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1. 发明申请

US20070248843A1 Corrosion-resistant granular magnetic media with improved recording performance and methods of manufacturing same 有权
标题翻译：具有改善记录性能的耐腐蚀颗粒磁性介质及其制造方法
公开(公告)号：US20070248843A1
公开(公告)日：2007-10-25
申请号：US11407927
申请日：2006-04-21
申请人： Michael Wu , Mason Lu , Kueir Chour , Connie Liu , Edward Yen , Lynn Li , Steve Hwang
发明人： Michael Wu , Mason Lu , Kueir Chour , Connie Liu , Edward Yen , Lynn Li , Steve Hwang
IPC分类号： G11B5/66
CPC分类号： G11B5/66 , G11B5/65
摘要： A corrosion-resistant granular magnetic recording medium with improved recording performance comprises a non-magnetic substrate having a surface; and a layer stack on the substrate surface, including, in order from the surface: a granular magnetic recording layer; an intermediate magnetic de-coupling layer; and a corrosion preventing magnetic cap layer. The intermediate magnetic de-coupling layer has an optimal thickness and/or composition for: (1) promoting magnetic exchange de-coupling between the granular magnetic recording layer and the magnetic cap layer; and (2) reducing the dynamic closure field (Hcl) for determining writeability and eraseability of the medium. Grain boundaries of the magnetic cap layer are substantially oxide-free, and have a greater density and lower average porosity and surface roughness than those of the granular magnetic recording layer.
摘要翻译：具有改善的记录性能的耐腐蚀颗粒状磁记录介质包括具有表面的非磁性基材; 以及在所述基板表面上的层叠体，包括从所述表面开始的顺序：粒状磁记录层; 中间磁解耦层; 和防腐磁性层。中间磁解耦层具有以下优化的最佳厚度和/或组成：（1）促进粒状磁记录层与磁帽层之间的磁交换去耦合; 和（2）减小用于确定介质的可写性和可擦除性的动态闭合场（HALT）。磁性盖层的晶粒边界基本上是无氧化物的，并且具有比颗粒状磁记录层的更大密度和更低的平均孔隙率和表面粗糙度。

2. 发明授权

US07691499B2 Corrosion-resistant granular magnetic media with improved recording performance and methods of manufacturing same 有权
标题翻译：具有改善记录性能的耐腐蚀颗粒磁性介质及其制造方法
公开(公告)号：US07691499B2
公开(公告)日：2010-04-06
申请号：US11407927
申请日：2006-04-21
申请人： Michael Zyee-Shan Wu , Mason Lu , Kueir W. Chour , Connie C. Liu , Edward T. Yen , Lynn Li , Steve Hwang
发明人： Michael Zyee-Shan Wu , Mason Lu , Kueir W. Chour , Connie C. Liu , Edward T. Yen , Lynn Li , Steve Hwang
IPC分类号： G11B5/66
CPC分类号： G11B5/66 , G11B5/65
摘要： A corrosion-resistant granular magnetic recording medium with improved recording performance comprises a non-magnetic substrate having a surface; and a layer stack on the substrate surface, including, in order from the surface: a granular magnetic recording layer; an intermediate magnetic de-coupling layer; and a corrosion preventing magnetic cap layer. The intermediate magnetic de-coupling layer has an optimal thickness and/or composition for: (1) promoting magnetic exchange de-coupling between the granular magnetic recording layer and the magnetic cap layer; and (2) reducing the dynamic closure field (Hcl) for determining writeability and eraseability of the medium. Grain boundaries of the magnetic cap layer are substantially oxide-free, and have a greater density and lower average porosity and surface roughness than those of the granular magnetic recording layer.
摘要翻译：具有改善的记录性能的耐腐蚀颗粒状磁记录介质包括具有表面的非磁性基材; 以及在所述基板表面上的层叠体，其从所述表面依次包括：粒状磁记录层; 中间磁解耦层; 和防腐磁性层。中间磁解耦层具有以下优化的最佳厚度和/或组成：（1）促进粒状磁记录层与磁帽层之间的磁交换去耦合; 和（2）减少用于确定介质的可写性和可擦除性的动态闭合场（Hcl）。磁性盖层的晶粒边界基本上是无氧化物的，并且具有比颗粒状磁记录层的更大密度和更低的平均孔隙率和表面粗糙度。

3. 发明申请

US20100119877A1 CORROSION-RESISTANT GRANULAR MAGNETIC MEDIA WITH IMPROVED RECORDING PERFORMANCE AND METHODS OF MANUFACTURING SAME 有权
标题翻译：具有改进的记录性能的耐腐蚀颗粒磁性介质及其制造方法
公开(公告)号：US20100119877A1
公开(公告)日：2010-05-13
申请号：US12687751
申请日：2010-01-14
申请人： Michael Zyee-Shan Wu , Mason Lu , Kueir W. Chour , Connie C. Liu , Edward T. Yen , Lynn Li , Steve Hwang
发明人： Michael Zyee-Shan Wu , Mason Lu , Kueir W. Chour , Connie C. Liu , Edward T. Yen , Lynn Li , Steve Hwang
IPC分类号： G11B5/66 , G11B5/84
CPC分类号： G11B5/66 , G11B5/65
摘要： A corrosion-resistant granular magnetic recording medium with improved recording performance comprises a non-magnetic substrate having a surface; and a layer stack on the substrate surface, including, in order from the surface: a granular magnetic recording layer; an intermediate magnetic de-coupling layer; and a corrosion preventing magnetic cap layer. The intermediate magnetic de-coupling layer has an optimal thickness and/or composition for: (1) promoting magnetic exchange de-coupling between the granular magnetic recording layer and the magnetic cap layer; and (2) reducing the dynamic closure field (Hcl) for determining writeability and eraseability of the medium. Grain boundaries of the magnetic cap layer are substantially oxide-free, and have a greater density and lower average porosity and surface roughness than those of the granular magnetic recording layer.
摘要翻译：具有改善的记录性能的耐腐蚀颗粒状磁记录介质包括具有表面的非磁性基材; 以及在所述基板表面上的层叠体，包括从所述表面开始的顺序：粒状磁记录层; 中间磁解耦层; 和防腐磁性层。中间磁解耦层具有以下优化的最佳厚度和/或组成：（1）促进粒状磁记录层与磁帽层之间的磁交换去耦合; 和（2）减少用于确定介质的可写性和可擦除性的动态闭合场（Hcl）。磁性盖层的晶粒边界基本上是无氧化物的，并且具有比颗粒状磁记录层的更大密度和更低的平均孔隙率和表面粗糙度。

4. 发明授权

US08728637B2 Corrosion resistant granular magnetic stack 有权
标题翻译：耐腐蚀颗粒磁性堆叠
公开(公告)号：US08728637B2
公开(公告)日：2014-05-20
申请号：US12687751
申请日：2010-01-14
申请人： Michael Zyee-Shan Wu , Mason Lu , Kueir W. Chour , Connie C. Liu , Edward T. Yen , Lynn Li , Steve Hwang
发明人： Michael Zyee-Shan Wu , Mason Lu , Kueir W. Chour , Connie C. Liu , Edward T. Yen , Lynn Li , Steve Hwang
IPC分类号： G11B5/66
CPC分类号： G11B5/66 , G11B5/65
摘要： A corrosion-resistant granular magnetic recording medium with improved recording performance comprises a non-magnetic substrate having a surface; and a layer stack on the substrate surface, including, in order from the surface: a granular magnetic recording layer; an intermediate magnetic de-coupling layer; and a corrosion preventing magnetic cap layer. The intermediate magnetic de-coupling layer has an optimal thickness and/or composition for: (1) promoting magnetic exchange de-coupling between the granular magnetic recording layer and the magnetic cap layer; and (2) reducing the dynamic closure field (Hcl) for determining writeability and eraseability of the medium. Grain boundaries of the magnetic cap layer are substantially oxide-free, and have a greater density and lower average porosity and surface roughness than those of the granular magnetic recording layer.
摘要翻译：具有改善的记录性能的耐腐蚀颗粒状磁记录介质包括具有表面的非磁性基材; 以及在所述基板表面上的层叠体，包括从所述表面开始的顺序：粒状磁记录层; 中间磁解耦层; 和防腐磁性层。中间磁解耦层具有以下优化的最佳厚度和/或组成：（1）促进粒状磁记录层与磁帽层之间的磁交换去耦合; 和（2）减少用于确定介质的可写性和可擦除性的动态闭合场（Hcl）。磁性盖层的晶粒边界基本上是无氧化物的，并且具有比颗粒状磁记录层的更大密度和更低的平均孔隙率和表面粗糙度。

5. 发明授权

US08734801B2 Anti-IL13 antibodies and uses thereof 有权
公开(公告)号：US08734801B2
公开(公告)日：2014-05-27
申请号：US13275684
申请日：2011-10-18
申请人： Sek Chung Fung , Matthew Moyle , Mason Lu , Changning Yan , Sanjaya Singh , Dan Huang
发明人： Sek Chung Fung , Matthew Moyle , Mason Lu , Changning Yan , Sanjaya Singh , Dan Huang
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/55522 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.

6. 发明申请

US20120214971A1 NOVEL ANTI-IL13 ANTIBODIES AND USES THEREOF 有权
标题翻译：新型抗IL13抗体及其用途
公开(公告)号：US20120214971A1
公开(公告)日：2012-08-23
申请号：US13308186
申请日：2011-11-30
申请人： Sek Chung Fung , Matthew Moyle , Mason Lu , Changning Yan , Sanjaya Singh , Dan Huang
发明人： Sek Chung Fung , Matthew Moyle , Mason Lu , Changning Yan , Sanjaya Singh , Dan Huang
IPC分类号： C07K16/24 , C07K16/46
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/55522 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.
摘要翻译：本发明涉及对糖基化和非糖基化的人IL13具有特异性和高亲和力结合的抗IL13抗体，不结合小鼠IL13，并以约2摩尔比（MAb：IL13）中和人IL13活性）。本发明还涉及这些抗体在治疗IL13介导的疾病中的用途，所述疾病包括过敏性疾病，如过敏性疾病，包括哮喘，过敏性哮喘，非过敏性（内源性）哮喘，过敏性鼻炎，特应性皮炎，过敏性结膜炎，湿疹，荨麻疹，食物过敏，慢性阻塞性肺疾病，溃疡性结肠炎，RSV感染，葡萄膜炎，硬皮病和骨质疏松症。

7. 发明申请

US20110014199A1 NOVEL ANTI-IL 13 ANTIBODIES AND USES THEREOF 有权
标题翻译：新型抗IL 13抗体及其用途
公开(公告)号：US20110014199A1
公开(公告)日：2011-01-20
申请号：US12240604
申请日：2008-09-29
申请人： Sek Chung Fung , Matthew Moyle , Mason Lu , Changning Yan , Sanjaya Singh , Dan Huang
发明人： Sek Chung Fung , Matthew Moyle , Mason Lu , Changning Yan , Sanjaya Singh , Dan Huang
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , A61P11/00 , A61P37/08 , C12N5/16 , C12N15/63 , C12N5/10
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/55522 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to anti IL13 antibodies that hind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.
摘要翻译：本发明涉及特异性且对糖基化和非糖基化的人IL13两者具有高亲和力的抗IL13抗体，不结合小鼠IL13，并以约2摩尔比（MAb：IL13）中和人IL13活性，。本发明还涉及这些抗体在治疗IL13介导的疾病中的用途，所述疾病包括过敏性疾病，如过敏性疾病，包括哮喘，过敏性哮喘，非过敏性（内源性）哮喘，过敏性鼻炎，特应性皮炎，过敏性结膜炎，湿疹，荨麻疹，食物过敏，慢性阻塞性肺疾病，溃疡性结肠炎，RSV感染，葡萄膜炎，硬皮病和骨质疏松症。

8. 发明授权

US08734797B2 Anti-IL13 antibodies and uses thereof 有权
标题翻译：抗IL13抗体及其用途
公开(公告)号：US08734797B2
公开(公告)日：2014-05-27
申请号：US13275658
申请日：2011-10-18
申请人： Sek Chung Fung , Matthew Moyle , Mason Lu , Changning Yan , Sanjaya Singh , Dan Huang
发明人： Sek Chung Fung , Matthew Moyle , Mason Lu , Changning Yan , Sanjaya Singh , Dan Huang
IPC分类号： A61K39/00
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/55522 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.
摘要翻译：本发明涉及对糖基化和非糖基化的人IL13具有特异性和高亲和力结合的抗IL13抗体，不结合小鼠IL13，并以约2摩尔比（MAb：IL13）中和人IL13活性）。本发明还涉及这些抗体在治疗IL13介导的疾病中的用途，所述疾病包括过敏性疾病，如过敏性疾病，包括哮喘，过敏性哮喘，非过敏性（内源性）哮喘，过敏性鼻炎，特应性皮炎，过敏性结膜炎，湿疹，荨麻疹，食物过敏，慢性阻塞性肺疾病，溃疡性结肠炎，RSV感染，葡萄膜炎，硬皮病和骨质疏松症。

9. 发明授权

US08088618B2 Anti-IL 13 antibodies and uses thereof 有权
标题翻译：抗IL 13抗体及其用途
公开(公告)号：US08088618B2
公开(公告)日：2012-01-03
申请号：US12240604
申请日：2008-09-29
申请人： Sek Chung Fung , Matthew Moyle , Mason Lu , Changning Yan , Sanjaya Singh , Dan Huang
发明人： Sek Chung Fung , Matthew Moyle , Mason Lu , Changning Yan , Sanjaya Singh , Dan Huang
IPC分类号： C12N5/10 , C07K16/24
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/55522 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.
摘要翻译：本发明涉及对糖基化和非糖基化的人IL13具有特异性和高亲和力结合的抗IL13抗体，不结合小鼠IL13，并以约2摩尔比（MAb：IL13）中和人IL13活性）。本发明还涉及这些抗体在治疗IL13介导的疾病中的用途，所述疾病包括过敏性疾病，如过敏性疾病，包括哮喘，过敏性哮喘，非过敏性（内源性）哮喘，过敏性鼻炎，特应性皮炎，过敏性结膜炎，湿疹，荨麻疹，食物过敏，慢性阻塞性肺疾病，溃疡性结肠炎，RSV感染，葡萄膜炎，硬皮病和骨质疏松症。

10. 发明申请

US20120156203A1 NOVEL ANTI-IL13 ANTIBODIES AND USES THEREOF 有权
公开(公告)号：US20120156203A1
公开(公告)日：2012-06-21
申请号：US13275684
申请日：2011-10-18
申请人： Sek Chung Fung , Matthew Moyle , Mason Lu , Changning Yan , Sanjaya Singh , Dan Huang
发明人： Sek Chung Fung , Matthew Moyle , Mason Lu , Changning Yan , Sanjaya Singh , Dan Huang
IPC分类号： A61K39/395 , A61P11/00 , A61P29/00
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/55522 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.

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