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1. 发明申请

US20050222139A1 Non-peptide gnrh antagonists 失效
公开(公告)号：US20050222139A1
公开(公告)日：2005-10-06
申请号：US10507595
申请日：2003-03-12
申请人： Michael Roe , Andrzej Batt , David Evans , Gary Pitt , David Rooker
发明人： Michael Roe , Andrzej Batt , David Evans , Gary Pitt , David Rooker
IPC分类号： C07D215/08 , A61K31/47 , A61K31/4709 , A61K31/498 , A61K31/538 , A61K31/5383 , A61P5/04 , A61P13/08 , A61P15/00 , A61P15/08 , A61P15/18 , A61P35/00 , C07D217/02 , C07D241/44 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D413/14 , C07D417/06 , C07D498/04 , A61K31/5415 , C07D413/02 , C07D417/02 , C07D43/02
CPC分类号： C07D413/14 , C07D217/02 , C07D241/44 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06
摘要： Compounds according to general formula 1, wherein A1-A3 are selected from A5 and A6 where A5 is either ═CR13— or ═N— and A6 is —NR14—, —O— or —S—; A4 is either a covalent bond or A5, provided that when A4 is a covalent bond one of A1-A3 must be A6 and the other two must be A5 and when A4 is A5 then all of A1-A3 must be A5; R1 is selected from H, NHY′ and COY2, in which case R2 is H, or R1 and R2 may both be methyl or together represent ═O; R3, R4 and R5 are each independently selected from H and lower alkyl groups; R6, R7, R8, R9, R10, R11 and R12 are each independently selected from H, lower alkyl groups, NH2, halogens (F, CI and Br) O-alkyl, CH2NM2 and CF3; R13 is selected from H, F, CI Br, NO2, NH2, OH, Me, Et, OMe, NMe2 and CF3; R14 is selected from H, methyl and ethyl; W is selected from ═CH— and ═N—; X is selected from CH2, O, S, SO2, NH and N lower alkyl; Y1 is selected from CO-lower alkyl, CO(CH2)bY3, CO(CH2)bCOY3 and CO(CH)NHCOY3, where b is 1-3; Y2 is selected from OR15, NR16R17 and NH(CH2)CCOY3, where c is 1-3; Y3 is selected from OR15 and NR16R17; R15 is selected from H, lower alkyl and (CH2)aR16, where a is 0-4; R16 and R17 are each independently selected from H, lower alkyl and (CH2)aR16 or together are —(CH2)2-Z-(CH2)2—; R18 is OH a phenyl group or an aromatic heterocycle selected from pyridyl, pyrimidinyl, pyrazinyl, furyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, triazolyl, oxadiazolyl and thiadiazolyl, each of which may optionally have a lower alkyl group substituent; and Z is selected from O, CH2, S, SO2, NH and N-lower alkyl, are new. They are useful in the treatment of breast and prostate cancer, endometriosis and benign prostate hyperplasia, in the regulation of fertility, and in in vitro fertilisation.

2. 发明申请

US20070197608A1 Piperazines as oxytocin agonists 审中-公开
标题翻译：哌嗪作为催产素激动剂
公开(公告)号：US20070197608A1
公开(公告)日：2007-08-23
申请号：US10570628
申请日：2004-09-02
申请人： Peter Hudson , Gary Pitt , Andrzej Batt , Michael Roe
发明人： Peter Hudson , Gary Pitt , Andrzej Batt , Michael Roe
IPC分类号： A01N43/82
CPC分类号： C07D487/04
摘要： Disclosed are novel compounds according to general formula (I), which have shown OT agonist activity.
摘要翻译：公开了根据通式（I）的新化合物，其显示OT激动剂活性。

3. 发明申请

US20050032777A1 Diazacycloalkanes as oxytocin agonists 审中-公开
标题翻译：二氮杂环烷烃作为催产素激动剂
公开(公告)号：US20050032777A1
公开(公告)日：2005-02-10
申请号：US10486715
申请日：2002-08-06
申请人： Peter Hudson , Andrezej Batt , Gary Pitt , David Rooker , Celine Heeney , Michael Roe
发明人： Peter Hudson , Andrezej Batt , Gary Pitt , David Rooker , Celine Heeney , Michael Roe
IPC分类号： A61K31/55 , A61K31/551 , A61K31/5517 , A61K31/553 , A61P15/04 , A61P15/10 , A61P43/00 , C07D471/14 , C07D487/04 , C07D495/04 , C07D498/04 , A61K31/519
CPC分类号： C07D471/14 , C07D487/04 , C07D495/04
摘要： Compounds according to general formula (1), wherein G1 is NR5R6 or a fused polycyclic group are novel. They are selective and potent oxytocin agonists. Pharmaceutical compositions of such compounds are useful in the treatment of, inter alia, erectile dysfunction.
摘要翻译：根据通式（1）的化合物，其中G 1为NR 5 R 6或稠合多环基团。它们是选择性和有效的催产素。这些化合物的药物组合物可用于治疗勃起功能障碍。

4. 发明申请

US20070031023A1 Machine vision equipmet 有权
标题翻译：机器视觉设备
公开(公告)号：US20070031023A1
公开(公告)日：2007-02-08
申请号：US10549787
申请日：2004-03-19
申请人： Ronald Wilson , Gary Pitt , Timothy Irons , William Everitt
发明人： Ronald Wilson , Gary Pitt , Timothy Irons , William Everitt
IPC分类号： G06K9/00
CPC分类号： A24C5/3412 , G01B11/10 , G01N21/8851 , G01N21/93 , G01N21/952
摘要： A method of setting-up machine vision equipment is disclosed. The equipment includes a camera defining a field of view, processing means for determining physical properties of a test object, and first supporting means for supporting a test object at a predetermined distance from the camera within the field of view. The method is characterised by providing second supporting means for supporting a reference object, placing a reference object having at least one known dimension on the second supporting means, moving one or more of the cameras, the first supporting means and the second supporting means to bring the reference object within the field of view at the predetermined distance from the camera, imaging the reference object to obtain an image, and processing the image to determine the optimum configuration of the imaging means, and adjusting the imaging means configuration to the optimum configuration.
摘要翻译：公开了一种设置机器视觉设备的方法。该设备包括定义视场的摄像机，用于确定测试对象的物理属性的处理装置，以及用于在视场内与摄像机预定距离地支撑测试对象的第一支撑装置。该方法的特征在于提供用于支撑参考对象的第二支撑装置，将具有至少一个已知尺寸的参考对象放置在第二支撑装置上，移动一个或多个相机，第一支撑装置和第二支撑装置以带来在距离照相机预定距离的视场内的参考对象，成像参考对象以获得图像，以及处理图像以确定成像装置的最佳配置，以及将成像装置配置调整到最佳配置。

5. 发明申请

US20060154916A1 Condensed azepines as vasopressin agonists 有权
标题翻译：浓缩吖庚因作为血管加压素激动剂
公开(公告)号：US20060154916A1
公开(公告)日：2006-07-13
申请号：US11370861
申请日：2006-03-09
申请人： Doreen Ashworth , Gary Pitt , Peter Hudson , Christopher Yea , Richard Franklin
发明人： Doreen Ashworth , Gary Pitt , Peter Hudson , Christopher Yea , Richard Franklin
IPC分类号： A61K31/553 , A61K31/551
CPC分类号： C07D403/12 , C07D413/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： This invention provides novel compounds according to general formula (1) wherein A is a bicyclic or tricyclic azepine derivative, V1 and V2 are both H, OMe or F, or one of V1 and V2 is Br, Cl, F, OH, OMe, OBn, OPh, O-acyl, N3, NH2, NHBn or NH-acyl and the other is H, or V1 and V2 together are ═O, —O(CH2)pO— or —S(CH2)pS—; W1 is either O or S; X1 and X2 are both H, or together are ═O or ═S; Y is OR5 or NR6R7; R1, R2, R3 and R4 are independently selected from H, lower alkyl, lower alkyloxy, F, Cl and Br; R5 is selected from H and lower alkyl; R6 and R7 are independently selected from H and lower alkyl, or together are —(CH2)n; n=3, 4, 5, 6; and p is 2 or 3. The compounds are agonists at the vasopressin V2 receptor and are useful as antidiuretics and procoagulants. The invention further comprises pharmaceutical compositions incorporating these vasopressin agonists, which compositions are particularly useful in the treatment of central diabetes insipidus, nocturnal enuresis and nocturia.
摘要翻译：本发明提供了根据通式（1）的新化合物，其中A是双环或三环吖庚因衍生物，V 1和V 2均为H，OMe或F，或 V 1和V 2之一是Br，Cl，F，OH，OMe，OBn，OPh，O-酰基，N 3， NH 2，NHBn或NH-酰基，另一个是H，或V 1和V 2一起是-O，-O（CH O - 或-S（CH 2）n -S-; -S-（CH 2）n - O 1或O 2是O或S; X 1和X 2均为H或一起为-O或-S; Y是OR 5或NR 6 R 7; R 1，R 2，R 3和R 4独立地选自H，低级烷基，低级烷氧基，F，Cl和Br; R 5选自H和低级烷基; R 6和R 7独立地选自H和低级烷基，或者一起是 - （CH 2）n ; n = 3,4,5,6; p是2或3.化合物是加压素V2受体的激动剂，可用作抗利尿剂和促凝剂。本发明还包括掺入这些加压素激动剂的药物组合物，该组合物特别可用于治疗中枢性尿崩症，夜间遗尿和夜尿症。

6. 发明授权

US08604034B2 Substituted imidazo[1,2-α]pyrrolo[1,2-d]pyrazines for treating respiratory syncytial virus (RSV) infections 有权
标题翻译：用于治疗呼吸道合胞病毒（RSV）感染的取代的咪唑并[1,2-α]吡咯并[1,2-d]吡嗪
公开(公告)号：US08604034B2
公开(公告)日：2013-12-10
申请号：US13023473
申请日：2011-02-08
申请人： Jeffrey Peter Mitchell , Gary Pitt , Alistair George Draffan , Penelope Anne Mayes , Laura Andrau , Kelly Anderson
发明人： Jeffrey Peter Mitchell , Gary Pitt , Alistair George Draffan , Penelope Anne Mayes , Laura Andrau , Kelly Anderson
IPC分类号： A61K31/495
CPC分类号： C07D487/14 , A61K31/407 , A61K31/4162 , A61K31/4188 , A61K31/4985 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D207/333 , C07D207/34 , C07D213/79 , C07D405/12
摘要： The present invention relates to compounds of formula (I) its salts, isomers or prodrugs thereof useful in the treatment of viral infections, in particular respiratory syncytial virus (RSV) infections. The present invention also relates to processes for preparing the compounds and intermediates used in their preparation.
摘要翻译：本发明涉及其用于治疗病毒感染，特别是呼吸道合胞病毒（RSV）感染的其盐，异构体或前药的式（I）化合物。本发明还涉及制备用于其制备的化合物和中间体的方法。

7. 发明申请

US20060098214A1 Method and apparatus for determining one or more physical properties of a rolled smoking article or filter rod 有权
标题翻译：用于确定卷烟制品或过滤棒的一种或多种物理性质的方法和装置
公开(公告)号：US20060098214A1
公开(公告)日：2006-05-11
申请号：US10549995
申请日：2004-03-19
申请人： Ronald Wilson , Gary Pitt , Timothy Irons , William Everitt
发明人： Ronald Wilson , Gary Pitt , Timothy Irons , William Everitt
IPC分类号： G01B11/02 , G01B11/06
CPC分类号： G01N21/952 , A24C5/3412 , G01B11/105
摘要： A method of determining one or more physical properties of a rolled smoking article is disclosed, the method comprising disposing a rolled smoking article within a field of view, illuminating the field of view, imaging the rolled smoking article to form an image, and analysing the image to determine one or more physical properties of the rolled smoking article. Preferably the image is a digital image, which may be electronically processed to determine the physical properties. The physical properties may include the length of the rolled smoking article, or its mean diameter, ovality, circumference, roundness or shape. Also disclosed is an apparatus for performing such method comprising imaging means defining the field of view, means for positioning a smoking article in the field of view, illuminating means for illuminating the field of view, and processing means for processing the image to determine one more physical properties.
摘要翻译：公开了一种确定卷烟制品的一种或多种物理性质的方法，所述方法包括在视场内布置卷烟制品，照亮视野，对卷烟制品成像以形成图像，并分析以确定卷烟制品的一种或多种物理性质。优选地，图像是数字图像，其可以被电子处理以确定物理性质。物理性质可以包括卷烟制品的长度，或其平均直径，椭圆度，圆周，圆度或形状。还公开了一种用于执行这种方法的装置，包括限定视野的成像装置，用于在视野中定位吸烟物品的装置，用于照亮视场的照明装置，以及用于处理图像以确定另一个的处理装置物理性质。

8. 发明授权

US06969110B2 Impact load transfer element 有权
公开(公告)号：US06969110B2
公开(公告)日：2005-11-29
申请号：US10632758
申请日：2003-08-01
申请人： Akram Ali , Jason Foster , Michael Gorecki , Gary Pitt , Michael Beavon , Mark Kirschmann , Christopher M Slon
发明人： Akram Ali , Jason Foster , Michael Gorecki , Gary Pitt , Michael Beavon , Mark Kirschmann , Christopher M Slon
IPC分类号： B60J5/04 , B60J5/00
CPC分类号： B60J5/0451
摘要： A door assembly includes an inner panel, an outer panel fixedly attached to the inner panel, and a load transfer element disposed within an interstitial space formed between the inner and outer panels. The load transfer element includes a main body defining a longitudinal axis extending from the inner panel to the outer panel and first and second reaction surfaces disposed on the main body. The first reaction surface is formed proximate the inner panel while the second reaction surface is formed generally opposite the first reaction surface and proximate the outer panel. The second reaction surface is operable to receive a load from the outer panel and to transmit the load through the main body to the first reaction surface and the door inner panel. The load transfer element is further configured to activate an air bag sensor when the load exceeds a predetermined magnitude.

9. 发明申请

US20050023859A1 Impact load transfer element 有权
标题翻译：冲击载荷传递元件
公开(公告)号：US20050023859A1
公开(公告)日：2005-02-03
申请号：US10632758
申请日：2003-08-01
申请人： Akram Ali , Jason Foster , Michael Gorecki , Gary Pitt , Michael Beavon , Mark Kirschmann , Christopher Slon
发明人： Akram Ali , Jason Foster , Michael Gorecki , Gary Pitt , Michael Beavon , Mark Kirschmann , Christopher Slon
IPC分类号： B60J5/04 , B60J5/00
CPC分类号： B60J5/0451
摘要： A door assembly includes an inner panel, an outer panel fixedly attached to the inner panel, and a load transfer element disposed within an interstitial space formed between the inner and outer panels. The load transfer element includes a main body defining a longitudinal axis extending from the inner panel to the outer panel and first and second reaction surfaces disposed on the main body. The first reaction surface is formed proximate the inner panel while the second reaction surface is formed generally opposite the first reaction surface and proximate the outer panel. The second reaction surface is operable to receive a load from the outer panel and to transmit the load through the main body to the first reaction surface and the door inner panel. The load transfer element is further configured to activate an air bag sensor when the load exceeds a predetermined magnitude.
摘要翻译：门组件包括内板，固定连接到内板的外板和设置在形成在内板和外板之间的间隙空间内的负载传递元件。负载传递元件包括限定从内板延伸到外板的纵向轴线的主体以及设置在主体上的第一和第二反作用表面。第一反应表面靠近内板形成，而第二反应表面通常与第一反应表面相对并且靠近外板形成。第二反应表面可操作以从外板接收负载并将负载通过主体传送到第一反作用表面和门内板。负载传递元件还被配置为当负载超过预定量值时激活气囊传感器。

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