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1. 发明申请

US20090060796A1 Acoustic Liquid Dispensing Apparatus 有权
标题翻译：声液分配装置
公开(公告)号：US20090060796A1
公开(公告)日：2009-03-05
申请号：US12197985
申请日：2008-08-25
申请人： Michael R. Van Tuyl , James Chiao , Michael J. Herrmann , Andrew M. Rose
发明人： Michael R. Van Tuyl , James Chiao , Michael J. Herrmann , Andrew M. Rose
IPC分类号： G01N21/11 , B01L3/02
CPC分类号： G01N29/343 , G01N9/24 , G01N11/10 , G01N29/024 , G01N29/028 , G01N29/032 , G01N29/221 , G01N29/222 , G01N2291/02809 , G01N2291/02818 , G01N2291/02836 , G01N2291/02881 , G01N2291/044
摘要： A liquid dispensing apparatus for dispensing droplets of a liquid, and methods for measuring various fluid parameters of the liquid are described. The liquid dispensing apparatus comprises a container having a chamber for holding a liquid. An orifice is positioned at an end of the chamber for dispensing droplets of the liquid, the orifice being configured to retain the liquid in the container if the container is positioned with the orifice facing in a downward direction. An acoustic transducer means is at least partially positioned in the chamber for periodically propagating a focused acoustic beam toward the orifice and through at least some of the liquid while the liquid is contained in the chamber, with the focused acoustic beam being capable of causing a droplet of the liquid to be ejected from the orifice when a free surface of the liquid is within the depth of field of the acoustic transducer means. Fluid parameters that can be measured include the sound velocity in the liquid, liquid level and liquid concentration, liquid acoustic impedance, liquid density ultrasonic attenuation and ultrasonic viscosity.
摘要翻译：描述了用于分配液体的液滴的液体分配装置以及用于测量液体的各种流体参数的方法。液体分配装置包括具有用于保持液体的室的容器。孔口位于腔室的端部，用于分配液体的液滴，如果容器定位成孔口朝向下方的方向，孔口被配置成将液体保持在容器中。声学换能器装置至少部分地定位在腔室中，用于在聚焦的声束能够引起液滴时，将聚焦的声束周期性地传播到孔口并通过至少一些液体，同时液体被容纳在腔室中当液体的自由表面在声换能器装置的深度范围内时，从喷嘴喷射的液体。可以测量的流体参数包括液体中的声速，液位和液体浓度，液体声阻抗，液体密度超声衰减和超声波粘度。

2. 发明授权

US07426866B2 Acoustic liquid dispensing apparatus 有权
标题翻译：声液分配装置
公开(公告)号：US07426866B2
公开(公告)日：2008-09-23
申请号：US11296131
申请日：2005-12-07
申请人： Michael R. Van Tuyl , James Chiao , Michael J. Herrmann , Andrew M. Rose
发明人： Michael R. Van Tuyl , James Chiao , Michael J. Herrmann , Andrew M. Rose
IPC分类号： G01H5/00 , G01S15/00
CPC分类号： G01N29/343 , G01N9/24 , G01N11/10 , G01N29/024 , G01N29/028 , G01N29/032 , G01N29/221 , G01N29/222 , G01N2291/02809 , G01N2291/02818 , G01N2291/02836 , G01N2291/02881 , G01N2291/044
摘要： A liquid dispensing apparatus for dispensing droplets of a liquid, and methods for measuring various fluid parameters of the liquid are described. The liquid dispensing apparatus comprises a container having a chamber for holding a liquid. An orifice is positioned at an end of the chamber for dispensing droplets of the liquid, the orifice being configured to retain the liquid in the container if the container is positioned with the orifice facing in a downward direction. An acoustic transducer means is at least partially positioned in the chamber for periodically propagating a focused acoustic beam toward the orifice and through at least some of the liquid while the liquid is contained in the chamber, with the focused acoustic beam being capable of causing a droplet of the liquid to be ejected from the orifice when a free surface of the liquid is within the depth of field of the acoustic transducer means. Fluid parameters that can be measured include the sound velocity in the liquid, liquid level and liquid concentration, liquid acoustic impedance, liquid density and ultrasonic viscosity.
摘要翻译：描述了用于分配液体的液滴的液体分配装置以及用于测量液体的各种流体参数的方法。液体分配装置包括具有用于保持液体的室的容器。孔口位于腔室的端部，用于分配液体的液滴，如果容器定位成孔口朝向下方的方向，孔口被配置成将液体保持在容器中。声学换能器装置至少部分地定位在腔室中，用于当液体容纳在腔室中时，将聚焦的声束周期性地传播到孔口并且通过至少一些液体，聚焦的声束能够引起液滴当液体的自由表面在声换能器装置的深度范围内时，从喷嘴喷射的液体。可以测量的流体参数包括液体中的声速，液位和液体浓度，液体声阻抗，液体密度和超声波粘度。

3. 发明授权

US08455827B1 Method and apparatus for determining the water content of organic solvent solutions 有权
标题翻译：用于测定有机溶剂溶液含水量的方法和装置
公开(公告)号：US08455827B1
公开(公告)日：2013-06-04
申请号：US12975233
申请日：2010-12-21
申请人： James Chiao , Charles A. Reichel , Michael R. Van Tuyl
发明人： James Chiao , Charles A. Reichel , Michael R. Van Tuyl
IPC分类号： G01J5/02
CPC分类号： G01N21/3554 , G01J2001/4252 , G01N21/274 , G01N21/359
摘要： A method and apparatus for determining the amount of water in an organic solvent solution, such as a DMSO solution. The apparatus comprises an infrared LED for emitting near infrared light; a laser diode collimator for forming a collimated light beam from the light emitted by the LED; a sample container holder for accepting a sample container containing a sample solution; a photodiode for generating an output signal that is related to the intensity of the collimated light beam after the collimated light beam has passed through the sample solution; and a control means for controlling the stability of the near infrared light emitted by the infrared LED by controlling an amount of current flowing through the infrared LED.
摘要翻译：用于测定有机溶剂溶液如DMSO溶液中的水量的方法和装置。该装置包括用于发射近红外光的红外LED; 激光二极管准直器，用于从LED发射的光形成准直光束; 用于容纳包含样品溶液的样品容器的样品容器保持器; 用于产生在准直光束已经通过样品溶液之后与准直光束的强度相关的输出信号的光电二极管; 以及控制装置，用于通过控制流过红外LED的电流量来控制由红外LED发射的近红外光的稳定性。

4. 发明授权

US08171798B2 Acoustic liquid dispensing apparatus 有权
标题翻译：声液分配装置
公开(公告)号：US08171798B2
公开(公告)日：2012-05-08
申请号：US12197985
申请日：2008-08-25
申请人： Michael R. Van Tuyl , James Chiao
发明人： Michael R. Van Tuyl , James Chiao
IPC分类号： G01H5/00
CPC分类号： G01N29/343 , G01N9/24 , G01N11/10 , G01N29/024 , G01N29/028 , G01N29/032 , G01N29/221 , G01N29/222 , G01N2291/02809 , G01N2291/02818 , G01N2291/02836 , G01N2291/02881 , G01N2291/044
摘要： A liquid dispensing apparatus for dispensing droplets of a liquid, and methods for measuring various fluid parameters of the liquid are described. The liquid dispensing apparatus comprises a container having a chamber for holding a liquid. An orifice is positioned at an end of the chamber for dispensing droplets of the liquid, the orifice being configured to retain the liquid in the container if the container is positioned with the orifice facing in a downward direction. An acoustic transducer means is at least partially positioned in the chamber for periodically propagating a focused acoustic beam toward the orifice and through at least some of the liquid while the liquid is contained in the chamber, with the focused acoustic beam being capable of causing a droplet of the liquid to be ejected from the orifice when a free surface of the liquid is within the depth of field of the acoustic transducer means. Fluid parameters that can be measured include the sound velocity in the liquid, liquid level and liquid concentration, liquid acoustic impedance, liquid density ultrasonic attenuation and ultrasonic viscosity.
摘要翻译：描述了用于分配液体的液滴的液体分配装置以及用于测量液体的各种流体参数的方法。液体分配装置包括具有用于保持液体的室的容器。孔口位于腔室的端部，用于分配液体的液滴，如果容器定位成孔口朝向下方的方向，孔口被配置成将液体保持在容器中。声学换能器装置至少部分地定位在腔室中，用于在聚焦的声束能够引起液滴时，将聚焦的声束周期性地传播到孔口并通过至少一些液体，同时液体被容纳在腔室中当液体的自由表面在声换能器装置的深度范围内时，从喷嘴喷射的液体。可以测量的流体参数包括液体中的声速，液位和液体浓度，液体声阻抗，液体密度超声衰减和超声波粘度。

5. 发明授权

US07429359B2 Source and target management system for high throughput transfer of liquids 有权
标题翻译：来源和目标管理系统，用于高产量转移液体
公开(公告)号：US07429359B2
公开(公告)日：2008-09-30
申请号：US10388960
申请日：2003-03-14
申请人： Charles A. Reichel , Michael J. Forbush , Tarlochan S. Jhutty , Marina Nasilevich , Michael R. Van Tuyl , James E. Sinclair , Humphrey W. Chow
发明人： Charles A. Reichel , Michael J. Forbush , Tarlochan S. Jhutty , Marina Nasilevich , Michael R. Van Tuyl , James E. Sinclair , Humphrey W. Chow
IPC分类号： B01L3/02
CPC分类号： B01L3/0268 , B01L9/523 , B01L2300/0829 , B01L2400/0439 , G01N35/028 , G01N2035/042 , G01N2035/0425 , G01N2035/1041
摘要： An apparatus for high-throughput screening and generation of chemical libraries. The apparatus comprises computer controlled mechanical displacement devices and storage queues capable of managing a large number of source well plates and target well plates. In one aspect of the invention, precession alignment mechanisms are provided for efficient transfer of liquid from source well plates to target well plates. The apparatus may be configured such that any source fluid in any of the source well plates may be transferred to any target location within any of the target well plates in any sequence defined by the user. The computer controller may track the location of all the source well plates and target well plates and allow user defined association of any source well with any target well in any order defined by the user, thus providing an effective platform for chemical and biochemical synthesis and screening.
摘要翻译：用于高通量筛选和化学文库生成的设备。该装置包括能够管理大量源井板和目标井板的计算机控制的机械位移装置和存储队列。在本发明的一个方面，提供了进动对准机构，用于将液体从源阱板有效转移到目标井板。该装置可以被配置成使得任何源阱板中的任何源流体可以按照用户定义的任何顺序传送到任何目标阱板内的任何目标位置。计算机控制器可以跟踪所有源井板和目标井板的位置，并允许用户根据用户定义的任何顺序将任何源井与任何目标井定义关联，从而为化学和生物化学合成和筛选提供有效的平台。

6. 发明授权

US06863362B2 Acoustically mediated liquid transfer method for generating chemical libraries 有权
标题翻译：用于生成化学文库的声学介质液体转移方法
公开(公告)号：US06863362B2
公开(公告)日：2005-03-08
申请号：US10388880
申请日：2003-03-14
申请人： Charles A. Reichel , Michael J. Forbush , Tarlochan S. Jhutty , Marina Nasilevich , Michael R. Van Tuyl , James E. Sinclair , Humphrey W. Chow
发明人： Charles A. Reichel , Michael J. Forbush , Tarlochan S. Jhutty , Marina Nasilevich , Michael R. Van Tuyl , James E. Sinclair , Humphrey W. Chow
IPC分类号： B05B1/08 , B41J29/393 , G01N35/00
CPC分类号： B01L3/0268 , B01L9/523 , B01L2300/0829 , B01L2400/0439 , G01N35/028 , G01N2035/042 , G01N2035/0425 , G01N2035/1041
摘要： An apparatus for high-throughput screening and/or generation of chemical libraries. In one aspect of the invention, a database is provided to track various parameters related to the source fluids in the source containment structure. Tracking changes of the source fluids in each source well may allow efficient utilization of source fluid and may also facilitate the high-throughput fluid transfer process. In one variation, data related to fluid level in each source well is maintained such that proper positioning of acoustic wave focus may be achieved. In another aspect of the invention, a database associated with one or more source fluid containment structure is provided and updated during the fluid transfer process. A second database providing a mapping profile with information regarding which fluid is to be transferred to what target is also provided. A third database may be generated to track fluid information in the target well plates.
摘要翻译：用于高通量筛选和/或生成化学文库的设备。在本发明的一个方面，提供数据库以跟踪与源容纳结构中的源流体相关的各种参数。跟踪每个源阱中的源流体的变化可以允许源流体的有效利用并且还可以促进高通量流体转移过程。在一个变型中，保持与每个源阱中的液位相关的数据，使得可以实现声波聚焦的适当定位。在本发明的另一方面，在流体转移过程期间提供并更新与一个或多个源流体容纳结构相关联的数据库。第二数据库提供映射配置文件，其中还提供了关于哪些流体要传送到什么目标的信息。可以生成第三数据库以跟踪目标井板中的流体信息。

7. 发明授权

US07118048B2 Apparatus and method for droplet steering 有权
公开(公告)号：US07118048B2
公开(公告)日：2006-10-10
申请号：US11231579
申请日：2005-09-21
申请人： Roger O. Williams , Michael R. Van Tuyl , Michael J. Forbush
发明人： Roger O. Williams , Michael R. Van Tuyl , Michael J. Forbush
IPC分类号： B05B1/28
CPC分类号： B41J2/14008
摘要： An apparatus and method for droplet steering is disclosed herein. A throated structure having a nozzle defines a converging throat with an inlet and an outlet and a vectored fluid stream directed therethrough. The fluid stream is driven through the system via a vacuum pump. As the fluid approaches the outlet, its velocity increases and is drawn away from the nozzle through a connecting channel. As a droplet is ejected from a liquid therebelow, it will have a first trajectory until it is introduced to the high velocity fluid stream at the perimeter of the interior walls of the nozzle. The fluid accordingly steers the momentum of the droplet such that it obtains a second or corrected trajectory. Alternative variations include an electrically chargeable member, e.g., a pin, positionable to be in apposition to the outlet and capillary tubes for controlling the ejection surface of the pool of source fluid.

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