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1. 发明申请

US20080260902A1 Process for Increasing Throughput of Corn for Oil Extraction 审中-公开
标题翻译：增加玉米提取油的过程
公开(公告)号：US20080260902A1
公开(公告)日：2008-10-23
申请号：US11587258
申请日：2005-04-14
申请人： Michael Van Houten , Michael J. Beaver , Aharon M. Eyal , Eugene J. Fox , Joel Ingvalson , Neal T. Jakel , Douglas C. Kotowski , Paul J. McWilliams , Alexander Patist , Michael J. Tupy , Troy T. Lohrmann
发明人： Michael Van Houten , Michael J. Beaver , Aharon M. Eyal , Eugene J. Fox , Joel Ingvalson , Neal T. Jakel , Douglas C. Kotowski , Paul J. McWilliams , Alexander Patist , Michael J. Tupy , Troy T. Lohrmann
IPC分类号： A23L1/105 , A23D9/00 , A23L1/10 , C10L5/44
CPC分类号： C08L99/00 , A23D9/00 , A23K10/37 , A23K20/158 , A23K40/20 , A23K40/25 , A23K50/10 , A23K50/20 , A23K50/30 , A23K50/40 , A23K50/75 , A23K50/80 , A23L7/198 , A23L33/115 , A61K8/922 , A61K8/97 , A61Q1/06 , A61Q1/10 , B02B1/00 , B02B5/02 , C08B30/02 , C08H99/00 , C10L1/026 , C11B1/04 , C11B1/06 , C11B1/10 , C11B1/104 , D21H17/02 , Y02A40/818 , Y02E50/10 , Y02E50/13 , Y02E50/30 , Y02P60/877
摘要： Corn oil is extracted from corn to form a corn meal. Processing the corn grain to obtain the oil, meal, and other product streams generally includes dividing the corn kernel by fractionating to create a higher oil fraction and a lower oil fraction, forming a solvent extractable structure from the higher oil fraction, and extracting the oil from the higher oil fraction. The extracted corn oil is useful for making nutritionally enhanced edible oil or cooking oil, lubricants, biodiesel, fuel, cosmetics and oil-based or oil-containing chemical products. The extracted corn meal is useful for making enhanced animal feed rations, snack food, blended food products, cosmetics, and fermentation broth additive. The lower oil fraction is useful for one or more processes such as fermentation, wet-milling, animal feed production, sweetener production, and starch production, making enhanced animal feed rations, snack food, blended food products, and cosmetics.
摘要翻译：从玉米中提取玉米油，形成玉米粉。加工玉米粒以获得油，粕和其他产品流通常包括通过分馏分离玉米粒以产生较高的油馏分和较低的油馏分，从较高的油馏分形成溶剂可萃取的结构，并提取油从较高的油分。提取的玉米油可用于制备营养增强的食用油或食用油，润滑剂，生物柴油，燃料，化妆品和油基或含油化学产品。提取的玉米粉可用于制造增强的动物饲料配给，小吃食品，混合食品，化妆品和发酵肉汤添加剂。较低的油馏分可用于发酵，湿磨，动物饲料生产，甜味剂生产和淀粉生产等一个或多个过程，增强动物饲料配给，零食，混合食品和化妆品。

2. 发明授权

US11306339B2 Method for the production of a rhamnolipid 有权
公开(公告)号：US11306339B2
公开(公告)日：2022-04-19
申请号：US16310152
申请日：2017-06-16
申请人： Superbrewed Food, Inc. , Aharon M. Eyal , Bryan P. Tracy , Christopher Joseph McWilliams
发明人： Aharon M. Eyal , Bryan P. Tracy , Christopher Joseph McWilliams
IPC分类号： C12P19/44 , C07H1/08 , C07H15/04 , A61K8/60 , C12P7/6409 , A61K8/04 , A61K9/00 , A61K9/12 , A61Q19/00
摘要： A method for the production of a rhamnolipid. The method includes culturing in a fermentation medium an organism capable of producing a rhamnolipid to form a fermentation broth comprising at least one rhamnolipid and having a pH>5; extracting at least one lipophilic impurity from said fermentation broth; acidulating said fermentation broth to form an aqueous medium of pH

3. 发明授权

US08304588B2 Recovery of higher alcohols from dilute aqueous solutions 有权
公开(公告)号：US08304588B2
公开(公告)日：2012-11-06
申请号：US13344464
申请日：2012-01-05
申请人： William A. Evanko , Aharon M. Eyal , David A. Glassner , Fudu Miao , Aristos A. Aristidou , Kent Evans , Patrick R. Gruber , Andrew C. Hawkins
发明人： William A. Evanko , Aharon M. Eyal , David A. Glassner , Fudu Miao , Aristos A. Aristidou , Kent Evans , Patrick R. Gruber , Andrew C. Hawkins
IPC分类号： C07C29/76
CPC分类号： C12M43/00 , C07C29/80 , C07C29/86 , C12C11/11 , C12M45/20 , C12P7/04 , C12P7/16 , Y02E50/10 , Y02E50/17 , Y10T29/49826 , C07C31/12
摘要： This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs.

4. 发明授权

US5892109A Lactic acid production, separation and/or recovery process 失效
标题翻译：乳酸生产，分离和/或回收过程
公开(公告)号：US5892109A
公开(公告)日：1999-04-06
申请号：US891467
申请日：1997-07-11
申请人： Avraham M. Baniel , Aharon M. Eyal , Joseph Mizrahi , Betty Hazan , Rod R. Fisher , Jeffrey J. Kolstad , Brenda F. Stewart
发明人： Avraham M. Baniel , Aharon M. Eyal , Joseph Mizrahi , Betty Hazan , Rod R. Fisher , Jeffrey J. Kolstad , Brenda F. Stewart
IPC分类号： C12P7/56 , C07C51/48
CPC分类号： C12P7/56
摘要： A process for the production of lactic acid and for the separation and/or recovery of lactic acid from a lactate feed solution. A lactate feed solution preferably obtained from a fermentation broth is combined with and extracted by a water immiscible trialkyl amine in the presence of carbon dioxide. Lactic acid is recovered from the resulting organic phase. Recovered carbonate or bicarbonate from the aqueous phase is preferably recycled to the fermentor and regenerated extractant is preferably recycled for use in the extraction.
摘要翻译：用于生产乳酸和从乳酸盐进料溶液中分离和/或回收乳酸的方法。优选从发酵液中获得的乳酸盐进料溶液在二氧化碳的存在下与水不混溶的三烷基胺组合并提取。从所得有机相中回收乳酸。从水相中回收的碳酸盐或碳酸氢盐优选再循环到发酵罐中，再生的萃取剂优选再循环用于萃取。

5. 发明授权

US5766439A Production and recovery of organic acids 失效
标题翻译：生产和回收有机酸
公开(公告)号：US5766439A
公开(公告)日：1998-06-16
申请号：US752803
申请日：1996-11-20
申请人： Aharon M. Eyal , William F. Lehnhardt
发明人： Aharon M. Eyal , William F. Lehnhardt
IPC分类号： C12P7/40 , C12P7/56 , C12P7/52 , C07C51/42 , C07C59/08 , C25B3/00
CPC分类号： C12P7/56 , C12P7/40 , Y10S435/803
摘要： A process is described for producing organic acids such as lactic acid. The process includes the steps of producing lactic acid by fermentation, resulting in an aqueous fermentation broth containing lactic acid, and adding a calcium base, such as calcium carbonate, to the fermentation broth, thereby producing calcium lactate in the broth. Biomass is removed from the broth, thereby leaving an aqueous solution or dispersion of calcium lactate. The calcium lactate is reacted with a source of ammonium ions, such as ammonium carbonate, or a mixture of ammonia and carbon dioxide, thereby producing an ammonium lactate. Contaminating cations can be removed by ion exchange. The free lactic acid or a derivative thereof can be separated from the ammonium ions, preferably by salt-splitting electrodialysis.
摘要翻译：描述了用于生产有机酸如乳酸的方法。该方法包括通过发酵生产乳酸的步骤，得到含有乳酸的含水发酵液，并向发酵液中加入钙碱如碳酸钙，从而在肉汤中产生乳酸钙。从肉汤中除去生物质，从而留下乳酸钙的水溶液或分散体。将乳酸钙与铵离子源如碳酸铵或氨和二氧化碳的混合物反应，从而产生乳酸铵。污染的阳离子可以通过离子交换去除。游离乳酸或其衍生物可以与铵离子分离，优选通过盐分解电渗析。

6. 发明授权

US5426220A Citric acid extraction 失效
标题翻译：柠檬酸提取
公开(公告)号：US5426220A
公开(公告)日：1995-06-20
申请号：US271248
申请日：1994-07-07
申请人： Avraham M. Baniel , Aharon M. Eyal
发明人： Avraham M. Baniel , Aharon M. Eyal
IPC分类号： C07C51/48 , C07C51/42
CPC分类号： C07C51/48
摘要： In the production of citric acid aqueous mother liquor originating from a lime/sulfuric acid process is subjected to a multi-stage counter-current extraction with an amine based organic extractant. A solution of a further amount of citric acid derived from direct extraction of a citric acid fermentation broth is judicously injected into the organic phase stream in the counter-current extraction and a combined extract is withdrawn from the operation. This extract can be subjected to any known treatment for the recovery of citric acid values.
摘要翻译：在生产柠檬酸水性母液的过程中，使用胺类有机萃取剂进行多级逆流萃取。将来自直接提取柠檬酸发酵液的更多量的柠檬酸的溶液在反向萃取中被司法注入有机相物流中，并从操作中取出合并的提取物。该提取物可以进行任何已知的柠檬酸回收处理。

7. 发明授权

US5231225A Concurrent production of citric acid and alkali citrates 失效
标题翻译：同时生产柠檬酸和柠檬酸碱
公开(公告)号：US5231225A
公开(公告)日：1993-07-27
申请号：US946169
申请日：1992-09-17
申请人： Avraham M. Baniel , Aharon M. Eyal
发明人： Avraham M. Baniel , Aharon M. Eyal
IPC分类号： C01F11/18 , C07C51/41 , C07C51/48
CPC分类号： C07C51/412 , C01F11/18 , C07C51/48
摘要： The known liming sulfuric acid process for the recovery of crystalline citric acid from a fermentation broth is modified by subjecting the mother liquor from the crystallization to extraction with a water-immiscible organic extraction that contains an amine. The resulting extract is neutralized with a recycled brine with alkali citrate and alkali citrate is crystallized from the concentrated brine obtained this way.
摘要翻译：用于从发酵液中回收结晶柠檬酸的已知的柠檬酸硫酸方法是通过将来自结晶的母液用含有胺的水不混溶有机萃取进行萃取来改性的。得到的提取物用碱性柠檬酸盐的再循环盐水中和，碱性柠檬酸盐从这样获得的浓缩盐水中结晶。

8. 发明授权

US08545885B2 Stable laquinimod preparations 有权
标题翻译：稳定的laquinimod制剂
公开(公告)号：US08545885B2
公开(公告)日：2013-10-01
申请号：US13471175
申请日：2012-05-14
申请人： Muhammad Safadi , Daniella Licht , Ioana Lovinger , Aharon M. Eyal , Tomas Fristedt , Karl Jansson
发明人： Muhammad Safadi , Daniella Licht , Ioana Lovinger , Aharon M. Eyal , Tomas Fristedt , Karl Jansson
IPC分类号： A61K9/20
CPC分类号： B65B25/00 , A61K9/1623 , A61K9/2004 , A61K9/2018 , A61K31/438 , A61K31/4704 , C07D209/34 , C07D209/42 , C07D471/10 , Y10T436/145555
摘要： The subject invention provides a pharmaceutical composition comprising N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide or the salt thereof; a pharmaceutically acceptable carrier; and not more than 0.5% w/w relative to N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide of 2-Chloro-6-(1-ethyl-N-methyl-2-oxoindoline-3-carboxamido)benzoic acid, 1H,3H-spiro[5-chloro-1-methylquinoline-2,4-dione-3,3′-[1]ethylindolin-[2]-one], or 5-Chloro-N-ethyl-3-hydroxy-1-methyl-2,4-dioxo-N-phenyl-1,2,3,4-tetrahydro-quinoline-3-carboxamide.
摘要翻译：本发明提供了包含N-乙基-N-苯基-1,2-二氢-4-羟基-5-氯-1-甲基-2-氧代喹啉-3-甲酰胺或其盐的药物组合物; 药学上可接受的载体; 并且相对于2-氯 - 苯基-1,2-二氢-4-羟基-5-氯-1-甲基-2-氧代喹啉-3-甲酰胺，相对于N-乙基-N-苯基-1,2-二氢-4-羟基-5-氯-1-甲基-2-氧代喹啉-3-甲酰胺为0.5％w / 6-（1-乙基-N-甲基-2-氧代二氢吲哚-3-甲酰氨基）苯甲酸，1H，3H-螺[5-氯-1-甲基喹啉-2,4-二酮-3,3' - [1] 乙醛基 - [2] - 酮]或5-氯-N-乙基-3-羟基-1-甲基-2,4-二氧代-N-苯基-1,2,3,4-四氢 - 甲酰胺。

9. 发明申请

US20130183730A9 RECOVERY OF HIGHER ALCOHOLS FROM DILUTE AQUEOUS SOLUTIONS 有权
公开(公告)号：US20130183730A9
公开(公告)日：2013-07-18
申请号：US13302775
申请日：2011-11-22
申请人： William A. Evanko , Aharon M. Eyal , David A. Glassner , Fudu Miao , Aristos A. Aristidou , Kent Evans , Patrick R. Gruber , Andrew C. Hawkins , Peter Meinhold , Reid M. Renny Feldman , Uvini Gunawardena , Jun Urano
发明人： William A. Evanko , Aharon M. Eyal , David A. Glassner , Fudu Miao , Aristos A. Aristidou , Kent Evans , Patrick R. Gruber , Andrew C. Hawkins , Peter Meinhold , Reid M. Renny Feldman , Uvini Gunawardena , Jun Urano
IPC分类号： C12P7/16
CPC分类号： C12M43/00 , C07C29/80 , C07C29/86 , C12C11/11 , C12M45/20 , C12P7/04 , C12P7/16 , Y02E50/10 , Y02E50/17 , Y10T29/49826 , C07C31/12
摘要： This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs.

10. 发明授权

US08101808B2 Recovery of higher alcohols from dilute aqueous solutions 无效
标题翻译：从稀水溶液中回收高级醇
公开(公告)号：US08101808B2
公开(公告)日：2012-01-24
申请号：US12342992
申请日：2008-12-23
申请人： William A. Evanko , Aharon M. Eyal , David A. Glassner , Fudu Miao , Aristos A. Aristidou , Kent Evans , Patrick R. Gruber , Andrew C. Hawkins
发明人： William A. Evanko , Aharon M. Eyal , David A. Glassner , Fudu Miao , Aristos A. Aristidou , Kent Evans , Patrick R. Gruber , Andrew C. Hawkins
IPC分类号： C07C29/76
CPC分类号： C12M43/00 , C07C29/80 , C07C29/86 , C12C11/11 , C12M45/20 , C12P7/04 , C12P7/16 , Y02E50/10 , Y02E50/17 , Y10T29/49826 , C07C31/12
摘要： This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs.
摘要翻译：本发明涉及从稀释的水溶液如发酵液中回收C3-C6醇的方法。这样的方法提供了用于发酵的改进的体积生产率并允许酒精回收。由于通过同时发酵和回收过程增加了醇产物的有效浓度，所以这种方法还允许在用过的发酵液的生产和干燥中减少能量消耗，这增加了每一批发酵液干燥产生和回收的醇的量。因此，本发明允许以低资本生产和回收C3-C6醇，降低运行成本。

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