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1. 发明申请

US20050165062A1 Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade 审中-公开
标题翻译：用于选择性抑制凝血级联的取代的多环芳基和杂芳基吡啶酮
公开(公告)号：US20050165062A1
公开(公告)日：2005-07-28
申请号：US11009787
申请日：2004-12-10
申请人： Michael South , Qingping Zeng , Ashton Hamme , Melvin Rueppel
发明人： Michael South , Qingping Zeng , Ashton Hamme , Melvin Rueppel
IPC分类号： C07D213/74 , C07D213/75 , C07D213/77 , C07D215/38 , C07D401/12 , C07D417/12 , C07D521/00 , A61K31/4439 , A61K31/4415 , C07D211/84 , C07D41/02
CPC分类号： C07D213/74 , C07D213/75 , C07D213/77 , C07D215/38 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D417/12
摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyridone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
摘要翻译：本发明涉及用作凝血级联丝氨酸蛋白酶抑制剂的取代多环芳基和杂芳基吡啶酮化合物，以及用于治疗和预防各种血栓形成病症（包括冠状动脉和脑血管疾病）的抗凝血治疗的化合物，组合物和方法。

2. 发明申请

US20050054643A1 Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade 审中-公开
标题翻译：用于选择性抑制凝血级联的取代的多环芳基和杂芳基嘧啶酮
公开(公告)号：US20050054643A1
公开(公告)日：2005-03-10
申请号：US10680873
申请日：2003-10-07
申请人： Michael South , Ashton Hamme , William Neumann , Darin Jones , Melvin Rueppel
发明人： Michael South , Ashton Hamme , William Neumann , Darin Jones , Melvin Rueppel
IPC分类号： C07D239/46 , C07D239/47 , C07D253/07 , C07D401/04 , C07D417/12 , A61K31/53
CPC分类号： C07D239/47 , C07D253/07 , C07D401/04 , C07D417/12
摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyrimidinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
摘要翻译：本发明涉及可用作凝血级联丝氨酸蛋白酶抑制剂的取代的多环芳基和杂芳基嘧啶酮化合物，以及用于治疗和预防各种血栓形成疾病（包括冠状动脉和脑血管疾病）的抗凝血治疗的化合物，组合物和方法。

3. 发明申请

US20050043313A1 Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade 审中-公开
公开(公告)号：US20050043313A1
公开(公告)日：2005-02-24
申请号：US10940693
申请日：2004-09-14
申请人： Michael South , Brenda Case , Thomas Dice , Ricky Fenton , Gary Franklin , Michael Hayes , Horng-Chih Huang , Wei Huang , Darin Jones , Carrie Kusturin , Richard Lindmark , Scott Long , William Neumann , David Reitz , John Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Matthew Mahoney , John Parlow , Melvin Rueppel
发明人： Michael South , Brenda Case , Thomas Dice , Ricky Fenton , Gary Franklin , Michael Hayes , Horng-Chih Huang , Wei Huang , Darin Jones , Carrie Kusturin , Richard Lindmark , Scott Long , William Neumann , David Reitz , John Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Matthew Mahoney , John Parlow , Melvin Rueppel
IPC分类号： A61K38/00 , C07D241/20 , C07D401/12 , C07D403/12 , C07D405/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/06 , C07K5/078 , A61K31/4965 , A61K31/497 , C07D43/02
CPC分类号： C07D401/12 , A61K38/00 , C04B35/632 , C07D241/20 , C07D403/12 , C07D405/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/06139 , C07K5/06191
摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.

4. 发明申请

US20050153965A1 Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade 审中-公开
标题翻译：用于选择性抑制凝血级联的取代的多环芳基和杂芳基吡啶
公开(公告)号：US20050153965A1
公开(公告)日：2005-07-14
申请号：US11004437
申请日：2004-12-03
申请人： Michael South , Brenda Case , Danny Garland , Michael Hayes , Horng-Chih Huang , Wei Huang , Darin Jones , William Neumann , John Parlow , David Reitz , Melvin Rueppel , Ronald Webber
发明人： Michael South , Brenda Case , Danny Garland , Michael Hayes , Horng-Chih Huang , Wei Huang , Darin Jones , William Neumann , John Parlow , David Reitz , Melvin Rueppel , Ronald Webber
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/4436 , A61K31/4439 , A61K45/00 , A61P7/02 , A61P9/10 , A61P11/00 , A61P35/00 , A61P43/00 , C07D213/74 , C07D213/89 , C07D401/10 , C07D409/04 , C07D43/02 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/53 , C07D41/02
CPC分类号： C07D213/74 , C07D213/89
摘要： The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
摘要翻译：本发明涉及化合物及其前药，可用于预防和治疗哺乳动物血栓形成病症的组合物和方法。本发明的化合物及其前药选择性地抑制凝血级联的某些蛋白酶。

5. 发明申请

US20050267123A1 6-Membered heterocyclic compounds useful for selective inhibition of the coagulation cascade 审中-公开
标题翻译：可用于选择性抑制凝血级联的6-元杂环化合物
公开(公告)号：US20050267123A1
公开(公告)日：2005-12-01
申请号：US11159877
申请日：2005-06-23
申请人： Michael South , Ronald Webber , Horng-Chih Huang , Mihaly Toth , Alan Moormann , Jeffery Snyder , Jeffrey Scholten , Danny Garland , Melvin Rueppel , William Neumann , Scott Long , Wei Huang , John Trujillo , John Parlow , Darin Jones , Brenda Case , Michael Hayes
发明人： Michael South , Ronald Webber , Horng-Chih Huang , Mihaly Toth , Alan Moormann , Jeffery Snyder , Jeffrey Scholten , Danny Garland , Melvin Rueppel , William Neumann , Scott Long , Wei Huang , John Trujillo , John Parlow , Darin Jones , Brenda Case , Michael Hayes
IPC分类号： C07D249/12 , A61K31/451 , A61K31/495 , A61K31/50 , A61K31/513 , A61K31/53 , A61K31/535 , A61K45/00 , A61P7/02 , A61P9/10 , A61P43/00 , C07C257/18 , C07D207/32 , C07D211/56 , C07D211/98 , C07D213/74 , C07D231/38 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D413/12 , C07D471/04 , C07D43/02
CPC分类号： C07D213/74 , C07C257/18 , C07C2601/04 , C07C2601/10 , C07D207/32 , C07D211/56 , C07D211/98 , C07D231/38 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D413/12 , C07D471/04
摘要： The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
摘要翻译：本发明涉及化合物及其前药，可用于预防和治疗哺乳动物血栓形成病症的组合物和方法。本发明的化合物及其前药选择性地抑制凝血级联的某些蛋白酶。

6. 发明申请

US20050239860A1 Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade 审中-公开
标题翻译：用于选择性抑制凝血级联的5元多环化合物
公开(公告)号：US20050239860A1
公开(公告)日：2005-10-27
申请号：US11159684
申请日：2005-06-23
申请人： Michael South , Ronald Webber , Horng-Chih Huang , Mihaly Toth , Alan Moormann , Jeffery Snyder , Jeffrey Scholten , Danny Garland , Melvin Rueppel , William Neumann , Scott Long , Wei Huang , John Trujillo , John Parlow , Darin Jones , Brenda Case , Michael Hayes
发明人： Michael South , Ronald Webber , Horng-Chih Huang , Mihaly Toth , Alan Moormann , Jeffery Snyder , Jeffrey Scholten , Danny Garland , Melvin Rueppel , William Neumann , Scott Long , Wei Huang , John Trujillo , John Parlow , Darin Jones , Brenda Case , Michael Hayes
IPC分类号： A61K31/166 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/4152 , A61K31/4168 , A61K31/4196 , A61K31/421 , A61K31/426 , A61P7/02 , A61P9/00 , A61P11/00 , A61P35/00 , A61P43/00 , C07C257/18 , C07D207/14 , C07D207/32 , C07D207/34 , C07D207/46 , C07D211/56 , C07D211/98 , C07D213/74 , C07D231/12 , C07D231/38 , C07D231/46 , C07D231/48 , C07D233/88 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/08 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/20 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D413/12 , C07D471/04 , C07D231/44
CPC分类号： C07D213/74 , C07C257/18 , C07C2601/04 , C07C2601/10 , C07D207/32 , C07D207/46 , C07D211/56 , C07D211/98 , C07D231/38 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D413/12 , C07D471/04
摘要： The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
摘要翻译：本发明涉及化合物及其前药，可用于预防和治疗哺乳动物血栓形成病症的组合物和方法。本发明的化合物及其前药选择性地抑制凝血级联的某些蛋白酶。

7. 发明授权

US06664255B1 Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade 失效
标题翻译：用于选择性抑制凝血级联的取代的多环芳基和杂芳基吡嗪酮
公开(公告)号：US06664255B1
公开(公告)日：2003-12-16
申请号：US09574752
申请日：2000-05-18
申请人： Michael South , John J. Parlow , Darin E. Jones , Brenda Case , Tom Dice , Richard Lindmark , Michael J. Hayes , Melvin L. Rueppel , Horng-Chih Huang , Wei Huang , Scott A. Long , Matthew Mahoney , William L. Neumann , David Reitz , John I. Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Rick Fenton , Gary W. Franklin , Carrie Kusturin
发明人： Michael South , John J. Parlow , Darin E. Jones , Brenda Case , Tom Dice , Richard Lindmark , Michael J. Hayes , Melvin L. Rueppel , Horng-Chih Huang , Wei Huang , Scott A. Long , Matthew Mahoney , William L. Neumann , David Reitz , John I. Trujillo , Ching-Cheng Wang , Rhonda Wood , Qingping Zeng , Rick Fenton , Gary W. Franklin , Carrie Kusturin
IPC分类号： C07D24120
CPC分类号： C07D417/12 , A61K38/00 , C07D241/20 , C07D401/12 , C07D403/12 , C07D405/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07K5/06139 , C07K5/06191
摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
摘要翻译：本发明涉及可用作凝血级联丝氨酸蛋白酶抑制剂的取代的多环芳基和杂芳基吡嗪酮化合物，以及用于治疗和预防各种血栓形成病症（包括冠状动脉和脑血管疾病）的抗凝血治疗的化合物，组合物和方法。

8. 发明授权

US09565220B2 Systems and methods for preventing fraud in an internet protocol telephony system 有权
标题翻译：用于防止互联网协议电话系统中的欺诈的系统和方法
公开(公告)号：US09565220B2
公开(公告)日：2017-02-07
申请号：US12971747
申请日：2010-12-17
申请人： Richard Petillo , Vishal Patel , William Lonergan , Nirav Kadakia , Michael South , Zhiyu Guo
发明人： Richard Petillo , Vishal Patel , William Lonergan , Nirav Kadakia , Michael South , Zhiyu Guo
IPC分类号： H04L29/06 , H04M3/38 , H04M7/00
CPC分类号： H04L65/1076 , H04L63/10 , H04L65/1069 , H04M3/38 , H04M7/0078
摘要： Systems and methods for preventing fraud in an IP based telephony system include noting when an IP based telephony device sent to a new customer is not installed and registered with the system. If a new customer never attempts to register a device which was sent to the new customer, the system will assume that the new customer submitted false or erroneous address information. A new customer is prevented from taking any actions that would result in new charges until the new customer has registered an IP device sent to the new customer. Likewise, the system will act to prevent a phone verification service from reaching a new customer at his newly assigned telephone number until after the new customer has registered an IP based telephony device sent to the new customer.
摘要翻译：在基于IP的电话系统中防止欺诈的系统和方法包括当发送给新客户的基于IP的电话设备未被安装并且向系统注册时注意到。如果新客户从未尝试注册发送给新客户的设备，系统将假设新客户提交虚假或错误的地址信息。新客户无法采取任何可能导致新费用的行为，直到新客户注册了发送给新客户的IP设备。同样，系统将采取行动，防止电话验证服务以新分配的电话号码到达新客户，直到新客户注册了发送给新客户的基于IP的电话设备。

9. 发明申请

US20120157098A1 METHOD AND APPARATUS FOR VOIP COMMUNICATION COMPLETION TO A MOBILE DEVICE 有权
标题翻译：用于移动设备的VOIP通信完成的方法和装置
公开(公告)号：US20120157098A1
公开(公告)日：2012-06-21
申请号：US13190698
申请日：2011-07-26
申请人： Sushant SINGH , Daniel Keil , Mark Loeser , Michael South , Pasquale Villani
发明人： Sushant SINGH , Daniel Keil , Mark Loeser , Michael South , Pasquale Villani
IPC分类号： H04W8/00
CPC分类号： H04L65/105 , H04L65/1069 , H04L65/1073
摘要： A system and method for establishing a voice over Internet protocol link to a called party's mobile telephony device utilizes push notifications to activate a communications application on the called party's mobile telephony communications device. When a request to establish a voice over Internet protocol link to a mobile device is received by an incoming proxy server of a voice over Internet protocol service provider, the service provider causes a push notification to be sent to the mobile device. The called party can respond to the push notification in a manner that causes a communications application on the mobile device to be activated. Once the push notification has caused the communications application to activate, the communications application sends a special registration request to an outbound proxy server. The special registration request causes the outbound proxy server to initiate messaging that is ultimately delivered to an inbound proxy server, the messaging identifying the outbound proxy server with which the communications application has registered. The inbound proxy server can then communicate with the outbound proxy server to obtain information that allows a voice over Internet protocol link to be established with the called party's mobile telephony device.
摘要翻译：用于建立到被叫方的移动电话设备的通过因特网协议语音的语音的系统和方法利用推送通知来激活被叫方的移动电话通信设备上的通信应用。当通过因特网协议服务提供商的语音的传入代理服务器接收到通过因特网协议建立语音通信链接到移动设备的请求时，服务提供商将推送通知发送到移动设备。被叫方可以以导致移动设备上的通信应用被激活的方式来响应推送通知。一旦推送通知使通信应用程序激活，通信应用程序就会向出站代理服务器发送特殊的注册请求。特殊注册请求导致出站代理服务器发起最终传递到入站代理服务器的消息，该消息标识通信应用程序已经注册的出站代理服务器。入站代理服务器然后可以与出站代理服务器通信，以获得允许与被叫方的移动电话设备建立互联网语音协议链路的信息。

10. 发明申请

US20120014382A1 SYSTEMS AND METHODS FOR TERMINATING COMMUNICATION REQUESTS 审中-公开
标题翻译：终止通信要求的系统和方法
公开(公告)号：US20120014382A1
公开(公告)日：2012-01-19
申请号：US13244883
申请日：2011-09-26
申请人： Nicholas P. LAZZARO , Marc Lefar , Michael South , John Erickson , Gregory Alan Hardy
发明人： Nicholas P. LAZZARO , Marc Lefar , Michael South , John Erickson , Gregory Alan Hardy
IPC分类号： H04L12/66
CPC分类号： H04W4/08 , G06Q30/04 , H04L12/14 , H04L12/1457 , H04L29/12754 , H04L29/12896 , H04L45/00 , H04L61/106 , H04L61/157 , H04L61/2007 , H04L61/2069 , H04L61/3085 , H04L61/605 , H04L65/1069 , H04L65/4038 , H04L65/4061 , H04M3/42263 , H04M3/465 , H04M7/0024 , H04M7/006 , H04M15/00 , H04M15/31 , H04M15/56 , H04M15/765 , H04M15/7652 , H04M15/77 , H04M15/771 , H04M15/773 , H04M15/774 , H04M15/8016 , H04M15/8033 , H04M2203/2044
摘要： A IP telephony service allows customers to form user groups. Each user group can include multiple telephony devices that are associated with one or more users. One or more group identifiers would be associated with each user group. When an incoming communication is directed to a user group, a group identifier is used to retrieve a list of the members of the group, or a list of devices that correspond to the members of the user group. The communication is then sent to one or more members of the group, or to one or more of the devices that correspond to members of the user group. Handling preferences may determine how the incoming communication is delivered. In some instances, the incoming communication could be a telephone call. In other instances, the incoming communication could be a SMS message or an instant message.
摘要翻译： IP电话服务允许客户组建用户组。每个用户组可以包括与一个或多个用户相关联的多个电话设备。一个或多个组标识符将与每个用户组相关联。当进入的通信被定向到用户组时，使用组标识符来检索组的成员的列表或与用户组的成员对应的设备的列表。然后将通信发送到该组的一个或多个成员，或者发送到对应于用户组成员的一个或多个设备。处理偏好可以确定传入通信的传送方式。在某些情况下，进入的通信可以是电话呼叫。在其他情况下，传入通信可以是SMS消息或即时消息。

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