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    • 7. 发明申请
    • Cell delivery matrices
    • 细胞递送矩阵
    • US20080160085A1
    • 2008-07-03
    • US11901138
    • 2007-09-13
    • Eugene D. BolandStuart K. WilliamsPaul E. Kosnik
    • Eugene D. BolandStuart K. WilliamsPaul E. Kosnik
    • A61K9/00A61K35/12
    • A61K9/4808A61K9/0019A61K35/36A61K35/44A61K47/42A61L27/16A61L27/18A61L27/225A61L27/24A61M25/104C12N5/0653C08L27/18C08L67/02
    • Cell delivery matrices and methods for facilitating local delivery of adipose derived endothelial cells to a target tissue, body cavity, or joint are described. The cell delivery matrix may be a three-dimensional matrix scaffold comprising fibrin derived from the patient's own body. The cell delivery matrix may be biocompatible and semi-permeable. The cell delivery matrix used in the methods of the invention may be comprised of any degradable, bioabsorbable or non-degradable, biocompatible polymer. Regenerative therapies comprising implanting in the subject cell delivery matrices localizing adipose derived endothelial cells are described. The cell delivery matrices maintain the adipose derived endothelial cells at the target for a therapeutically effective amount of time. The adipose derived endothelial cells can be allogenic or syngenic to the subject. The endothelial cells may be delivered alone or in combination with other therapeutic agents.
    • 描述了用于促进将脂肪来源的内皮细胞局部递送至靶组织,体腔或关节的细胞递送基质和方法。 细胞递送基质可以是包含衍生自患者本身的纤维蛋白的三维基质支架。 细胞递送基质可以是生物相容性的和半渗透性的。 用于本发明方法的细胞递送基质可以由任何可降解的,生物可吸收的或不可降解的生物相容性聚合物组成。 描述了包含植入本发明的细胞递送基质定位脂肪来源的内皮细胞的再生疗法。 细胞递送基质将靶向脂肪来源的内皮细胞维持在治疗有效的时间量。 脂肪来源的内皮细胞可以是同种异体的或与受试者同源的。 内皮细胞可以单独递送或与其它治疗剂组合递送。