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1. 发明授权

US06245737B1 Conjugates of antiviral proteins or peptides and virus or viral envelope glycoproteins 有权
标题翻译：抗病毒蛋白或肽与病毒或病毒包膜糖蛋白的结合物
公开(公告)号：US06245737B1
公开(公告)日：2001-06-12
申请号：US09137134
申请日：1998-08-19
申请人： Michael R. Boyd , Kirk R. Gustafson , Robert H. Shoemaker , James B. McMahon
发明人： Michael R. Boyd , Kirk R. Gustafson , Robert H. Shoemaker , James B. McMahon
IPC分类号： A61K3808
CPC分类号： C07K14/195 , A61K38/164 , A61K47/645 , A61K47/6817 , A61L2/0088 , A61L2/18 , Y10S514/841
摘要： The present invention provides antiviral proteins, peptides and conjugates, as well as methods of obtaining these agents. The antiviral proteins, peptides and conjugates of the present invention can be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the infectivity, replication and cytopathic effects of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2, in the treatment or prevention of viral infection.
摘要翻译：本发明提供抗病毒蛋白，肽和缀合物，以及获得这些试剂的方法。本发明的抗病毒蛋白质，肽和缀合物可以单独使用或与组合物中的其它抗病毒药物组合使用，例如药物组合物，以抑制病毒（例如逆转录病毒）的感染性，复制和细胞病变效应，特别是人类免疫缺陷病毒，特别是HIV-1或HIV-2，用于治疗或预防病毒感染。

2. 发明授权

US5998587A Anti-cyanovirin antibody 失效
标题翻译：抗花青素抗体
公开(公告)号：US5998587A
公开(公告)日：1999-12-07
申请号：US969249
申请日：1997-11-13
申请人： Michael R. Boyd , Kirk R. Gustafson , Robert H. Shoemaker , James B. McMahon
发明人： Michael R. Boyd , Kirk R. Gustafson , Robert H. Shoemaker , James B. McMahon
IPC分类号： C12N15/09 , A61K35/14 , A61K36/02 , A61K38/00 , A61K38/16 , A61K38/46 , A61K47/48 , A61K48/00 , A61L2/00 , A61L2/18 , A61P31/12 , C07K14/195 , C07K14/405 , C07K16/14 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/31 , C12P21/02 , C12R1/19 , C12R1/84 , C12R1/91 , C07K16/08
CPC分类号： A61K47/48315 , A61K38/164 , A61K47/48438 , A61L2/0088 , A61L2/18 , C07K14/195 , Y10S514/841
摘要： The present invention provides antiviral proteins (collectively referred to as cyanovirins), conjugates thereof, DNA sequences ending such agents, host cells containing such DNA sequences, antibodies directed to such agents, compositions comprising such agents, and methods of obtaining and using such agents.
摘要翻译：本发明提供了抗病毒蛋白质（统称为氰洛维林），其结合物，结束这些试剂的DNA序列，含有这些DNA序列的宿主细胞，针对这些试剂的抗体，包含这些试剂的组合物，以及获得和使用这些试剂的方法。

3. 发明授权

US5869522A Antiviral naphthoquinone compounds, compositions and uses thereof 失效
标题翻译：抗病毒萘醌化合物，其组合物和用途
公开(公告)号：US5869522A
公开(公告)日：1999-02-09
申请号：US455679
申请日：1995-05-31
申请人： Michael R. Boyd , John H. Cardelina, II , Kirk R. Gustafson , Laurent A. Decosterd , Ian Parsons , Lewis Pannell , James B. McMahon , Gordon M. Cragg
发明人： Michael R. Boyd , John H. Cardelina, II , Kirk R. Gustafson , Laurent A. Decosterd , Ian Parsons , Lewis Pannell , James B. McMahon , Gordon M. Cragg
IPC分类号： C07D211/46 , A61K31/00 , A61K31/12 , A61K31/35 , A61K31/352 , A61K31/37 , A61K31/505 , A61K31/52 , A61K31/70 , A61K38/00 , A61K38/17 , A61K38/21 , A61K45/06 , A61P31/00 , A61P31/12 , A61P31/18 , C07C46/00 , C07C46/10 , C07C50/32 , C07D311/46 , C07D311/54 , C07D311/56 , C07D311/92 , A01N43/16 , C07C50/04 , C07D311/02 , C07D311/04
CPC分类号： C07D311/92 , A61K31/12 , A61K31/35 , A61K31/352 , A61K31/37 , A61K31/70 , A61K38/1774 , A61K38/212 , A61K45/06 , C07C46/00 , C07C46/10 , C07C50/32 , C07D311/56
摘要： The present invention provides novel antiviral naphthoquinone compounds, which may be isolated from plants of the genus Conospermum or synthesized chemically, in accordance with the present inventive methods. The antiviral naphthoquionone compounds, derivatives thereof, and prodrugs thereof, may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2, in the treatment or prevention of viral infection.
摘要翻译：本发明提供了新的抗病毒萘醌化合物，其可以根据本发明的方法从科氏菌属植物中分离或者化学合成。抗病毒萘醌酮化合物，其衍生物及其前药可以单独使用或与组合物如药物组合物中的其它抗病毒剂组合使用，以抑制病毒如逆转录病毒，特别是人的生长或复制免疫缺陷病毒，特别是HIV-1或HIV-2，用于治疗或预防病毒感染。

4. 发明授权

US5843882A Antiviral proteins and peptides 失效
标题翻译：抗病毒蛋白和肽
公开(公告)号：US5843882A
公开(公告)日：1998-12-01
申请号：US429965
申请日：1995-04-27
申请人： Michael R. Boyd , Kirk R. Gustafson , Robert H. Shoemaker , James B. McMahon
发明人： Michael R. Boyd , Kirk R. Gustafson , Robert H. Shoemaker , James B. McMahon
IPC分类号： C12N15/09 , A61K35/14 , A61K36/02 , A61K38/00 , A61K38/16 , A61K38/46 , A61K47/48 , A61K48/00 , A61L2/00 , A61L2/18 , A61P31/12 , C07K14/195 , C07K14/405 , C07K16/14 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/31 , C12P21/02 , C12R1/19 , C12R1/84 , C12R1/91 , A61K38/08 , A61K38/10
CPC分类号： A61K47/48315 , A61K38/164 , A61K47/48438 , A61L2/0088 , A61L2/18 , C07K14/195 , Y10S514/841
摘要： The present invention provides antiviral proteins, peptides and conjugates, as well as methods of obtaining these agents. The antiviral proteins, peptides and conjugates of the present invention can be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the infectivity, replication and cytopathic effects of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2, in the treatment or prevention of viral infection.
摘要翻译：本发明提供抗病毒蛋白，肽和缀合物，以及获得这些试剂的方法。本发明的抗病毒蛋白质，肽和缀合物可以单独使用或与组合物中的其它抗病毒药物组合使用，例如药物组合物，以抑制病毒（例如逆转录病毒）的感染性，复制和细胞病变效应，特别是人类免疫缺陷病毒，特别是HIV-1或HIV-2，用于治疗或预防病毒感染。

5. 发明授权

US08741947B2 Biologically active macrolides, compositions, and uses thereof 有权
标题翻译：生物活性大环内酯类，组合物及其用途
公开(公告)号：US08741947B2
公开(公告)日：2014-06-03
申请号：US12851691
申请日：2010-08-06
申请人： Michael R. Boyd , Kirk R. Gustafson , Charles L. Cantrell
发明人： Michael R. Boyd , Kirk R. Gustafson , Charles L. Cantrell
IPC分类号： A01N43/02 , A61K31/335 , C07D309/00
CPC分类号： A61K31/395 , A61K31/365 , A61K31/7048 , C07D498/06 , C07D498/08
摘要： The present invention provides a compound of the formula (I) or (II, wherein R1 is H, alkyl, alkenyl or aryl, R2 is H, alkyl or aryl, R3 is H, a alkyl, alkenyl or aryl, R4 and R4-R8 are independently R10, C(O)R10 or SO2R10, wherein R10 is H, alkyl, alkenyl or aryl, and R9 is R9a, C(O)R9a or SO2R9a, wherein R9a is H, alkyl, alkenyl or aryl. R9a can be unsubstituted or substituted with one or more oxo(═O), OR9b, OC(O)R9b, OSO2R9b, NHR9b, NHC(O)R9b and NHSO2R9b groups. R9b is H, alkyl, alkenyl, or aryl. R9b can be unsubstituted or substituted with one or more groups such as oxo(═O), OR9c, CO2R9c, CO2R9c and OC(O)R9c. R9c is H, or a unsubstituted or substituted alkyl, alkenyl or aryl. The present invention further provides a composition comprising at least one compound of the present invention and a pharmaceutically acceptable carrier, alone or in combination with at least one additional active agent. The present invention further provides a method of treating a condition treatable by the inhibition of vacuolar-type (H+)-ATPase and a method of treating cancer.
摘要翻译：本发明提供式（I）或（II）化合物，其中R 1为H，烷基，烯基或芳基，R 2为H，烷基或芳基，R 3为H，烷基，烯基或芳基，R 4和R 4 - R8独立地为R10，C（O）R10或SO2R10，其中R10为H，烷基，烯基或芳基，R9为R9a，C（O）R9a或SO2R9a，其中R9a为H，烷基，烯基或芳基。被取代或被一个或多个氧代（= O），OR 9 b，OC（O）R 9b，OSO 2 R 9 b，NHR 9 b，NHC（O）R 9b和NHSO 2 R 9 b基团取代的R 9b是氢，烷基，链烯基或芳基。或被一个或多个基团取代，例如氧代（= O），OR 9c，CO 2 R 9c，CO 2 R 9c和OC（O）R 9c。R9c是H或未取代或取代的烷基，烯基或芳基，本发明还提供一种组合物，本发明的至少一种化合物和药学上可接受的载体，单独或与至少一种另外的活性剂组合。本发明还提供一种治疗可治疗的疾病的方法，抑制液泡型（H +） - ATPase和一种治疗癌症的方法。

6. 发明授权

US07144918B2 Biologically active macrolides, compositions, and uses thereof 有权
标题翻译：生物活性大环内酯类，组合物及其用途
公开(公告)号：US07144918B2
公开(公告)日：2006-12-05
申请号：US10333710
申请日：2001-07-24
申请人： Michael R. Boyd , Kirk R. Gustafson , Charles L. Cantrell
发明人： Michael R. Boyd , Kirk R. Gustafson , Charles L. Cantrell
IPC分类号： A01N43/02 , A61K31/335 , C07D309/00
CPC分类号： A61K31/395 , A61K31/365 , A61K31/7048 , C07D498/06 , C07D498/08
摘要： The present invention provides a compound of the formula (I).The present invention further provides a composition comprising at least one compound of the present invention and a pharmaceutically acceptable carrier, alone or in combination with at least one additional active agent. The present invention further provides a method of treating a condition treatable by the inhibition of vacuolar-type (H+)-ATPase and a method of treating cancer.
摘要翻译：本发明提供式（I）的化合物。本发明还提供包含至少一种本发明化合物和药学上可接受的载体的组合物，其单独或与至少一种另外的活性剂组合。本发明还提供了通过抑制液泡型（H +）-ATP酶处理可治疗的病症的方法和治疗癌症的方法。

7. 发明授权

US5859049A Calanolide and related antiviral compounds, compositions, and uses thereof 失效
公开(公告)号：US5859049A
公开(公告)日：1999-01-12
申请号：US653006
申请日：1996-05-24
申请人： Michael R. Boyd , John H. Cardellina, II , Kirk R. Gustafson , James B. McMahon , Richard W. Fuller , Gordon M. Cragg , Yoel Kashman , Doel Soejarto
发明人： Michael R. Boyd , John H. Cardellina, II , Kirk R. Gustafson , James B. McMahon , Richard W. Fuller , Gordon M. Cragg , Yoel Kashman , Doel Soejarto
IPC分类号： A61K31/365 , A61K31/366 , A61K36/18 , A61K45/06 , A61P31/12 , A61P31/18 , C07D493/14 , C07D493/22 , A61K31/37
CPC分类号： C07D493/14 , C07D493/22
摘要： The present invention provides novel antiviral compounds, refered to as calanolides, related compounds, and their derivatives, which may be isolated from plants, or derived from compounds from plants, of the genus Calophyllum in accordance with the present inventive method. The compounds and their derivatives may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2.

8. 发明授权

US5783598A Antiretroviral naphthoquinone compounds compositions and uses thereof 失效
标题翻译：抗逆转录病毒萘醌化合物组合物及其用途
公开(公告)号：US5783598A
公开(公告)日：1998-07-21
申请号：US613162
申请日：1996-03-08
申请人： Michael R. Boyd , John H. Cardellina, II , Kirk R. Gustafson , Laurent A. Decosterd , Ian Parson , Lewis Pannell , James B. McMahon , Gordon M. Cragg
发明人： Michael R. Boyd , John H. Cardellina, II , Kirk R. Gustafson , Laurent A. Decosterd , Ian Parson , Lewis Pannell , James B. McMahon , Gordon M. Cragg
IPC分类号： C07D211/46 , A61K31/00 , A61K31/12 , A61K31/35 , A61K31/352 , A61K31/37 , A61K31/505 , A61K31/52 , A61K31/70 , A61K38/00 , A61K38/17 , A61K38/21 , A61K45/06 , A61P31/00 , A61P31/12 , A61P31/18 , C07C46/00 , C07C46/10 , C07C50/32 , C07D311/46 , C07D311/54 , C07D311/56 , C07D311/92 , C07D407/14
CPC分类号： C07D311/92 , A61K31/12 , A61K31/35 , A61K31/352 , A61K31/37 , A61K31/70 , A61K38/1774 , A61K38/212 , A61K45/06 , C07C46/00 , C07C46/10 , C07C50/32 , C07D311/56
摘要： The present invention provides novel antiviral naphthoquinone compounds, which may be isolated from plants of the genus Conospermum or synthesized chemically, in accordance with the present inventive methods. The antiviral naphthoquionone compounds, derivatives thereof, and prodrugs thereof, may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2, in the treatment or prevention of viral infection.
摘要翻译：本发明提供了新的抗病毒萘醌化合物，其可以根据本发明的方法从科氏菌属植物中分离或者化学合成。抗病毒萘醌酮化合物，其衍生物及其前药可以单独使用或与组合物如药物组合物中的其它抗病毒剂组合使用，以抑制病毒如逆转录病毒，特别是人的生长或复制免疫缺陷病毒，特别是HIV-1或HIV-2，用于治疗或预防病毒感染。

9. 发明授权

US08278348B2 Chondropsin-class antitumor V-atpase inhibitor compounds, compositions and methods of use thereof 有权
标题翻译：软骨素类抗肿瘤剂V-atpase抑制剂化合物，组合物及其使用方法
公开(公告)号：US08278348B2
公开(公告)日：2012-10-02
申请号：US12909979
申请日：2010-10-22
申请人： Michael R. Boyd , Kirk R. Gustafson
发明人： Michael R. Boyd , Kirk R. Gustafson
IPC分类号： A61K31/35 , A61P35/00 , A61P35/02 , A61P25/28 , A61P19/10 , A61P27/06 , A61P15/08 , A61P13/00 , A61P31/10 , A61P35/04 , A61P19/08
CPC分类号： C07D498/08 , C07D309/06
摘要： A composition comprising a substantially purified compound of the formula: in combination with at least one additional therapeutic agent, and methods of preventing or treating cancer and a condition treatable by the inhibition of vacuolar-type (H+)-ATPase.
摘要翻译：一种组合物，其包含基本上纯化的下式的化合物：与至少一种另外的治疗剂组合，以及预防或治疗癌症的方法以及通过抑制液泡型（H +）-ATPase可治疗的病症。

10. 发明申请

US20110034547A1 CHONDROPSIN-CLASS ANTITUMOR V-ATPASE INHIBITOR COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF 有权
标题翻译：抗抑郁剂类抗生素V-ATP酶抑制剂化合物，组合物及其使用方法
公开(公告)号：US20110034547A1
公开(公告)日：2011-02-10
申请号：US12909979
申请日：2010-10-22
申请人： Michael R. Boyd , Kirk R. Gustafson
发明人： Michael R. Boyd , Kirk R. Gustafson
IPC分类号： A61K31/35 , A61K31/625 , A61P35/00 , A61P35/02 , A61P25/28 , A61P19/10 , A61P27/06 , A61P15/08 , A61P13/00 , A61P31/10 , A61P35/04 , A61P19/08
CPC分类号： C07D498/08 , C07D309/06
摘要： A composition comprising a substantially purified compound of the formula: in combination with at least one additional therapeutic agent, and methods of preventing or treating cancer and a condition treatable by the inhibition of vacuolar-type (H+)-ATPase.
摘要翻译：一种组合物，其包含基本上纯化的下式的化合物：与至少一种另外的治疗剂组合，以及预防或治疗癌症的方法以及通过抑制液泡型（H +）-ATP酶可治疗的病症。

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