专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5831067A Agent for stimulating animal cell division 失效
标题翻译：促进动物细胞分裂的药剂
公开(公告)号：US5831067A
公开(公告)日：1998-11-03
申请号：US511836
申请日：1995-08-07
申请人： Michael Strauss , Andre Lieber
发明人： Michael Strauss , Andre Lieber
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C07K14/82 , C12N15/113 , C07H21/00 , C12P19/34
CPC分类号： C12N15/1135 , C07K14/4705 , C07K14/4746 , C07K14/705 , C07K14/82 , A61K38/00
摘要： Agents for stimulating the dividing activity of mammalian cells are presented, which have as an active substance a nucleotide sequence with a complimentary sequence (anti-sense) to a domain of the mRNA of tumor suppressor retinoblastoma or p16 genes acting on cell dividing activity. For Rb, the agents are nucleotide sequences 5'-GGTTTTGGGCGGCATGAC-3' (SEQ ID NO: 1) and 5'-CTCAGTAAAAGTGAACGA-3' (SEQ ID NO: 2); a nucleotide sequence comprising 49 base pairs, wherein the domain of the mRNA comprises nucleotides 124 to 152; and a 360 base pair nucleotide wherein the domain of the mRNA comprises an Hpa I restriction endonuclease site, an ASP718 endonuclease site, a portion of the 5' untranslated domain of the Rb gene, and a first exon of the Rb gene. For p16, the agent comprises GATCCATGCT GCTCC (SEQ ID NO: 3).
摘要翻译：提出了用于刺激哺乳动物细胞分裂活性的试剂，其具有作为细胞分裂活性的肿瘤抑制基因视网膜母细胞瘤或p16基因mRNA的结构域具有互补序列（反义）的核苷酸序列作为活性物质。对于Rb，试剂是核苷酸序列5'-GGTTTTGGGCGGCATGAC-3'（SEQ ID NO：1）和5'-CTCAGTAAAAGTGAACGA-3'（SEQ ID NO：2）。包含49个碱基对的核苷酸序列，其中所述mRNA的结构域包含核苷酸124至152; 和360碱基对核苷酸，其中mRNA的结构域包含Hpa I限制性内切核酸酶位点，ASP718内切核酸酶位点，Rb基因的5'非翻译区的一部分和Rb基因的第一外显子。对于p16，该试剂包含GATCCATGCT GCTCC（SEQ ID NO：3）。

2. 再颁专利

USRE37411E1 Expression cassette for antisense expression of ribozyme 失效
标题翻译：用于核酶反义表达的表达盒
公开(公告)号：USRE37411E1
公开(公告)日：2001-10-16
申请号：US09089594
申请日：1998-06-02
申请人： Andre Lieber , Michael Strauss
发明人： Andre Lieber , Michael Strauss
IPC分类号： C12Q168
CPC分类号： C12N15/113 , C07K14/61
摘要： The invention is an expression cassette for the antisense expression of ribozyme, having a strong promotor, suitably a T7 promotor, an adenoviral va-RNA gene, a stable loop region, and an insertion site for the antisense/ribozyme sequence in the loop region.
摘要翻译：本发明是用于反义表达核酶的表达盒，其具有强启动子，合适的T7启动子，腺病毒va-RNA基因，稳定环区，以及环区中反义/核酶序列的插入位点。

3. 发明授权

US6130092A Ribozyme gene library and method for making 失效
标题翻译：核酶基因库及其制备方法
公开(公告)号：US6130092A
公开(公告)日：2000-10-10
申请号：US887674
申请日：1997-07-03
申请人： Andre Lieber , Michael Strauss, deceased
发明人： Andre Lieber , Michael Strauss, deceased
IPC分类号： C07K14/61 , C12N15/10 , C12N15/113 , C12N15/09 , C12N15/63 , C12P19/34 , C12Q1/68
CPC分类号： C12N15/1093 , C07K14/61 , C12N15/113 , C12N2310/111 , C12N2310/121
摘要： A ribozyme library which comprises a collection of ribozyme genes encoding a hammerhead structure and flanking sequences of random nucleotides cloned at least once into an expression cassette for ribozyme expression.
摘要翻译：一种核酶文库，其包含编码锤头结构的核酶基因和将至少一次克隆到用于核酶表达的表达盒中的随机核苷酸侧翼序列的集合。

4. 发明授权

US5695992A Expression cassette for antisense expression of ribozyme 失效
标题翻译：用于核酶反义表达的表达盒
公开(公告)号：US5695992A
公开(公告)日：1997-12-09
申请号：US314588
申请日：1994-09-28
申请人： Andre Lieber , Michael Strauss
发明人： Andre Lieber , Michael Strauss
IPC分类号： C07K14/61 , C12N15/113 , C12N15/85 , C12Q1/68
CPC分类号： C12N15/113 , C07K14/61
摘要： The invention is an expression cassette for the antisense expression of ribozyme, having a strong promotor, suitably a T7 promotor, an adenoviral va-RNA gene, a stable loop region, and an insertion site for the antisense/ribozyme sequence in the loop region.
摘要翻译：本发明是用于反义表达核酶的表达盒，其具有强启动子，合适的T7启动子，腺病毒va-RNA基因，稳定环区，以及环区中反义/核酶序列的插入位点。

5. 发明申请

US20060281090A1 Capsid-modified adenovirus vectors and methods of using the same 审中-公开
标题翻译：衣壳修饰的腺病毒载体及其使用方法
公开(公告)号：US20060281090A1
公开(公告)日：2006-12-14
申请号：US10559752
申请日：2004-05-03
申请人： Andre Lieber , Dmitry Shayakhmetov
发明人： Andre Lieber , Dmitry Shayakhmetov
IPC分类号： C12Q1/68 , C12P21/06
CPC分类号： C12N15/86 , C07K14/005 , C12N7/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2810/50
摘要： Adenovirus fiber mutated in the regions involved in the recognition and the binding of blood factor proteins, and adenoviruses comprising such fibers are provided.
摘要翻译：提供了在涉及血液因子蛋白质的识别和结合的区域中突变的腺病毒纤维，以及包含这种纤维的腺病毒。

6. 发明授权

US08722853B2 Methods and systems for adenovirus interaction with desmoglein 2 (DSG2) 有权
公开(公告)号：US08722853B2
公开(公告)日：2014-05-13
申请号：US13158246
申请日：2011-06-10
申请人： Andre Lieber , Hongjie Wang
发明人： Andre Lieber , Hongjie Wang
IPC分类号： A61K38/00 , C07K14/47 , A01N37/18 , A61P31/12
CPC分类号： C07K14/005 , A61K38/162 , A61K39/39558 , A61K45/06 , C07K16/28 , C07K2317/76 , C12N7/00 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , G01N33/5076 , A61K2300/00
摘要： The present invention provides compositions, compounds, and methods relating to recombinant adenoviral-based polypeptides for treating disorders associated with epithelial tissues.

7. 发明授权

US6107028A Ribozymes for treating hepatitis C 失效
标题翻译：用于治疗丙型肝炎的核酶
公开(公告)号：US6107028A
公开(公告)日：2000-08-22
申请号：US648272
申请日：1996-05-15
申请人： Mark A. Kay , Andre Lieber
发明人： Mark A. Kay , Andre Lieber
IPC分类号： C12N15/09 , A61K31/70 , A61K35/76 , A61K38/46 , A61K38/48 , A61K48/00 , A61P1/16 , A61P31/12 , C12N7/00 , C12N9/72 , C12N15/113 , C07H21/04 , C12N15/63 , C12Q1/68
CPC分类号： C12N15/1131 , A61K38/482 , A61K48/00 , C12N9/6456 , C12N9/6459 , C12Y304/21069 , C12N2310/121 , C12N2799/022 , C12N2799/027
摘要： A method of inhibiting hepatitis C virus RNA replication or expression is provided. The method consists of introducing two or more ribozymes specific for hepatitis C virus RNA into a cell infected with hepatitis C virus. The ribozymes specific for hepatitis C virus RNA can specifically cleave hepatitis C RNA in a HCV 5' non-coding sequence, the capsid sequence, the NS-5 sequence or any other conserved region of the hepatitis C RNA. The ribozymes can also be selected so as to be specific for opposite strands of the virus genome. A method of inhibiting hepatitis C virus RNA replication or expression is also provided which consists of introducing into a cell infected with hepatitis C virus at least one ribozyme specific for hepatitis C virus which is selected from the group consisting of GGGAGGTCTCGTAGA [SEQ ID NO: 1], GCACCATGAGCACGA [SEQ ID NO: 2], CCCACAGGACGTCAA [SEQ ID NO: 3], CAACCGTCGCCCACA [SEQ ID NO: 4], TAAACCTCAAAGAAA [SEQ ID NO: 5] GTAAGGTCATCGATA [SEQ ID NO: 6]. Compositions consisting of two or more ribozymes specific for hepatitis C virus RNA is also provided.
摘要翻译：提供了抑制丙型肝炎病毒RNA复制或表达的方法。该方法包括将丙型肝炎病毒RNA特异性的两种或更多种核酶引入感染丙型肝炎病毒的细胞中。丙型肝炎病毒RNA特异性的核酶可以特异性切割丙型肝炎病毒5'非编码序列，衣壳序列，NS-5序列或丙型肝炎病毒RNA任何其他保守区域的丙型肝炎病毒RNA。也可以选择核酶以便对病毒基因组的相反链具有特异性。还提供了一种抑制丙型肝炎病毒RNA复制或表达的方法，其包括将感染丙型肝炎病毒的细胞引入至少一种对丙型肝炎病毒特异性的核酶，其选自GGGAGGTCTCGTAGA [SEQ ID NO：1 ]，GCACCATGAGCACGA [SEQ ID NO：2]，CCCACAGGACGTCAA [SEQ ID NO：3]，CAACCGTCGCCCACA [SEQ ID NO：4]，TAAACCTCAAAGAAA [SEQ ID NO：5] GTAAGGTCATCGATA [SEQ ID NO：6]。还提供了由丙型肝炎病毒RNA特异性的两种或更多种核酶组成的组合物。

8. 发明授权

US6107027A Ribozymes for treating hepatitis C 失效
标题翻译：用于治疗丙型肝炎的核酶
公开(公告)号：US6107027A
公开(公告)日：2000-08-22
申请号：US534220
申请日：1995-09-11
申请人： Mark A. Kay , Andre Lieber
发明人： Mark A. Kay , Andre Lieber
IPC分类号： C12N15/09 , A61K31/70 , A61K35/76 , A61K38/46 , A61K38/48 , A61K48/00 , A61P1/16 , A61P31/12 , C12N7/00 , C12N9/72 , C12N15/113 , C07H21/04 , A61K35/00 , C12N15/85 , C12Q1/68
CPC分类号： C12N15/1131 , A61K38/482 , A61K48/00 , C12N9/6456 , C12N9/6459 , C12Y304/21069 , C12N2310/121 , C12N2799/022 , C12N2799/027
摘要： Adenoviral vectors are used for high efficiency transduction of ribozymes specific for hepatitis C virus RNA. Hepatocytes are transduced with a recombinant adenovirus vector that expresses a ribozyme capable of specifically cleaving HCV RNA. The compositions and methods thus provide new means for treating HCV, and further provide transgenic non-human animals having human hepatocytes which are useful in models of HCV disease for developing therapeutic and preventative agents.
摘要翻译：腺病毒载体用于丙型肝炎病毒RNA特异性核酶的高效转导。用表达可以特异性切割HCV RNA的核酶的重组腺病毒载体转导肝细胞。因此，组合物和方法提供了治疗HCV的新手段，并进一步提供了具有人肝细胞的转基因非人动物，其可用于HCV疾病模型用于开发治疗和预防剂。

9. 发明申请

US20060073123A1 Adenovirus vectors for immunotherapy 审中-公开
标题翻译：用于免疫治疗的腺病毒载体
公开(公告)号：US20060073123A1
公开(公告)日：2006-04-06
申请号：US10511918
申请日：2003-04-30
申请人： Jie Mi , Andre Lieber
发明人： Jie Mi , Andre Lieber
IPC分类号： A61K48/00 , C12N15/861
CPC分类号： C12N15/86 , A61K39/0011 , A61K39/12 , A61K39/292 , A61K48/00 , A61K48/0075 , A61K2039/5154 , A61K2039/5156 , A61K2039/5256 , C07K2319/01 , C07K2319/02 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2730/10134
摘要： The present invention provides compositions, methods and kits comprising viral vectors that may be used for performing immunotherapy. In particular, the present invention provides viral vectors having subgroup B adenoviral capsid fibers that are configured to express a transgene sequence in antigen presenting cells (e.g. dendritic cells) with a high transduction efficiency. Preferably, the transgene sequence is a retrogen cassette and the adenoviral capsid fibers are Ad11 fibers.
摘要翻译：本发明提供包含可用于进行免疫治疗的病毒载体的组合物，方法和试剂盒。特别地，本发明提供具有亚组B腺病毒衣壳纤维的病毒载体，其被配置为以高转导效率在抗原呈递细胞（例如树突状细胞）中表达转基因序列。优选地，转基因序列是一种回收素盒，腺病毒衣壳纤维是Ad11纤维。

10. 发明申请

US20110305634A1 Methods and systems for adenovirus interaction with desmoglein 2 (DSG2) 有权
标题翻译：与桥粒蛋白2（DSG2）的腺病毒相互作用的方法和系统
公开(公告)号：US20110305634A1
公开(公告)日：2011-12-15
申请号：US13158246
申请日：2011-06-10
申请人： Andre Lieber , Hongjie Wang
发明人： Andre Lieber , Hongjie Wang
IPC分类号： A61K51/08 , C12N15/34 , C12N15/63 , C12N1/00 , C12N1/21 , C12N5/10 , C12N5/071 , C12N5/09 , C12N5/077 , G01N33/566 , G01N21/64 , C12Q1/02 , C07K14/08 , C07K16/18 , A61K38/16 , A61P35/00 , A61P29/00 , A61P1/04 , A61P11/06 , A61P3/00 , A61P11/00 , A61P9/12 , A61P25/00 , A61P17/06 , A61P13/12 , A61P3/10 , A61K39/44 , A61K39/385 , A61K35/76 , A61P1/00 , A61P11/08 , A61P31/06 , A61P1/18 , A61P17/00 , A61P31/14 , A61P5/14 , A61P31/00 , C12N7/00
CPC分类号： C07K14/005 , A61K38/162 , A61K39/39558 , A61K45/06 , C07K16/28 , C07K2317/76 , C12N7/00 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , G01N33/5076 , A61K2300/00
摘要： The present invention provides compositions and methods for treating disorders associated with epithelial tissues.
摘要翻译：本发明提供了用于治疗与上皮组织相关的疾病的组合物和方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式