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1. 发明申请

US20050084522A1 Cationic lipids for nuclei acid delivery 审中-公开
标题翻译：用于核酸递送的阳离子脂质
公开(公告)号：US20050084522A1
公开(公告)日：2005-04-21
申请号：US10686262
申请日：2003-10-15
申请人： Michalakis Savva
发明人： Michalakis Savva
IPC分类号： A61K9/127 , A61K48/00 , C12N15/74 , C12N15/88
CPC分类号： C12N15/88 , A61K9/127
摘要： The invention describes the synthetic methods for a series of pH-sensitive cationic lipids with diamido linkages between the 1,2-diamino-3-propanol backbone and the hydrocarbon chains. Their in vitro biological activity of the resulting lipid-DNA complexes is also described.
摘要翻译：本发明描述了在1,2-二氨基-3-丙醇主链和烃链之间具有二酰氨基键的一系列pH敏感阳离子脂质的合成方法。还描述了其所得脂质DNA复合物的体外生物活性。

2. 发明申请

US20050095280A1 Single-component pH-sensitive liposomes of reduced solid-to-liquid phase transition temperatures 审中-公开
标题翻译：降低固 - 液相转变温度的单组分pH敏感脂质体
公开(公告)号：US20050095280A1
公开(公告)日：2005-05-05
申请号：US10686374
申请日：2003-10-15
申请人： Michalakis Savva
发明人： Michalakis Savva
IPC分类号： A61K9/127 , C07C233/36 , C07C271/20 , C12N15/88 , A61K48/00
CPC分类号： C07C271/20 , A61K9/1272 , C12N15/88
摘要： The current invention relates to the synthesis of novel cationic lipids and their use as delivery vectors for nucleic acids, peptides and other synthetic drugs, in vitro and in vivo. The cationic lipids described herein form stable lamellar structures (liposomes) at physiological pH but destabilize to micelles at acidic and alkaline pH. These structures are characterized of high elasticity, increased fluidity and high transfection activity relative to the corresponding 1,2-dialkyl cationic derivatives and other phospholipids analogues.
摘要翻译：本发明涉及新型阳离子脂质的合成及其在体外和体内用作核酸，肽和其它合成药物的递送载体的用途。本文所述的阳离子脂质在生理pH下形成稳定的层状结构（脂质体），但在酸性和碱性pH下不稳定至胶束。这些结构的特征在于相对于相应的1,2-二烷基阳离子衍生物和其它磷脂类似物，具有高弹性，增加的流动性和高的转染活性。

3. 发明授权

US07831393B2 Methods and products for error determination of drug dose in pharmaceutical mixtures 失效
标题翻译：药物混合物药物剂量误差测定方法及产品
公开(公告)号：US07831393B2
公开(公告)日：2010-11-09
申请号：US11465633
申请日：2006-08-18
申请人： Michalakis Savva
发明人： Michalakis Savva
IPC分类号： G01N33/48
CPC分类号： A61K9/00
摘要： The present invention discloses a computer program and a method including an algorithm for computing the uncertainty of drug concentration in pharmaceutical dosage forms. The invention also provides a computer system, a website and an IC chip incorporating the program product. The invention determines the allowable sensitivity of the instruments measuring each of the components and the least allowable weight (LAW) within a maximum allowable error of each ingredient at the predetermined assay standard. The method and products allow the accurate error evaluation of drug dose in pharmaceutical mixtures and unit dosage forms, which may be composed of an infinite number of ingredients that are measured on multiple equipments of variable sensitivities. Thus this invention provides instant guidance on the pharmaceutical ingredient preparation.
摘要翻译：本发明公开了一种计算机程序和方法，其包括用于计算药物剂型中药物浓度的不确定性的算法。本发明还提供一种包含该程序产品的计算机系统，网站和IC芯片。本发明确定了在预定的测定标准下每种成分的最大允许误差中测量每种成分的仪器和最小容许重量（LAW）的允许灵敏度。该方法和产品允许在药物混合物和单位剂型中药物剂量的准确误差评估，其可以由在可变灵敏度的多个设备上测量的无数个成分组成。因此本发明提供关于药物成分制剂的即时指导。

4. 发明申请

US20080046188A1 METHODS AND PRODUCTS FOR ERROR DETERMINATION OF DRUG DOSE IN PHARMACEUTICAL MIXTURES 失效
标题翻译：用于药物混合物中药物剂量错误测定的方法和产品
公开(公告)号：US20080046188A1
公开(公告)日：2008-02-21
申请号：US11465633
申请日：2006-08-18
申请人： Michalakis Savva
发明人： Michalakis Savva
IPC分类号： G06F19/00
CPC分类号： A61K9/00
摘要： The present invention discloses a computer program and a method including an algorithm for computing the uncertainty of drug concentration in pharmaceutical dosage forms. The invention also provides a computer system, a website and an IC chip incorporating the program product. The invention determines the allowable sensitivity of the instruments measuring each of the components and the least allowable weight (LAW) within a maximum allowable error of each ingredient at the predetermined assay standard. The method and products allow the accurate error evaluation of drug dose in pharmaceutical mixtures and unit dosage forms, which may be composed of an infinite number of ingredients that are measured on multiple equipments of variable sensitivities. Thus this invention provides instant guidance on the pharmaceutical ingredient preparation.
摘要翻译：本发明公开了一种计算机程序和方法，其包括用于计算药物剂型中药物浓度的不确定性的算法。本发明还提供一种包含该程序产品的计算机系统，一个网站和一个IC芯片。本发明确定了在预定的测定标准下每种成分的最大允许误差中测量每种成分的仪器和最小容许重量（LAW）的允许灵敏度。该方法和产品允许在药物混合物和单位剂型中药物剂量的准确误差评估，其可以由在可变灵敏度的多个设备上测量的无数个成分组成。因此本发明提供关于药物成分制剂的即时指导。

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