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1. 发明授权

US11319361B2 Treatment of intestinal dysbiosis with immunoglobin 有权
公开(公告)号：US11319361B2
公开(公告)日：2022-05-03
申请号：US16678780
申请日：2019-11-08
申请人： Michael R. Simon
发明人： Michael R. Simon
IPC分类号： C07K16/06 , A61K9/48 , A61K39/395 , A61P1/00 , A61K9/50 , A61P37/08
摘要： A process is provided for inhibiting symptoms of intestinal dysbiosis in a subject that includes the oral administration to the subject suffering from intestinal dysbiosis an IgA, IgM, or a combination thereof. When administered in a therapeutic quantity based on the subject characteristics and the type of IgA or IgM, symptoms of intestinal dysbiosis in that subject are inhibited. Even non-secretory forms of IgA or IgM are effective when administered orally.

2. 发明授权

US09273129B2 Treatment of food intolerance and food allergy with IgM 有权
标题翻译：用IgM治疗食物不耐受和食物过敏
公开(公告)号：US09273129B2
公开(公告)日：2016-03-01
申请号：US14264053
申请日：2014-04-28
申请人： Michael R. Simon
发明人： Michael R. Simon
IPC分类号： A61K39/395 , C07K16/18 , C07K16/00 , G06F3/147 , C07K16/16 , A61K39/00 , G02F1/167 , G02F1/1333
CPC分类号： C07K16/44 , A61K9/0053 , A61K38/14 , A61K39/39583 , A61K39/40 , A61K2039/505 , A61K2039/507 , A61K2039/542 , A61K2039/577 , C07K16/00 , C07K16/1282 , C07K16/16 , C07K16/18 , C07K2317/75 , C07K2317/76 , G02F1/167 , G02F2001/133388 , G06F3/147 , G09G2310/0232 , G09G2340/04 , G09G2340/0407 , G09G2380/14
摘要： A process is provided for inhibiting symptoms of food allergy or food intolerance in a subject that includes the oral administration to the subject suffering from food allergy or food intolerance an IgM. When administered in a therapeutic quantity based on the subject characteristics and the type of IgM, symptoms of food allergy or food intolerance in that subject are inhibited. Even non-secretory forms of IgM are effective when administered orally.
摘要翻译：提供了一种方法，用于抑制受试者中食物过敏或食物不耐症的症状，包括口服给患有食物过敏或食物不耐受的受试者IgM。当基于受试者特征和IgM的类型以治疗量施用时，抑制该受试者的食物过敏或食物不耐受的症状。即使非分泌形式的IgM在口服给药时也是有效的。

3. 发明授权

US08709413B2 Treatment of celiac disease with IgA 有权
标题翻译：用IgA治疗乳糜泻
公开(公告)号：US08709413B2
公开(公告)日：2014-04-29
申请号：US13214952
申请日：2011-08-22
申请人： Michael R. Simon
发明人： Michael R. Simon
IPC分类号： A61K39/395
CPC分类号： C07K16/44 , A61K9/0053 , A61K38/14 , A61K39/39583 , A61K39/40 , A61K2039/505 , A61K2039/507 , A61K2039/542 , A61K2039/577 , C07K16/00 , C07K16/1282 , C07K16/16 , C07K16/18 , C07K2317/75 , C07K2317/76 , G02F1/167 , G02F2001/133388 , G06F3/147 , G09G2310/0232 , G09G2340/04 , G09G2340/0407 , G09G2380/14
摘要： A process is provided for inhibiting symptoms of food allergy or food intolerance in a subject that includes the oral administration to the subject suffering from food allergy or food intolerance an IgA or an IgM. When administered in a therapeutic quantity based on the subject characteristics and the type of IgA or IgM, symptoms of food allergy or food intolerance in that subject are inhibited. Even non-secretory forms of IgA and IgM are effective when administered orally.
摘要翻译：提供了一种方法，其用于抑制受试者的食物过敏或食物不耐症的症状，所述对象包括口服给患有食物过敏或食物不耐受的受试者IgA或IgM。当基于受试者特征和IgA或IgM的类型以治疗量施用时，抑制该受试者的食物过敏症或食物不耐受症状。即使非分泌形式的IgA和IgM在口服给药时也是有效的。

4. 发明申请

US20110305753A1 Treatment of celiac disease with IgA 有权
标题翻译：用IgA治疗乳糜泻
公开(公告)号：US20110305753A1
公开(公告)日：2011-12-15
申请号：US13214952
申请日：2011-08-22
申请人： Michael R. Simon
发明人： Michael R. Simon
IPC分类号： A61K39/395 , A61P1/00 , A61P29/00 , A61P1/04
CPC分类号： C07K16/44 , A61K9/0053 , A61K38/14 , A61K39/39583 , A61K39/40 , A61K2039/505 , A61K2039/507 , A61K2039/542 , A61K2039/577 , C07K16/00 , C07K16/1282 , C07K16/16 , C07K16/18 , C07K2317/75 , C07K2317/76 , G02F1/167 , G02F2001/133388 , G06F3/147 , G09G2310/0232 , G09G2340/04 , G09G2340/0407 , G09G2380/14
摘要： A process is provided for inhibiting symptoms of food allergy or food intolerance in a subject that includes the oral adminstration to the subject suffering from food allergy or food intolerance an IgA or an IgM. When administered in a therapeutic quantity based on the subject characteristics and the type of IgA or IgM, symptoms of food allergy or food intolerance in that subject are inhibited. Even non-secretory forms of IgA and IgM are effective when administered orally.
摘要翻译：提供了一种抑制受试者的食物过敏或食物不耐症的症状的方法，其包括对患有食物过敏或食物不耐受的受试者口服给药IgA或IgM。当基于受试者特征和IgA或IgM的类型以治疗量施用时，抑制该受试者的食物过敏症或食物不耐受症状。即使非分泌形式的IgA和IgM在口服给药时也是有效的。

5. 发明授权

US07597891B2 Synthesis of human secretory IgA for the treatment of Clostridium difficile associated diseases 有权
标题翻译：人类分泌型IgA的合成用于治疗难辨梭状芽孢杆菌相关疾病
公开(公告)号：US07597891B2
公开(公告)日：2009-10-06
申请号：US11839781
申请日：2007-08-16
申请人： Michael R. Simon
发明人： Michael R. Simon
IPC分类号： A61K39/00 , A61K49/00 , A61K39/02
CPC分类号： C07K16/1282 , A61K31/415 , A61K38/14 , C07K2317/21 , C07K2317/52 , C07K2317/76
摘要： A composition for treating a subject is provided. The composition includes dimeric or polymeric secretory IgA therapeutic. Formulating agents are mixed with the dimeric or polymeric secretory IgA to yield a dosing form of a capsule, tablet, and a suppository. A process for manufacturing a medicament for the treatment of C. difficile associated disease in a human is also provided wherein dimeric or polymeric IgA is modified with secretory component to form a dimeric or polymeric secretory IgA therapeutic. The dimeric or polymeric secretory IgA therapeutic is then mixed with formulating agents to create a capsule, tablet, or suppository dosing form. The therapeutic is amenable to enrobement directly through microencapsulation or the dosing form is coated with an enteric coating. A method of C. difficile treatment with the therapeutic is also provided that is amenable to supplementation with concurrent or prior antibiotic administration.
摘要翻译：提供了一种用于治疗受试者的组合物。该组合物包括二聚体或聚合物分泌型IgA治疗剂。将制剂与二聚体或聚合物分泌物IgA混合以产生胶囊，片剂和栓剂的给药形式。还提供了制备用于治疗人类艰难梭菌相关疾病的药物的方法，其中用分泌组分修饰二聚体或聚合物IgA以形成二聚体或聚合物分泌型IgA治疗剂。然后将二聚体或聚合物分泌型IgA治疗剂与配制剂混合以产生胶囊，片剂或栓剂给药形式。该治疗剂适于直接通过微胶囊包被或剂量形式用肠溶衣包被。还提供了用治疗剂进行艰难梭菌治疗的方法，其适于补充同时或之前的抗生素给药。

6. 发明申请

US20080260822A1 SYNTHESIS OF HUMAN SECRETORY IgA AND IgM AND THE FORMATION OF A MEDICAMENT THEREFROM 有权
标题翻译：人类秘密IgA和IgM的合成及其药物的形成
公开(公告)号：US20080260822A1
公开(公告)日：2008-10-23
申请号：US12138758
申请日：2008-06-13
申请人： Michael R. Simon , Stephanie M. Chervin , Stephen C. Brown
发明人： Michael R. Simon , Stephanie M. Chervin , Stephen C. Brown
IPC分类号： A61K9/48 , A61K39/44 , A61K9/28 , A61P31/04
CPC分类号： C07K16/1282 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/76
摘要： A composition for treating a subject is provided. The composition includes antigen specific dimeric secretory IgA and pentameric IgM therapeutic. A process for manufacturing a medicament for the treatment of C. difficile associated disease in a human is also provided that the modification of antigen specific dimeric secretory IgA and pentameric IgM with secretory component to form a antigen specific dimeric secretory IgA and pentameric secretory IgM therapeutic. The antigen specific dimeric secretory IgA and the pentameric secretory IgM therapeutic is then mixed with formulating agents to create a capsule, tablet, liquid or suppository dosing form. The therapeutic is amenable to enrobement directly through microencapsulation or the dosing form is coated with an enteric coating. A method of C. difficile treatment with the therapeutic is also provided that is amenable to supplementation with concurrent or prior antibiotic administration.
摘要翻译：提供了一种用于治疗受试者的组合物。该组合物包括抗原特异性二聚体分泌型IgA和五聚体IgM治疗剂。还提供了用于制备用于治疗人类艰难梭菌相关疾病的药物的方法，其中所述抗原特异性二聚体分泌型IgA和具有分泌成分的五聚体IgM的修饰形成抗原特异性二聚分泌型IgA和五聚体分泌型IgM治疗剂。然后将抗原特异性二聚体分泌型IgA和五聚体分泌型IgM治疗剂与配制剂混合以产生胶囊，片剂，液体或栓剂给药形式。该治疗剂适于直接通过微胶囊包被或剂量形式用肠溶衣包被。还提供了用治疗剂进行艰难梭菌治疗的方法，其适于补充同时或之前的抗生素给药。

7. 发明授权

US11623948B2 Process for preparation of secretory IgA and secretory IgM 有权
公开(公告)号：US11623948B2
公开(公告)日：2023-04-11
申请号：US16401322
申请日：2019-05-02
申请人： Stephen C. Brown , Michael R. Simon
发明人： Stephen C. Brown , Michael R. Simon
IPC分类号： B01D15/38 , C07K16/00 , C07K16/06 , C07K14/735 , C07K16/18 , C07K1/14 , A61K39/00
摘要： A process for synthesizing and separating secretory IgA from a mixture of IgA monmer and IgA dimer is provided. The process includes covalently binding affinity tagged or epitope tagged recombinant secretory component to the IgA dimer in the mixture and binding the affinity tagged or an epitope tagged secretory IgA to immobilized moieties on the solid phase support resin to which the affinity tag or epitope tag binds and then eluting the affinity tagged or an epitope tagged secretory IgA with release buffer. A process for synthesizing and separating secretory IgM from a mixture of IgM and other plasma proteins is also provided. The process includes covalently binding affinity tagged or an epitope tagged recombinant secretory component to the IgM in the mixture and binding the affinity tagged or an epitope tagged secretory IgM to immobilized moieties on the solid phase support resin and then eluting the peptide tagged secretory IgM with a release buffer.

8. 发明授权

US10912955B2 Treatment of celiac disease, C. difficile infection, food intolerance and food allergy with secretory IgA/IgM 有权
公开(公告)号：US10912955B2
公开(公告)日：2021-02-09
申请号：US15205359
申请日：2016-07-08
申请人： Michael R. Simon
发明人： Michael R. Simon
IPC分类号： C07K16/12 , C07K16/00 , A61K39/00 , A61P1/00 , G06F3/147 , C07K16/16 , C07K16/18 , C07K16/44 , A61K9/00 , A61K38/14 , A61K39/395 , A61K39/40 , G02F1/167 , G02F1/1333
摘要： A process is provided for inhibiting symptoms of celiac disease, Clostridium difficile associated diseases such as Clostridium difficile colitis, pseudomembranous colitis and antibiotic associated diarrhea, food allergy or food intolerance in a subject that includes the oral administration to the subject suffering from food allergy or food intolerance an IgM. When administered in a, therapeutic quantity based on the subject characteristics and the type of IgM, symptoms of food allergy or food intolerance in that subject are inhibited. Even non-secretory forms of IgM are effective when administered orally.

9. 发明授权

US10385117B2 Process for preparation of secretory IgA and secretory IgM 有权
公开(公告)号：US10385117B2
公开(公告)日：2019-08-20
申请号：US14476559
申请日：2014-09-03
申请人： Stephen C. Brown , Michael R. Simon
发明人： Stephen C. Brown , Michael R. Simon
IPC分类号： A61K39/00 , C07K1/14 , C07K19/00 , B01D15/38 , C07K16/00 , C07K16/06 , C07K16/18 , C07K14/735
摘要： A process for synthesizing and separating secretory IgA from a mixture of IgA monomer and IgA dimer is provided. The process includes covalently binding affinity tagged or epitope tagged recombinant secretory component to the IgA dimer in the mixture and binding the affinity tagged or an epitope tagged secretory IgA to immobilized moieties on the solid phase support resin to which the affinity tag or epitope tag binds and then eluting the affinity tagged or an epitope tagged secretory IgA with release buffer. A process for synthesizing and separating secretory IgM from a mixture of IgM and other plasma proteins is also provided. The process includes covalently binding affinity tagged or an epitope tagged recombinant secretory component to the IgM in the mixture and binding the affinity tagged or an epitope tagged secretory IgM to immobilized moieties on the solid phase support resin and then eluting the peptide tagged secretory IgM with a release buffer.

10. 发明申请

US20160319039A1 TREATMENT OF CELIAC DISEASE, C. DIFFICILE INFECTION, FOOD INTOLERANCE AND FOOD ALLERGY WITH SECRETORY IgA/IgM 审中-公开
标题翻译：治疗CELIAC疾病，C.差异感染，食物不耐受和食物过敏与秘密IgA / IgM
公开(公告)号：US20160319039A1
公开(公告)日：2016-11-03
申请号：US15205359
申请日：2016-07-08
申请人： Michael R. Simon
发明人： Michael R. Simon
IPC分类号： C07K16/44 , A61K9/00 , A61K39/395 , A61K39/40 , C07K16/12 , A61K38/14
CPC分类号： C07K16/44 , A61K9/0053 , A61K38/14 , A61K39/39583 , A61K39/40 , A61K2039/505 , A61K2039/507 , A61K2039/542 , A61K2039/577 , C07K16/00 , C07K16/1282 , C07K16/16 , C07K16/18 , C07K2317/75 , C07K2317/76 , G02F1/167 , G02F2001/133388 , G06F3/147 , G09G2310/0232 , G09G2340/04 , G09G2340/0407 , G09G2380/14
摘要： A process is provided for inhibiting symptoms of celiac disease, Clostridium difficile associated diseases such as Clostridium difficile colitis, pseudomembranous colitis and antibiotic associated diarrhea, food allergy or food intolerance in a subject that includes the oral adminstration to the subject suffering from food allergy or food intolerance an IgM. When administered in a, therapeutic quantity based on the subject characteristics and the type of IgM, symptoms of food allergy or food intolerance in that subject are inhibited. Even non-secretory forms of IgM are effective when administered orally.
摘要翻译：提供了一种抑制肠道疾病症状的方法，艰难梭菌相关疾病如难辨梭状芽孢杆菌结肠炎，假膜性结肠炎和抗生素相关性腹泻，食物过敏或食物不耐受性，包括对患有食物过敏或食物的受试者的口服不耐受的IgM。当基于受试者特征和IgM的类型以治疗量施用时，该受试者的食物过敏症或食物不耐受症状被抑制。即使非分泌形式的IgM在口服给药时也是有效的。

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