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1. 发明申请

US20060159707A1 Lawsonia derived gene and related FlgE polypeptides, peptides and proteins and their uses 审中-公开
标题翻译： Lawsonia衍生的基因和相关的FlgE多肽，肽和蛋白质及其用途
公开(公告)号：US20060159707A1
公开(公告)日：2006-07-20
申请号：US11386138
申请日：2006-03-21
申请人： Michael Panaccio , Everett Rosey , Meri Sinistaj , Detlef Hasse , Jim Parsons , Robert Ankenbauer
发明人： Michael Panaccio , Everett Rosey , Meri Sinistaj , Detlef Hasse , Jim Parsons , Robert Ankenbauer
IPC分类号： A61K39/02 , C07H21/04 , C12P21/06 , C07K14/195 , C12N1/21 , C12N15/74
CPC分类号： C07K14/195 , A61K39/00 , C07K14/205 , C12Q1/689
摘要： The present invention relates generally to therapeutic compositions for the treatment and/or prophylaxis of intestinal disease conditions in animals and birds caused or exacerbated by Lawsonia intracellularis or similar or otherwise related microorganism. In particular, the present invention provides a novel gene derived from Lawsonia intracellularis which encodes an immunogenic FlgE peptide, polypeptide or protein that is particularly useful as an antigen in vaccine preparation for conferring humoral immunity against Lawsonia intracellularis and related pathogens in animal hosts. The present invention is also directed to methods for the treatment and/or prophylaxis of such intestinal disease conditions and to diagnostic agents and procedures for detecting Lawsonia intracellularis or similar or otherwise related microorganisms.
摘要翻译：本发明一般涉及用于治疗和/或预防由劳森氏菌或类似物或其它相关微生物引起或加剧的动物和鸟类中肠道疾病状况的治疗组合物。特别地，本发明提供了源自细胞内劳森氏菌的新基因，其编码免疫原性FlgE肽，多肽或蛋白质，其特别可用作疫苗制剂中的抗原，以赋予动物宿主中针对胞内劳森氏菌和相关病原体的体液免疫。本发明还涉及用于治疗和/或预防这种肠道疾病状况的方法以及用于检测细胞内劳森氏菌或相似或相关微生物的诊断剂和方法。

2. 发明申请

US20050143561A1 LAWSONIA INTRACELLULARIS PROTEINS, AND RELATED METHODS AND MATERIALS 审中-公开
标题翻译： LAWSONIA细胞内蛋白质，以及相关方法和材料
公开(公告)号：US20050143561A1
公开(公告)日：2005-06-30
申请号：US10449648
申请日：2003-05-30
申请人： Everett Rosey
发明人： Everett Rosey
IPC分类号： A61K39/00 , C07K14/195 , C07K14/205 , C12N1/21 , C12N9/52 , A61K39/02 , A61K38/00 , C07K1/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00
CPC分类号： C07K14/195 , A61K39/00 , A61K2039/522 , A61K2039/523 , A61K2039/53 , C07K14/205 , C07K2319/00 , C12N9/52
摘要： Isolated polynucleotide molecules contain a nucleotide sequence that encodes a L. intracellularis HtrA, PonA, HypC, LysS, YcfW, ABC1, or Omp100 protein, a substantial portion of the sequences, or a homologous sequence. Related polypeptides, immunogenic compositions and assays are described.
摘要翻译：分离的多核苷酸分子含有编码细胞内源性细胞因子HtrA，PonA，HypC，LysS，YcfW，ABC1或Omp100蛋白，大部分序列或同源序列的核苷酸序列。描述相关多肽，免疫原性组合物和测定。

3. 发明申请

US20060233823A1 Nucleic acids and proteins of the mycoplasma hyopneumoniae mhp3 gene and uses thereof 审中-公开
标题翻译：猪肺炎支原体mhp3基因的核酸和蛋白质及其用途
公开(公告)号：US20060233823A1
公开(公告)日：2006-10-19
申请号：US11069093
申请日：2006-07-03
申请人： Kendall King , Rebecca Madura , Everett Rosey
发明人： Kendall King , Rebecca Madura , Everett Rosey
IPC分类号： C07K14/35 , A61K39/02
CPC分类号： A61K39/0241 , A61K2039/53 , C07K14/30 , C07K14/35 , C07K2319/00
摘要： The present invention relates to mhp3 nucleic acids and proteins encoded by the foregoing. The present invention further relates to novel apoprotein antigens encoded by mhp3 for use in vaccines to prevent and treat diseases caused by infection with Mycoplasma hyopneumoniae. The invention further relates to methods for the recombinant production of such antigens.
摘要翻译：本发明涉及由上述编码的mhp3核酸和蛋白质。本发明还涉及由mhp3编码的用于疫苗预防和治疗由猪肺炎支原体感染引起的疾病的新型载脂蛋白抗原。本发明还涉及重组产生这种抗原的方法。

4. 发明授权

US06713071B1 Proteins from actinobacillus pleuropneumoniae 失效
标题翻译：来自胸膜肺炎放线杆菌的蛋白质
公开(公告)号：US06713071B1
公开(公告)日：2004-03-30
申请号：US09418980
申请日：1999-10-14
申请人： Robert G. Ankenbauer , Mary Jo Baarsch , Manuel Campos , Robin Keich , Everett Rosey , Brian Suiter , Lynn Warren-Stewart
发明人： Robert G. Ankenbauer , Mary Jo Baarsch , Manuel Campos , Robin Keich , Everett Rosey , Brian Suiter , Lynn Warren-Stewart
IPC分类号： A61K3902
CPC分类号： C07K14/285 , A61K39/00 , A61K39/102 , A61K2039/52 , G01N33/56911
摘要： The present invention is directed to five novel, low molecular weight proteins from Actinobacillus pleuropneumoniae (APP), which are capable of inducing, or contributing to the induction of, a protective immune response in swine against APP. The present invention is further directed to polynucleotide molecules having nucleotide sequences that encode the proteins, as well as vaccines comprising the proteins or polynucleotide molecules, and methods of making and using the same.
摘要翻译：本发明涉及来自胸膜肺炎放线杆菌（APP）的五种新颖的低分子量蛋白质，其能诱导或有助于诱导针对APP的猪的保护性免疫应答。本发明还涉及具有编码蛋白质的核苷酸序列的多核苷酸分子以及包含蛋白质或多核苷酸分子的疫苗以及制备和使用该蛋白质的方法。

5. 发明申请

US20050232939A1 Novel therapeutic compositions for treating infection by Lawsonia spp. 审中-公开
标题翻译：用于治疗劳森氏菌感染的新型治疗组合物
公开(公告)号：US20050232939A1
公开(公告)日：2005-10-20
申请号：US11021823
申请日：2004-12-22
申请人： Everett Rosey , Kendall King , Robert Good , Richard Strugnell
发明人： Everett Rosey , Kendall King , Robert Good , Richard Strugnell
IPC分类号： A61K39/00 , C07K14/195 , C07K14/205 , C12N1/21 , A61K39/02 , C07H21/04 , C12N15/74
CPC分类号： C07K14/195 , A61K39/00 , A61K2039/53 , C07K14/205
摘要： The present invention relates generally to therapeutic compositions for the treatment and/or prophylaxis of intestinal disease conditions in animals and birds caused or exacerbated by Lawsonia intracellularis or similar or otherwise related microorganism. In particular, the present invention provides a novel gene derived from Lawsonia intracellularis, which encodes an immunogenic polypeptide that is particularly useful as an antigen in a vaccine preparation for conferring humoral immunity against Lawsonia intracellularis and related pathogens in animal hosts, wherein said polypeptide is selected from the group consisting of flhB, fliR, ntrC, glnH, motA, motB, tlyC, ytfM, and ytfN polypeptides, or a homologue, analogue or derivative of any one or more of said polypeptides. The present invention is also directed to methods for the treatment and/or prophylaxis of such intestinal disease conditions and to diagnostic agents and procedures for detecting Lawsonia intracellularis or similar or otherwise related microorganisms.
摘要翻译：本发明一般涉及用于治疗和/或预防由劳森氏菌或类似物或其它相关微生物引起或加剧的动物和鸟类中肠道疾病状况的治疗组合物。特别地，本发明提供了源自细胞内劳森氏菌的新基因，其编码免疫原性多肽，其特别可用作疫苗制剂中的抗原，用于赋予动物宿主中对细胞内劳森氏菌和相关病原体的体液免疫，其中选择所述多肽来自由flhB，fliR，ntrC，glnH，motA，motB，tlyC，ytfM和ytfN多肽组成的组，或任何一种或多种所述多肽的同源物，类似物或衍生物。本发明还涉及用于治疗和/或预防这种肠道疾病状况的方法以及用于检测细胞内劳森氏菌或相似或相关微生物的诊断剂和方法。

6. 发明申请

US20070116722A1 Ovo vaccination of campylobacter in avian species 有权
标题翻译：禽流感疫苗接种疫苗
公开(公告)号：US20070116722A1
公开(公告)日：2007-05-24
申请号：US10578162
申请日：2004-11-22
申请人： Tonia Agin , Everett Rosey , Frederick Weber
发明人： Tonia Agin , Everett Rosey , Frederick Weber
IPC分类号： A61K39/02
CPC分类号： A61K39/105 , A61K2039/552
摘要： The present invention provides a method of inducing an immune response against Campylobacter in an avian species, especially a domesticated avian species such as chicken, turkey, duck, goose and quail, by administering, in ovo, live cells of Campylobacter.
摘要翻译：本发明提供了一种在鸟类物种，特别是驯养的禽类物种如鸡，火鸡，鸭，鹅和鹌鹑中诱导针对弯曲杆菌的免疫应答的方法，通过在卵内施用弯曲杆菌的活细胞。

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