专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100248387A1 Method for Measuring Luminescence at a Luminescence Detection Workstation 有权
标题翻译：发光检测工作站测量发光的方法
公开(公告)号：US20100248387A1
公开(公告)日：2010-09-30
申请号：US12716219
申请日：2010-03-02
申请人： Michael R. Gambini , John C. Voyta , John Atwood , Susan A. Atwood-Stone , Bruce E. DeSimas, II , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
发明人： Michael R. Gambini , John C. Voyta , John Atwood , Susan A. Atwood-Stone , Bruce E. DeSimas, II , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
IPC分类号： G01N21/76
CPC分类号： G01N21/763 , G01N21/15 , G01N21/274 , G01N21/276 , G01N21/31 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/76 , G01N33/581 , G01N2021/6471 , G01N2333/90241 , Y10T436/115831
摘要： A luminescence detecting apparatus and method for analyzing luminescent samples is disclosed. Luminescent samples are placed in a plurality of sample wells in a tray, and the tray is placed in a visible-light impervious chamber containing a charge coupled device camera. The samples may be injected in the wells, and the samples may be injected with buffers and reagents, by an injector. In the chamber, light from the luminescent samples pass through a collimator, a Fresnel field lens, a filter, and a camera lens, whereupon a focused image is created by the optics on the charge-coupled device (CCD) camera. The use of a Fresnel field lens, in combination with a collimator and filter, reduces crosstalk between samples below the level attainable by the prior art. Preferred embodiments of the luminescence detecting apparatus and method disclosed include central processing control of all operations, multiple wavelength filter wheel, and robot handling of samples and reagents. Preferred embodiments of processing software integrated with the invention include elements for mechanical alignment, outlier shaving, edge detection and masking, manipulation of multiple integration times to expand the dynamic range, crosstalk correction, dark subtraction interpolation and drift correction, multi-component analysis applications specifically tailored for luminescence, and uniformity correction.
摘要翻译：公开了一种用于分析发光样品的发光检测装置和方法。将发光样品放置在托盘中的多个样品孔中，并且将托盘放置在包含电荷耦合器件照相机的可见光不透水室中。样品可以注入孔中，样品可以通过注射器注入缓冲液和试剂。在室中，来自发光样品的光通过准直仪，菲涅尔场透镜，滤光器和照相机镜头，由此电荷耦合器件（CCD）照相机上的光学器件产生聚焦图像。使用菲涅耳场透镜与准直器和滤光器结合使得样品之间的串扰降低到现有技术可获得的水平以下。发光检测装置和方法的优选实施例包括所有操作，多波长滤光轮和样品和试剂的机器人处理的中央处理控制。与本发明集成的处理软件的优选实施例包括用于机械对准，异常刮削，边缘检测和掩蔽的元件，多次积分时间的操纵以扩大动态范围，串扰校正，暗减法内插和漂移校正，特别是多组分分析应用适合发光和均匀性校正。

2. 发明授权

US07670848B2 Method for measuring luminescence at a luminescence detection workstation 有权
标题翻译：用于在发光检测工作站测量发光的方法
公开(公告)号：US07670848B2
公开(公告)日：2010-03-02
申请号：US11251873
申请日：2005-10-18
申请人： Michael R. Gambini , John C. Voyta , John Atwood , Susan A. Atwood-Stone, legal representative , Bruce E. DeSimas, II , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
发明人： Michael R. Gambini , John C. Voyta , John Atwood , Bruce E. DeSimas, II , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
IPC分类号： G01N21/76 , G01T1/10
CPC分类号： G01N21/763 , G01N21/15 , G01N21/274 , G01N21/276 , G01N21/31 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/76 , G01N33/581 , G01N2021/6471 , G01N2333/90241 , Y10T436/115831
摘要： In a luminescence detecting apparatus and method for analyzing luminescent samples, luminescent samples are placed in a plurality of sample wells in a tray, and the tray is placed in a visible-light impervious chamber containing a charge coupled device camera. In the chamber, light from the luminescent samples pass through a collimator, a Fresnel field lens, an infrared filter, and a camera lens, whereupon a focused image is created by the optics on the camera. The use of an infrared filter suppresses stray IR radiation resulting from plate phosphorescence (which can result in abnormally high backgrounds and/or alteration of the image received by the camera).
摘要翻译：在用于分析发光样品的发光检测装置和方法中，将发光样品放置在托盘中的多个样品孔中，并将该托盘放置在包含电荷耦合器件相机的可见光不透过室中。在室中，来自发光样品的光通过准直仪，菲涅尔场透镜，红外滤光镜和照相机镜头，由相机上的光学器件产生聚焦图像。使用红外滤光器可抑制板状磷光产生的杂散红外辐射（可能导致摄像机接收的图像异常高的背景和/或变化）。

3. 发明申请

US20120309103A1 METHOD FOR MEASURING LUMINESCENCE AT A LUMINESCENCE DETECTION WORKSTATION 有权
标题翻译：用于在发光检测工作站测量发光的方法
公开(公告)号：US20120309103A1
公开(公告)日：2012-12-06
申请号：US13584628
申请日：2012-08-13
申请人： Michael Gambini , John C. Voyta , John Atwood , Susan A. Atwood-Stone , Bruce E. DeSimas, II , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
发明人： Michael Gambini , John C. Voyta , John Atwood , Susan A. Atwood-Stone , Bruce E. DeSimas, II , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
IPC分类号： G01N21/76
CPC分类号： G01N21/763 , G01N21/15 , G01N21/274 , G01N21/276 , G01N21/31 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/76 , G01N33/581 , G01N2021/6471 , G01N2333/90241 , Y10T436/115831
摘要： A luminescence detecting apparatus and method for analyzing luminescent samples is disclosed. Luminescent samples are placed in a plurality of sample wells in a tray, and the tray is placed in a visible-light impervious chamber containing a charge coupled device camera. The samples may be injected in the wells, and the samples may be injected with buffers and reagents, by an injector. In the chamber, light from the luminescent samples pass through a collimator, a Fresnel field lens, a filter, and a camera lens, whereupon a focused image is created by the optics on the charge-coupled device (CCD) camera. The use of a Fresnel field lens, in combination with a collimator and filter, reduces crosstalk between samples below the level attainable by the prior art. Preferred embodiments of the luminescence detecting apparatus and method disclosed include central processing control of all operations, multiple wavelength filter wheel, and robot handling of samples and reagents. Preferred embodiments of processing software integrated with the invention include elements for mechanical alignment, outlier shaving, edge detection and masking, manipulation of multiple integration times to expand the dynamic range, crosstalk correction, dark subtraction interpolation and drift correction, multi-component analysis applications specifically tailored for luminescence, and uniformity correction.
摘要翻译：公开了一种用于分析发光样品的发光检测装置和方法。将发光样品放置在托盘中的多个样品孔中，并且将托盘放置在包含电荷耦合器件照相机的可见光不透水室中。样品可以注入孔中，样品可以通过注射器注入缓冲液和试剂。在室中，来自发光样品的光通过准直仪，菲涅尔场透镜，滤光器和照相机镜头，由此电荷耦合器件（CCD）照相机上的光学器件产生聚焦图像。使用菲涅耳场透镜与准直器和滤光器结合使得样品之间的串扰降低到现有技术可获得的水平以下。发光检测装置和方法的优选实施例包括所有操作，多波长滤光轮和样品和试剂的机器人处理的中央处理控制。与本发明集成的处理软件的优选实施例包括用于机械对准，异常刮削，边缘检测和掩蔽的元件，多次积分时间的操纵以扩大动态范围，串扰校正，暗减法内插和漂移校正，特别是多组分分析应用适合发光和均匀性校正。

4. 发明授权

US06518068B1 Luminescence detection workstation 有权
标题翻译：发光检测工作站
公开(公告)号：US06518068B1
公开(公告)日：2003-02-11
申请号：US09621961
申请日：2000-07-21
申请人： Michael R. Gambini , John C. Voyta , John Atwood , Bruce E. DeSimas, II , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
发明人： Michael R. Gambini , John C. Voyta , John Atwood , Bruce E. DeSimas, II , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
IPC分类号： G01N2164
CPC分类号： G01N21/763 , G01N21/15 , G01N21/274 , G01N21/276 , G01N21/31 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/76 , G01N33/581 , G01N2021/6471 , G01N2333/90241 , Y10T436/115831
摘要： A luminescence detecting apparatus and method for analyzing luminescent samples is disclosed. Luminescent samples are placed in a plurality of sample wells in a tray, and the tray is placed in a visible-light impervious chamber containing a charge coupled device camera. The samples may be injected in the wells, and the samples may be injected with buffers and reagents, by an injector. In the chamber, light from the luminescent samples pass through a collimator, a Fresnel field lens, a filter, and a camera lens, whereupon a focused image is created by the optics on the charge-coupled device (CCD) camera. The use of a Fresnel field lens, in combination with a collimator and filter, reduces crosstalk between samples below the level attainable by the prior art. Preferred embodiments of the luminescence detecting apparatus and method disclosed include central processing control of all operations, multiple wavelength filter wheel, and robot handling of samples and reagents. Preferred embodiments of processing software integrated with the invention include elements for mechanical alignment, outlier shaving, masking, manipulation of multiple integration times to expand the dynamic range, crosstalk correction, dark subtraction interpolation and drift correction, multi-component analysis applications specifically tailored for luminescence, and uniformity correction.
摘要翻译：公开了一种用于分析发光样品的发光检测装置和方法。将发光样品放置在托盘中的多个样品孔中，并且将托盘放置在包含电荷耦合器件照相机的可见光不透水室中。样品可以注入孔中，样品可以通过注射器注入缓冲液和试剂。在室中，来自发光样品的光通过准直仪，菲涅尔场透镜，滤光器和照相机镜头，由此电荷耦合器件（CCD）照相机上的光学器件产生聚焦图像。使用菲涅耳场透镜与准直器和滤光器结合使得样品之间的串扰降低到现有技术可获得的水平以下。发光检测装置和方法的优选实施例包括所有操作，多波长滤光轮和样品和试剂的机器人处理的中央处理控制。与本发明集成的处理软件的优选实施例包括用于机械对准，异常剃刮，掩蔽，操纵多个积分时间以扩展动态范围，串扰校正，暗减法内插和漂移校正的元件，专门用于发光的多分量分析应用，均匀性校正。

5. 发明授权

US08865473B2 Luminescence detecting apparatuses and methods 有权
标题翻译：发光检测装置及方法
公开(公告)号：US08865473B2
公开(公告)日：2014-10-21
申请号：US13584628
申请日：2012-08-13
申请人： Michael Gambini , Jeff Levi , John Voyta , Bruce E. DeSimas, II , Edward Lakatos , Israel Metal , George Sabak , Yongdong Wang , Susan A. Atwood-Stone
发明人： Michael Gambini , Jeff Levi , John Voyta , John Atwood , Bruce E. DeSimas, II , Edward Lakatos , Israel Metal , George Sabak , Yongdong Wang
IPC分类号： G01N21/76 , G01T1/10 , G01N21/64 , G01N21/27 , G01N21/31 , G01N21/15
CPC分类号： G01N21/763 , G01N21/15 , G01N21/274 , G01N21/276 , G01N21/31 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/76 , G01N33/581 , G01N2021/6471 , G01N2333/90241 , Y10T436/115831
摘要： A luminescence detecting apparatus and method for analyzing luminescent samples is disclosed. A detecting apparatus may be configured so that light from luminescent samples pass through a collimator, a first lens, a filter, and a camera lens, whereupon an image is created by the optics on the charge-coupled device (CCD) camera. The detecting apparatus may further include central processing control of all operations, multiple wavelength filter wheel, and/or a robot for handling of samples and reagents.
摘要翻译：公开了一种用于分析发光样品的发光检测装置和方法。检测装置可以被配置为使得来自发光样品的光通过准直仪，第一透镜，滤光器和相机透镜，于是由电荷耦合器件（CCD）照相机上的光学器件产生图像。检测装置还可以包括用于处理样品和试剂的所有操作，多波长滤光轮和/或机器人的中央处理控制。

6. 发明授权

US08278114B2 Method for measuring luminescence at a luminescence detection workstation 有权
标题翻译：用于在发光检测工作站测量发光的方法
公开(公告)号：US08278114B2
公开(公告)日：2012-10-02
申请号：US12716219
申请日：2010-03-02
申请人： Michael Gambini , Jeff Levi , John Voyta , John Atwood , Susan Atwood-Stone, legal representative , Bruce De Simas , Edward Lakatos , Israel Metal , George Sabak , Yongdong Wang
发明人： Michael Gambini , Jeff Levi , John Voyta , John Atwood , Bruce De Simas , Edward Lakatos , Israel Metal , George Sabak , Yongdong Wang
IPC分类号： G01N21/76 , G01T1/10
CPC分类号： G01N21/763 , G01N21/15 , G01N21/274 , G01N21/276 , G01N21/31 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/76 , G01N33/581 , G01N2021/6471 , G01N2333/90241 , Y10T436/115831
摘要： A luminescence detecting apparatus and method for analyzing luminescent samples is disclosed. A detecting apparatus may be configured so that light from luminescent samples pass through a collimator, a a first lens, a filter, and a camera lens, whereupon an image is created by the optics on the charge-coupled device (CCD) camera. The detecting apparatus may further include central processing control of all operations, multiple wavelength filter wheel, and/or a robot for handling of samples and reagents.
摘要翻译：公开了一种用于分析发光样品的发光检测装置和方法。检测装置可以被配置为使得来自发光样品的光通过准直仪，第一透镜，滤光器和相机透镜，于是由电荷耦合器件（CCD）照相机上的光学器件产生图像。检测装置还可以包括用于处理样品和试剂的所有操作，多波长滤光轮和/或机器人的中央处理控制。

7. 发明申请

US20060088444A1 Luminescence detection workstation 有权
标题翻译：发光检测工作站
公开(公告)号：US20060088444A1
公开(公告)日：2006-04-27
申请号：US11251873
申请日：2005-10-18
申请人： Michael Gambini , John Voyta , John Atwood , Susan Atwood Stone , Bruce DeSimas , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
发明人： Michael Gambini , John Voyta , John Atwood , Susan Atwood Stone , Bruce DeSimas , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
IPC分类号： G01N21/64
CPC分类号： G01N21/763 , G01N21/15 , G01N21/274 , G01N21/276 , G01N21/31 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/76 , G01N33/581 , G01N2021/6471 , G01N2333/90241 , Y10T436/115831
摘要： In a luminescence detecting apparatus and method for analyzing luminescent samples, luminescent samples are placed in a plurality of sample wells in a tray, and the tray is placed in a visible-light impervious chamber containing a charge coupled device camera. In the chamber, light from the luminescent samples pass through a collimator, a Fresnel field lens, an infrared filter, and a camera lens, whereupon a focused image is created by the optics on the camera. The use of an infrared filter suppresses stray IR radiation resulting from plate phosphorescence (which can result in abnormally high backgrounds and/or alteration of the image received by the camera).
摘要翻译：在用于分析发光样品的发光检测装置和方法中，将发光样品放置在托盘中的多个样品孔中，并将该托盘放置在包含电荷耦合器件相机的可见光不透过室中。在室中，来自发光样品的光通过准直仪，菲涅尔场透镜，红外滤光镜和照相机镜头，由相机上的光学器件产生聚焦图像。使用红外滤光器可抑制板状磷光产生的杂散红外辐射（可能导致摄像机接收的图像异常高的背景和/或变化）。

8. 发明授权

US5552791A Fiber optic telemetry array calibration system 失效
标题翻译：光纤遥测阵列校准系统
公开(公告)号：US5552791A
公开(公告)日：1996-09-03
申请号：US418313
申请日：1995-04-07
申请人： Israel Metal
发明人： Israel Metal
IPC分类号： G01S7/40 , G01S7/481 , G01S7/497 , G01S13/42
CPC分类号： G01S7/4021 , G01S13/426 , G01S7/4052 , G01S2007/4069 , G01S7/4818 , G01S7/497 , G01S7/52004
摘要： An apparatus and method for calibrating a plurality of sensors having a predetermined spatial distribution. The method according to the invention herein can include the steps of transmitting a first calibration signal in a first direction through a transmission medium to at least one of the sensors; receiving from the sensor a first portion of the first calibration signal through the transmission medium; determining at least one first calibration signal parameter from the first calibration signal and the first portion according to a first predetermined method; transmitting a second calibration signal in a second direction through the transmission medium to the sensor; receiving from the sensor a second portion of the second calibration signal through the transmission medium; determining at least one second calibration signal parameter from the second calibration signal and the second portion according to a second predetermined method; and determining at least one calibration parameter from the first calibration signal parameter and the second calibration signal according to a third predetermined method. The first predetermined method can include determining a first transfer ratio of the first calibration signal to the first portion; the second predetermined method can include determining a second transfer ratio of the second calibration signal to the second portion; the third predetermined method can include determining a product of the second transfer ratio and the first transfer ratio; and the fourth predetermined method can include determining a transfer ratio of the reference calibration parameter and a test calibration parameter.
摘要翻译：一种用于校准具有预定空间分布的多个传感器的装置和方法。根据本发明的方法可以包括以下步骤：通过传输介质将第一校准信号沿第一方向发送到至少一个传感器; 通过所述传输介质从所述传感器接收所述第一校准信号的第一部分; 根据第一预定方法从所述第一校准信号和所述第一部分确定至少一个第一校准信号参数; 通过所述传输介质将第二校准信号沿第二方向发送到所述传感器; 通过所述传输介质从所述传感器接收所述第二校准信号的第二部分; 根据第二预定方法从所述第二校准信号和所述第二部分确定至少一个第二校准信号参数; 以及根据第三预定方法从所述第一校准信号参数和所述第二校准信号确定至少一个校准参数。第一预定方法可以包括确定第一校准信号与第一部分的第一传送比; 第二预定方法可以包括确定第二校准信号与第二部分的第二传送比率; 第三预定方法可以包括确定第二传送比和第一传送比的乘积; 并且第四预定方法可以包括确定参考校准参数和测试校准参数的传送比。

9. 发明授权

US4413183A Gamma camera 失效
标题翻译：伽玛相机
公开(公告)号：US4413183A
公开(公告)日：1983-11-01
申请号：US221225
申请日：1980-12-29
申请人： Israel Metal , Vincent Berluti, Jr.
发明人： Israel Metal , Vincent Berluti, Jr.
IPC分类号： G01T1/164 , G01T1/20
CPC分类号： G01T1/1642
摘要： A gamma camera having an array of photodetectors arranged to locate a flash of light produced by a scintillator in response to an incident gamma ray photon. A current pulse is produced by each one of the photodetectors in response to each incident gamma ray photon, the amount of charge produced by each one of such photodetectors being a measure of the portion of the energy of the photon detected by such one of the photodetectors. Each integrator produces a voltage which rises from an initial reference level, typically ground potential, to a peak level, such peak voltage level being representative of the amount of charge in the current pulse and hence the peak level of such voltage is a measure of the portion of the energy of the photon detected by such one of the photodetector. The outputs of the integrators are combined to provide X and Y coordinate location signals. The output of the integrator is reset to the initial reference level a predetermined time after the production of the current pulse, such predetermined time corresponding to the time the integrator output is substantially at its peak voltage and has provided a measure of the portion of the energy level of the photon detected by such one of the photodetectors coupled thereto thereby enabling such integrator to properly respond to a current pulse produced by the photodetector in response to succeeding incident gamma ray photon.
摘要翻译：一种具有光电检测器阵列的伽马照相机，其布置成响应于入射的伽马射线光子来定位由闪烁体产生的闪光。响应于每个入射的伽马射线光子，每个光电检测器产生电流脉冲，由这些光电检测器中的每一个产生的电荷量是由这种光电检测器检测到的光子的能量部分的量度。每个积分器产生从初始参考电平（通常为地电位）上升到峰值电平的电压，这种峰值电压电平代表电流脉冲中的电荷量，因此这种电压的峰值电平是由光电检测器之一检测到的光子能量的一部分。积分器的输出被组合以提供X和Y坐标位置信号。积分器的输出在产生电流脉冲之后的预定时间内复位到初始参考电平，这样的预定时间对应于积分器输出的时间基本上处于其峰值电压，并且提供了能量部分的量度由耦合到其上的这种光电探测器检测到的光子的电平使得这种积分器可以响应于随后的入射伽马射线光子而适当地响应由光电检测器产生的电流脉冲。

10. 发明授权

US4434369A Radiographic camera 失效
标题翻译：射线照相机
公开(公告)号：US4434369A
公开(公告)日：1984-02-28
申请号：US222182
申请日：1981-01-02
申请人： Israel Metal
发明人： Israel Metal
IPC分类号： G01T1/164 , G01T1/20
CPC分类号： G01T1/1642 , A61B6/4258
摘要： A radiographic camera is provided having a scintillator and a plurality of photodetectors positioned to face the scintillator for providing position electrical signals. The photodetectors are disposed at different, progressively increasing, predetermined distances from a reference point to a distal point adjacent the outer periphery of a nominal field of view of the camera. The position electrical signal provided by each one of the plurality of photodetectors has an amplitude related to the distance between such one of the photodetectors and the point of impingement of radiation on the scintillator. Circuitry, responsive to a plurality of the position electrical signals, is provided for producing an extrapolated correction electrical signal, such correction electrical signal having an amplitude representative of the distance between the point of an impingement of radiation on the scintillator and a point beyond the distal point and outside of the nominal field of view of the camera. Additional circuitry, responsive to the position electrical signals and the correction electrical signal is provided for producing a pair of electrical signals representing the location of the impingement of the radiation on the scintillator relative to a reference point. With such arrangement, the nominal field of view of the camera is extended.
摘要翻译：提供一种放射照相机，具有闪烁体和多个光电探测器，定位成面对闪烁体以提供位置电信号。光电探测器被设置在从参考点到邻近摄像机的标称视场的外周边的远端点不同的，逐渐增加的预定距离。由多个光电检测器中的每一个提供的位置电信号具有与这种光电检测器之间的距离和闪烁体上的辐射冲击点相关的振幅。提供响应于多个位置电信号的电路，用于产生外插校正电信号，该校正电信号具有表示闪烁体上的辐射点与远端之间的距离之间的距离的振幅点和外面的相机的标称视场。提供了响应于位置电信号和校正电信号的附加电路，用于产生一对电信号，该电信号表示相对于参考点的辐射在闪烁体上的冲击的位置。通过这样的布置，相机的标称视野被扩展。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式