专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4992442A Pyrrolo(3,2-e)pyrazolo(1,5-a)pyrimidine derivative and medicine comprising the same 失效
标题翻译：吡咯并（3,2-e）吡唑并（1,5-a）嘧啶衍生物和包含它们的药物
公开(公告)号：US4992442A
公开(公告)日：1991-02-12
申请号：US416524
申请日：1989-10-03
申请人： Michihiko Tsujitani , Kenichi Kishii , Masato Inazu , Toshihiro Morimoto , Yoshiaki Motoki , Ichiro Matsuo
发明人： Michihiko Tsujitani , Kenichi Kishii , Masato Inazu , Toshihiro Morimoto , Yoshiaki Motoki , Ichiro Matsuo
IPC分类号： C07D487/14
CPC分类号： C07D487/14
摘要： Pyrrolo[3,2-e]pyrazolo[1,5-a]pyrimidine derivatives are disclosed. The compounds are represented by the formula (I), ##STR1## wherein R.sub.1 and R.sub.2 individually represent a hydrogen atom, a linear or branched alkyl group which may have a substituent, a cycloalkyl or phenyl group which may have a substituent, or a heterocyclic group which may have a substituent, and R.sub.3 is a hydrogen atom or a cyano group. The compounds have excellent circulatory disease curing activities as well as bronchodilation activities.

2. 发明授权

US5747493A Dopamine re-uptake inhibitor 失效
标题翻译：多巴胺再摄取抑制剂
公开(公告)号：US5747493A
公开(公告)日：1998-05-05
申请号：US557167
申请日：1995-12-21
申请人： Takayuki Namiki , Toshihiro Morimoto , Kenichi Kishii , Nobuyuki Kawakatsu , Makoto Kimura , Kyoko Yamasaki , Mariko Onoda , Yuji Yoshiko , Kazunori Harada , Masayuki Yanagi , Takeshi Yamamoto , Masato Inazu , Masaki Mitani
发明人： Takayuki Namiki , Toshihiro Morimoto , Kenichi Kishii , Nobuyuki Kawakatsu , Makoto Kimura , Kyoko Yamasaki , Mariko Onoda , Yuji Yoshiko , Kazunori Harada , Masayuki Yanagi , Takeshi Yamamoto , Masato Inazu , Masaki Mitani
IPC分类号： A61K31/495 , C07D213/74 , C07D295/13
CPC分类号： A61K31/495 , C07D213/74 , C07D295/13
摘要： A method for inhibiting dopamine re-uptake and treating Parkinson's disease is disclosed comprising administering a compound represented by formula (1) or a physiologically acceptable salt thereof as the active ingredient: ##STR1## wherein R.sup.1 and R.sup.2 represent each hydrogen or halogen, R.sup.3 represents hydrogen, alkyl or acyl, R.sup.4 represents hydrogen, alkyl, acyl, alkylsulfonyl or optionally esterified carboxyl, Ar represents optionally substituted phenyl or nitrogenous monocyclic heteroaromatic group, m represents a number of 1 to 5, and n represents a number of 0 to 5.
摘要翻译： PCT No.PCT / JP94 / 00728 Sec。 371 1995年12月21日第 102（e）日期1995年12月21日PCT 1994年4月28日PCT PCT。出版物WO95 / 00149 1995年1月5日公开了一种抑制多巴胺再摄取和治疗帕金森病的方法，包括给予式（1）表示的化合物或其生理学上可接受的盐作为活性成分：其中R1和R2 代表每个氢或卤素，R 3表示氢，烷基或酰基，R 4表示氢，烷基，酰基，烷基磺酰基或任意酯化的羧基，Ar表示任选取代的苯基或含氮单环杂芳基，m表示1至5的数，n表示代表0到5的数字。

3. 发明授权

US5391552A Diphenylpiperazine derivative and drug for circulatory organ containing the same 失效
标题翻译：二苯基哌嗪衍生物和含有其的循环器官的药物
公开(公告)号：US5391552A
公开(公告)日：1995-02-21
申请号：US988911
申请日：1993-05-10
申请人： Masato Inazu , Yoshiyuki Miyata , Toshihiro Morimoto , Takeshi Yamamoto , Yuji Yoshiko , Kazunori Harada , Yoshiharu Momota , Masayuki Yanagi , Ryoko Yokota , Tetsuo Katoh , Takayuki Namiki , Makoto Kimura , Nobuyuki Kawakatsu
发明人： Masato Inazu , Yoshiyuki Miyata , Toshihiro Morimoto , Takeshi Yamamoto , Yuji Yoshiko , Kazunori Harada , Yoshiharu Momota , Masayuki Yanagi , Ryoko Yokota , Tetsuo Katoh , Takayuki Namiki , Makoto Kimura , Nobuyuki Kawakatsu
IPC分类号： C07D295/088 , C07D295/092 , C07D295/13 , A61K31/495
CPC分类号： C07D295/088 , C07D295/13
摘要： A diphenylpiperazine derivative represented by general formula (1), salt thereof, and drug for the circulatory organs containing the same as the active ingredient: ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different from each other and each represents hydrogen, halogen, alkyl, alkoxy, nitro, amino, hydroxy, optionally esterified carboxyl or trifluoromethyl; R.sup.3 represents hydrogen, alkyl, aralkyl, acyl, nitro or optionally esterified carboxymethyl; Ar represents phenyl or naphthyl which may have one to three substituents such as halogen, alkyl, alkoxy, aryloxy, aralkyloxy, nitro, amino, cyano, acyl, hydroxy, optionally esterified carboxyl, substituted sulfonyl, aryl or trifluoromethyl; Z represents sulfur or -NR.sup.4 - wherein R.sup.4 represents hydrogen, alkyl, aralkyl, acyl, aryl, substituted sulfonyl or optionally esterified carboxyl; m represents a number of 1 to 5; and n represents a number of 0 to 5.
摘要翻译： PCT No.PCT / JP91 / 01227 Sec。 371日期：1993年5月10日 102（e）日期1993年5月10日PCT 1991年9月13日PCT PCT。出版物WO92 / 05165 1992年4月2日，由通式（1）表示的二苯基哌嗪衍生物及其盐，以及含有与活性成分相同的循环器官的药物：其中，R1和R2可以相同或各自表示氢，卤素，烷基，烷氧基，硝基，氨基，羟基，任意酯化的羧基或三氟甲基; R3表示氢，烷基，芳烷基，酰基，硝基或任意酯化的羧甲基; 卤素，烷基，烷氧基，芳氧基，芳烷氧基，硝基，氨基，氰基，酰基，羟基，任意酯化的羧基，取代的磺酰基，芳基或三氟甲基的苯基或萘基。 Z表示硫或-NR4-，其中R4表示氢，烷基，芳烷基，酰基，芳基，取代的磺酰基或任选酯化的羧基; m表示1〜5的数; n表示0〜5的数。

4. 发明授权

US6100280A Narcotic antagonist 失效
标题翻译：麻醉拮抗剂
公开(公告)号：US6100280A
公开(公告)日：2000-08-08
申请号：US85463
申请日：1998-05-28
申请人： Masato Inazu , Mariko Harada , Tomoko Masuda
发明人： Masato Inazu , Mariko Harada , Tomoko Masuda
IPC分类号： C07D295/12 , A61K31/495 , A61P25/30
CPC分类号： A61K31/495
摘要： A narcotic antagonist comprising, as its active component, a compound represented by the following formula (1) or a physiologically acceptable salt thereof: wherein each of R.sup.1 and R.sup.2, which may be identical to or different from each other, represents a hydrogen atom or a halogen atom; R.sup.3 represents a hydrogen atom, an alkyl group, or an acyl group; R.sup.4 represents a hydrogen atom, an alkyl group, an acyl group, an alkylsulfonyl group, or a carboxyl group which may be esterified; Ar represents a phenyl group which may have 1 to 3 substituents selected from the group consisting of a halogen atom, an alkyl group, an alkoxyl group, a nitro group, an amino group, an alkylamino group, and a hydroxyl group or Ar represents a monocyclic aromatic heterocyclic ring having a nitrogen atom; m represents a number of 1 to 5 inclusive; and n represents a number of 0 to 5 inclusive. Also, a medicament for the prevention and treatment of narcotic dependence is provided. The medicament is effective in the prevention and treatment of narcosic dependence due to cocaine, etc.
摘要翻译：作为其活性成分的麻醉性拮抗剂含有下述式（1）所示的化合物或其生理学上可接受的盐，其中R1和R2各自可以相同或不同，表示氢原子或卤素原子; R3表示氢原子，烷基或酰基; R4表示可被酯化的氢原子，烷基，酰基，烷基磺酰基或羧基; Ar表示可以具有1〜3个选自卤素原子，烷基，烷氧基，硝基，氨基，烷基氨基和羟基的取代基的苯基，或者Ar表示具有氮原子的单环芳族杂环; m表示1〜5的数; n表示0〜5的数。此外，提供了用于预防和治疗麻醉依赖性的药物。该药物有效预防和治疗可卡因等引起的麻醉依赖。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式