoir of optically active material). In general, any number of different types of optically active material may be used to form the plugs, where two or more different materials may be used in the same structure, and introduced in an alternating fashion.
摘要翻译：形成微结构化光波导以在内包层空气隧道内包括光学活性材料的“插塞”的周期性序列。插头被用作用于产生谐振和周期性结构的光栅结构。波导（在一个实施例中，光纤）可通过改变插头的间距（例如，加热结构，改变结构内的压力等）来调节，或通过在形成期间修改塞子的初始间隔来调节的微结构光波导（即，通过将波导的“浸渍频率”改变为光学活性材料的储存器）。通常，可以使用任何数量的不同类型的光学活性材料来形成插塞，其中可以以相同的结构使用两种或更多种不同的材料，并以交替方式引入。

4. 发明授权

US06782148B2 Modifying birefringence in optical fibers 有权
标题翻译：修改光纤双折射
公开(公告)号：US06782148B2
公开(公告)日：2004-08-24
申请号：US10098229
申请日：2002-03-15
申请人： Benjamin John Eggleton , Charles Kerbage
发明人： Benjamin John Eggleton , Charles Kerbage
IPC分类号： G02B600
CPC分类号： G02B6/02366 , G02B6/02109 , G02B6/02333 , G02B6/02371 , G02B6/02376 , G02B6/02385 , G02B6/0239 , G02B6/105 , G02F1/0115 , G02F1/0136 , G02F1/0147 , G02F1/073 , G02F2202/32
摘要： Embodiments of the invention include an optical fiber device such as a tunable birefringent optical fiber having a core region, a cladding layer therearound, and a controllable active material disposed in, e.g., selective capillaries or pockets formed in the cladding layer. The active materials include, e.g., electro-optic material, magneto-optic material, photorefractive material, thermo-optic material and/or materials such as laser dyes that provide tunable gain or loss. The application of, e.g., temperature, light or an electric or magnetic field varies optical properties of the active material, which, in turn, varies or affects the propagation properties of optical signals in the device. The optical device can include a tapered region or long period grating that causes the core mode to spread or couple into the cladding region and, simultaneously, allows the active material to be relatively close to the propagated modes, thus allowing interaction between the active material and the propagating modes.
摘要翻译：本发明的实施例包括诸如具有芯区域，其周围的包层的可调双折射光纤的光纤器件和设置在例如形成在包层中的选择性毛细管或凹穴的可控有源材料。活性材料包括例如电光材料，磁光材料，光折射材料，热光材料和/或诸如提供可调谐增益或损耗的激光染料的材料。例如温度，光或电场或磁场的应用改变了活性材料的光学性质，其又改变或影响装置中光信号的传播特性。光学器件可以包括锥形区域或长周期光栅，其使核心模式扩展或耦合到包层区域中，并且同时允许活性材料相对接近传播模式，从而允许活性材料和传播模式。

5. 发明申请

US20130135580A1 System and Method for Detecting Amyloid Proteins 有权
标题翻译：检测淀粉样蛋白的系统和方法
公开(公告)号：US20130135580A1
公开(公告)日：2013-05-30
申请号：US13814677
申请日：2011-08-12
申请人： Paul D. Hartung , Vincent Valvo , Charles Kerbage , Gerald D. Cagle , Dennis J. Nilan
发明人： Paul D. Hartung , Vincent Valvo , Charles Kerbage , Gerald D. Cagle , Dennis J. Nilan
IPC分类号： A61B3/00 , A61B3/11 , A61B3/117
CPC分类号： A61B5/14546 , A61B3/0008 , A61B3/1005 , A61B3/107 , A61B3/111 , A61B3/117 , A61B3/1173 , A61B3/135 , A61B5/0068 , A61B5/0071 , A61B5/1455 , A61B5/4088 , A61B5/6821 , A61B2562/0238 , A61B2562/0242
摘要： In accordance with an embodiment of the invention, there is provided a device and method for detecting an amyloid protein in an eye of a mammal. A method comprises illuminating the eye with a light source having at least one of a wavelength property, a polarization property or a combination thereof, each appropriate to produce fluorescence in at least an amyloid-binding compound when the amyloid-binding compound is bound to the amyloid protein, the amyloid-binding compound having been introduced to the eye and specifically binding to the amyloid protein indicative of the amyloidogenic disorder; and determining a time decay rate of fluorescence for at least the fluorescence produced by the amyloid-binding compound bound to the amyloid protein, the determining permitting distinguishing of the presence of the amyloid-binding compound bound to the amyloid protein in the eye based on at least the time decay rate.
摘要翻译：根据本发明的一个实施方案，提供了用于检测哺乳动物眼睛中淀粉样蛋白质的装置和方法。一种方法包括用具有波长特性，极化性质或其组合中的至少一种的光源照射眼睛，当淀粉样蛋白结合化合物与淀粉样蛋白，已经引入到眼睛中的淀粉样蛋白结合化合物与指示淀粉样变性疾病的淀粉样蛋白特异性结合; 以及确定至少由与淀粉样蛋白结合的淀粉样蛋白结合化合物产生的荧光的荧光的时间衰减速率，所述确定允许基于在...的区别在眼睛中结合到淀粉样蛋白的淀粉样蛋白结合化合物的存在时间衰减率最小。

6. 发明授权

US09220403B2 System and method for detecting amyloid proteins 有权
标题翻译：用于检测淀粉样蛋白的系统和方法
公开(公告)号：US09220403B2
公开(公告)日：2015-12-29
申请号：US13814677
申请日：2011-08-12
申请人： Paul D. Hartung , Vincent Valvo , Charles Kerbage , Gerald D. Cagle , Dennis J. Nilan
发明人： Paul D. Hartung , Vincent Valvo , Charles Kerbage , Gerald D. Cagle , Dennis J. Nilan
IPC分类号： A61B3/10 , A61B3/00 , A61B3/14 , A61B3/117 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B3/11 , A61B3/135
CPC分类号： A61B5/14546 , A61B3/0008 , A61B3/1005 , A61B3/107 , A61B3/111 , A61B3/117 , A61B3/1173 , A61B3/135 , A61B5/0068 , A61B5/0071 , A61B5/1455 , A61B5/4088 , A61B5/6821 , A61B2562/0238 , A61B2562/0242
摘要： In accordance with an embodiment of the invention, there is provided a device and method for detecting an amyloid protein in an eye of a mammal. A method comprises illuminating the eye with a light source having at least one of a wavelength property, a polarization property or a combination thereof, each appropriate to produce fluorescence in at least an amyloid-binding compound when the amyloid-binding compound is bound to the amyloid protein, the amyloid-binding compound having been introduced to the eye and specifically binding to the amyloid protein indicative of the amyloidogenic disorder; and determining a time decay rate of fluorescence for at least the fluorescence produced by the amyloid-binding compound bound to the amyloid protein, the determining permitting distinguishing of the presence of the amyloid-binding compound bound to the amyloid protein in the eye based on at least the time decay rate.
摘要翻译：根据本发明的一个实施方案，提供了用于检测哺乳动物眼睛中淀粉样蛋白质的装置和方法。一种方法包括用具有波长特性，极化性质或其组合中的至少一种的光源照射眼睛，当淀粉样蛋白结合化合物与淀粉样蛋白，已经引入到眼睛中的淀粉样蛋白结合化合物与指示淀粉样变性疾病的淀粉样蛋白特异性结合; 以及确定至少由与淀粉样蛋白结合的淀粉样蛋白结合化合物产生的荧光的荧光的时间衰减速率，所述确定允许基于在...的区别在眼睛中结合到淀粉样蛋白的淀粉样蛋白结合化合物的存在时间衰减率最小。

7. 发明授权

US07110646B2 Tunable microfluidic optical fiber devices and systems 有权
公开(公告)号：US07110646B2
公开(公告)日：2006-09-19
申请号：US10094093
申请日：2002-03-08
申请人： Benjamin John Eggleton , Charles Kerbage , Peter Mach , John A. Rogers , Robert Scott Windeler
发明人： Benjamin John Eggleton , Charles Kerbage , Peter Mach , John A. Rogers , Robert Scott Windeler
IPC分类号： G06C1/00
CPC分类号： G02B6/021 , G02B6/02333 , G02B6/02338 , G02B6/02366 , G02B6/02371 , G02B6/02376 , G02B6/02385 , G02B6/0239
摘要： A tunable optical fiber device comprises a length of fiber having a core having a certain refractive index; a cladding peripherally surrounding the core with a refractive index less than the refractive index of the core; and at least one hollow region disposed within the cladding in proximity to the core or within the core itself. Fluid (typically liquid) controllably moved within the hollow region modifies the effective index of the fiber and thereby tunes its characteristics.

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