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1. 发明申请

US20150030560A1 TREATMENT OF AUTOIMMUNE CONDITIONS WITH COPOLYMER 1 AND RELATED COPOLYMERS 审中-公开
标题翻译：用共聚物1和相关共聚物处理自动调节条件
公开(公告)号：US20150030560A1
公开(公告)日：2015-01-29
申请号：US14188531
申请日：2014-02-24
申请人： Rina Aharoni , Dvora Teitelbaum , Ruth Arnon , Michael Sela , Masha Fridkis-Hareli , Jack L. Strominger
发明人： Rina Aharoni , Dvora Teitelbaum , Ruth Arnon , Michael Sela , Masha Fridkis-Hareli , Jack L. Strominger
IPC分类号： A61K31/785 , C08G73/02
CPC分类号： A61K31/785 , A61K38/16 , C08G73/02 , G01N33/6842 , Y10S424/81 , Y10S514/866 , Y10S514/885 , Y10S514/886 , Y10S514/903
摘要： The present invention is directed to polypeptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at least one amino acid is an aliphatic amino acid. In a preferred embodiment the polypeptide contains three or four of the following amino acids: tyrosine, alanine, glutamic acid or lysine. According to the present invention, the present polypeptides bind to antigen presenting cells, purified human lymphocyte antigens (HLA) and/or Copolymer 1-specific T cells. Moreover, according to the present invention, these polypeptides can be formulated into pharmaceutical compositions for treating autoimmune disease. The present invention further contemplates methods of treating an autoimmune disease in a mammal by administering a pharmaceutically effective amount of any one of the present polypeptides to the mammal.
摘要翻译：本发明涉及含有以线性阵列随机连接的至少三个氨基酸的多肽; 其中所述三个氨基酸中的至少一个是芳族氨基酸，所述三个氨基酸中的至少一个是带电荷的氨基酸，并且至少一个氨基酸是脂族氨基酸。在优选的实施方案中，多肽含有三个或四个以下氨基酸：酪氨酸，丙氨酸，谷氨酸或赖氨酸。根据本发明，本发明的多肽与抗原呈递细胞，纯化的人淋巴细胞抗原（HLA）和/或共聚物1-特异性T细胞结合。此外，根据本发明，这些多肽可以配制成用于治疗自身免疫疾病的药物组合物。本发明进一步考虑了通过向哺乳动物施用药学上有效量的本发明多肽的任何一种来治疗哺乳动物自身免疫性疾病的方法。

2. 发明授权

US07279172B2 Treatment of autoimmune conditions with copolymer 1 and related copolymers 有权
标题翻译：用共聚物1和相关共聚物治疗自身免疫病症
公开(公告)号：US07279172B2
公开(公告)日：2007-10-09
申请号：US09768872
申请日：2001-01-23
申请人： Rina Aharoni , Dvora Teitelbaum , Ruth Arnon , Michael Sela , Masha Fridkis-Hareli , Jack L. Strominger
发明人： Rina Aharoni , Dvora Teitelbaum , Ruth Arnon , Michael Sela , Masha Fridkis-Hareli , Jack L. Strominger
IPC分类号： A61K38/02
CPC分类号： G01N33/6842 , A61K38/16 , A61K39/0008 , A61L27/22 , A61L27/227 , C07K5/1019 , C07K7/06 , C07K7/08 , C07K14/001 , Y10S424/81 , Y10S530/806
摘要： The present invention provides heteropolymer compositions and peptide compositions, and methods of making and using therapeutic compositions comprising amino acid heteropolymers for treatment of a subject for an autoimmune or an inflammatory disease, the heteropolymer compositions made by solid state synthesis. The invention also provides kits for assaying binding of a composition to a water-soluble MHC protein.
摘要翻译：本发明提供了异源聚合物组合物和肽组合物，以及制备和使用包含用于治疗自身免疫性或炎症性疾病的受试者的氨基酸杂聚物的治疗组合物的方法，所述杂合聚合物组合物通过固相合成制备。本发明还提供用于测定组合物与水溶性MHC蛋白质结合的试剂盒。

3. 发明申请

US20100298227A1 Treatment of autoimmune conditions with Copolymer 1 and related copolymers 审中-公开
标题翻译：用共聚物1和相关共聚物治疗自身免疫病症
公开(公告)号：US20100298227A1
公开(公告)日：2010-11-25
申请号：US12231292
申请日：2008-08-29
申请人： Rina Aharoni , Dvora Teitelbaum , Ruth Arnon , Michael Sela , Masha Fridkis-Hareli , Jack L. Strominger
发明人： Rina Aharoni , Dvora Teitelbaum , Ruth Arnon , Michael Sela , Masha Fridkis-Hareli , Jack L. Strominger
IPC分类号： A61K38/02 , A61P37/00 , A61P19/02 , A61P25/28 , A61P29/00
CPC分类号： A61K31/785 , A61K38/16 , C08G73/02 , G01N33/6842 , Y10S424/81 , Y10S514/866 , Y10S514/885 , Y10S514/886 , Y10S514/903
摘要： The present invention is directed to polypeptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at least one amino acid is an aliphatic amino acid. In a preferred embodiment the polypeptide contains three or four of the following amino acids: tyrosine, alanine, glutamic acid or lysine. According to the present invention, the present polypeptides bind to antigen presenting cells, purified human lymphocyte antigens (HLA) and/or Copolymer 1-specific T cells. Moreover, according to the present invention, these polypeptides can be formulated into pharmaceutical compositions for treating autoimmune disease. The present invention further contemplates methods of treating an autoimmune disease in a mammal by administering a pharmaceutically effective amount of any one of the present polypeptides to the mammal.
摘要翻译：本发明涉及含有以线性阵列随机连接的至少三个氨基酸的多肽; 其中所述三个氨基酸中的至少一个是芳族氨基酸，所述三个氨基酸中的至少一个是带电荷的氨基酸，并且至少一个氨基酸是脂族氨基酸。在优选的实施方案中，多肽含有三个或四个以下氨基酸：酪氨酸，丙氨酸，谷氨酸或赖氨酸。根据本发明，本发明的多肽与抗原呈递细胞，纯化的人淋巴细胞抗原（HLA）和/或共聚物1-特异性T细胞结合。此外，根据本发明，这些多肽可以配制成用于治疗自身免疫疾病的药物组合物。本发明进一步考虑了通过向哺乳动物施用药学上有效量的本发明多肽的任何一种来治疗哺乳动物自身免疫性疾病的方法。

4. 发明授权

US07425332B2 Treatment of autoimmune conditions with Copolymer 1 and related Copolymers 有权
标题翻译：用共聚物1和相关共聚物治疗自身免疫病症
公开(公告)号：US07425332B2
公开(公告)日：2008-09-16
申请号：US11528894
申请日：2006-09-27
申请人： Michael Sela , Masha Fridkis-Hareli , Jack L. Strominger , Rina Aharoni , Dvora Teitelbaum , Ruth Arnon
发明人： Michael Sela , Masha Fridkis-Hareli , Jack L. Strominger , Rina Aharoni , Dvora Teitelbaum , Ruth Arnon
IPC分类号： A61K38/02 , A61K45/00
CPC分类号： A61K31/785 , A61K38/16 , C08G73/02 , G01N33/6842 , Y10S424/81 , Y10S514/866 , Y10S514/885 , Y10S514/886 , Y10S514/903
摘要： The present invention is directed to polypeptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at least one amino acid is an aliphatic amino acid. In a preferred embodiment the polypeptide contains three or four of the following amino acids: tyrosine, alanine, glutamic acid or lysine. According to the present invention, the present polypeptides bind to antigen presenting cells, purified human lymphocyte antigens (HLA) and/or Copolymer 1-specific T cells. Moreover, according to the present invention, these polypeptides can be formulated into pharmaceutical compositions for treating autoimmune disease. The present invention further contemplates methods of treating an autoimmune disease in a mammal by administering a pharmaceutically effective amount of any one of the present polypeptides to the mammal.
摘要翻译：本发明涉及含有以线性阵列随机连接的至少三个氨基酸的多肽; 其中所述三个氨基酸中的至少一个是芳族氨基酸，所述三个氨基酸中的至少一个是带电荷的氨基酸，并且至少一个氨基酸是脂族氨基酸。在优选的实施方案中，多肽含有三个或四个以下氨基酸：酪氨酸，丙氨酸，谷氨酸或赖氨酸。根据本发明，本发明的多肽与抗原呈递细胞，纯化的人淋巴细胞抗原（HLA）和/或共聚物1-特异性T细胞结合。此外，根据本发明，这些多肽可以配制成用于治疗自身免疫疾病的药物组合物。本发明进一步考虑了通过向哺乳动物施用药学上有效量的本发明多肽的任何一种来治疗哺乳动物自身免疫性疾病的方法。

5. 发明申请

US20070021341A1 Treatment of autoimmune conditions with Copolymer 1 and related Copolymers 有权
标题翻译：用共聚物1和相关共聚物治疗自身免疫病症
公开(公告)号：US20070021341A1
公开(公告)日：2007-01-25
申请号：US11528894
申请日：2006-09-27
申请人： Michael Sela , Masha Fridkis-Hareli , Jack Strominger , Rina Aharoni , Dvora Teitelbaum , Ruth Arnon
发明人： Michael Sela , Masha Fridkis-Hareli , Jack Strominger , Rina Aharoni , Dvora Teitelbaum , Ruth Arnon
IPC分类号： C07K14/47 , A61K38/16
CPC分类号： A61K31/785 , A61K38/16 , C08G73/02 , G01N33/6842 , Y10S424/81 , Y10S514/866 , Y10S514/885 , Y10S514/886 , Y10S514/903
摘要： The present invention is directed to polypeptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at least one amino acid is an aliphatic amino acid. In a preferred embodiment the polypeptide contains three or four of the following amino acids: tyrosine, alanine, glutamic acid or lysine. According to the present invention, the present polypeptides bind to antigen presenting cells, purified human lymphocyte antigens (HLA) and/or Copolymer 1-specific T cells. Moreover, according to the present invention, these polypeptides can be formulated into pharmaceutical compositions for treating autoimmune disease. The present invention further contemplates methods of treating an autoimmune disease in a mammal by administering a pharmaceutically effective amount of any one of the present polypeptides to the mammal.
摘要翻译：本发明涉及含有以线性阵列随机连接的至少三个氨基酸的多肽; 其中所述三个氨基酸中的至少一个是芳族氨基酸，所述三个氨基酸中的至少一个是带电荷的氨基酸，并且至少一个氨基酸是脂族氨基酸。在优选的实施方式中，多肽含有三个或四个以下氨基酸：酪氨酸，丙氨酸，谷氨酸或赖氨酸。根据本发明，本发明的多肽与抗原呈递细胞，纯化的人淋巴细胞抗原（HLA）和/或共聚物1-特异性T细胞结合。此外，根据本发明，这些多肽可以配制成用于治疗自身免疫疾病的药物组合物。本发明进一步考虑了通过向哺乳动物施用药学上有效量的本发明多肽的任何一种来治疗哺乳动物自身免疫性疾病的方法。

6. 发明授权

US09066905B2 Synthetic peptides and methods of use for autoimmune disease therapies 有权
标题翻译：合成肽及其自身免疫疾病治疗方法
公开(公告)号：US09066905B2
公开(公告)日：2015-06-30
申请号：US12008250
申请日：2008-01-09
申请人： Jack L. Strominger , Masha Fridkis-Hareli
发明人： Jack L. Strominger , Masha Fridkis-Hareli
IPC分类号： A61K38/08 , A61K38/10 , C07K4/00 , A61K38/16 , A61K39/00 , A61L27/22 , C07K5/11 , C07K7/06 , C07K7/08 , C07K14/00 , G01N33/68 , C07K14/74
CPC分类号： A61K38/16 , A61K38/08 , A61K38/10 , A61K39/0008 , A61L27/22 , C07K4/00 , C07K5/1019 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/70539 , G01N33/6842
摘要： The invention provides heteropolymer compositions and peptide compositions, and methods of making and using therapeutic compositions comprising amino acid heteropolymers for treatment of a subject for an autoimmune or an inflammatory disease, the heteropolymer compositions made by solid state synthesis. The invention also provides kits for assaying binding of a composition to a water-soluble MHC protein.
摘要翻译：本发明提供了异源聚合物组合物和肽组合物，以及制备和使用包含用于治疗自身免疫性或炎症性疾病的受试者的氨基酸杂聚物的治疗组合物的方法，所述杂合聚合物组合物通过固相合成制备。本发明还提供用于测定组合物与水溶性MHC蛋白质结合的试剂盒。

7. 发明申请

US20080207526A1 Synthetic peptides and methods of use for autoimmune disease therapies 有权
标题翻译：合成肽及其自身免疫疾病治疗方法
公开(公告)号：US20080207526A1
公开(公告)日：2008-08-28
申请号：US12008250
申请日：2008-01-09
申请人： Jack L. Strominger , Masha Fridkis-Hareli
发明人： Jack L. Strominger , Masha Fridkis-Hareli
IPC分类号： A61K38/00 , C07K7/00 , A61P37/00 , C07K14/00
CPC分类号： A61K38/16 , A61K38/08 , A61K38/10 , A61K39/0008 , A61L27/22 , C07K4/00 , C07K5/1019 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/70539 , G01N33/6842
摘要： The invention provides heteropolymer compositions and peptide compositions, and methods of making and using therapeutic compositions comprising amino acid heteropolymers for treatment of a subject for an autoimmune or an inflammatory disease, the heteropolymer compositions made by solid state synthesis. The invention also provides kits for assaying binding of a composition to a water-soluble MHC protein.
摘要翻译：本发明提供了异源聚合物组合物和肽组合物，以及制备和使用包含用于治疗自身免疫性或炎症性疾病的受试者的氨基酸杂聚物的治疗组合物的方法，所述杂合聚合物组合物通过固相合成制备。本发明还提供用于测定组合物与水溶性MHC蛋白质结合的试剂盒。

8. 发明授权

US07566767B2 Synthetic peptides and methods of use for autoimmune disease therapies 失效
标题翻译：合成肽及其自身免疫疾病治疗方法
公开(公告)号：US07566767B2
公开(公告)日：2009-07-28
申请号：US10438538
申请日：2003-05-15
申请人： Jack L. Strominger , Masha Fridkis-Hareli
发明人： Jack L. Strominger , Masha Fridkis-Hareli
IPC分类号： A61K38/00 , A61K31/74
CPC分类号： A61K38/16 , A61K38/08 , A61K38/10 , A61K39/0008 , A61L27/22 , C07K4/00 , C07K5/1019 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/70539 , G01N33/6842
摘要： The invention provides peptide compositions, and methods of making and using therapeutic compositions for treatment of a subject for an autoimmune or an inflammatory disease. The invention also provides kits for assaying binding of a composition to a water-soluble MHC protein.
摘要翻译：本发明提供肽组合物，以及制备和使用治疗组合物治疗自身免疫性疾病或炎性疾病的受试者的方法。本发明还提供用于测定组合物与水溶性MHC蛋白质结合的试剂盒。

9. 发明授权

US07381790B2 Copolymers for suppression of autoimmune diseases, and methods of use 有权
标题翻译：用于抑制自身免疫疾病的共聚物及其使用方法
公开(公告)号：US07381790B2
公开(公告)日：2008-06-03
申请号：US10406783
申请日：2003-04-03
申请人： Jack L. Strominger , Masha Fridkis-Hareli
发明人： Jack L. Strominger , Masha Fridkis-Hareli
IPC分类号： A61K38/00 , A61K38/03 , A61K38/16 , A61K39/00 , C07K14/00
CPC分类号： C07K14/001 , A61K38/02 , A61K38/2026 , A61K38/2066 , A61K38/215 , Y10S435/975 , A61K2300/00
摘要： Random three- and four-amino acid copolymers having lengths of 14-, 35- and 50-amino acid residues are provided. Fifty-mers of FEAK were effective inhibitors of MBP 85-99- or proteolipid protein (PLP) 40-60-specific HLA-DR-2-restricted T cell clones. These copolymers efficiently suppressed the mouse disease EAE, which was induced in a susceptible SJL/J (H-2S) strain of mice with either whole spinal cord homogenate (WSCH) or with the encephalitogenic epitope PLP 139-151 (SEQ ID NO:4). YFAK 50-mer having a molar ratio of about Y 0.8:F 0.2 inhibited binding of biotinylated MBP 85-99 epitope to HLA-DR-2 molecules more efficiently than either unlabeled MBP 85-99 or Copaxone®. YFAK and FAK copolymers efficiently suppressed EAE induced in SJL/J (H-2S) mice with the encephalitogenic epitope PLP 139-151. Copolymers YFAK, VYAK and tryptophan-containing VWAK were efficacious in alleviating severity and duration of symptoms of EAE induced by MBP 85-99 (SEQ ID NO:2), in a humanized mouse model expressing genes for both an HLA-DR-2 linked to multiple sclerosis (MS) in humans and for a T cell receptor from an MS patient.
摘要翻译：提供长度为14-，35-和50-氨基酸残基的随机三和四氨基酸共聚物。 FEAK的五十位是MBP 85-99或蛋白脂质蛋白（PLP）40-60特异性HLA-DR-2限制性T细胞克隆的有效抑制剂。这些共聚物有效地抑制小鼠疾病EAE，其在具有全脊髓匀浆（WSCH）或与致脑炎表位PLP 139的小鼠的易感SJL / J（H-2）S ）菌株中诱导 -151（SEQ ID NO：4）。具有约Y 0.8：F 0.2的摩尔比的YFAK 50聚体比任何未标记的MBP 85-99或Copaxone更有效地抑制生物素化MBP 85-99表位与HLA-DR-2分子的结合。 YFAK和FAK共聚物有效地抑制了具有致脑炎表位PLP 139-151的SJL / J（H-2小鼠）小鼠诱导的EAE。在表达HLA-DR-2连锁的基因的人源化小鼠模型中，共聚物YFAK，VYAK和含色氨酸的VWAK在减轻由MBP 85-99（SEQ ID NO：2）诱导的EAE症状的严重性和持续时间方面是有效的到人的多发性硬化症（MS）和来自MS患者的T细胞受体。

10. 发明授权

US07456252B2 Therapeutic peptides for demyelinating conditions 有权
标题翻译：用于脱髓鞘病症的治疗肽
公开(公告)号：US07456252B2
公开(公告)日：2008-11-25
申请号：US11150755
申请日：2005-06-10
申请人： Jack L. Strominger , Masha Fridkis-Hareli
发明人： Jack L. Strominger , Masha Fridkis-Hareli
IPC分类号： C07K2/00 , C07K7/08 , A61K38/10 , A61K38/16
CPC分类号： C07K14/4713 , A61K38/00 , Y10S435/81 , Y10S435/975
摘要： The invention provides peptide compositions and methods of making and using therapeutic compositions comprising peptides for the treatment of a subject having a demyelinating condition.
摘要翻译：本发明提供肽组合物和制备和使用治疗组合物的方法，所述治疗组合物包含用于治疗具有脱髓鞘状况的受试者的肽。

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