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1. 发明申请

US20050009178A1 Tissue scaffold having aligned fibrils, apparatus and method for producing the same, and artificial tissue and methods of use thereof 有权
标题翻译：具有对齐原纤维的组织支架，其制造方法和人造组织及其使用方法
公开(公告)号：US20050009178A1
公开(公告)日：2005-01-13
申请号：US10861664
申请日：2004-06-04
申请人： Michael Yost , C. Gore , Louis Terracio , Richard Goodwin , Edie Goldsmith
发明人： Michael Yost , C. Gore , Louis Terracio , Richard Goodwin , Edie Goldsmith
IPC分类号： A61F2/02 , A61F2/04 , A61F2/06 , A61K38/17 , C12M3/00 , C12N20060101 , C12N5/08 , C12N11/02
CPC分类号： B29C47/24 , B29C47/0023 , C12M21/08 , C12M25/14
摘要： A tubular tissue scaffold is described which comprises a tube having a wall, wherein the wall includes biopolymer fibrils that are aligned in a helical pattern around the longitudinal axis of the tube where the pitch of the helical pattern changes with the radial position in the tube wall. The scaffold is capable of directing the morphological pattern of attached and growing cells to form a helical pattern around the tube walls. Additionally, an apparatus for producing such a tubular tissue scaffold is disclosed, the apparatus comprising a biopolymer gel dispersion feed pump that is operably connected to a tube-forming device having an exit port, where the tube-forming device is capable of producing a tube from the gel dispersion while providing an angular shear force across the wall of the tube, and a liquid bath located to receive the tubular tissue scaffold from the tube-forming device. A method for producing the tubular tissue scaffolds is also disclosed. Also, artificial tissue comprising living cells attached to a tubular tissue scaffold as described herein is disclosed. Methods for using the artificial tissue are also disclosed.
摘要翻译：描述了一种管状组织支架，其包括具有壁的管，其中所述壁包括围绕所述管的纵向轴线以螺旋形图案对准的生物聚合物原纤维，其中螺旋形图案的间距随管壁中的径向位置而变化。支架能够引导附着和生长的细胞的形态模式以在管壁周围形成螺旋图案。此外，公开了一种用于生产这种管状组织支架的装置，该装置包括生物聚合物凝胶分散体供给泵，其可操作地连接到具有出口的管形成装置，其中管形成装置能够产生管从所述凝胶分散体提供穿过所述管壁的角度剪切力，以及液体浴，其位于从所述管形成装置接收所述管状组织支架。还公开了一种用于生产管状组织支架的方法。此外，公开了包含附着在本文所述的管状组织支架上的活细胞的人造组织。还公开了使用人造组织的方法。

2. 发明授权

US07878786B2 Apparatus for producing tissue scaffold having aligned fibrils 有权
标题翻译：用于生产具有对准原纤维的组织支架的装置
公开(公告)号：US07878786B2
公开(公告)日：2011-02-01
申请号：US12072150
申请日：2008-02-25
申请人： Michael J. Yost , C. Michael Gore , Louis Terracio , Richard L. Goodwin , Edie C. Goldsmith
发明人： Michael J. Yost , C. Michael Gore , Louis Terracio , Richard L. Goodwin , Edie C. Goldsmith
IPC分类号： B29C47/24
CPC分类号： B29C47/24 , B29C47/0023 , C12M21/08 , C12M25/14
摘要： An apparatus for producing a tubular tissue scaffold having aligned biopolymer fibrils including a biopolymer gel dispersion feed pump that is operably connected to a tube-forming device having an exit port, where the tube-forming device is capable of producing a tube from the gel dispersion while providing an angular shear force across the wall of the tube, and a liquid bath located to receive the tubular tissue scaffold from the tube-forming device.
摘要翻译：一种用于生产具有对准的生物聚合物原纤维的管状组织支架的装置，包括生物聚合物凝胶分散体进料泵，其可操作地连接到具有出口的管形成装置，其中管形成装置能够从凝胶分散体同时提供穿过管壁的角度剪切力，以及位于从管形成装置接收管状组织支架的液体浴。

3. 发明授权

US07338517B2 Tissue scaffold having aligned fibrils and artificial tissue comprising the same 有权
标题翻译：具有对齐的原纤维的组织支架和包含其的人造组织
公开(公告)号：US07338517B2
公开(公告)日：2008-03-04
申请号：US10861664
申请日：2004-06-04
申请人： Michael J. Yost , C. Michael Gore , Louis Terracio , Richard L. Goodwin , Edie C. Goldsmith
发明人： Michael J. Yost , C. Michael Gore , Louis Terracio , Richard L. Goodwin , Edie C. Goldsmith
IPC分类号： A61F2/06 , A61F2/00
CPC分类号： B29C47/24 , B29C47/0023 , C12M21/08 , C12M25/14
摘要： A tubular tissue scaffold is described which comprises a tube having a wall, wherein the wall includes biopolymer fibrils that are aligned in a helical pattern around the longitudinal axis of the tube where the pitch of the helical pattern changes with the radial position in the tube wall. The scaffold is capable of directing the morphological pattern of attached and growing cells to form a helical pattern around the tube walls. Additionally, an apparatus for producing such a tubular tissue scaffold is disclosed, the apparatus comprising a biopolymer gel dispersion feed pump that is operably connected to a tube-forming device having an exit port, where the tube-forming device is capable of producing a tube from the gel dispersion while providing an angular shear force across the wall of the tube, and a liquid bath located to receive the tubular tissue scaffold from the tube-forming device. A method for producing the tubular tissue scaffolds is also disclosed. Also, artificial tissue comprising living cells attached to a tubular tissue scaffold as described herein is disclosed. Methods for using the artificial tissue are also disclosed.
摘要翻译：描述了一种管状组织支架，其包括具有壁的管，其中所述壁包括围绕所述管的纵向轴线以螺旋形图案对准的生物聚合物原纤维，其中螺旋形图案的间距随管壁中的径向位置而变化。支架能够引导附着和生长的细胞的形态模式以在管壁周围形成螺旋图案。此外，公开了一种用于生产这种管状组织支架的装置，该装置包括生物聚合物凝胶分散体供给泵，其可操作地连接到具有出口的管形成装置，其中管形成装置能够产生管从所述凝胶分散体提供穿过所述管壁的角度剪切力，以及液体浴，其位于从所述管形成装置接收所述管状组织支架。还公开了一种用于生产管状组织支架的方法。此外，公开了包含附着在本文所述的管状组织支架上的活细胞的人造组织。还公开了使用人造组织的方法。

4. 发明授权

US07727441B2 Method for producing tissue scaffold having aligned fibrils 有权
标题翻译：具有对准原纤维的组织支架的方法
公开(公告)号：US07727441B2
公开(公告)日：2010-06-01
申请号：US12072167
申请日：2008-02-25
申请人： Michael J. Yost , C. Michael Gore , Louis Terracio , Richard L. Goodwin , Edie C. Goldsmith
发明人： Michael J. Yost , C. Michael Gore , Louis Terracio , Richard L. Goodwin , Edie C. Goldsmith
IPC分类号： B29C47/40 , B29C47/20
CPC分类号： B29C47/24 , B29C47/0023 , C12M21/08 , C12M25/14
摘要： A tubular tissue scaffold is described which comprises a tube having a wall, wherein the wall includes biopolymer fibrils that are aligned in a helical pattern around the longitudinal axis of the tube where the pitch of the helical pattern changes with the radial position in the tube wall. The scaffold is capable of directing the morphological pattern of attached and growing cells to form a helical pattern around the tube walls. Additionally, an apparatus for producing such a tubular tissue scaffold is disclosed, the apparatus comprising a biopolymer gel dispersion feed pump that is operably connected to a tube-forming device having an exit port, where the tube-forming device is capable of producing a tube from the gel dispersion while providing an angular shear force across the wall of the tube, and a liquid bath located to receive the tubular tissue scaffold from the tube-forming device. A method for producing the tubular tissue scaffolds is also disclosed. Also, artificial tissue comprising living cells attached to a tubular tissue scaffold as described herein is disclosed. Methods for using the artificial tissue are also disclosed.
摘要翻译：描述了一种管状组织支架，其包括具有壁的管，其中所述壁包括围绕所述管的纵向轴线以螺旋形图案对准的生物聚合物原纤维，其中螺旋形图案的间距随管壁中的径向位置而变化。支架能够引导附着和生长的细胞的形态模式以在管壁周围形成螺旋图案。此外，公开了一种用于生产这种管状组织支架的装置，该装置包括生物聚合物凝胶分散体供给泵，其可操作地连接到具有出口的管形成装置，其中管形成装置能够产生管从所述凝胶分散体提供穿过所述管壁的角度剪切力，以及液体浴，其位于从所述管形成装置接收所述管状组织支架。还公开了一种用于生产管状组织支架的方法。此外，公开了包含附着在本文所述的管状组织支架上的活细胞的人造组织。还公开了使用人造组织的方法。

5. 发明申请

US20080217820A1 Tissue scaffold having aligned fibrils, apparatus and method for producing the same, and artificial tissue and methods of use thereof 有权
公开(公告)号：US20080217820A1
公开(公告)日：2008-09-11
申请号：US12072167
申请日：2008-02-25
申请人： Michael J. Yost , C. Michael Gore , Louis Terracio , Richard L. Goodwin , Edie C. Goldsmith
发明人： Michael J. Yost , C. Michael Gore , Louis Terracio , Richard L. Goodwin , Edie C. Goldsmith
IPC分类号： B29D23/00 , B29C47/00
CPC分类号： B29C47/24 , B29C47/0023 , C12M21/08 , C12M25/14
摘要： A tubular tissue scaffold is described which comprises a tube having a wall, wherein the wall includes biopolymer fibrils that are aligned in a helical pattern around the longitudinal axis of the tube where the pitch of the helical pattern changes with the radial position in the tube wall. The scaffold is capable of directing the morphological pattern of attached and growing cells to form a helical pattern around the tube walls. Additionally, an apparatus for producing such a tubular tissue scaffold is disclosed, the apparatus comprising a biopolymer gel dispersion feed pump that is operably connected to a tube-forming device having an exit port, where the tube-forming device is capable of producing a tube from the gel dispersion while providing an angular shear force across the wall of the tube, and a liquid bath located to receive the tubular tissue scaffold from the tube-forming device. A method for producing the tubular tissue scaffolds is also disclosed. Also, artificial tissue comprising living cells attached to a tubular tissue scaffold as described herein is disclosed. Methods for using the artificial tissue are also disclosed.

6. 发明申请

US20080147199A1 Tissue scaffold having aligned fibrils, apparatus and method for producing the same, and artificial tissue and methods of use thereof 审中-公开
标题翻译：具有对齐原纤维的组织支架，其制造方法和人造组织及其使用方法
公开(公告)号：US20080147199A1
公开(公告)日：2008-06-19
申请号：US12072232
申请日：2008-02-25
申请人： Michael J. Yost , C. Michael Gore , Louis Terracio , Richard L. Goodwin , Edie C. Goldsmith
发明人： Michael J. Yost , C. Michael Gore , Louis Terracio , Richard L. Goodwin , Edie C. Goldsmith
IPC分类号： A61F2/02 , C12Q1/02 , C12N5/02
CPC分类号： C12M21/08 , B29C48/09 , B29C48/30 , B29C48/33 , C12M25/14
摘要： A tubular tissue scaffold is described which comprises a tube having a wall, wherein the wall includes biopolymer fibrils that are aligned in a helical pattern around the longitudinal axis of the tube where the pitch of the helical pattern changes with the radial position in the tube wall. The scaffold is capable of directing the morphological pattern of attached and growing cells to form a helical pattern around the tube walls. Additionally, an apparatus for producing such a tubular tissue scaffold is disclosed, the apparatus comprising a biopolymer gel dispersion feed pump that is operably connected to a tube-forming device having an exit port, where the tube-forming device is capable of producing a tube from the gel dispersion while providing an angular shear force across the wall of the tube, and a liquid bath located to receive the tubular tissue scaffold from the tube-forming device. A method for producing the tubular tissue scaffolds is also disclosed. Also, artificial tissue comprising living cells attached to a tubular tissue scaffold as described herein is disclosed. Methods for using the artificial tissue are also disclosed.
摘要翻译：描述了一种管状组织支架，其包括具有壁的管，其中所述壁包括围绕所述管的纵向轴线以螺旋形图案对准的生物聚合物原纤维，其中螺旋形图案的间距随管壁中的径向位置而变化。支架能够引导附着和生长的细胞的形态模式以在管壁周围形成螺旋图案。此外，公开了一种用于生产这种管状组织支架的装置，该装置包括生物聚合物凝胶分散体供给泵，其可操作地连接到具有出口的管形成装置，其中管形成装置能够产生管从所述凝胶分散体提供穿过所述管壁的角度剪切力，以及液体浴，其位于从所述管形成装置接收所述管状组织支架。还公开了一种用于生产管状组织支架的方法。此外，公开了包含附着在本文所述的管状组织支架上的活细胞的人造组织。还公开了使用人造组织的方法。

7. 发明授权

US06592623B1 Engineered muscle 有权
标题翻译：工程肌肉
公开(公告)号：US06592623B1
公开(公告)日：2003-07-15
申请号：US09386273
申请日：1999-08-31
申请人： Gary L. Bowlin , Gary Wnek , David G. Simpson , Louis Terracio
发明人： Gary L. Bowlin , Gary Wnek , David G. Simpson , Louis Terracio
IPC分类号： A61F208
CPC分类号： A61L27/383 , A61F2/08 , A61L27/18 , A61L27/24 , A61L27/34 , A61L27/3817 , A61L27/3826 , A61L27/3873 , A61L27/507 , A61L2430/30 , C08L67/04 , C08L89/06
摘要： A muscle implant includes an extracellular matrix, tendon and muscle cells. The extracellular matrix is made of a matrix of electrospun polymer fibers. The tendon is made of extruded collagen fibers and the muscle cells are disposed on the extracellular matrix in such a manner that the combination of components will functionally and structurally act as normal muscle tissue. Cardiac and smooth muscles may be similarly formed without tendons but including the extracellular matrix and muscle cells.
摘要翻译：肌肉植入物包括细胞外基质，肌腱和肌肉细胞。细胞外基质由电纺聚合物纤维基质制成。肌腱由挤出的胶原纤维制成，并且肌细胞以这样的方式设置在细胞外基质上，使得组分的组合将在功能上和结构上作为正常肌肉组织起作用。心肌和平滑肌可以类似地形成，没有肌腱，但包括细胞外基质和肌肉细胞。

8. 发明申请

US20080220506A1 Tissue scaffold having aligned fibrils, apparatus and method for producing the same, and artificial tissue and methods of use thereof 有权
公开(公告)号：US20080220506A1
公开(公告)日：2008-09-11
申请号：US12072150
申请日：2008-02-25
申请人： Michael J. Yost , C. Michael Gore , Louis Terracio , Richard L. Goodwin , Edie C. Goldsmith
发明人： Michael J. Yost , C. Michael Gore , Louis Terracio , Richard L. Goodwin , Edie C. Goldsmith
IPC分类号： C12M1/00
CPC分类号： B29C47/24 , B29C47/0023 , C12M21/08 , C12M25/14
摘要： A tubular tissue scaffold is described which comprises a tube having a wall, wherein the wall includes biopolymer fibrils that are aligned in a helical pattern around the longitudinal axis of the tube where the pitch of the helical pattern changes with the radial position in the tube wall. The scaffold is capable of directing the morphological pattern of attached and growing cells to form a helical pattern around the tube walls. Additionally, an apparatus for producing such a tubular tissue scaffold is disclosed, the apparatus comprising a biopolymer gel dispersion feed pump that is operably connected to a tube-forming device having an exit port, where the tube-forming device is capable of producing a tube from the gel dispersion while providing an angular shear force across the wall of the tube, and a liquid bath located to receive the tubular tissue scaffold from the tube-forming device. A method for producing the tubular tissue scaffolds is also disclosed. Also, artificial tissue comprising living cells attached to a tubular tissue scaffold as described herein is disclosed. Methods for using the artificial tissue are also disclosed.

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